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1.
J. oral res. (Impresa) ; 10(2): 1-7, abr. 30, 2021. ilus
Article in English | LILACS | ID: biblio-1381531

ABSTRACT

Introduction: The head and neck are frequent sites for the development of cutaneous cancer and squamous cell carcinoma of the skin (SCC), one of the more frequent malignant non-melanoma skin neoplasms in Chile (436 per 100,000 inhabitants). Between 5-10% skin SCC progresses aggressively generating metastasis to parotid and cervical lymph nodes. Case Report: A 82 years old male, presents painful increased volume lesion in the mandibular area. He has a history of chronic arterial hypertension, acute renal failure, SCC of the scalp, extra-pulmonary tuberculosis, chronic sun exposure and smoking. Extraoral examination showed a 4 cm lesion in the posterior third of the mandibular branch, with undefined edges, a firm consistency and painful on palpation. Intraorally, erythematous mucosa is observed, as well as lack of lubrication, tenderness and cortical bone expansion. Incisional biopsy is performed, imaging and histological exams are requested. The results indicate the presence of SCC, and therefore referral to secondary care. Many risk factors are associated with SCC development, with ultraviolet radiation the most relevant in this case, favoring its appearance on the scalp. The probability of metastasis is low, but when it happens, the majority of cases that started in the scalp, disseminate to the parotid and cervical region. Conclusion: The SCC has a good prognosis. However, there are antecedents, such as size and location, that must alert the professional to perform the monitoring, early screening, control of metastatic nodes in maxillofacial area.


Introducción: La cabeza y el cuello son sitios frecuentes de desarrollo de cáncer cutáneo y el carcinoma epidermoide de piel (CEC) es una de las neoplasias malignas sin melanoma más frecuentes en Chile (436 por 100.000 habitantes). Entre el 5% y el 10% del CCE cutáneo progresa de forma agresiva y genera metástasis en los ganglios linfáticos parótidos y cervicales. Reporte de Caso: Varón de 82 años, presenta lesión dolorosa de aumento de volumen en zona mandibular. Tiene antecedentes de hipertensión arterial crónica, insuficiencia renal aguda, CCE del cuero cabelludo, tuberculosis extrapulmonar, exposición crónica al sol y tabaquismo. El examen extraoral mostró una lesión de 4 cm en el tercio posterior de la rama mandibular, con bordes indefinidos, consistencia firme y dolorosa a la palpación. Intraoralmente se observa mucosa eritematosa, así como falta de lubricación, dolor a la palpación y expansión del hueso cortical. Se realiza biopsia incisional, se solicitan exámenes de imagen e histológicos. Los resultados indican la presencia de CCE y, por tanto, derivación a atención secundaria. Son muchos los factores de riesgo asociados al desarrollo de CEC, siendo la radiación ultravioleta la más relevante en este caso, favoreciendo su aparición en el cuero cabelludo. La probabilidad de metástasis es baja, pero cuando ocurre, la mayoría de los casos que comenzaron en el cuero cabelludo se diseminan a la región parotídea y cervical. Conclusión: El SCC tiene un buen pronóstico. Sin embargo, existen antecedentes, como tamaño y ubicación, que deben alertar al profesional para realizar el seguimiento, cribado precoz, control de ganglios metastásicos en zona maxilofacial.


Subject(s)
Humans , Male , Aged, 80 and over , Scalp/pathology , Skin Neoplasms/diagnosis , Parotid Neoplasms/secondary , Carcinoma, Squamous Cell/secondary , Head and Neck Neoplasms/diagnosis , Mouth Neoplasms , Parotid Neoplasms/diagnosis , Carcinoma, Squamous Cell/diagnosis , Tomography, X-Ray Computed , Neoplasm Metastasis
2.
Article in English | WPRIM | ID: wpr-921382

ABSTRACT

Parotid gland tumors are usually solitary tumors, and multiple tumors of the parotid gland are extremely rare. We present a highly unusual case of bilateral and simultaneous pleomorphic adenoma and basal cell adenoma of the parotid gland. We review the literature and discuss the clinical manifestations, diagnosis, and treatment of these two rare tumors.


Subject(s)
Adenoma, Pleomorphic , Humans , Parotid Gland , Parotid Neoplasms/diagnosis
3.
Int. j. odontostomatol. (Print) ; 14(3): 407-416, 2020. tab, graf
Article in Spanish | LILACS | ID: biblio-1114915

ABSTRACT

El adenocarcinoma NOS (no especificado de otra manera) es un tumor salival sin patrón especial poco mencionado en la literatura; su diagnóstico es un desafío porque estructuralmente no se identifica con otros carcinomas salivales más definidos. Por otro lado, Ki67 es un marcador de proliferación celular que brinda información pronóstica de las neoplasias. En cuanto a la mucina humana transmembrana MUC-1 se sobre-expresa en las neoplasias malignas perdiendo su localización exclusivamente apical. Presentamos dos casos de adenocarcinoma NOS diagnosticados con H/E y correlacionamos la expresión de Ki67 y la localización y sobreexpresión de MUC-1 con su grado histológico y pronóstico. Cortes histológicos de dos adenocarcinomas NOS de parótida en mujeres de 62 y 63 años respectivamente se colorearon con H/E e inmunomarcaron para Ki67 y MUC-1. En ambos tumores predominaban estructuras ductales, algunas quísticas, cordones celulares ramificados e islotes sólidos. Las formaciones glandulares presentaban células claras y algunas de aspecto oncocítico. Había importante atipia celular, comedonecrosis, invasión perineural, áreas hemorrágicas y compromiso de los márgenes quirúrgicos. La marcación nuclear con Ki67 fue importante; MUC-1 presentó una fuerte coloración en membranas y citoplasmas. Las dos lesiones se diagnosticaron como de alto grado de malignidad. Nuestros resultados demuestran que existe una importante proliferación marcada con Ki67 y una sobre-expresión de MUC-1 asociadas a atipia celular, infiltración perineural, necrosis y compromiso de márgenes quirúrgicos, factores asociados a un peor pronóstico. El reconocimiento de este tumor es trascendente para médicos y odontólogos ya que por la ausencia de rasgos distintivos que sí presentan otros carcinomas más específicos es fundamental el diagnóstico de exclusión.


Adenocarcinoma NOS (not otherwise specified) is a no special pattern salivary tumor briefly mentioned in the literature; its diagnosis is a challenge because structurally it is not identified with other more definite salivary carcinomas. On the other hand, Ki67 is a marker of cellular proliferation that provides prognostic information of neoplasms. As for human transmembrane mucin, MUC-1 is overexpressed in malignant neoplasms, losing their exclusively apical location. We present two cases of adenocarcinoma NOS diagnosed with H/E and correlate the expression of Ki67 and the location and over-expression of MUC-1 with its histological grade and prognosis. Histological sections of two NOS adenocarcinomas of parotid in women of 62 and 63 ages respectively were stained with H/E and immunolabelled for Ki67 and MUC-1. Both are predominated by ductal structures, some cystic, branched cell cords and solid islets. The glandular formations presented clear cells and some of oncocytic appearance. There was important cellular atypia, comedonecrosis, perineural growth, haemorrhagic areas and compromise of surgical margins. Nuclear marking with Ki67 was important; MUC-1 presented a strong staining in membranes and cytoplasms. They were diagnosed as high-grade malignancy. Our results show that there is an important proliferation marked with Ki67 and overexpression of MUC-1 associated with cellular atypia, perineural growth, necrosis and compromise of surgical margins, factorsassociated with a poor prognosis. The recognition of this tumor is transcendent for physicians and dentists since, due to the absence of distinctive features that other more specific carcinomas present, the diagnosis of exclusion is essential.


Subject(s)
Humans , Female , Middle Aged , Parotid Neoplasms/diagnosis , Parotid Neoplasms/metabolism , Parotid Neoplasms/pathology , Adenocarcinoma/metabolism , Adenocarcinoma/pathology , Prognosis , Salivary Gland Neoplasms , Immunohistochemistry , Adenocarcinoma/diagnosis , Biomarkers, Tumor , Mucin-1/metabolism , Ki-67 Antigen/metabolism , Cell Proliferation
4.
Article in Spanish | LILACS, BNUY, UY-BNMED | ID: biblio-1088690

ABSTRACT

Introducción y Objetivo: La utilidad de la citología por punción aspiración con aguja fina en la valoración de tumores parotídeos es controvertida, ya que existe gran variabilidad en cuanto a la sensibilidad y especificidad en las distintas series publicadas. Nuestro objetivo es evaluar la utilidad de la punción aspiración con aguja fina (PAAF) de los tumores de glándula parótida en nuestro medio. Métodos: Se realizó un estudio retrospectivo y observacional con una muestra de 77 pacientes con tumores de glándula parótida, en el periodo 2000-2017 en dos centros hospitalarios de Montevideo, Uruguay, que fueron sometidos a punción aspiración con aguja fina preoperatoria y que posteriormente se correlacionó con el estudio anatomopatológico definitivo. Resultados: La edad media fue de 54 años con un rango comprendido entre los 14 y 87 años. El 56,8% eran mujeres y el 44,2% hombres. La sensibilidad de la punción aspiración con aguja fina para el diagnóstico de malignidad fue del 30% y la especificidad fue del 98,46%, con un valor predictivo positivo del 75% y un valor predictivo negativo del 90,14%. Conclusiones: La punción aspiración con aguja fina es un método diagnóstico muy útil a la hora de estudiar un tumor de glándula parótida, sobre todo por su valor predictivo negativo, lo que permite afirmar con alta probabilidad la benignidad del proceso.


Introduction and objectives: the usage of fine needle aspiration cytology in the evaluation of parotid gland tumors is controversial, since there is great variability in terms of sensitivity and specificity in different series published. Our objective is to evaluate the usage of fine needle aspiration cytology in the study of parotid gland tumors in our population. Methods: A retrospective study was conducted using a sample of 77 patients with parotid gland tumors between 2000-2017 in two hospital centers in Montevideo, Uruguay, who underwent preoperative diagnostic fine needle aspiration cytology and subsequently were treated with surgery and anatomopathological study. Results: The mean age was 54 years old, with interval between 14-87 years of age. 56.8% were female. The sensitivity of the fine needle aspiration cytology for the diagnosis of malignancy was 30%, and the specificity was 98.46% with a positive predictive value of 75% and a negative predictive value of 90.14% Conclusions: fine needle aspiration cytology is a very useful diagnostic method in the evaluation of parotid gland tumors, mainly due to its high negative predictive value.


Introdução e objetivo: a utilidade da citologia por punção com aspiração com agulha fina na avaliação de tumores parotídeos é controversa, ja que existe uma grande variabilidade em termos de sensibilidade e especificidade nas diferentes séries publicadas. Nosso objetivo é avaliar a utilidade da punção de aspiração de agulha fina de tumores da glândula parótida em nosso meio. Métodos: realizou-se estudo retrospectivo e observacional com uma amostra de 77 pacientes com tumores da glândula parótida, no período 2000-2017 em dois hospitais em Montevidéu, Uruguai, que foram sobmetidos a punção de aspiração com agulha fina pré-operatória e posteriormente correlacionou-se com o estudo anatomopatológico definitivo. Resultados: A idade média foi de 54 anos, numa faixa entre 14 e 87 anos. 56,8% eram mulheres e 44,2% eram homens. A sensibilidade da punção de aspiração com agulha fina para o diagnóstico de malignidade foi de 30% ea especificidade foi de 98,46%, com um valor preditivo positivo de 75% e um valor preditivo negativo de 90,14%. Conclusões: A punção de aspiração com agulha fina é um método de diagnóstico muito útil na hora de estudar um tumor da glândula parótida, principalmente seu valor preditivo negativo, o que permite afirmar a benignidade do processo com alta probabilidade.


Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Aged , Aged, 80 and over , Parotid Gland/pathology , Biopsy, Needle/statistics & numerical data , Parotid Neoplasms/diagnosis , Predictive Value of Tests , Retrospective Studies , Sensitivity and Specificity , Surgical Clearance
5.
Rev. otorrinolaringol. cir. cabeza cuello ; 78(4): 385-391, dic. 2018. tab, graf
Article in Spanish | LILACS | ID: biblio-985743

ABSTRACT

RESUMEN Introducción: La glándula parótida es el sitio más común de tumores de glándulas salivales, correspondiendo al 75%-85% de éstos y al 3% de todos los tumores de cabeza y cuello. Ochenta por ciento de ellos corresponden a tumores benignos. Objetivos: Analizar la experiencia quirúrgica en tumores parotídeos operados en el Hospital Guillermo Grant Benavente. Material y método: Revisión de todos los pacientes con tumores parotídeos operados en el Servicio de Otorrinolaringología y Cirugía de Cabeza y Cuello, del Hospital Guillermo Grant Benavente entre enero del año 2011 y abril del año 2016. Las cirugías fueron realizadas por el mismo equipo quirúrgico. Se registraron datos demográficos, clínicos, quirúrgicos, histológicos y resultados posoperatorios. Resultados: En el periodo descrito se operó un total de 94 pacientes. 84,3% correspondieron a tumores benignos y 15,7% a tumores malignos. El 62,9% corresponde a pacientes de sexo femenino y 37,1% de sexo masculino, representando una relación de 1,69:1. La incidencia de parálisis facial transitoria fue de 16,1%, y de ellos solo un paciente mantuvo una parálisis permanente. Conclusión: Los tumores malignos representaron el 15,7%, siendo menor a lo reportado en la literatura. Se presenta una gran serie de tumores parotídeos tratados quirúrgicamente a nivel nacional, con una baja tasa de complicaciones.


Abstract Introduction: Parotid gland is the most common site of salivary gland tumors, corresponding to 75-85% of these and 3% of all head and neck tumors. 80% of them correspond to benign tumors. Aim: To analyze the surgical experience in parotid tumors operated in the Guillermo Grant Benavente Hospital. Material and Method: Review of all patients with parotid tumors operated in the Otorhinolaryngology and Head and Neck Surgery Unit of Hospital Guillermo Grant Benavente between January 2011 and April 2016. All surgeries were performed by the same surgical team. Demographic, clinical, surgical, histological and postoperative results were recorded. Results: In the period described, a total of 94 patients were operated on. 84.3% corresponded to benign tumors and 15.7% to malignant tumors. 62.9% corresponds to female patients and 37.1% male, representing a ratio of 1.69:1. The incidence of transient facial paralysis was 16.1%, and of these, only one patient maintained permanent paralysis. Conclusions: Malignant tumors represented 15.7% of cases, being less than reported in the literature. This article presents a large series of parotid tumors treated surgically in our country, with a low associated complication rate.


Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Aged , Aged, 80 and over , Young Adult , Parotid Gland/surgery , Parotid Neoplasms/surgery , Parotid Neoplasms/diagnosis , Chile/epidemiology , Retrospective Studies , Adenoma, Pleomorphic , Facial Nerve Injuries/etiology , Facial Paralysis/etiology
6.
Rev. chil. cir ; 68(5): 376-378, oct. 2016. ilus
Article in Spanish | LILACS | ID: lil-797348

ABSTRACT

Objetivo: Reportar casos de linfadenoma sebáceo, un tumor raro, localizado principalmente en la glándula parótida, con muy pocos casos descritos en la literatura. Casos clínicos: Presentamos 2 casos de esta rara afección, tratados en el Hospital Universitario Miguel Servet de Zaragoza, de enero de 2010 a diciembre de 2014. El diagnóstico, tanto por imagen como citológico, es difícil debido a su baja prevalencia y a la gran variedad de tumores de glándula parótida que existen. En los 2 casos presentados ha sido necesaria la exéresis para llegar al diagnóstico. El tratamiento curativo consiste en la exéresis completa de la tumoración.


Aim: To report a rare parotid tumour: sebaceous lymphadenoma, with very few cases reported in the literature. Cases report: We present 2 cases of lymphadenoma sebaceous of the parotid gland treated by surgery at University Hospital Miguel Servet of Zaragoza between January 2010 and December 2014. The diagnosis, both radiological and cytological, is difficult because of their low prevalence and the great variety of parotid gland tumors existent. In our 2 cases described, excision has been required for diagnosis. A complete excision of the tumor is required for curative treatment.


Subject(s)
Humans , Aged , Aged, 80 and over , Parotid Gland/pathology , Parotid Neoplasms/surgery , Adenolymphoma/surgery , Parotid Gland/surgery , Parotid Neoplasms/diagnosis , Adenolymphoma/diagnosis , Retrospective Studies
8.
Braz. j. otorhinolaryngol. (Impr.) ; 81(3): 301-306, May-Jun/2015. tab
Article in English | LILACS | ID: lil-751900

ABSTRACT

INTRODUCTION: Benign tumors of the parotid gland comprise the majority of salivary gland tumors. OBJECTIVE: To review the clinical characteristics of parotid gland tumors submitted to surgical treatment by the same surgeon. METHODS: Retrospective study with 154 patients who had parotid gland tumors. Clinical and histological data, type of surgery, and complications were assessed and described. RESULTS: The main manifestation was a mass with a median evolution of 12 months for benign tumors and five months for malignant tumors. Ultrasonography was the most frequent complementary exam. Pleomorphic adenoma was the most common of the benign tumors, and mucoepidermoid carcinoma was the most frequent malignant tumor. Superficial parotidectomy with preservation of the facial nerve was the most common surgical procedure and reversible paresis of branches of the facial nerve was the most common complication. CONCLUSIONS: Pleomorphic adenoma is the most common parotid gland tumor and superficial parotidectomy with preservation of the facial nerve is the most common and appropriate treatment for most low-morbidity tumors. .


INTRODUÇÃO: Os tumores de parótida são frequentemente de natureza benigna e correspondem à maioria dos tumores de glândulas salivares. OBJETIVO: Revisar as características clínicas de neoplasias de parótidas submetidas a tratamento cirúrgico pelo mesmo cirurgião. MÉTODO: Estudo retrospectivo, onde foram avaliados 154 pacientes com neoplasia de parótida. Dados clínicos, histológicos, tipo de cirurgia e complicações foram compilados e descritos. RESULTADOS: A principal manifestação foi a de uma massa tumoral com uma mediana de tempo de evolução de 12 meses para os tumores benignos e 5 meses para os tumores malignos. A ecografia foi o exame complementar mais indicado. Dentre os tumores benignos, o adenoma pleomórfico foi o mais comum e o carcinoma mucoepidermóide o mais frequente dentre os malignos. A parotidectomia superficial com preservação do nervo facial foi a cirurgia mais indicada e a paresia reversível de ramos do nervo facial, a complicação mais prevalente. Conclusões: O adenoma pleomórfico é o tumor mais comum da glândula parótida e a parotidectomia superficial com preservação do nervo facial é o tratamento mais adequado para a maioria dos tumores de baixa morbidade. .


Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Aged , Aged, 80 and over , Young Adult , Adenoma, Pleomorphic/pathology , Parotid Neoplasms/pathology , Adenoma, Pleomorphic/diagnosis , Adenoma, Pleomorphic/surgery , Parotid Neoplasms/diagnosis , Parotid Neoplasms/surgery , Postoperative Complications , Retrospective Studies
9.
Rev. chil. cir ; 66(4): 367-370, ago. 2014. ilus
Article in Spanish | LILACS | ID: lil-719121

ABSTRACT

Objective: To report a case of carcinoma ex pleomorphic adenoma on a young patient. Introduction: Carcinoma ex pleomorphic adenoma typically presents in patients in the sixth decade of life, with a history of parotid tumor of long standing. Alarm symptoms are present in 50 percent of cases and survival is mainly correlated with the degree of differentiation and tumor invasion. Case report: A 33 years old woman with right parotid tumor of five years of evolution with slow growing and no symptoms. During the last year, present accelerated growth and stabbing pain. Total parotidectomy was performed without complications or sequelae. The biopsy confirms carcinoma ex pleomorphic adenoma. Discussion: The long-standing pleomorphic adenoma may present malignant transformation in up to 12 percent. We discuss risk factors, clinical presentation and diagnosis of carcinoma ex pleomorphic adenoma.


Objetivo: Presentar un caso clínico de carcinoma ex adenoma pleomorfo en una paciente joven. Introducción: El carcinoma ex adenoma pleomorfo se presenta típicamente en pacientes en la sexta década de la vida, con historia de tumor de parótida de larga data. Tiene síntomas de alarma en el 50 por ciento de los casos y la sobrevida se correlaciona principalmente con el grado de diferenciación y de invasión del tumor. Caso clínico: Paciente de 33 años con tumor de parótida derecho de 5 años de evolución, de lento crecimiento y asintomático. Que durante el último año de evolución presenta dolor punzante y crecimiento acelerado. Se realiza parotidectomía total sin complicaciones ni secuelas. La biopsia confirma un carcinoma ex adenoma pleomorfo. Discusión: El adenoma pleomorfo de larga data puede presentar malignización en hasta un 12 por ciento. Se discute los factores de riesgo, forma de presentación y diagnóstico del carcinoma ex adenoma pleomorfo.


Subject(s)
Humans , Adult , Female , Carcinoma in Situ/surgery , Carcinoma in Situ/diagnosis , Parotid Neoplasms/surgery , Parotid Neoplasms/diagnosis
11.
Rev. Hosp. Clin. Univ. Chile ; 25(4): 273-276, 2014. ilus
Article in Spanish | LILACS | ID: lil-786564

ABSTRACT

To report a case of basal cell adenoma in an adult patient. Introduction: The basal cell adenoma is a rare tumor, it represents the 1-2percent of the major salivary gland tumors. It has a low malignancy rate and a good prognosis, but it has high recurrency. It is tipically presented during the fifth decade of life, and its usually as a firm and movable mass of slow growth. Case Report: A 58-year-old man with a left parotid tumor of 4 months of evolution, with no other symptoms. A total parotidectomy is performed without any incidents, or sequels. The deferred biopsy showed a basal cell adenoma. Discussion: The histopathological analysis is essential for the differential diagnosis with malignant tumors. As there are case reports that shows malignancy of the basal cell adenoma the surgical excision has become the treatment of choice, along with a patient follow-up...


Subject(s)
Humans , Male , Middle Aged , Adenoma/surgery , Adenoma/diagnosis , Parotid Neoplasms/surgery , Parotid Neoplasms/diagnosis
12.
Rev. AMRIGS ; 57(4): 315-317, out.-dez. 2013. ilus
Article in English | LILACS | ID: biblio-847586

ABSTRACT

As neoplasias mesenquimais primárias das glândulas salivares são raras. Os autores descrevem um caso de angiossarcoma primário da glândula parótida em um homem com 84 anos (AU)


Primary mesenchymal neoplasms of the salivary glands are rare. The authors report a case of primary angiosarcoma of the parotid gland in a 84-year old male (AU)


Subject(s)
Humans , Male , Aged, 80 and over , Parotid Neoplasms/pathology , Hemangiosarcoma/pathology , Parotid Gland/abnormalities , Parotid Neoplasms/diagnosis , Hemangiosarcoma/surgery , Hemangiosarcoma/diagnosis
13.
Int. j. morphol ; 31(3): 1056-1061, set. 2013. ilus
Article in Spanish | LILACS | ID: lil-695000

ABSTRACT

El carcinoma de células claras es una neoplasia rara de bajo grado que se desarrolla casi exclusivamente en glándulas salivales menores humanas. El objetivo de esta comunicación es analizar las características estructurales, histoquímicas e inmunohistoquímicas (IHQ) de dos casos de carcinoma de células claras de parótida y realizar el diagnóstico diferencial con otros tumores salivales primarios y metastásicos que presentan células claras. Cortes de ambos tumores fueron procesados para H/E, tricrómicos de Masson y Dane, Azul de toluidina, Azul alciano, PAS y PAS/diastasa; marcaciones IHQ para citoqueratinas de bajo y alto peso molecular, ki67, HMB45, p63 y proteína S-100. El patrón estructural de estos tumores estaba determinado por nidos y cordones de células claras delimitados por un estroma no hialinizado. En un tumor se observó una neoplasia maligna a células claras con manifiesta anaplasia. La expresión de ki67 fue importante. El otro tumor estaba constituido por células claras monomorfas sin signos manifiestos de atipia y casi nula expresión de ki67. Con PAS se demostró la presencia de glucógeno y no se observó un desarrollo importante del estroma colágeno en ambas neoplasias. En ambos casos resultó francamente positiva la inmunomarcación para citoqueratinas de bajo y alto peso molecular. Por el contrario resultó negativa para HMB45 y p63. La proteína S-100 tuvo su expresión en células aisladas. Se concluye que los casos presentados son de localización poco común (parótida) según lo descripto en la bibliografía; corresponden a la variedad no hialinizante ya que no está presente un importante estroma colágeno hialinizado, y ambos tumores son primarios de glándulas salivales, de origen epitelial, no melanocítico ni hematopoyético (linfomas) como lo demuestran las marcaciones IHQ.


The clear cell carcinoma is a rare neoplam of low level grade that develops almost exclusively in human minor salivary glands. The objective of this present work is to analyze the structural, histochemical and inmunohistochemical (IHQ) characteristics of two cases of parotid clear cell carcinoma and make a differential diagnosis with other primary and metastatic salivary tumors that clear cells show. Serial cuts of both tumors were processed for H/E, Masson and Dane trichromes, Toluidine blue, Alcian blue, PAS and PAS/diastase; IHQ marking of both high-and low-molecular weight cytokeratins, ki67, HMB45, p63 and S-100 protein. The structural pattern of these tumors were determined by nests and cords of clear cells delimited by a stroma non hyaline. In a tumor a malign neoplasia was observed in clear cells with anaplasia. The ki67 expression was important. The other tumor was constitued of clear monomorph cells without manifestation signs of atypia and almost no ki67 expression. With PAS was confirmed the presence of glycogen and not observed an important development of the collagen stroma in both neoplasms. Both cases resulted very positive the immunostaining of both high and low molecular weight cytokeratins. It resulted negative for the HMB45 and p63. The protein S-100 has it´s expression in isolated cells. We conclude that: the presented cases are very uncommon localization (parotid) as described by the literature; it matches a non hyalinizing variety because a very important hyalinized collagen stroma is not present, both primary tumors of salivary glands, of epithelial origin, non melanocytic, renal or hematopoietic lymphomas which shows immunostaining IHQ.


Subject(s)
Humans , Male , Female , Middle Aged , Adenocarcinoma, Clear Cell/pathology , Parotid Neoplasms/pathology , Adenocarcinoma, Clear Cell/diagnosis , Diagnosis, Differential , Immunohistochemistry , Parotid Neoplasms/diagnosis
14.
Acta otorrinolaringol. cir. cabeza cuello ; 41(1): 65-67, ene.-mar. 2013. ilus
Article in Spanish | LILACS | ID: lil-694381

ABSTRACT

Los tumores parotídeos representan en nuestro medio una patología relativamente común, como una neoplasia de tipo benigno. El tipo histológico más frecuente es el tumor mixto de parótida, denominado adenoma pleomórfico, el cual tiene un crecimiento lento, que al cabo del tiempo se puede transformar en maligno. El caso que se presenta corresponde a una paciente atemorizada por los riesgos posibles de una cirugía, y tomó la decisión de recluirse en su casa por más de diez años, hasta que se vio obligada a consultar por un evento hemorrágico de la masa tumoral…


Parotid tumors represent pathology in our relatively common one, like a benign type aneoplasia. The most common histologic type is called mixed tumor of parotid pleomorphic adenoma called, which has slow growth, which over time can transform into malignant. The case presented is from a frightened by the possible risks of a surgery, and made the decision to retreat his home for ten years, until he was forced to consult a hemorrhagic event in tumor mass…


Subject(s)
Female , Adenoma, Pleomorphic , Parotid Neoplasms , Parotid Neoplasms/diagnosis
15.
Rev. chil. cir ; 64(6): 560-562, dic. 2012. ilus
Article in Spanish | LILACS | ID: lil-660015

ABSTRACT

Introduction: Sebaceous carcinoma of the parotid gland is an extremely rare neoplasm, whose treatment is complex by the possible consequences that may occur due to its location. Material and Methods: We report a case of a 54 year old patient with a left parotid tumor without facial nerve dysfunction. The imaging study reports the presence of a left parotid tumor of 2.3 cm, without lymphadenopathy. Results: We performed a left partial parotidectomy whose final pathological diagnosis was a sebaceous carcinoma of the parotid gland.


Introducción: El carcinoma sebáceo de la glándula parótida es una neoplasia extremadamente infrecuente, cuyo manejo es complejo por las posibles secuelas que pueden suceder dada su localización. Material y Método: Se reporta el caso de una paciente de 54 años con un tumor parotídeo izquierdo de larga data sin compromiso de la función del VII par. Resultados: El estudio por imágenes informó la presencia de un tumor parotídeo izquierdo de 2,2 cm, sin linfoadenopatías regionales. Se realizó una parotidectomía parcial izquierda cuyo diagnóstico patológico definitivo fue un carcinoma sebáceo de glándula parótida.


Subject(s)
Humans , Female , Middle Aged , Adenocarcinoma, Sebaceous/surgery , Adenocarcinoma, Sebaceous/diagnosis , Parotid Neoplasms/surgery , Parotid Neoplasms/diagnosis , Sebaceous Gland Neoplasms/surgery , Sebaceous Gland Neoplasms/diagnosis , Treatment Outcome
17.
Indian J Pathol Microbiol ; 2012 Jul-Sept 55(3): 392-395
Article in English | IMSEAR | ID: sea-142279

ABSTRACT

Warthin's tumor also known as papillary cystadenoma lymphomatosum is a common benign salivary gland neoplasm that occurs exclusively in parotid gland. Rarely, the tumor can undergo carcinomatous or lymphomatous transformation of epithelial or lymphoid component, respectively. Herein, we describe a case of 55-year-old female who had undergone parotidectomy for a rapidly growing tumor in the right parotid gland. The case was diagnosed as mucoepidermoid carcinoma developed in a setting of Warthin's tumor based on the histomorphology, special staining characters, and immunohistochemical findings. The pathogenesis and differential diagnoses of such rare malignancy has been discussed briefly.


Subject(s)
Adenolymphoma/complications , Adenolymphoma/diagnosis , Adenolymphoma/pathology , Adenolymphoma/surgery , Carcinoma, Mucoepidermoid/complications , Carcinoma, Mucoepidermoid/diagnosis , Carcinoma, Mucoepidermoid/pathology , Carcinoma, Mucoepidermoid/surgery , Female , Histocytochemistry , Humans , Microscopy , Middle Aged , Parotid Gland/pathology , Parotid Gland/surgery , Parotid Neoplasms/diagnosis , Parotid Neoplasms/pathology , Parotid Neoplasms/surgery
18.
Rev. otorrinolaringol. cir. cabeza cuello ; 72(1): 79-86, abr. 2012. ilus
Article in Spanish | LILACS | ID: lil-627564

ABSTRACT

Los linfomas de las glándulas salivales son una entidad poco frecuente, estimándose una incidencia del 5 por ciento. La localización más habitual es la glándula parótida, seguida de la submaxilary la sublingual. La mayoría de los linfomas parotídeos son linfomas no Hodgkin (LNH) y se consideran derivados del tejido linfoide asociado a mucosas (MALT). Infrecuentemente se han reportado estos casos y suelen ser subdiagnosticados por su presentación relativamente benigna, comportándose de forma localizada, de lento crecimiento, con varios años de evolución. Presentamos un caso clínico de linfoma tipo MALT de parótida de acuerdo a las características clínicas, histológicas e inmunohistoquímicas de este tumor. Además una revisión de la literatura de este caso.


Lymphomas of the salivary glands are a rare entity, with an estimated incidence of 5 percent. The most frequent location is parotid gland, followed by the submandibular and sublingual. The majority of parotid lymphomas are non-Hodgkin's lymphoma NHL and are considered derived from mucosa-associated lymphoid tissue (MALT). Infrequently these cases have been reported and are often underdiagnosed for their presentation is relatively benign, localized behaving, slow growing, with several years of evolution. We report a case of parotid MALT lymphoma according to the clinical, histological and immunohistochemical characteristics of this tumor. In addition, a literature review of this case.


Subject(s)
Humans , Male , Aged , Lymphoma, B-Cell, Marginal Zone/diagnosis , Parotid Neoplasms/diagnosis , Parotid Neoplasms/surgery , Parotid Neoplasms/radiotherapy , Parotid Neoplasms/diagnostic imaging , Tomography, X-Ray Computed , Lymphoma, B-Cell, Marginal Zone/surgery , Lymphoma, B-Cell, Marginal Zone/radiotherapy , Lymphoma, B-Cell, Marginal Zone/diagnostic imaging , Immunohistochemistry , Lymphoma, B-Cell, Marginal Zone/pathology , Parotid Neoplasms/pathology
20.
Braz. j. otorhinolaryngol. (Impr.) ; 77(5): 639-644, Sept.-Oct. 2011. tab
Article in English | LILACS | ID: lil-601864

ABSTRACT

Primary malignant lymphomas in the salivary glands are relatively rare. Clinical presentation is not characteristic and the disease is often overlooked resulting in diagnosis and treatment delays. AIM: To stress the importance of the diagnostic process and combined management, we present a series of eight patients with malignant lymphoma of the parotid who were diagnosed only after surgery and managed with radiation and chemotherapy. METHODS: Retrospective series of patients with primary malignant lymphoma of the parotid gland managed with radiotherapy and diagnostic surgical partial resection. RESULTS: After treatment completion we achieved a loco-regional control rate of 87.5 percent. Toxicity was charted according to the Common Toxicity Criteria and it was seen in six patients (75 percent). Six patients are still alive without evidence of recurrent disease in their last follow-up. CONCLUSION: Our study confirms that primary early stage Non-Hodgkin Lymphoma of the parotid gland is a disease with an excellent prognosis and a good local control rate, with minimal morbidity.


Linfomas primários das glândulas salivares são relativamente raros. Sua apresentação clínica não écaracterística e, frequentemente, a doença passa despercebida, resultando em atrasos no diagnóstico e tratamento. OBJETIVO: Enfatizar a importância do diagnóstico e tratamento combinado. Apresentamos uma casuística de oito pacientes com linfoma maligno da parótida, que foram diagnosticados somente após a cirurgia e tratados com radio e quimioterapia. MÉTODOS: Estudo retrospectivo de pacientes com linfoma maligno primário da glândula parótida, tratados com radioterapia e ressecção cirúrgica parcial diagnóstica. RESULTADOS: Após a conclusão do tratamento, atingimos uma taxa de controle loco-regional de 87,5 por cento. A toxicidade foi classificada de acordo com os Critérios Comuns de Toxicidade e afetou seis pacientes (75 por cento). Seis pacientes ainda estão vivos, sem evidência de doença na mais recente consulta de acompanhamento. CONCLUSÃO: Nosso estudo confirma que o Linfoma primário Não-Hodgkin em estágios iniciais da glândula parótida é uma doença com excelente prognóstico e boa taxa de controle local, com mínima morbidade.


Subject(s)
Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Lymphoma, Non-Hodgkin/therapy , Parotid Neoplasms/therapy , Combined Modality Therapy/methods , Lymphoma, Non-Hodgkin/diagnosis , Parotid Neoplasms/diagnosis , Retrospective Studies , Treatment Outcome
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