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1.
An. bras. dermatol ; 96(6): 726-729, Nov.-Dec. 2021. graf
Article in English | LILACS | ID: biblio-1355633

ABSTRACT

Abstract Carney complex is a rare genodermatosis characterized by cardiac and cutaneous myxomas, among other tumors. In the majority of cases, cutaneous myxomas precede the diagnosis of cardiac myxomas, which are the main cause of death in these patients. Despite the fact that the diagnosis of cutaneous myxomas is histopathological, high-frequency ultrasonography plays an essential role in the differential diagnosis with other cutaneous and subcutaneous tumors. The authors of the present study describe, for the first time in the literature, the ultrasonographic features of both variants of cutaneous myxomas, superficial and subcutaneous, in a patient with a Carney complex.


Subject(s)
Humans , Skin Neoplasms/diagnostic imaging , Carney Complex/diagnostic imaging , Heart Neoplasms/diagnostic imaging , Myxoma/diagnostic imaging , Diagnosis, Differential
2.
Rev. ADM ; 78(4): 235-239, jul.-ago. 2021. ilus
Article in Spanish | LILACS | ID: biblio-1337563

ABSTRACT

El mixoma odontogénico es una neoplasia de origen mesenquimal, con crecimiento lento pero localmente invasivo y agresivo, que cuenta con un aspecto histológico característico. Radiográficamente, la mayoría de las lesiones tienen un aspecto radiolúcido multilocular, descrito en la literatura como «panal de abejas¼ o «burbujas de jabón¼, que ocasionan desplazamiento dental y expansión corticales. En el ámbito histopatológico, se caracteriza por células estelares o fusiformes con prolongaciones citoplasmáticas, en una sustancia mucoide o mixoide con presencia o no de colágena, cuando contiene grandes cantidades de tejido fibroso celular maduro se le llama mixofibroma. Se presenta un caso clínico de hombre de 38 años, que acude al Hospital General de Uruapan, Michoacán con aumento de volumen en región maxilar derecha; se toma biopsia incisional y se emite el diagnóstico histopatológico de mixofibroma odontogénico, 33.6% de los casos se presenta en el maxilar, con una distribución uniforme por todas las áreas llegando a erosionar el seno maxilar. Tiene una tasa de recurrencia de 10 a 33%, y el tratamiento ideal es la resección en bloque con márgenes de seguridad (AU)


Odontogenic myxoma is a slow-growing locally invasive intraosseous lesion with defined microscopic appearance. Radiographic appearance, is described as multilocular radiolucent lesion, which is reported in scientific literature as «honeycomb¼ or «soap bubbles¼ appearance most of the time; it exhibits dental displacement and cortical expansion. Histopathologically, stellate and spindle cells with cytoplasmic processes are observed in a mucoid or myxoid substance, with or without collagen; when it contains large amounts of mature cellular fibrous tissue, it is called myxofibroma. The present article presents the case of a 38 year old male, who attended the General Hospital in Uruapan, Michoacán due to an increased volume in the right maxillary region. Incisional biopsy was performed and the histopathological diagnosis of odontogenic myxofibroma was emitted. 33.6% of cases occur in the maxilla with a uniform distribution throughout the areas, and can erode the maxillary sinus. It has a recurrence rate of 10 to 33%, therefore ideal treatment is bloc resection leaving safety margins (AU)


Subject(s)
Humans , Male , Adult , Fibroma , Myxoma , Biopsy/methods , Oral Surgical Procedures , Dental Service, Hospital , Mexico
3.
Odontol. Clín.-Cient ; 20(2): 79-84, abr.-maio 2021. ilus
Article in Portuguese | LILACS, BBO | ID: biblio-1369198

ABSTRACT

O mixoma odontogênico é um tumor benigno que acomete os maxilares, de rara ocorrência que tem origem a partir do componente ectomesenquimatoso de um germe dentário, seja ao nível da papila dentária, ao nível do folículo ou ainda ao nível do ligamento periodontal. Tem predileção pelo sexo feminino, podendo comprometer com mais significância a faixa etária da segunda à quarta década de vida. O tratamento dos mixomas odontogênicos pode ser conservador ou radical. Com relação à escolha do tratamento, deve o cirurgião levar em consideração principalmente a extensão do envolvimento da lesão. O tratamento conservador pode ser considerado como primeira escolha, evitando efeitos associados a morbidade, comprometimento de estruturas anatômicas nobres e diminuição da qualidade de vida. Por se tratar de lesão recidivante, métodos complementares de tratamento têm sido empregados, tais como osteotomia periférica, uso do nitrogênio líquido e a solução de Carnoy. Este trabalho teve como objetivo relatar um caso de mixoma odontogênico em corpo mandibular de paciente do sexo feminino, leucoderma, 25 anos, solteira, natural de Recife-PE- Brasil, tratado de forma conservadora através de curetagem, osteotomia periférica e uso de solução de Carnoy, que até o presente momento não ocorreu sinais de recidiva... (AU)


Odontogenic myxoma is a rare benign tumor that affects the jaws. It´s originates from the ectomesenchymatous component of a dental germ, either at the level of the dental papilla, at the level of the follicle or at the level of the periodontal ligament. It has a predilection for the female sex, being able to compromise with more significance the age group from the 2nd to the 4th. decade of life. The treatment of odontogenic myxomas can be conservative or radical. Regarding the choice of treatment, the surgeon must take into account mainly the extent of the lesion's involvement. Conservative treatment can be considered as the first choice, avoiding effects associated with morbidity, impairment of noble anatomical structures and decreased quality of life. As it is a recurrent lesion, complementary treatment methods have been used, such as peripheral osteotomy, use of liquid nitrogen and Carnoy's solution. This study aimed to report a case of odontogenic myxoma in the mandibular body of a female patient, leucoderma, 25 years old, single, born in Recife-PE- Brazil, treated conservatively through curettage, peripheral osteotomy and use of a solution of Carnoy, that until now there have been no signs of recurrence... (AU)


Subject(s)
Humans , Female , Adult , Osteotomy , Jaw Neoplasms , Mandible , Myxoma , Conservative Treatment , Jaw , Neoplasms
4.
Article in Spanish | LILACS, BINACIS | ID: biblio-1353933

ABSTRACT

El síndrome de Mazabraud es una rara asociación de lesiones del sistema musculoesquelético. Resulta de la combinación de uno o varios mixomas intramusculares y displasia fibrosa. Presentamos a un hombre de 46 años con lesiones óseas compatibles con displasia fibrosa asociada a mixoma intramuscular configurando un síndrome de Mazabraud y una revisión de la bibliografía. Nivel de Evidencia: IV


Mazabraud's Syndrome is a rare association of lesions to the musculoskeletal system. It results from the combination of one or more intramuscular myxomas and fibrous dysplasia. We present a case of a 46-year-old man with bone lesions compatible with fibrous dysplasia associated with intramuscular myxoma, configuring Mazabraud's Syndrome and a review of the literature. Level of Evidence: IV


Subject(s)
Middle Aged , Muscle Neoplasms , Fibrous Dysplasia of Bone , Myxoma
6.
Article in English | AIM, AIM | ID: biblio-1366935

ABSTRACT

Primary cardiac tumors are very rare, accounting for 0,001 ­0,03% in autopsy series, cardiac myxoma (CM) account for approximately 50% of them. Association between CM and cerebral aneurysm is well documented in this condition but the occurrence of cerebral aneurysm after resection of CM is very rare, with only 40 reports in medical literature. We present a case of a 45 years old female patient with multiple cerebral aneurysms 2 years after a successful resection of cardiac myxoma, submitted to radiosurgery for 2 bigger aneurysms with good results. This report ads to literature new clinical findings and a hypothesis of radiosurgery as an effective option of treatment for cerebral aneurysms with origin in CM. Keywords: Cardiac Myxoma; Cerebral aneurysm; Radiosurgery; Neurosurgery.


Subject(s)
Humans , Intracranial Aneurysm , Radiosurgery , Myxoma , Neurosurgery
7.
Rev. cuba. med. mil ; 49(4): e352, graf
Article in Spanish | LILACS, CUMED | ID: biblio-1156523

ABSTRACT

Introducción: De los tumores cardiacos primarios, el 75 por ciento son benignos y más de la mitad corresponde a mixomas. Pueden ser asintomáticos o generar manifestaciones cardíacas, sistémicas o embólicas, estas últimas frecuentes. Objetivo: Divulgar la importancia de tener presente el tumor primario cardiaco como causa de enfermedad embólica cerebral. Caso clínico: Hombre de 53 años de edad, con mareos, cefalea, malestar general, decaimiento, dolores articulares, palpitaciones, disnea y ortopnea. Sufrió pérdida de la conciencia y posteriormente pérdida de la fuerza muscular del hemicuerpo izquierdo debido a un accidente vascular encefálico de tipo embólico. Con el ecocardiograma transtorácico, se confirmó el diagnóstico de un tumor primario cardiaco. Después de la operación, se comprobó en anatomía patológica, que era un mixoma. Conclusiones: El mixoma es un tumor que puede producir fenómenos cardioembólicos y se debe tener presente en pacientes como el que se presenta(AU)


Introduction: Of the primary cardiac tumors, 75 percent are benign and more than half correspond to myxomas. They can be asymptomatic or generate cardiac, systemic or embolic manifestations, the latter frequent. Objective: To remark the importance of considering the primary cardiac tumor as a cause of cerebral embolic disease. Clinical case: 53-year-old man with dizziness, headache, general malaise, weakness, joint pain, palpitations, dyspnea and orthopnea. He suffered loss of consciousness and later loss of muscle strength in the left half of the body due to an embolic-type stroke. With the transthoracic echocardiogram, the diagnosis of a primary cardiac tumor was confirmed. After the operation, it was verified in pathological anatomy, that it was a myxoma. Conclusions: Myxoma is a tumor that can produce cardioembolic phenomena and must be taken into account in patients like the one presented(AU)


Subject(s)
Humans , Echocardiography/methods , Cerebral Infarction/epidemiology , Myxoma/diagnosis
8.
Rev. colomb. obstet. ginecol ; 71(4): 384-394, oct.-dic. 2020. tab, graf
Article in Spanish | LILACS | ID: biblio-1149816

ABSTRACT

RESUMEN Objetivos: Presentar el caso de una paciente con diagnóstico de angiomixoma agresivo de vagina, y hacer una revisión de la literatura del diagnóstico, tratamiento y pronóstico. Materiales y métodos: Mujer de 46 años de edad, quien consulta por disuria y sensación de masa en vagina. Tras la exploración física y los estudios imagenológicos se observa tumoración en vagina con extensión hacia cavidad pélvica, la cual es extraída por cirugía vaginal. La patología quirúrgica mostró angiomixoma agresivo de vagina. La lesión presentó recurrencia al tercer mes posoperatorio requiriendo una nueva cirugía por vía retrorrectal. Se realizó una búsqueda en las bases de datos Medline vía PubMed, LILACS, SciELO y Google Scholar, con los términos: "Angiomixoma", "Agresivo" y "Vagina",incluyendo artículos de revisión, reportes y series de caso en inglés y español publicados desde 1995. Se extrajo información sobre el diagnóstico referente a síntomas, signos, pruebas de inmunohistoquímica e imágenes utilizadas, el tipo de tratamiento -quirúrgico o de otro tipo- y el pronóstico. Se hace descripción narrativa de los hallazgos Resultados: Se identificaron 23 títulos, de los cua- les 14 reportes de caso, 2 series de casos clínicos y un artículo de revisión cumplieron los criterios de inclusión. El 65 % de las pacientes tenía entre 30 y 50 años. El diagnóstico se hizo con estudios de inmunohistoquímica en 8 de los casos y se utilizaron imágenes diagnósticas en 12 casos; la tomografía mostró mejor delimitación de las lesiones. El trata- miento quirúrgico se aplicó en todos los reportes y se complementó con terapia hormonal en 4 casos. Se hizo seguimiento a 14 de los 17 casos reportados. Conclusión: El angiomixoma agresivo de vagina es una entidad poco frecuente. Es necesario evaluar la utilidad de las diferentes pruebas de inmunohistoquímica en los casos identificados como angiomixoma agresivo por histopatología. Se requiere evaluación del tratamiento hormonal como coadyuvante de la cirugía. El pronóstico es bueno.


ABSTRACT Objectives: To present the case of a patient diagnosed with aggressive angiomyxoma of the vagina and to conduct a review of the diagnosis, treatment and prognosis of this disease condition. Materials and Methods: A 46-year old female patient complaining of dysuria and vaginal mass sensation. Physical exploration and imaging studies revealed a tumor extending into the pelvic cavity. The mass was resected through a vaginal approach and pathology of the surgical specimen showed an aggressive angiomyxoma of the vagina. New retrorectar surgery was performed three months after the initial resection because of recurrence. A search was conducted in the Medline via PubMed, Lilacs, Scielo and Google Scholar databases using the terms "Angiomyxoma," "Aggressive" and "Vagina." The search included review articles, case reports and case series published in English and Spanish since 1995. The information extracted included diagnosis, symptoms, signs, immunohistochemistry and imaging studies used, type of treatment surgical or other - and prognosis. Findings are described in narrative form. Results: Overall, 23 titles were identified, of which 14 case reports, 2 clinical case series and 1 review article met the inclusion criteria. Sixty-five per cent of the patients were between 30 and 50 years of age. Diagnosis was made by immunohistochemistry in 8 cases, and diagnostic imaging was used in 12 cases. Computed tomography showed sharper contours of the lesions. Surgical treatment was applied in all reports, supplemented by hormonal therapy in 4 cases. There was follow-up in 14 of the 17 cases reported. Conclusion: Aggressive angiomyxoma of the vagina is rare. Assessment of the role of various immunohistochemical tests is needed in cases identified as aggressive angiomyxoma on histopathology. Evaluation of hormonal treatment as an adjunct to surgery is required. Prognosis is good.


Subject(s)
Humans , Female , Myxoma , Prognosis , Therapeutics , Vagina , Diagnosis
9.
Rev. bras. ortop ; 55(6): 804-807, Nov.-Dec. 2020. graf
Article in English | LILACS | ID: biblio-1156184

ABSTRACT

Abstract Neurothekeomas, also known as neural sheath myxomas, are rare benign tumors of the neural sheath affecting most commonly the head, arms and shoulder of women in their 2nd and 3rd decades of life. Due to the low prevalence and undefined clinical picture, they are hardly considered in the initial differential diagnosis of skin tumors. We report the case of a 24 year-old woman who was seen in 2016 reporting > 1 year of moderate pain and limited mobility of her left shoulder. Clinical evaluation revealed restricted mobility of the affected shoulder and nuclear magnetic resonance imaging showed a T2-weighted contrast-enhanced multilobular mass in the quadrilateral area apparently invading the adjacent humeral cortical region. Histopathology of a needle sample material revealed loose fibroconnective tissue with no signs of invasion, mitosis or atypical figures. Successful surgical excision was performed and the diagnosis of neurothekeoma was confirmed after detailed histopathology, including immunohistochemistry. The patient was asymptomatic at 18 months of follow-up, with full recovery of shoulder movement and no signs of relapse.


Resumo Neurotecomas, também conhecidos como mixomas da bainha neural, são tumores benignos raros da bainha neural afetando mais comumente a cabeça, braços e ombros de mulheres entre 20 e 40 anos de idade. Devido à baixa prevalência e quadro clínico mal definido, essas lesões são raramente consideradas no diagnóstico diferencial de tumores cutâneos. Relatamos o caso de uma mulher de 24 anos de idade que procurou atendimento em 2016 relatando dor moderada por mais de um ano e limitação dos movimentos do ombro esquerdo. Ao exame, foi constatada restrição da mobilidade dessa articulação e uma ressonância magnética revelou imagem multilobular com aumento de sinal em T2 na região quadrilateral, aparentando invasão da região cortical do úmero subjacente. A histopatologia de uma biópsia incisional mostrou lesão composta por tecido conjuntivo frouxo, sem sinais de invasão, figuras de mitose ou atipias. Foi realizada excisão completa da lesão e o diagnóstico de neurotecoma foi confirmado após análise histopatológica que incluiu painel imunohistoquímico. À revisão de 18 meses, a paciente estava assintomática com recuperação completa do movimento e sem evidência de recidiva da lesão.


Subject(s)
Humans , Female , Adult , Arm , Recurrence , Skin Neoplasms , Axilla , Biopsy , Magnetic Resonance Spectroscopy , Neurothekeoma , Connective Tissue , Shoulder Pain , Diagnosis, Differential , Head , Joints , Mitosis , Myxoma , Neoplasms
10.
Rev. colomb. cardiol ; 27(6): 607-610, nov.-dic. 2020. graf
Article in Spanish | LILACS, COLNAL | ID: biblio-1289279

ABSTRACT

Resumen Se presenta el caso de un varón de 70 años de edad, quien debutó con fibrilación auricular no valvular, en quien, dos meses después y mediante ecocardiografía, se objetivaron dos masas contiguas en la aurícula derecha. Las masas eran dependientes de la válvula de Eustaquio, alcanzaban el septo interauricular y se asemejaban a un mixoma. Ambas fueron resecadas mediante cirugía, sin complicaciones intraoperatorias ni postoperatorias. El estudio anatomo-patológico concluyó que eran compatibles con trombos sin componente tumoral. Durante el seguimiento permaneció asintomático y en ritmo de fibrilación auricular.


Abstract The case is presented on a 70 year-old male who debuted with non-valvular atrial fibrillation. Two months later, and using cardiac ultrasound, two contiguous masses were observed in the right atrium. The masses were hanging from the Eustachian (inferior vena cave) valve, reached the interatrial septum and resembled a myxoma. Both were surgically resected, with no intra- or post-operative complications. The patient remained asymptomatic and in atrial fibrillation rhythm during follow-up.


Subject(s)
Humans , Male , Aged , Atrial Function, Right , Atrial Fibrillation , Thrombosis , Echocardiography , Myxoma
11.
Rev. colomb. cardiol ; 27(6): 602-606, nov.-dic. 2020. graf
Article in Spanish | LILACS, COLNAL | ID: biblio-1289278

ABSTRACT

Resumen Los mixomas son los tumores cardíacos primarios más comunes. La mayoría tiene curso benigno y pueden tratarse de hallazgos incidentales o ser casi asintomáticos. Los síntomas dependen de su ubicación, en cuyo caso la más frecuente es la aurícula izquierda, de ahí que el riesgo embólico sea elevado. El principal lugar de embolia es el sistema nervioso central; sin embargo, en ocasiones puede afectar los sistemas respiratorio, periférico o coronario(1). Se expone el caso de una paciente con mixoma auricular izquierdo, el cual se manifiesta con accidente cerebral isquémico transitorio, seguido de infarto agudo de miocardio con elevación del segmento ST en la pared ínfero-posterior.


Abstract The myxomas are the most common primary cardiac tumours. The majority of them are benign and can be an incidental finding or be almost asymptomatic. The symptoms depend on their location, with the most common being the left atrium, which carries an increased risk of clots. The main effects of the clots are on the central nervous system, but occasionally they can involve the respiratory, peripheral, or coronary system. The case is presented of a patient with left atrial myxoma, as well as a transient ischaemic stroke and acute myocardial infarction with ST elevation in the inferior-posterior wall.


Subject(s)
Humans , Female , Middle Aged , Myxoma , Angiography , Thrombolytic Therapy , Cerebral Infarction , Angioplasty , Myocardial Infarction
12.
Gac. méd. boliv ; 43(1): 103-106, ago. 2020. ilus
Article in Spanish | LILACS | ID: biblio-1124810

ABSTRACT

Los tumores cardíacos primarios son poco frecuentes y representan solo el 5% de todos los tumores cardíacos. El 75% de estos tumores son benignos, y el mixoma es el tumor benigno más común en el adulto (50%). La mayoría de los mixomas cardíacos se localizan en la aurícula izquierda, solo el 18-20% se localizan en la aurícula derecha, y es aún más infrecuente la aparición de un tumor bilobulado, los signos y síntomas con los que se presentan son inespecíficos y varían de acuerdo a su comportamiento. Presentamos un caso con estas características en una paciente escolar de 9 años de edad que ingresó al Hospital del Niño Manuel Ascencio Villarroel


Primary cardiac tumors are rare and represent only 5% of all cardiac tumors. 75% of these tumors are benign, and myxoma is the most common benign tumor in adults (50%). Most cardiac myxomas are located in the left atrium, only 18-20% are located in the right atrium, and the appearance of a bilobed tumor is even more infrequent, the signs and symptoms with which they occur are nonspecific and they vary according to their behavior. We present a case with these characteristics in a 9-year-old school patient who was admitted to Manuel Ascencio Villarroel Children's Hospital.


Subject(s)
Myxoma
13.
Odontoestomatol ; 22(35): 52-61, jul. 2020. ilus.
Article in Spanish | LILACS, BNUY, BNUY-Odon | ID: biblio-1103063

ABSTRACT

Con el fin de tener una mayor comprensión sobre el comportamiento biológico del mixoma odontogénico (MO), se realizó inmunohistoquímica en 31 muestras, utilizando marcadores relacionados con mecanismos de progresión tumoral (adhesión, angiogénesis, apoptosis, inflamación y proliferación celular). El epitelio odontogénico fue detectado en cuatro muestras mediante CK19 y CD138, este último, mostró expresión baja en matriz extracelular (MEC) y alta en las células tumorales. La microdensidad vascular (MDV) media fue de 7.51 y 5.35 vasos marcados con CD34 y VEGF-A respectivamente. Una alta expresión de Orosomucoide-1 y Mast Cell Tryptase se observó células tumorales y en MEC. El MO mostró negatividad para Calretinina. Este perfil inmunohistoquímico, la baja expresión para Ki-67, Bcl-2 y p53, y la relativamente baja MDV, sugieren que la actividad proliferativa, anti-apoptótica o angiogénica no representan los principales mecanismos de crecimiento del MO, los cuales podrían estar asociados a eventos como inmunomodulación y degradación de la MEC.


Immunohistochemistry tests were performed in 31 samples to elucidate the biological behavior of the odontogenic myxoma (OM), using markers related to mechanisms of tumor progression (adhesion, angiogenesis, apoptosis, inflammation and cell proliferation). Odontogenic epithelium was detected in four samples with CK19 and CD138; the latter had a low expression in the extracellular matrix (ECM) and a high expression in tumor cells. The mean microvascular density (MVD), assessed with CD34 and VEGF-A, was 7.51 and 5.35 blood vessels. A high expression of orosomucoid-1 and mast cell tryptase was observed in tumor cells and ECM, while calretinin was negative. The immunohistochemical profile mentioned above, as well as the low expression of Ki67, Bcl-2 and p53 and the relatively low MVD, suggest that the proliferative, antiapoptotic and angiogenic activities do not represent the main growing mechanisms of OM, which could be associated to other events, such as immunomodulation and ECM degradation.


Para melhor compreensão do comportamento biológico do mixoma odontogênico (MO), imuno-histoquímica foi realizada em 31 amostras, utilizando marcadores relacionados aos mecanismos de progressão tumoral (adesão, angiogênese, apoptose, inflamação e proliferação celular). Epitélio odontogênico foi detectado em quatro amostras por CK19 e CD138, o último mostrou baixa expressão na matriz extracelular (MEC) e alta em células tumorais. A microdensidade vascular (MDV) média foi de 7.51 e 5.35 vasos marcados com CD34 e VEGF-A, respectivamente. Uma alta expressão de Orosomucoide-1 e Mast Cell Tryptase foi observada nas células tumorais e na MEC. O MO mostrou negatividade para Calretinina. O perfil imuno-histoquímico mencionado acima, a baixa expressão de Ki-67, Bcl-2 e p53 e a relativamente baixa MDV, sugerem que a atividade proliferativa, anti-apoptótica ou angiogênica não representam os principais mecanismos de crescimento do MO, os quais poderiam estar associados com eventos como imunomodulação e degradação da MEC.


Subject(s)
Immunohistochemistry , Biomarkers, Tumor , Myxoma , Neovascularization, Pathologic
15.
Rev. méd. Chile ; 148(3): 327-335, mar. 2020. tab, graf
Article in Spanish | LILACS | ID: biblio-1115796

ABSTRACT

Background: Primary cardiac tumors have a low incidence, and their presentation form and clinical course are not well known. Aim: To describe the characteristics, treatment, follow up and survival of patients with primary cardiac tumors (PCT). Material and Methods: Review of all surgical procedures for PCT performed between 1984 and 2019 in a regional general hospital. The information was obtained from surgical protocols, surgical and pathology databases, medical records and registries of the Chilean National Identification Service. The clinical features of patients, immediate and long term outcomes are described. Results: Seventy-two surgical procedures for PCT were reviewed. Patients' age was 55 ± 15 years and 60% were women. The most common histological types were myxoma in 49 patients (68%), papillary fibroelastoma in 13 (18%) and sarcoma in 6 (8.3%). Forty-nine (68.1%) were symptomatic and all tumors were found on echocardiography. Fifty-one (71%) were in the left atrium, 10 (14%) in the aortic valve and eight (11%) in the right atrium. The surgical procedures were tumor resection in 48 patients (67%) and resection and repair with patch in 23 (32%). Mean postoperative stay was 6.6 ± 4.4 days, eight patients (11%) had complications and no patient died in the immediate postoperative period. Long term survival was higher in patients with benign PCT as compared with those with malignant tumors. Conclusions: Most PCTs in this group of patients were benign neoplasms and the most common tumors were myxomas. The main diagnostic method is echocardiography and the prognosis of surgical treatment is excellent when the tumors are benign. (Rev Med Chile 2020; 148: 327-335)


Subject(s)
Humans , Male , Female , Heart Neoplasms , Sarcoma , Chile , Retrospective Studies , Myxoma
16.
Rev. colomb. cardiol ; 27(1): 41-43, ene.-feb. 2020. graf
Article in Spanish | LILACS, COLNAL | ID: biblio-1138752

ABSTRACT

Resumen Los tumores cardíacos primarios son poco frecuentes y a menudo asintomáticos. Tienen una incidencia que varía de 0,0017% a 0,28%. El diagnóstico diferencial de masas cardíacas incluye vegetaciones, trombos y tumores. Puede involucrar el endocardio, miocardio o epicardio. La afectación secundaria del corazón por tumores extracardíacos es rara. Los tumores benignos constituyen el 80% de las neoplasias cardíacas primarias y los mixomas son el tipo predominante. El tumor cardíaco maligno más frecuente es el angiosarcoma, y se caracteriza por crecimiento rápido, invasión local y metástasis a distancia. Se presenta el caso de paciente adulta joven con síntomas cardiovasculares inespecíficos asociados a pérdida de peso, cuyo diagnóstico ecocardiográfico e histopatológico es compatible con mixoma cardíaco.


Abstract Primary cardiac tumours are rare and are often asymptomatic, with an incidence that varies from 0.0017% to 0.28%. The differential diagnosis of cardiac masses includes, growth, clots, and tumours. It can involve the endocardium, myocardium or epicardium. The secondary involvement of the heart due to extra-cardiac tumours is rare. Benign tumours make up 80% of the primary cardiac neoplasms, and myxomas are the most predominant type. The most common malignant cardiac tumour is the angiosarcoma, and is characterised by rapid growth, local invasion, and distant metastases. A case is presented of a young adult patient, with non-specific cardiovascular symptoms together with a loss of weight. Her echocardiographic and histopathology diagnosis was compatible with a cardiac myxoma.


Subject(s)
Humans , Female , Adult , Dyspnea , Heart Neoplasms , Neoplasms , Weight Loss , Diagnosis, Differential , Myxoma
17.
Rev. méd. Chile ; 148(1): 78-82, Jan. 2020. tab, graf
Article in Spanish | LILACS | ID: biblio-1094209

ABSTRACT

Background: The incidence rates of cardiac tumors are low. Aim: To report the clinical presentation of cardiac myxomas and long-term evolution after resection. Material and Methods: Review of a database of surgical patients undergoing surgical resection of a cardiac myxoma in a public hospital between 1990 and 2018. Results: Seventy-eight patients aged 53 ± 15 years (65% females) were included. The most frequent comorbidities were arterial hypertension (40.5%), hypothyroidism (15%) and diabetes mellitus (12%). The main presenting symptoms were dyspnea (33%), neurological deficit secondary to embolism (30%) and acute pulmonary edema (5%). The most common location was the left atrium, in 87%. During surgery, cardiopulmonary bypass and aortic cross-clamp times were 50.2 ± 19.6 and 33.4 ± 15.2 min, respectively. One patient died due to severe neurological involvement. Follow-up was completed in seventy-seven patients, with a mean echocardiographic follow-up time of 10.4 ± 7.7 years. Thirty-four patients were followed for more than 10 years. Six patients (7.7%) died during the follow-up and in six patients (7%) a recurrence was identified. Conclusions: Cardiac myxoma usually has nonspecific symptoms. Surgical excision offers excellent short and long-term results. Complications and recurrence rates are low in non-hereditary myxomas but obligates to perform echocardiographic follow-up for early diagnosis of recurrence.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Heart Neoplasms , Myxoma , Echocardiography , Heart Atria , Neoplasm Recurrence, Local
18.
Autops. Case Rep ; 10(4): e2020178, 2020. graf
Article in English | LILACS | ID: biblio-1131846

ABSTRACT

Atrial myxomas are rare primary cardiac tumours with neurological manifestations being reported in 30% of cases. Though a rare cause of ischemic stroke in young patients, considering it as a possibility in absence of any obvious risk factors can help avoid misdiagnosis at early stages. We present a case of left atrial myxoma in a 36-year-old male with no known co-morbidities, showing an unusual clinical presentation of isolated bilateral painless vision loss. With multiple infarcts on Non Contrast Computerised Tomography (NCCT) and a suspicion of Atrial Myxoma on Transesophageal Echocardiography (TEE), patient was successfully managed surgically with confirmation of diagnosis on histopathology.


Subject(s)
Humans , Male , Adult , Stroke/etiology , Myxoma , Thrombosis , Heart Diseases/diagnosis , Neurologic Manifestations
19.
Rev. cuba. med. mil ; 48(4): e254, oct.-dic. 2019. graf
Article in Spanish | LILACS, CUMED | ID: biblio-1126656

ABSTRACT

Introducción: De los tumores cardiacos primarios, más del 50 por ciento son mixomas. La variabilidad sintomática del mixoma cardiaco, puede llevar a confusiones diagnósticas. Objetivo: Presentar un caso donde se destaca la variabilidad de síntomas del mixoma cardíaco. Caso clínico: Paciente masculino de 51 años, atendido con manifestaciones de insuficiencia cardíaca, trastornos del ritmo cardíaco, micro embolias cerebrales, convulsiones tónico clónicas, hemoptisis, trastornos psiquiátricos, síndrome general con astenia, anorexia y pérdida de peso. Durante dos años, fue atendido en varias instituciones, con múltiples estudios y tratamientos. En el Servicio de Cardiología de Morón, Ciego de Ávila, mediante el estudio clínico y ecocardiográfico, se diagnosticó un tumor cardíaco. Se traslada al Cardiocentro de Santa Clara y allí se le extirpó el tumor. Histológicamente era un mixoma. Evolucionó muy bien, con excelente calidad de vida. Conclusiones: El mixoma cardíaco ocasiona síntomas obstructivos, embólicos y constitucionales, con cuadro clínico muy equívoco(AU)


Introduction: Of the primary cardiac tumors, more than 50 percent are myxomas. Symptomatic variability of cardiac myxoma can lead to diagnostic confusion. Objective: To present a case where the variability of cardiac myxoma symptoms is highlighted. Clinical case: A 51-year-old male patient, attended with manifestations of heart failure, heart rhythm disorders, micro cerebral embolisms, clonic tonic seizures, hemoptysis, psychiatric disorders, general syndrome with asthenia, anorexia and weight loss. For two years, he was treated in several institutions, with multiple analyses and treatments. In the Cardiology Department of Morón, Ciego de Ávila, through a clinical and echocardiographic study, a cardiac tumor was diagnosed. He moved to the Cardiocentro of Santa Clara and there, the tumor was removed. Histologically it was a myxoma. It evolved very well, with excellent quality of life. Conclusions: Cardiac myxoma causes obstructive, embolic and constitutional symptoms, with a very equivocal clinical picture(AU)


Subject(s)
Humans , Male , Middle Aged , Seizures , Cardiology , Heart Neoplasms/diagnostic imaging , Myxoma/diagnostic imaging
20.
CorSalud ; 11(4): 342-347, oct.-dic. 2019. tab, graf
Article in Spanish | LILACS | ID: biblio-1124634

ABSTRACT

RESUMEN El mixoma auricular es un tumor cardíaco benigno de origen primario que se localiza mayormente en la aurícula izquierda. El presente trabajo tiene como objetivo describir las formas clínicas de presentación de un mixoma de aurícula derecha, a través de la presentación de un caso con el diagnóstico de síndrome de hipertensión pulmonar secundaria al mencionado tumor cardíaco, en una paciente de 54 años de edad. Las características clínicas de los mixomas están determinadas por su localización, tamaño y movilidad. En este caso, la obstrucción intracardíaca producida por el mixoma, con movimiento paradójico del septum, dió lugar a alteraciones en el llenado ventricular, signos de bajo gasto e hipertensión pulmonar grave. El abordaje clínico y quirúrgico inmediato tras el diagnóstico evitó el desarrollo de complicaciones mayores. Este caso enfatiza la vital importancia del juicio clínico y el uso de diversas técnicas de imagen cardíaca en la toma de decisiones.


ABSTRACT Atrial myxoma is a benign primary cardiac tumor that is mostly found in the left atrium. This paper aims to describe the clinical presentation of a right atrial myxoma through the case report of a 54-year-old patient diagnosed with pulmonary hypertension syndrome secondary to the above-mentioned cardiac tumor. The clinical features of myxomas are determined by their location, size and mobility. In this case, intracardiac obstruction produced by the myxoma, with paradoxical movement of the septum, resulted in ventricular filling alterations, low cardiac output signs and severe pulmonary hypertension. Immediate clinical and surgical management after diagnosis successfully prevented the development of major complications. This case highlights the paramount importance of clinical judgment and the use of various cardiac imaging techniques in decision making.


Subject(s)
Heart Failure , Heart Neoplasms , Hypertension, Pulmonary , Myxoma
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