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1.
Enferm. actual Costa Rica (Online) ; (38): 121-135, Jan.-Jun. 2020. tab
Article in Portuguese | LILACS (Americas), BDENF | ID: biblio-1090091

ABSTRACT

Resumo O objetivo deste estudo é analisar as representações sociais de profissionais do sexo sobre HIV / AIDS. É delineado como um estudo qualitativo, descritivo-exploratório das representações sociais com uma abordagem processual. Quinze profissionais do sexo participaram do estudo, esses homens fazendo sexo com homens, homossexuais, travestis e mulheres transexuais. Os dados foram coletados por meio de entrevista estruturada e questionário sociodemográfico, no período de março de 2015 a março de 2016. A análise de conteúdo da avaliação foi utilizada como técnica. As representações sociais dos sujeitos do estudo sobre HIV / AIDS apresentaram elementos conceituais sobre vírus e doenças, vulnerabilidade; Consequências; Prevenção; e transmissão. Conclui-se que os participantes mostraram em suas representações o déficit de estratégias de promoção da saúde sobre o tema, focado em suas necessidades e especificidades dos profissionais do sexo.


Abstract The objective of this study is to analyze the social representations of sex workers about HIV / AIDS. It is outlined as a qualitative, descriptive-exploratory study of social representations with a procedural approach. Fifteen sex workers participated in the study, these men having sex with men, homosexuals, transvestites and transsexualwomen. Data were collected through a structured interview and sociodemographic questionnaire, from March 2015 to March 2016. The evaluation content analysis was used as a technique. The social representations of the subjects of the study on HIV / AIDS presented conceptual elements on the virus and disease, vulnerability; Consequences; Prevention; and transmission. It is concluded that the participants showed in their representations the deficit of health promotion strategies on the subject, focused on their needs and specificities of sex workers.


Resumen El objetivo de este estudio es analizar las representaciones sociales de los trabajadores sexuales sobre el VIH / SIDA. Se perfila como un estudio cualitativo, descriptivo-exploratorio, de representaciones sociales con abordaje procesual. Participaron del estudio quince trabajadores sexuales, siendo estos hombres que tienen sexo con hombres, homosexuales, travestis y mujeres transexuales. Los datos fueron recolectados a través de entrevista de tipo estructurada y cuestionario sociodemográfico, de marzo de 2015 a marzo de 2016. Se utilizó como técnica el análisis de contenido evaluativo. Las representaciones sociales de los sujetos del estudio sobre el VIH/SIDA presentaron elementos conceptuales sobre el virus y la enfermedad, vulnerabilidad; Consecuencias; Prevención; y transmisión. Se concluye que los participantes se mostraron en sus representaciones el déficit de las estrategias de promoción de la salud sobre el tema, enfocadas a sus necesidades y especificidades de los trabajadores sexuales.


Subject(s)
Humans , Male , Female , Transvestism , Brazil , Homosexuality , Acquired Immunodeficiency Syndrome , HIV , Sex Workers , Transgender Persons , Sexual and Gender Minorities , Health Promotion
2.
Washington; Organización Panamericana de la Salud; abr. 1, 2020. 8 p.
Non-conventional in Spanish | LILACS (Americas) | ID: biblio-1096609

ABSTRACT

La enfermedad por coronavirus 2019 (COVID-19) es una infección del tracto respiratorio causada por un nuevo coronavirus emergente, que se identificó por primera vez en Wuhan, China, en diciembre de 2019. La secuenciación genética del virus sugiere que es un coronavirus beta estrechamente relacionado con el virus SARS, por ello, se le denomina SARS-CoV-2.


Subject(s)
Humans , Pneumonia, Viral/prevention & control , HIV/immunology , Coronavirus Infections/prevention & control , Anti-Retroviral Agents/therapeutic use , Pandemics/prevention & control , Betacoronavirus
3.
Ciudad Autónoma de Buenos Aires; Ministerio de Salud de la Nación; Marzo 2020.
Monography in Spanish | LILACS (Americas), BINACIS, ARGMSAL, UNISALUD | ID: biblio-1053215

ABSTRACT

En el marco de la contingencia por COVID 19 que está atravesando nuestro país, es preciso establecer, el manejo personas con VIH


Subject(s)
Humans , HIV , Coronavirus Infections/prevention & control , Coronavirus
4.
Washington; Organización Panamericana de la Salud; mar. 23 2020. Coronavirus disease (COVID-19) and HIV: key issues and actions p.
Non-conventional in Spanish | LILACS (Americas) | ID: biblio-1096598

ABSTRACT

La comunidad y la respuesta al VIH tienen mucho que ofrecer a la preparación y la resiliencia a la enfermedad por coronavirus 2019 (COVID-19). Contar con organizaciones dirigidas por la comunidad, como las redes de personas que viven con VIH, para que participen en las mesas de planificación y respuesta desde el principio, es fundamental para fomentar la confianza, asegurar un intercambio productivo de información y sentar las bases para la adopción de medidas conjuntas de solución de problemas. | Ver versión HTML |


Subject(s)
Humans , Pneumonia, Viral/prevention & control , HIV/immunology , Coronavirus Infections/nursing , Coronavirus Infections/prevention & control , Pandemics/prevention & control , Betacoronavirus
6.
Article in English | WPRIM (Western Pacific) | ID: wprim-810949

ABSTRACT

BACKGROUND: Statistical data of undiagnosed people living with human immunodeficiency virus (PLHIV) are of great importance to human immunodeficiency virus (HIV) infection control. This study estimated the total number of PLHIV using nationwide claims data.METHODS: This study used data of the incident HIV cases identified by the National Health Insurance System between 2009 and 2015. The number of patients with acquired immune deficiency syndrome (AIDS) was identified by diagnoses or prescription records. The estimated number of PLHIV and the time to diagnosis were calculated from the incident numbers of HIV and AIDS cases using the HIV Modeling Tool of the European Center for Disease Prevention and Control.RESULTS: Between 2009 and 2015, a total of 7,033 PLHIV and 2,899 AIDS patients were diagnosed. In 2009, the number of incident HIV cases was 873 (460 AIDS patients), increasing to 995 (337 AIDS patients) in 2015. Besides, the estimated number of prevalent cases was 10,753 in 2009, compared to 14,880 in 2015. Patients visiting health facilities accounted for 42.9% (4,616/10,753) in 2009 and 64.1% (9,544/14,880) in 2015. In 2009, there were 8,363 (77.8%) undiagnosed HIV cases, experiencing a decline to 6,215 (41.8%) in 2015. It took a mean of 6.96 years to diagnose after HIV infection.CONCLUSION: This study estimates the total burden of HIV infection in Korea for the first time using an internationally recognized HIV modeling tool. Claims data can be used to estimate the number of undiagnosed cases by identifying the total number of PLHIV and AIDS patients visiting health facilities.


Subject(s)
Acquired Immunodeficiency Syndrome , Diagnosis , Health Facilities , HIV Infections , HIV , Humans , Infection Control , Korea , National Health Programs , Prescriptions
7.
Article in English | WPRIM (Western Pacific) | ID: wprim-810946

ABSTRACT

No abstract available.


Subject(s)
HIV , Korea
8.
Rev. Pesqui. (Univ. Fed. Estado Rio J., Online) ; 12: 123-128, jan.-dez. 2020. tab, ilus
Article in English, Portuguese | LILACS (Americas), BDENF | ID: biblio-1048296

ABSTRACT

Objetivo: analisar a esperança de vida e a depressão em pessoas vivendo com HIV/Aids. Método: trata­se de uma pesquisa descritiva, quantitativa realizada com 17 pessoas com HIV/Aids que recebem atendimento em um Hospital de Referência para Doenças Infectocontagiosas no município de João Pessoa/PB, Brasil. Para coleta de dados utilizou-se uma Escala de Esperança de Vida e a Escala de Depressão HAM-D. Resultados: quanto ao tipo de exposição que levou ao diagnóstico de HIV/Aids 88,2%(15) revelaram o sexo desprotegido, o estado civil de maior prevalência foi o solteiro 58,8%(10). Os dados referentes a esperança de vida apresentaram escore médio 38,47±7,45, mediana 39, máximo 48 e mínimo 27. Conclusão: a fé e a esperança têm importantes valores, contribuindo na capacidade de lidar com situações difíceis e na manutenção da qualidade de vida, sendo facilitadoras das consequências psicossociais acerratadas por essa condição


Objective: to analyze life expectancy and depression in people living with HIV / Aids. Method: this is a descriptive, quantitative study of 17 people with HIV/Aids who receive care at a Reference Hospital for Infectious Diseases in the city of João Pessoa / PB, Brazil. A Life Expectancy Scale and the HAM-D Depression Scale were used for data collection. Results: regarding the type of exposure that led to the diagnosis of HIV/Aids, 88.2% (15) revealed unprotected sex, the single most prevalent civil status was the unmarried 58.8% (10). Life expectancy data presented a mean score of 38.47 ± 7.45, median 39, maximum 48 and minimum 27. Conclusion: faith and hope have important values, contributing to the capacity to deal with difficult situations and to maintain the quality of life, facilitating the psychosocial consequences of this condition


Objetivo: analizar la esperanza de vida y la depresión en las personas que viven con el VIH / SIDA. Método: se trata de una investigación descriptiva, cuantitativa realizada con 17 personas con VIH/SIDA que reciben atención en un Hospital de Referencia para Enfermedades Infectocontagiosas en el municipio de João Pessoa / PB, Brasil. Para la recolección de datos se utilizó una Escala de Esperanza de Vida y la Escala de Depresión HAM-D. Resultados: en cuanto al tipo de exposición que llevó al diagnóstico de VIH / SIDA el 88,2% (15) reveló el sexo desprotegido, el estado civil de mayor prevalencia fue el 58,8% (10). Los datos referentes a la esperanza de vida presentaron escore promedio 38,47 ± 7,45, mediana 39, máximo 48 y mínimo 27. Conclusión: la fe y la esperanza tienen importantes valores, contribuyendo en la capacidad de lidiar con situaciones difíciles y en el mantenimiento de la situación calidad de vida, siendo facilitadoras de las consecuencias psicosociales acorraladas por esa condición


Subject(s)
Humans , Life Expectancy , HIV , Depression , Brazil
9.
Rev. Pesqui. (Univ. Fed. Estado Rio J., Online) ; 12: 505-509, jan.-dez. 2020. tab
Article in English, Portuguese | LILACS (Americas), BDENF | ID: biblio-1097201

ABSTRACT

Objetivo: avaliar a eficácia antimicrobiana da terapia fotodinâmica no tratamento da candidíase oral em pessoas vivendo com HIV/aids. Método: estudo experimental, qualitativo e descritivo com 18 pessoas vivendo com HIV/aids que manifestavam a candidíase oral, maiores de 18 anos, que estavam em tratamento no Hospital Universitário Gaffrée e Guinle. Este grupo subdividiu-se em um grupo controle, composto por sete pessoas, que recebeu tratamento com a terapia fotodinâmica e antifúngicos, e um grupo experimental, com 11, que recebeu apenas a terapia fotodinâmica. A evolução do tratamento de cada participante foi acompanhada por registros fotográficos em duas consultas, inicial e final. Esta pesquisa foi aprovada pelo Comitê de Ética em Pesquisa do hospital, parecer número 2.431.107. Resultados: a maioria dos participantes apresentou melhora clínica, ainda que discreta, e em apenas um houve piora clínica. Conclusão: a terapia fotodinâmica antimicrobiana pode ser eficaz no tratamento da candidíase oral em pessoas vivendo com HIV/Aids


Objective: evaluate the antimicrobial efficacy of photodynamic therapy in the treatment of oral candidiasis in people living with HIV/ aids. Method: experimental, qualitative and descriptive study with 18 people living with HIV/aids who presented oral candidiasis, over 18 years of age, who were being treated at the Gaffrée and Guinle University Hospital. This group was subdivided into a control group, composed of seven people, who received treatment with photodynamic and antifungal therapy, and an experimental group, with 11, who received only the photodynamic therapy. The evolution of the treatment of each participant was followed by photographic registers in two appointments, initial and final. This research was approved by the Research Ethics Committee from the hospital, dictum number 2.431.107. Results: most of the participants showed clinical improvement, albeit discrete, and in only one there was clinical worsening. Conclusion: antimicrobial photodynamic therapy may be effective in the treatment of oral candidiasis in people living with HIV/Aids


Objetivo: evaluar la eficacia antimicrobiana de la terapia fotodinámica en el tratamiento de la candidiasis bucal en personas que viven con VIH/sida. Método: estudio experimental, cualitativo y descriptivo con 18 personas viviendo con VIH/sida que manifestaban la candidiasis bucal, mayores de 18 años, que estaban en tratamiento en el Hospital Universitario Gaffrée y Guinle. Este grupo se subdividió en grupo control, compuesto por siete personas, que recibió tratamiento con la terapia fotodinámica y antifúngicos, y un grupo experimental, con 11, que recibió sólo la terapia fotodinámica. La evolución del tratamiento de cada participante fue acompañada por registros fotográficos en dos consultas, inicial y final. La investigación fue aprobada por el Comité de Ética en Investigación del lugar, dictamen número 2.431.107. Resultados: la mayoría de los participantes presentó mejoría clínica, aunque discreta, y en apenas uno hubo empeoramiento clínico. Conclusión: la terapia fotodinámica antimicrobiana puede ser eficaz en el tratamiento de la candidiasis bucal en personas que viven con el VIH/Sida


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Aged, 80 and over , Photochemotherapy/statistics & numerical data , Candidiasis, Oral/therapy , AIDS-Related Opportunistic Infections/therapy , Photochemotherapy/methods , Candidiasis, Oral/epidemiology , Acquired Immunodeficiency Syndrome/therapy , HIV , Drug Resistance, Fungal
10.
Nursing (Säo Paulo) ; 23(262): 3672-3677, abr.2020.
Article in Portuguese | LILACS (Americas), BDENF | ID: biblio-1100493

ABSTRACT

Objetivo: investigar a qualidade de vida de pessoas vivendo com HIV e aids, segundo dimensões psicológica e espiritual. Método: Investigação exploratória, descritiva, com enfoque misto. Participaram do estudo 18 usuários de um Hospital Escola em João Pessoa - PB. Utilizou-se a técnica de gravação em aparelho mp3, as quais foram transcritas na íntegra, no programa de texto Notepad. Após essa etapa, para análise das respostas utilizou-se o software IRAMUTEQ. Resultados: 83,3% eram do sexo feminino, 38,8% encontravam-se entre 19 e 32 anos de idade e 55,5% eram casados. 50% concluiu o segundo grau e 44,4% são católicos. Dos discursos, emergiram as categorias dimensão psicológica relacionada à necessidade de ajuda; dimensão espiritual relacionada à necessidade de ajuda e dimensão espiritual de cuidado e saúde do ser humano. Conclusão: As dimensões emocional e espiritual devem ser abordadas no cuidado às pessoas que vivem com HIV e aids. (AU)


Objective: to investigate the quality of life of people living with HIV and aids, according to psychological and spiritual dimensions. Method: Exploratory, descriptive research, with a mixed focus. Eighteen users of a teaching hospital in João Pessoa - PB participated in the study. The recording technique on an mp3 device was used, which were fully transcribed in the Notepad text program. After this step, the IRAMUTEQ software was used to analyze the responses. Results: 83.3% were female, 38.8% were between 19 and 32 years of age and 55.5% were married. 50% completed high school and 44.4% are catholic. From the speeches, the categories psychological dimension related to the need for help emerged; spiritual dimension related to the need for help and spiritual dimension of care and health of the human being. Conclusion: The emotional and spiritual dimensions must be addressed in caring for people living with HIV and aids.(AU)


Objetivo: investigar la calidad de vida de las personas que viven con HIV y sida, de acuerdo con las dimensiones psicológicas y espirituales. Método: investigación exploratoria, descriptiva, con un enfoque mixto. Dieciocho usuarios de un hospital docente en João Pessoa - PB participaron en el estudio. Se utilizó la técnica de grabación de mp3, que se transcribió en su totalidad, en el programa de texto del Bloc de notas. Después de este paso, se utilizó el software IRAMUTEQ para analizar las respuestas. Resultados: 83.3% eran mujeres, 38.8% tenían entre 19 y 32 años y 55.5% estaban casados. 50% completaron la escuela secundaria y 44.4% son católicos. A partir de los discursos, surgieron las categorías psicológicas relacionadas con la necesidad de ayuda; dimensión espiritual relacionada con la necesidad de ayuda y dimensión espiritual del cuidado y la salud del ser humano. Conclusión: las dimensiones emocionales y espirituales deben abordarse en el cuidado de las personas que viven con el HIV y sida.(AU)


Subject(s)
Humans , Quality of Life , Patient Acceptance of Health Care , Acquired Immunodeficiency Syndrome/psychology , Spirituality , Health Promotion , Socioeconomic Factors , HIV , Treatment Adherence and Compliance
11.
Article in French | AIM (Africa) | ID: afr-201791

ABSTRACT

Introduction: en 2014, moins de 3 enfants sur dix (823 000 enfants environ) vivant avec le VIH avaient accès à un traitement antirétroviral (TAR), contre plus de quatre adultes sur dix. En conséquence, les enfants survivants qui ont une chance d´accéder au TAR sont traités souvent tardivement, à un stade avancé de la maladie. À Lubumbashi (RDC), les études sur l´évaluation du TAR chez l´enfant sont quasi nulles. Cette étude avait comme objectif décrire les caractéristiques sociodémographiques, cliniques, immunologiques et thérapeutiques des enfants infectés par le VIH et sous TAR et identifier les facteurs associés à un échec thérapeutique. Méthodes: il s'agit d'une étude transversale, réalisée du 1er janvier au 31 mars 2015 et portant sur une cohorte d'enfants de moins de 15 ans infectés par le VIH, suivis dans le service de Pédiatrie de l´hôpital Jason Sendwe. Résultats: 62 enfants âgés de moins de 15 ans infectés par le VIH ont été mis sous TAR. Les filles étaient prédominants (54,8%). 83,9% étaient à un stade clinique avancé (3 ou 4) lors de l´initiation au TAR. Notre étude montre que l´échec thérapeutique était significativement associé à l´âge ≥10 ans lors de l´évaluation de la prise en charge. Conclusion: l´étude a permis de montrer le retard avec lequel la prise en charge de l´enfant infecté VIH à Lubumbashi s´effectue; suggérant ainsi un renforcement du programme de la PTME et un dépistage précoce en vue d´une prise en charge précoce et la mise en place d´un mécanisme de rétention des enfants suivis.


Subject(s)
HIV/diagnosis , Congo
12.
Article in English | AIM (Africa) | ID: afr-201796

ABSTRACT

Introduction: regular use of Antiretroviral Therapy (ART) in pregnancy and breastfeeding reduces the odds of Mother-to-Child HIV Transmission (MTCT). However, adherence to ART is critical for MTCT to be successful. The present study investigated factors that influence adherence to ART among HIV infected pregnant women in Zambia. Methods: a cross-sectional study design was conducted involving 71 HIV infected pregnant women who were advised to join the Prevention of Mother-to-Child HIV Transmission (PMTCT) program during their routine Antenatal clinic (ANC) visit and were on ART for more than six months. We used the Medication Possession Ratio (MPR) to quantify adherence levels. We used logistic regression to establish factors that influence adherence to ART. Results: a total of 71 HIV infected pregnant women with a median age of 27years (IQR, 25-30) were enrolled in the study. There was evidence of a difference in adherence levels between pregnant women above 30 years and ones between 15 years and 30 years (P<0.001). Median adherence levels in this group were found to be at 96%(IQR 89-97). The main predictor of adherence in this population was marital status (being on separation) and age. The women who were on separation were 0.14 times less likely to adhere to option B+ compared to married women. Conclusion: adherence to option B+ among pregnant women is low. Adherence was significantly influenced by marital status (being on separation) and age. Efforts to improve adherence should be directed towards women on separation and young adults (< 30 years of age).


Subject(s)
HIV , Infections/diagnosis , Infections/therapy , Therapeutics , Therapeutics , Compliance , Health , Zambia
13.
Article in English | AIM (Africa) | ID: afr-201803

ABSTRACT

Senior High School (SHS) students fall within the age group (15-24 years) hardest hit by HIV/AIDS. Since about 90% of HIV transmission in sub-Saharan Africa (SSA) is through heterosexual intercourse, it is assumed that these students engage in risky sexual behaviours. Hohoe municipality has one of the highest HIV prevalence in Ghana (3.4%). The current study investigated the demographic determinants of risky sexual behaviours among senior high school students in the Hohoe municipality, Ghana.Methods: a descriptive cross-sectional design was employed in the study. A pretested structured questionnaire was used to collect data from a multistage sample of 270 SHS students who consented to participate in January 2019. Descriptive and inferential statistics were performed using Stata version 14.0 software program at the 0.05 level of significance.Results: of 270 respondents, 112 (41.5%) were engaged in risky sexual behaviours. Single students were 82% less likely to engage in risky sexual behaviours than their married counterparts (p=0.032) and muslims were 89% less likely to engage in risky sexual behaviours than christians (p=0.032).Conclusion: religion and marital status were the two socio-demographic characteristics that were significantly associated with risky sexual behaviour. Health promotion interventions to curb risky sexual behaviours among the SHS students should target the christian and married students.


Subject(s)
Behavior , HIV , Infections/transmission , Risk , Population , Students , Ghana
14.
Article in English | AIM (Africa) | ID: afr-201860

ABSTRACT

Infectious diseases pandemics have devastating health, social and economic consequences, especially in developing countries such as South Africa. Scarce medical resources must often be rationed effectively to contain the disease outbreak. In the case of COVID-19, even the best-resourced countries will have inadequate intensive care facilities for the large number of patients needing admission and ventilation. The scarcity of medical resources creates the need for national governments to establish admission criteria that are evidence-based and fair. Questions have been raised whether infection with HIV or tuberculosis (TB) may amplify the risk of adverse COVID-19 outcomes and therefore whether these conditions should be factored in when deciding on the rationing of intensive care facilities. In light of these questions, clinical evidence regarding inclusion of these infections as comorbidities relevant to intensive care unit admission triage criteria is investigated in the first of a two-part series of articles. There is currently no evidence to indicate that HIV or TB infection on their own predispose to an increased risk of infection with SARS-CoV-2 or worse outcomes for COVID-19. It is recommended that, as for other medical conditions, validated scoring systems for poor prognostic factors should be applied. A subsequent article examines the ethicolegal implications of limiting intensive care access of persons living with HIV or TB.


Subject(s)
Coronavirus Infections , HIV , Infections , Tuberculosis , Comorbidity , Africa
15.
Article in English | AIM (Africa) | ID: afr-201861

ABSTRACT

The COVID-19 pandemic has brought discussions around the appropriate and fair rationing of scare resources to the forefront. This is of special importance in a country such as South Africa (SA), where scarce resources interface with high levels of need. A large proportion of the SA population has risk factors associated with worse COVID-19 outcomes. Many people are also potentially medically and socially vulnerable secondary to the high levels of infection with HIV and tuberculosis (TB) in the country. This is the second of two articles. The first examined the clinical evidence regarding the inclusion of HIV and TB as comorbidities relevant to intensive care unit (ICU) admission triage criteria. Given the fact that patients with HIV or TB may potentially be excluded from admission to an ICU on the basis of an assumption of lack of clinical suitability for critical care, in this article we explore the ethicolegal implications of limiting ICU access of persons living with HIV or TB. We argue that all allocation and rationing decisions must be in terms of SA law, which prohibits unfair discrimination. In addition, ethical decision-making demands accurate and evidence-based strategies for the fair distribution of limited resources. Rationing decisions and processes should be fair and based on visible and consistent criteria that can be subjected to objective scrutiny, with the ultimate aim of ensuring accountability, equity and fairness.


Subject(s)
Coronavirus Infections , HIV , Infections , Tuberculosis , Comorbidity , Ethics , Africa
16.
South African Medical Journal ; 110(6), p.473-475, 2020
Article in English | AIM (Africa) | ID: afr-201888

ABSTRACT

The first critically ill patient admitted to our hospital in Cape Town, South Africa, during the COVID-19 pandemic was co-infected with HIV and SARS-CoV-2. Pneumocystis jirovecii pneumonia (PCP) and other respiratory opportunistic infections share many clinical features with severe COVID-19. Our understanding of the nuances of co-management of HIV and COVID-19 is evolving. We describe the diagnostic and therapeutic challenges presented by this case.


Subject(s)
Coronavirus Infections , HIV , Infections , Coinfection , Diagnosis , Africa
18.
South African Journal of Child Health ; 14(2), p.62-65, tab., 2020
Article in English | AIM (Africa) | ID: afr-201931

ABSTRACT

Background. HIV infection can lead to the development of HIV-associated nephropathy (HIVAN) with the majority of patients progressing to end-stage kidney disease. Previous studies have recognised basic fibroblast growth factor (bFGF) as a biomarker for HIVAN, since significant levels of bFGF low-affinity receptors have been found in the kidneys of HIV-infected children.Objective. To assess the association between bFGF and kidney disease in the development of focal segmental glomerulosclerosis (FSGS) in HIV-positive and negative children.Methods. The study group consisted of 31 children; HIVAN (n=11) and idiopathic FSGS (n=20). The control group consisted of both HIV-positive (n=20) and HIV-negative (n=20) children with no kidney disease. Serum samples from all patients in both the study and control groups were analysed for bFGF.Results. The concentration of bFGF was higher, in comparison with idiopathic FSGS children, in HIVAN children (p=0.0167). There was also a significant elevation of serum bFGF levels in children with HIVAN when compared with HIV-positive (p=0.0288) and HIV-negative (p=0.0043) control groups.Conclusion. This study demonstrated statistically significant differences between bFGF levels in children with HIVAN and a control group, although it failed to distinguish significant differences in bFGF levels between HIVAN and idiopathic FSGS children.


Subject(s)
HIV Infections , Glomerulonephritis , HIV , Acquired Immunodeficiency Syndrome , Biomarkers , Child , Africa
19.
Article in English | WPRIM (Western Pacific) | ID: wprim-820814

ABSTRACT

BACKGROUND AND PURPOSE: To adequately evaluate the extent of neurocognitive impairment in patient living with human immunodeficiency virus (PLHIV), a battery of neuropsychological tests is typically administered which are neither cost effective nor time efficient in the outpatient clinical setting. The aim of the study was to assess neurocognitive status and functional ability of people living with HIV and find a brief screening tool to identify those who would benefit from a full diagnostic evaluation.METHODS: The study enrolled 160 PLHIV (80 pre-antiretroviral therapy [ART] and 80 on ART) fulfilling the inclusion and exclusion criteria. Neurocognitive assessment and an assessment of Functional ability was done by using the Montreal Cognitive Assessment (MoCA) and Lawton and Brody Instrumental Activities of Daily Living Scale scale, respectively.RESULTS: The study population consisted of 75.6% males and 24.4% females with mean age of 44±10 years. The overall prevalence of HIV associated neurocognitive disorder (HAND) in the study subjects was 52.5%. Of these, 47.5% had asymptomatic neurocognitive impairment and 5% had minor neurocognitive disorder. In MoCA, the most frequently affected domains were Language (97.6%), visuospatial ability (92.9%) and memory (71.4%).CONCLUSIONS: The prevalence of HAND in both groups were similar suggesting that neurocognitive impairment starts early in HIV infection. Memory and Visuospatial function impairment had the most predictive potential for detecting the presence of HAND. HAND screening is recommended in all PLHIV at enrolment into care. Simple tools like MoCA can be used in busy outpatient settings by healthcare workers to screen for HAND.


Subject(s)
Activities of Daily Living , Delivery of Health Care , Female , Hand , HIV , HIV Infections , Humans , Male , Mass Screening , Memory , Methylenebis(chloroaniline) , Neurocognitive Disorders , Neuropsychological Tests , Outpatients , Prevalence
20.
Blood Research ; : 49-56, 2020.
Article in English | WPRIM (Western Pacific) | ID: wprim-820803

ABSTRACT

BACKGROUND: Human immunodeficiency virus (HIV)-negative plasmablastic lymphoma (PBL) is a rare entity of diffuse large B-cell lymphoma (DLBCL). The clinicopathological features of and optimal treatment for HIV-negative PBL remain largely unknown.METHODS: To gain insight into this distinct lymphoma, we summarized the clinicopathologic characteristics of 8 unpublished HIV-negative PBLs and performed a comprehensive review of 394 published cases.RESULTS: Of the 8 unpublished PBLs, the median patient age was 53.0 years. Four patients presented with stage IV disease. All 8 patients showed a plasma cell-like immunophenotype. Of the six patients who received anthracycline-based chemotherapy, including two who received bortezomib, three patients achieved a continuous complete response, two patients died due to disease progression, and one patient was lost to follow-up. The other two patients achieved continuous complete response after receiving chemotherapy combined with radiotherapy and surgery. Of the 402 patients, the majority were male, with a mean age of 58.0 years. EBV infection was detected in 55.7% of the patients. The median survival times of the patients who received CHOP or CHOP-like regimens and intensive regimens were not reached and 23.0 months, respectively, and the intensive regimen did not improve the survival outcome (P=0.981). Multivariate analysis showed that EBER remained the only independent factor affecting overall survival (OS).CONCLUSION: HIV-negative PBL is a distinct entity with a predilection for elderly and immunosuppressed individuals. Intensive chemotherapy had no apparent survival benefits over the CHOP regimen in terms of OS; the prognosis of this disease is poor with current chemotherapy methods, and treatment remains a challenge.


Subject(s)
Aged , Bortezomib , Disease Progression , Drug Therapy , Epstein-Barr Virus Infections , HIV , Humans , Lost to Follow-Up , Lymphoma , Lymphoma, B-Cell , Male , Multivariate Analysis , Plasma , Plasmablastic Lymphoma , Prognosis , Radiotherapy
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