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1.
Prensa méd. argent ; 107(3): 129-134, 20210000. tab, ilus
Article in Spanish | LILACS, BINACIS | ID: biblio-1359534

ABSTRACT

La enfermedad por arañazo de gato (EAG) es una zoonosis emergente causada por Bartonella henselae. Puede presentarse de forma atípica, incluyendo meningitis, neuroretinitis, endocarditis y compromiso hepatoesplénico, lo cual es poco frecuente en adultos inmunocompetentes. Su manejo terapéutico es controvertido dada la ausencia de ensayos aleatorizados al respecto. Se describen 5 casos de EAG con compromiso hepato-esplénico, donde la correcta anamnesis epidemiológica permitió la sospecha diagnóstica, evitando la realización de procedimientos invasivos en la mayoría de los casos. La posibilidad de realización de PCR y serología para Bartonella spp. fueron de vital importancia


Cat scratch disease (CSD) is an emerging zoonosis caused by Bartonella henselae. It can occur atypically including meningitis, neuroretinitis, endocarditis and hepatosplenic involvement, a rare occurrence in immunocompetent adults. Therapeutic management is controversial, supported by case series and retrospective data published literature. Five cases of CSD with hepatosplenic involvement are described. The correct clinical and epidemiological anamnesis allow the diagnostic and avoid the performance of invasive procedures in most cases. The possibility of performing Bartonella spp PCR and serology is crucial


Subject(s)
Humans , Adult , Middle Aged , Rifampin/therapeutic use , Cat-Scratch Disease/diagnosis , Cat-Scratch Disease/therapy , Ultrasonography , Immunocompromised Host , Azithromycin/therapeutic use , Blood Culture , Duration of Therapy , Liver Abscess/therapy
2.
Rev. Ateneo Argent. Odontol ; 63(2): 39-54, nov. 2020. ilus
Article in Spanish | LILACS | ID: biblio-1150748

ABSTRACT

La búsqueda por encontrar métodos para acortar la duración de los tratamientos de ortodoncia tiene un pasado reciente, un presente y un futuro. Las fuerzas ortodóncicas que se ejercen sobre la membrana periodontal producen movimientos dentarios por modificaciones histológicas y biomoleculares. El conocimiento de los procesos biológicos da lugar a implementar cambios para favorecer la aceleración de los procesos resortivos y neoformativos. El objetivo de esta publicación es hacer una breve síntesis de lo acontecido con este tema y exponer el procedimiento de las micro-osteoperforaciones (MOPs) como una opción complementaria al tratamiento de ortodoncia convencional. Aún no existe suficiente apoyo de ensayos clínicos en humanos para aseverar su éxito. Más aún, distintos autores publican conclusiones contradictorias. Es de esperar que, en breve, nuevas investigaciones contribuyan a respaldarlo o desestimarlo (AU)


The quest to find methods to shorten the duration of orthodontic treatments has a recent past, a present, and a future. Orthodontic forces exerted on the periodontal membrane produce tooth movements by histological and biomolecular modifications. Knowledge of biological processes results in changes to promote the acceleration of spring and neoformative processes. The objective of this publication is to make a brief synthesis of what happened with this topic and expose the micro-osteoperforations (MOPs) procedure as a complementary option to conventional orthodontic treatment. There is not yet enough support from human clinical trials to assert its success. Moreover, different authors publish conflicting conclusions. It is to be expected that, shortly, further investigations will help to support or dismiss it (AU)


Subject(s)
Humans , Tooth Movement Techniques/methods , Biological Phenomena , Oral Surgical Procedures , Microsurgery , Osteotomy/methods , Bone Resorption/physiopathology , Low-Level Light Therapy , RANK Ligand , Duration of Therapy
3.
Rev. cir. (Impr.) ; 72(2): 101-106, abr. 2020. tab, graf
Article in Spanish | LILACS | ID: biblio-1092899

ABSTRACT

Resumen Introducción El cáncer diferenciado de tiroides (CDT) presenta un aumento a nivel mundial. El uso selectivo de terapia con radioyodo (RAI) es un pilar de su tratamiento. Su efecto terapéutico se debe a la radiación beta, mientras que la gamma hace que sea necesaria la hospitalización para limitar la exposición de terceros. Objetivo Describir la seguridad de la administración de altas dosis de RAI en pacientes con CDT. Materiales y Método Estudio retrospectivo descriptivo. Se incluyó a todos los pacientes con diagnóstico de CDT que requirieron hospitalización para administración de RAI ≥ 30 mCi en el Hospital Regional de Talca (HRT) entre agosto-diciembre de 2018. Resultados Durante el período descrito 10 pacientes recibieron RAI bajo régimen hospitalario. La mediana de dosis de RAI administrada fue de 100 mCi (rango: 50-150 mCi). Todos los pacientes fueron manejados con asilamiento estricto. El promedio de hospitalización fue 28 horas, siendo dados de alta al reportar una tasa de dosis absorbida < 70 µSv/h a 1 metro. Se entregaron instrucciones al alta para minimizar el riesgo de irradiación o contaminación a terceras personas. Conclusiones Nuestro protocolo de administración de RAI permite tratar de manera segura a pacientes con CDT disminuyendo la exposición a radiación de terceros. Las salas de asilamiento de radioyodoterapia, podrían dar cobertura al 100% de la demanda de terapia con RAI en CDT a nivel local.


Introduction Differentiated thyroid cancer (CDT) presents an increase in global levels. The selective use of radioiodine therapy (RAI) is a pillar of its treatment. Its therapeutic effect is due to beta radiation, while gamma makes hospitalization necessary to limit exposure. Aim To describe the safety treated with RAI inpatients and the functioning of the radioactive isolation rooms of our center. Materials and Method Retrospective descriptive study. All patients diagnosed with CDT who required RAI therapy under a hospital regimen at the Regional Hospital of Talca (HRT) between August-December 2018 were included. Results During the period described, 10 patients were treated. The median dose of RAI administered was 100 mCi (range: 50-150 mCi). The average of hospitalization was 28 hours, being discharged when reporting an absorbed dose rate < 70 μSv/h at 1 meter, giving the patient instructions, so that they follow to minimize the risk of irradiation or contamination of people in their environment. Conclusions Our RAI administration protocol allows patients with CDT to be treated safely. The radioactive isolation rooms could cover 100% of the demand for RAI therapy in CDT at the local level.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Thyroid Neoplasms/radiotherapy , Iodine Radioisotopes/therapeutic use , Duration of Therapy , Iodine Radioisotopes/administration & dosage
4.
Rev. Hosp. Ital. B. Aires (2004) ; 40(1): 4-10, mar. 2020. ilus, tab
Article in Spanish | LILACS | ID: biblio-1100756

ABSTRACT

Se realizó un estudio prospectivo y descriptivo, incluyendo 103 pacientes que fueron tratados por cáncer de laringe en etapa inicial (T1-T2) con cirugía transoral. De ellos, 55 se diagnosticaron en estadio T1, 16 en estadio T1-b y 32 en estadio T2. El control local inicial (CLI) en pacientes con tumores malignos de laringe estadificados T1 fue 91%, el control local con rescate (CLR) 96%, la preservación de la función de la laringe (PFL) 93% y la sobrevida específica 96%. En T1-b, el CLI fue 81%, el CLR 94%, la PFL 94% y la sobrevida específica 94%. En T2, el CLI fue 63%, el CLR 94%, la PFL 72% y la sobrevida específica 78%. La cirugía transoral en cáncer de laringe con T inicial tiene resultados oncológicos similares a otros tratamientos (cirugía externa o radioterapia), pero consideramos que es la mejor opción por su baja morbilidad, menor duración del tratamiento, y porque deja abiertas todas las posibilidades para tratar posibles recurrencias. (AU)


A prospective and descriptive study was conducted, including 103 patients who were treated for early stage laryngeal cancer (T1-T2) with transoral surgery. Of these, 55 were diagnosed in stage T1, 16 in stage T1-b and 32 in stage T2. The initial local control (CLI) in patients with malignant T1 laryngeal tumors was: 91%, local control with rescue (CLR) 96%, preservation of larynx function (PFL) 93% and specific survival 96%. In T1-b the CLI was 81%, the CLR 94%, the PFL 94% and the specific survival 94%. In T2 the CLI was 63%, the CLR 94%, the PFL 72% and the specific survival 78%. Transoral surgery in laryngeal cancer with initial T has oncological results similar to other treatments (external surgery or radiotherapy), but we consider that it is the best option because of its low morbidity, shorter duration of treatment, and because it leaves open all the possibilities to treat possible recurrences. (AU)


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Aged, 80 and over , Laryngeal Neoplasms/surgery , Neoplasm Recurrence, Local/prevention & control , Postoperative Complications/prevention & control , Surgical Procedures, Operative/methods , Vocal Cords/pathology , Voice Quality , Tracheostomy/statistics & numerical data , Laryngeal Neoplasms/classification , Laryngeal Neoplasms/diagnosis , Laryngeal Neoplasms/physiopathology , Laryngeal Neoplasms/mortality , Laryngeal Neoplasms/radiotherapy , Prospective Studies , Epiglottis/pathology , Duration of Therapy , Intubation, Gastrointestinal/statistics & numerical data
5.
Evid. actual. práct. ambul ; 23(1): e002045, 2020. tab
Article in Spanish | LILACS | ID: biblio-1103172

ABSTRACT

Una mujer de 36 años, diagnosticada con síndrome de intestino irritable a predominio de diarrea (SII-D) acude a la consulta médica. Ella pregunta si el uso de probióticos sería útil para controlar los episodios de diarrea, ya que los fármacos con los que está siendo tratada no le resultan eficaces. Se realizó una búsqueda bibliográfica con el objetivo de en contrar evidencia en respuesta a su consulta, tras la cual se seleccionaron dos ensayos clínicos y una revisión sistemática. Se evidenciaron diversos resultados en cuanto al uso de probióticos en el SII-D y se discutieron los riesgos y beneficios del tratamiento, así como las implicancias en la vida de la paciente. (AU)


A 36-year-old woman diagnosed with diarrhea predominant irritable bowel syndrome (D-IBS) goes to meet the doctor. She raises whether the use of probiotics would be useful for controlling diarrhea episodes, since the drugs which she is being treated with, are not effective. A bibliographic search was conducted with the objective of finding evidence in response toher query. Two clinical trials and a systematic review were found. Variable results were found regarding the use of probioticsin D-IBS. The risks and benefits of the treatment were discussed, as well as the implications in the patient's lifestyle. (AU)


Subject(s)
Humans , Female , Adult , Probiotics/therapeutic use , Irritable Bowel Syndrome/therapy , Diarrhea/therapy , Parasympatholytics/therapeutic use , Quality of Life , Review Literature as Topic , Abdominal Pain/therapy , Cholestyramine Resin/therapeutic use , Clinical Trials as Topic , Probiotics/administration & dosage , Probiotics/adverse effects , Irritable Bowel Syndrome/diagnosis , Irritable Bowel Syndrome/etiology , Diarrhea/complications , Duration of Therapy , Gastrointestinal Motility/immunology , Intestinal Mucosa/immunology , Loperamide/therapeutic use , Antidepressive Agents/therapeutic use
6.
Borno Med. J. (Online) ; 17(1): 1-8, 2020. tab
Article in English | AIM, AIM | ID: biblio-1259676

ABSTRACT

Background: Appropriate infant feeding is still a challenge to HIV-positive mothers especially in the developing world despite their desire to breast feeding beyond the WHO recommended 12 months' duration. Objective: To determine the duration of breast feeding and correlate with outcome of HIV-exposed infants in UDUTH, Sokoto. Methods: This descriptive observational study was conducted among HIV-exposed infants attending Paediatric ART(PMTCT) clinic, UDUTH, Sokoto. The demographics, infant post-exposure prophylaxis, duration of breast feeding and results of early infant diagnosis (EID) of the infants using HIV-DNA PCR machine; and maternal highly active antiretroviral therapy (HAART) history were documented. The data were analyzed using SPSS version 24.0. A p-value of ≤0.05 was taken as significant. Results: One hundred and sixty-three HIV-positive mother-infant pairs were studied, 103(61.7%) of the HIV-positive mothers were aged 25-34 years, 105(62.9%) were of lower socio-economic class and 94(56.3%) had informal education. One hundred and fifteen (62.5%) were on TDF/3TC/EFV and 143 (85.6%) were on HAARTs prior to the index pregnancy. One hundred and sixty-three of the HIV-exposed infants studied were breast-fed and 165 (98.8%) had nevirapine as infant PEP. The mean duration of breast feeding among HIV-exposed infants was 13.2(±3.5) months with a range 6 ­ 20 months. Ninety-eight (60.1%) infants were breastfed beyond 12months. All the HIV-exposed infants were not infected at the end of breastfeeding for 12 months or more. Conclusion: Majority of the HIV-positive mother's breastfed beyond WHO recommended 12 months and their infants were uninfected. This may support the upward review of the duration of breast feeding of HIV-exposed infants in our community


Subject(s)
Breast Feeding , Duration of Therapy , HIV Seropositivity , Infant , Nigeria , Patient Outcome Assessment
7.
Int. j. odontostomatol. (Print) ; 13(3): 321-324, set. 2019. tab, graf
Article in Spanish | LILACS | ID: biblio-1012430

ABSTRACT

RESUMEN: La duración de los tratamientos de ortodoncia siempre ha sido una de las mayores preocupaciones, tanto en los pacientes como en los Ortodoncistas. El proposito de esta investigacion fue determinar la magnitud de las inasistencias a los controles por parte de los pacientes y como estas y otras variables, influyen en la duración de los tratamientos de Ortodoncia en el Centro de Salud Familiar (CESFAM) Dr. Victor Manuel Fernandez, Servicio de Salud de Concepcion, Chile. Se realizo un estudio descriptivo, de tipo transversal, retrospectivo, en el que se utilizaron las fichas clínicas de todos los pacientes que fueron dados de alta por los Ortodoncistas del CESFAM Dr. V. M. F. durante el año 2017. La tabulación se realizó en Microsoft Excel y el análisis estadístico se hizo en InfoStat 17. Se incluyeron 246 pacientes, con una edad de ingreso promedio de 13,6 años. La maloclusion predominante fue la Clase I de Angle (71 %). Estos pacientes tuvieron una duracion de tratamiento promedio de 33,9 meses. Se concluyó que a mayor cantidad de inasistencias, el tratamiento de ortodoncia tuvo una duración mayor.


ABSTRACT: The duration of orthodontic treatments has always been one of the biggest concerns, both in patients and for orthodontists. The purpose of this investigation was to determine the magnitude of the absences to the controls of the patients and how they influence the duration of the orthodontic treatments in the CESFAM Dr. Victor Manuel Fernandez, Concepcion, Chile. A descriptive, cross-sectional, retrospective study was carried out, in which the clinical records of all patients discharged by the Orthodontists of CESFAM Dr. V.M.F. during the year 2017 were analyzed. The tabulation was performed in Microsoft Excel and the statistical analysis was carried out in InfoStat 17. In total, 246 patients were included, with an average age of admission of 13.6 years. The predominant malocclusion was Class I of Angle (71 %). These patients had an average treatment duration of 33.9 months. It was further concluded that the length of orthodontic treatment, was also affected by the increased number of times patients failed to show for treatment.


Subject(s)
Humans , Male , Female , Adolescent , Community Health Centers , Orthodontic Appliances, Fixed , Molar , Appointments and Schedules , Database Management Systems/instrumentation , Software , Chile , Public Health , Models, Statistical , Treatment Outcome , No-Show Patients/statistics & numerical data , Duration of Therapy , Malocclusion
8.
Clinics ; 74: e1197, 2019. tab
Article in English | LILACS | ID: biblio-1039566

ABSTRACT

OBJECTIVES: An objective of clinical autopsies is to determine the final cause of death and the pathological changes that may have triggered it. Despite advances in Medicine, the level of discrepancy between clinical and autopsy diagnoses remains significant. The aim of this study was to compare the data obtained from autopsies carried out at the São Bernardo do Campo/SP Death Verification Section with clinical diagnostic hypotheses proposed during medical care. METHOD: This was a retrospective study involving the comparison of necroscopic reports issued by the São Bernardo do Campo/São Paulo Death Verification Section in 2014 and 2015 and the Cadaver Referral Guides completed by attending physicians prior to the necroscopic examination. RESULTS: A total of 465 cases were analyzed. In general, discrepancies between the clinical diagnostic hypothesis and the autopsy diagnosis occurred in 28% of the cases. A logistic regression model, with diagnostic discrepancy as a response variable and sex, age, duration of care, type of institution providing medical care and organ system as explanatory variables, was fit to the data; the results indicated that all explanatory variables with the exception of organ system are not significant (p>0.132). CONCLUSIONS: Discrepancies between clinical diagnostic hypotheses and autopsy diagnoses continue to occur, despite new developments in complementary examinations and therapies. The odds of a discrepancy when patients present with diseases of the cardiac system are greater than those when there are problems in the vascular, endocrine and neurological systems.


Subject(s)
Humans , Female , Infant , Child, Preschool , Child , Adolescent , Adult , Middle Aged , Aged , Young Adult , Autopsy/statistics & numerical data , Diagnostic Errors/statistics & numerical data , Reference Values , Time Factors , Logistic Models , Retrospective Studies , Cause of Death , Age Factors , Duration of Therapy
9.
Rev. med. Risaralda ; 24(2): 75-80, jul.-dic. 2018. tab, graf
Article in Spanish | LILACS, COLNAL | ID: biblio-985674

ABSTRACT

Resumen Introducción: El uso de antibióticos, enfrenta grandes problemas que deben ser resueltos en pro de la calidad de vida de los pacientes buscando un equilibrio en el costo-efectividad. Los análisis farmacoeconómicos son una herramienta útil para determinar qué fármacos deben estar disponibles en guías farmacoterapéuticas. Aunque el método de selección de fármacos varía en cada institución, el principio general es que deben ser elegidos los más efectivos al menor costo. El objetivo fue establecer el costo de los tratamientos, la evaluación de susceptibilidad y resistencia a los antibióticos en una Unidad de Cuidados Intensivos de Montería. Métodos: La muestra se integró por todos los pacientes ingresados a la UCI, que recibieron tratamiento antibiótico, durante doce meses. De las historias clínicas, se identificaron y se clasificaron los tratamientos aplicados, duración del tratamiento, costo del tratamiento por paciente, consumos por paciente de los antibióticos con el fin de estimar los costos de los antibióticos utilizados en pacientes de la UCI. Resultados: Se registraron 670 ingresos, de los cuales el 48,40% recibieron terapia antimicrobiana. Las principales causas de ingreso a la UCI fueron: evento coronario agudo (16,69%), insuficiencia respiratoria aguda (13,83%), sepsis (12,48%). Los microorganismos encontrados fueron: E. coli, K. pneumoniae, S. aureus, P. aeruginosa, S. epidermidis, A. baumanni, A. haemolyticus. Conclusión: Los sistemas estandarizados de vigilancia para el uso de antibióticos es una herramienta esencial en el uso racional y en el control de la resistencia antibacteriana.


Abstract The use of antibiotics, faces major problems that must be solved to ensure high-quality care of patients, which seeking a balance in cost-effectiveness. Pharmacoeconomics analyzes are a useful tool for determining which drugs should be available for pharmacotherapy strategies. Although the method of drug selection varies in each institution, the general principle is that the most effective ones should be chosen amongst the lowest-cost. The objective was to establish the cost of treatments, susceptibility assessment and resistance to antibiotics in an Intensive Care Unit in Montería. The sample was integrated by all the patients admitted to the ICU, who received antibiotic treatment, during twelve months. From the clinical records served, the treatments applied, duration of treatment, cost of treatment per patient, consumption per patient of the antibiotics were identified and classified to estimate the costs in relation to the therapeutic effectiveness of the antibiotics used in patients in the ICU. A total of 670 patients were registered, of whom 48,40% received antimicrobial therapy. The main causes of ICU admission were: acute coronary event (16,69%), acute respiratory failure (13,83%), sepsis (12,48%). The strains were: E. coli, K. pneumoniae, S. aureus, P. aeruginosa, S. epidermidis, A. baumanni, A. haemolyticus. Standardized surveillance systems for the use of antibiotics are an essential strategic intervention for the rational use and control antimicrobial resistance.


Subject(s)
Humans , Drug Resistance, Microbial , Sepsis , Disease Susceptibility , Intensive Care Units , Quality of Life , Therapeutics , Pharmaceutical Preparations , Colombia , Economics, Pharmaceutical , Surveillance , Escherichia coli , Duration of Therapy , Anti-Bacterial Agents
10.
HU rev ; 37(4): 403-407, dez. 2011.
Article in Portuguese | LILACS | ID: lil-661227

ABSTRACT

O objetivo deste estudo foi avaliar a duração do tratamento e o número de sessões de controle necessárias para a remissão da dor miofacial em pacientes com Desordem Temporomandibular que fizeram uso da placa neuromiorrelaxante. Foram avaliados 300 prontuários de pacientes voluntários sem distinção de raça e gênero, com idades entre 18 e 60 anos tratados na clínica do Serviço ATM da Faculdade de Odontologia da Universidade Federal de Juiz de Fora. Estes pacientes foram diagnósticados com desordem temporomandibular baseado no eixo I do protocolo de Critérios de Diagnóstico para pesquisa das Disfunções Temporomandibulares (RDC/TMD). O exame clínico e as mensurações presentes nos prontuários foram realizados por três examinadores previamente calibrados (índice kappa = 0.71). Para análise dos resultados, utilizou-se o teste t de Student, com nível de significância de 0,05% (p-valor < 0,05). Encontrou-se que o número mínimo de sessões necessárias para a remissão da sintomatologia dolorosa foi 02 sessões, e que o número máximo foi de 13 sessões. Mais da metade dos pacientes avaliados (56%) apresentaram remissão da sintomatologia dolorosa em 05 a 07 sessões de tratamento. Já quanto ao tempo de tratamento, o tempo mínimo necessário para remissão da sintomatologia dolorosa foi de 01 mês e o tempo máximo foi de 24 meses. Cerca de 60% dos pacientes apresentaram remissão completa da sintomatologia dolorosa em 07 meses de tratamento. Concluiu-se que ocorreu uma grande variação no período de tratamento e no número de sessões para uma efetiva redução da dor miofacial nos pacientes portadores de DTM avaliados, o que impossibilitou o estabelecimento de um número exato de sessões e de meses de tratamento ideais.


Subject(s)
Temporomandibular Joint , Facial Pain , Pain , Temporomandibular Joint Disorders , Occlusal Splints , Dentistry , Duration of Therapy
11.
Article in English | AIM, AIM | ID: biblio-1268354

ABSTRACT

Introduction: the World Health Organization (WHO) recommends that in malaria endemic areas with moderate to high transmission rates, pregnant women presenting for antenatal clinic (ANC) should receive at least three doses of intermittent preventive treatment in pregnancy (IPTp) for malaria between the 16th and 36th weeks of pregnancy at intervals of 4 weeks between doses. Several challenges remain in effective implementation of IPTp policy making the targeted coverage (80%) of the third doses of IPTp far from being achieved. The main objective of this study was to assess factors associated with the uptake of IPTp among pregnant women attending ANCs in the Bamenda Health District. Methods: to reach our objectives, we carried out a cross-sectional study following informed consent with thirty-nine (39) healthcare workers (HCW) and four hundred (400) pregnant women who were either in the third trimester of pregnancy or had recently given birth in any of thirty-six (36) health facilities (HF) within the Bamenda Health District (BHD) from May to August 2014. All sites within the BHD were included. The participants were selected by simple random sampling. The principal research instrument was a structured and pre-tested questionnaire that was designed to capture socio-demographic data and data related to stage of pregnancy and knowledge about IPTp. Data was entered using Ms Excel and analysed using SPSS v20.0. Descriptive statistics (frequencies and percentages) was used to report findings. We used Chi-Square test to compare the categorical variables (Fischer's exact test was used in cases were conditions for Chi-Square test were not met). Results: uptake for at least one dose of IPTp was 95.3% (381/400) and 54.9% (209/400) had received all three doses, 15.5% (59/400) received only one dose and 4.8% (19/400) did not receive any of the doses of IPTp. Knowledge about IPTp was associated with an increase uptake of IPTp (P<0.001). All health care providers were knowledgeable about the importance and use of IPTp. However, 35.9% reported not receiving any training on IPTp. Among the health providers, 28.2% did not know when to start IPTp and 43.59% did not know when to stop IPTp. Out of all the health care providers, 30.77% complained of medication (sulfadoxine-Pyrimethamine) stock out and 84.62% practiced the policy of direct observed therapy. Conclusion: the uptake of the third dose of IPTp is poor in the Bamenda Health District and this may be attributed to medication stock out and inadequacy of routine trainings for the health providers. The good practice observed was that of direct observed therapy by HCWs. Patient knowledge about IPTp in our study was associated with better uptake of IPTp. Encouraging education of pregnant women on the importance of IPTp, providing routine training to HCWs and promoting direct observation of therapy may improve on IPTp uptake during pregnancy


Subject(s)
Cameroon , Duration of Therapy , Malaria/diagnosis , Malaria/prevention & control , Malaria/therapy , Pregnancy
12.
Rev. cuba. enferm ; 22(3)jul.-sept. 2006. tab
Article in Spanish | LILACS, CUMED | ID: lil-465320

ABSTRACT

La medicina herbolaria tiene mucho que ofrecer a los pacientes que acuden a las consultas con determinadas enfermedades, pues su uso terapéutico ha demostrado un alto poder curativo; además de los beneficios económicos que reporta. Se realizó un estudio prospectivo descriptivo en una muestra de 90 pacientes atendidos en el Departamento de Medicina Natural Tradicional en el Hospital Clínico Quirúrgico Amalia Simoni Argilagos, en el período comprendido de enero a abril de 2005; con el objetivo de demostrar los beneficios del Aloe Vera l (sábila) en las afecciones de la piel. Se diseñó un formulario que incluyó las variables: lesiones tratadas de la piel, tiempo de duración del tratamiento y evolución clínica final de los pacientes. La afección más frecuente fue la psoriasis, que se registró en 40 pacientes; el tiempo de duración del tratamiento estipulado fue de 40 a 60 días y en cuanto a la evolución clínica se estimó como mejorado el 47,7 por ciento y curado el 45,5 por ciento(AU)


Herbal medicine has much to offer to the patients visiting the offices with certain diseases, since its therapeutic use has showed a high curative power, in addition to the economic benefits being reported. A prospective and descriptive study was undertaken in a sample of 90 patients seen at the Department of Traditional Natural Medicine of "Amalia Simoni Argilagos" Clinical and Surgical Hospital from January to April, 2005 aimed at showing the benefits of Aloe Vera l. in the skin affections. A questionnaire was designed that included the following variables: skin lesions treated, duration of the treatment and final clinical evolution of the patients. The most frequent affection was psoriasis that was reported in 40 patients. The duration of the stipulated treatment was between 40 and 60 days. As regards the clinical evolution, 47.7 percent of the cases improved and 45.5 percent were cured(AU)


Subject(s)
Humans , Skin Diseases/therapy , Herbal Medicine/methods , Aloe , Epidemiology, Descriptive , Prospective Studies , Duration of Therapy
13.
Rev. colomb. reumatol ; 13(3): 189-197, jul.-sep. 2006. ilus
Article in Spanish | LILACS | ID: lil-636735

ABSTRACT

Introducción: la falla ovárica prematura es una consecuencia del manejo a largo plazo con ciclofosfamida, su prevalencia en pacientes con LES ha sido informada entre el 11 y el 59%, dependiendo de la ruta y dosis de administración. Estudios sobre la toxicidad gonadal con el régimen propuesto por el NIH son escasos en la literatura, por lo cual se realizó este estudio para determinar la prevalencia y los factores de riesgo asociados al desarrollo de falla ovárica en una población latinoamericana. Métodos: se tomaron 56 pacientes con LES tratadas con bolos de CFM mensuales, menores de 40 años y con menstruación normal al momento de iniciar la terapia y se compararon con respecto a la frecuencia de amenorrea con 43 pacientes con LES sin tratamiento con ciclofosfamida como grupo control. Posteriormente estudiamos en el grupo de CYC, las diferencias entre aquellas que hicieron amenorrea y las que continuaron con ciclos regulares. Este es un estudio descriptivo de corte transversal. Se aplicó chi-cuadrado, test exacto de Fisher y Mann-Withney según estuviese indicado. P menor de 0,05 se consideró significativo. Resultados: el 16,1% de los pacientes con CYC desarrollaron falla ovárica frente al 4,3% del grupo control. Con respecto al grupo que recibió CYC, se encontró un promedio de edad mayor en el grupo que desarrolló amenorrea que en aquellas con ciclos regulares, 35,2 frente a 26,7 años (p= 0,003), determinándose como punto de corte de riesgo ser mayor de 28 años al inicio de la CFM. La evolución de la enfermedad fue mayor en el grupo de amenorrea en comparación con las que continuaban con menstruación normal con una p= 0,003 (10,2 frente a 4,4 años). No se encontró diferencia en la dosis acumulativa, duración de la terapia o perfil inmunológico de las pacientes. Conclusión: la prevalencia de falla ovárica en mujeres colombianas tiende a presentarse a una edad más temprana y con mayor tiempo de evolución de la enfermedad a pesar de dosis acumuladas inferiores a las informadas en la literatura planteando una mayor labilidad al efecto tóxico de la CFM.


Background: premature ovarian failure is a cyclophosphamide (CYC) treatment adverse effect. The report of prevalence is among 11% and 59%, the variability depend on the route and dosage of CYC. There are few studies about gonadal toxicity with NHI CYC treatment protocol. We decided to establish the prevalence and risk factors associated with premature ovarian failure in a group of Latin-American lupus patients. Methods: 56 SLE patients under 40 years treated with intravenous CYC, with regular menstrual cycle at the beginning of the treatment, were compared with respect to the frequency of amenorrhea with 43 SLE patients without treatment with CYC as a control group. After that, we studied in the CYC group the differences between those who made amenorrhea and those that continued with regular cycles. This is a cross sectional and descriptive study. The data were analyzed by chi-square, Fisher’s exact test and Mann-Withney when it was necessary. P < 0.05 was considered significant. Results: 16.1% of SLE patients under intravenous CYC treatment get premature ovarian failure vs. 4.3% in the control group. With respect to CYC group, the mean age in the amenorrhea group was higher than the age in patients with regular menstrual cycles 35.2 vs. 26.7 years (p=0.03). We found than patients older than 28 years have a mayor risk for amenorrhea induced by intravenous CYC. The mean disease duration was higher in the amenorrhea group than in the regular menstrual cycle patients, p= 0.003 (10.2 vs. 4.4 years). No significant differences were observed in cumulative dosage, treatment duration or immunologic findings between groups. Conclusion: the prevalence of ovarian failure in Colombian women tends to appear at an early age and with a greater time of evolution of the disease in spite of inferior accumulated doses than those that are informed in the Literature, suggesting a mayor susceptibility to toxic effect of CYC.


Subject(s)
Humans , Female , Adolescent , Adult , Ovarian Function Tests , Prevalence , Risk Factors , Cyclophosphamide , Lupus Erythematosus, Systemic , Therapeutics , Control Groups , Research Report , Duration of Therapy , Injections, Intravenous
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