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Rev. Assoc. Med. Bras. (1992) ; 66(10): 1323-1326, Oct. 2020. tab
Article in English | LILACS, SES-SP | ID: biblio-1136147


The Guidelines Project, an initiative of the Brazilian Medical Association, aims to combine information from the medical field in order to standardize producers to assist the reasoning and decision-making of doctors. The information provided through this project must be assessed and criticized by the physician responsible for the conduct that will be adopted, depending on the conditions and the clinical status of each patient.

Humans , Female , Pregnancy , Pregnancy Trimester, First , Brazil , Ultrasonography
Rev. cuba. med. mil ; 49(3): e796, jul.-set. 2020. tab, fig
Article in Portuguese | LILACS, CUMED | ID: biblio-1144471


Introducción: La pandemia por la COVID-19 ha causado más 350 000 muertes a nivel mundial. Objetivo: Caracterizar clínicamente a las pacientes obstétricas con sospecha de la COVID-19. Métodos: Se realizó un estudio retrospectivo, descriptivo, de corte transversal. Fueron incluidas todas las pacientes obstétricas que ingresaron en el Hospital Militar Central "Dr. Luis Díaz Soto", entre el 12 de marzo y 20 de mayo de 2020. Se dividieron en dos grupos; en el I se incluyeron las que presentaron el PCR en tiempo real para SARS-CoV-2 negativo y en el grupo II, las que resultaron positivas. Las variables analizadas fueron la edad, antecedentes obstétricos, antecedentes patológicos personales, historia epidemiológica, cuadro clínico, complicaciones, ingreso en la unidad de terapia intensiva y mortalidad materna. Resultados: Ingresaron 60 pacientes obstétricas y 6 (10 por ciento) resultaron positivas al SARS-CoV-2, de las provincias La Habana, Mayabeque y Artemisa. La edad promedio fue de 25 años. Se encontraban en el primer trimestre del embarazo el 25,9 por ciento del grupo I y el 66,6 por ciento del grupo II. Presentó comorbilidad el 38,8 por ciento y 16,6 por ciento, del grupo I y grupo II respectivamente. Se encontraban asintomáticas 50 por ciento de las positivas. Se observó leucopenia en 10 (18,5 por ciento) del grupo I y en 5 (83,3 por ciento) del grupo II. Se presentó un aborto espontáneo en el grupo II. No hubo neumonía por la COVID-19, ni muertes maternas. Conclusiones: La COVID -19 se presentó con mayor frecuencia en las gestantes durante el primer trimestre, predominó la forma leve de la enfermedad, no existió neumonía por la COVID-19 ni muertes(AU)

Introduction: The COVID-19 pandemic has caused more than 350,000 deaths worldwide. Objective: To clinically characterize obstetric patients with suspected COVID-19. Methods: A retrospective, descriptive, cross-sectional study was performed. All obstetric patients admitted to the Hospital Militar Central "Dr. Luis Díaz Soto" between March 12 and May 20, 2020. They were divided into two groups; Group I included those with negative RT-PCR for SARS-CoV-2 and group II with positive results. The variables analyzed were age, obstetric history, personal pathological history, epidemiological history, clinical picture, complications, admission to the intensive care unit and maternal mortality. Results: 60 obstetric patients were admitted and 6 (10 percent) were positive for SARS-CoV-2, from the provinces of Havana, Mayabeque and Artemisa. The average age was 25 years. 25.9 percent of group I and 66.6 percent of group II were in the 1st trimester of pregnancy. 38.8 percent and 16.6 percent, of group I and group II, respectively, presented comorbidity. 50 percent of the positives were asymptomatic. Leukopenia was observed in 10 (18.5 percent) cases in group I and in 5 (83.3 percent) in group II. Spontaneous abortion occurred in group II. There was no COVID-19 pneumonia, nor maternal death. Conclusions: COVID-19 occurred more frequently in pregnant women during the first trimester, the mild form of the disease prevailed, with no COVID-19 pneumonia or deaths from this disease(AU)

Humans , Female , Pregnancy , Pregnancy Trimester, First , Abortion, Spontaneous/drug therapy , Cross-Sectional Studies , Coronavirus Infections , Pregnant Women , Maternal Death , Betacoronavirus , Epidemiology, Descriptive
Int. j. morphol ; 38(4): 1018-1025, Aug. 2020. graf
Article in English | LILACS | ID: biblio-1124891


The equine placenta is a simple apposition of fetal and maternal tissues, becoming more complex with the formation of microcotyledons around days 75 and 100 of gestation. The present study aimed to describe the gross and microscopic morphology of early equine placenta. Embryonic/fetal membranes from thirty-seven mares were submitted to macroscopic description, light, scanning and transmission microscopy. Overall the gross characteristics of membranes were similar with already described for older stages. However, transmission electron microscopy evidenced high metabolic rate in chorion and allantois, and high secretion profile in amnion and even higher in yolk sac. Gene ontologies enrichment, using published data, pointed several common ontologies in allantoic and amniotic fluids, related to oxygen and iron transport, extracellular space and high-density lipoprotein receptor binding. Overall, the morphological and ontology enrichment could indicate allantois and amnion crosstalk.

La placenta equina es una simple aposición de tejidos fetales y maternos, que se vuelve más compleja con la formación de microcotiledones alrededor de los días 75 y 100 de gestación. El presente estudio tuvo como objetivo describir la morfología macroscópica y microscópica de la placenta equina temprana. Las membranas embrionarias / fetales de treinta y siete yeguas fueron sometidas a descripción macroscópica, luz, escaneo y microscopía de transmisión. En general, las características generales de las membranas fueron similares a las ya descritas para las etapas más antiguas. Sin embargo, la microscopía electrónica de transmisión mostró una alta tasa metabólica en corion y alantoides, y un alto perfil de secreción en amnios e incluso mayor en el saco vitelino. El enriquecimiento de ontologías génicas, utilizando datos publicados, señaló varias ontologías comunes en fluidos alantoideos y amnióticos, relacionados con el transporte de oxígeno y hierro, espacio extracelular y unión a receptores de lipoproteínas de alta densidad. En general, el enriquecimiento morfológico y ontológico podría indicar alantoides y diafonía de amnios.

Animals , Female , Pregnancy , Placenta/anatomy & histology , Horses , Placenta/ultrastructure , Pregnancy Trimester, First , Chorion , Allantois , Amnion , Microscopy/methods
Article in English | WPRIM | ID: wpr-877687


INTRODUCTION@#Pregnant women are reported to be at increased risk of severe coronavirus disease 2019 (COVID-19) due to underlying immunosuppression during pregnancy. However, the clinical course of COVID-19 in pregnancy and risk of vertical and horizontal transmission remain relatively unknown. We aim to describe and evaluate outcomes in pregnant women with COVID-19 in Singapore.@*METHODS@#Prospective observational study of 16 pregnant patients admitted for COVID-19 to 4 tertiary hospitals in Singapore. Outcomes included severe disease, pregnancy loss, and vertical and horizontal transmission.@*RESULTS@#Of the 16 patients, 37.5%, 43.8% and 18.7% were infected in the first, second and third trimesters, respectively. Two gravidas aged ≥35 years (12.5%) developed severe pneumonia; one patient (body mass index 32.9kg/m2) required transfer to intensive care. The median duration of acute infection was 19 days; one patient remained reverse transcription polymerase chain reaction (RT-PCR) positive >11 weeks from diagnosis. There were no maternal mortalities. Five pregnancies produced term live-births while 2 spontaneous miscarriages occurred at 11 and 23 weeks. RT-PCR of breast milk and maternal and neonatal samples taken at birth were negative; placenta and cord histology showed non-specific inflammation; and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific immunoglobulins were elevated in paired maternal and umbilical cord blood (n=5).@*CONCLUSION@#The majority of COVID-19 infected pregnant women had mild disease and only 2 women with risk factors (obesity, older age) had severe infection; this represents a slightly higher incidence than observed in age-matched non-pregnant women. Among the women who delivered, there was no definitive evidence of mother-to-child transmission via breast milk or placenta.

Abortion, Spontaneous/epidemiology , Adult , COVID-19/transmission , COVID-19 Nucleic Acid Testing , COVID-19 Serological Testing , Cohort Studies , Disease Transmission, Infectious/statistics & numerical data , Female , Fetal Blood/immunology , Humans , Infectious Disease Transmission, Vertical/statistics & numerical data , Live Birth/epidemiology , Maternal Age , Milk, Human/virology , Obesity, Maternal/epidemiology , Placenta/pathology , Pregnancy , Pregnancy Complications, Infectious/physiopathology , Pregnancy Outcome/epidemiology , Pregnancy Trimester, First , Pregnancy Trimester, Second , Prospective Studies , RNA, Viral/analysis , Risk Factors , SARS-CoV-2 , Severity of Illness Index , Singapore/epidemiology , Umbilical Cord/pathology , Young Adult
Rev. cuba. obstet. ginecol ; 45(4): e440, oct.-dic. 2019. tab
Article in Spanish | LILACS, CUMED | ID: biblio-1126709


RESUMEN Introducción: La pesquisa prenatal de anomalías cromosómicas, mediante el uso de marcadores epidemiológicos y ecográficos del primer trimestre permite identificar gestantes con riesgo incrementado de síndrome de Down. Objetivos: Analizar la edad materna, la translucencia nucal, el ductus venoso y el hueso nasal, durante el cribaje del primer trimestre, en las gestantes que se realizaron diagnóstico prenatal citogenético, con el fin de evaluar la efectividad del mismo en la detección temprana del síndrome Down y su utilidad para la reducción del número de pruebas invasivas. Métodos: Se realizó un estudio descriptivo retrospectivo de corte transversal y se analiza una muestra de 3439 gestantes a las que se realizó el estudio citogenético indicado en el Centro Provincial de Genética Médica de La Habana, en el período comprendido entre el 3 de enero de 2006 y el 30 de diciembre de 2008. Resultados: La edad materna avanzada mostró una sensibilidad de un 87 por ciento del test y una tasa de falsos positivos de 99 por ciento. La translucencia nucal se comportó con una sensibilidad de 10 por ciento. El hueso nasal no mostró asociación con los cariotipos positivos para síndrome de Down. Al no realizarse sistemáticamente la presencia del ductus venoso, no se pudo establecer una asociación estadística. La estimación de riesgo de síndrome de Down basada únicamente en la edad materna avanzada determina una alta tasa de falsos positivos. Por lo que este marcador, unido a la evaluación de los marcadores ecográficos del primer trimestre para recalcular el riesgo individual, puede aumentar la efectividad en el diagnóstico y disminuir el número de pruebas invasivas. Conclusiones: La estimación de riesgo de síndrome de Down basada únicamente en la edad materna avanzada determina una alta tasa de falsos positivos. Por lo que este marcador, unido a la evaluación de los marcadores ecográficos del primer trimestre para recalcular el riesgo individual, puede aumentar la efectividad en el diagnóstico y disminuir el número de pruebas invasivas(AU)

ABSTRACT Introduction: The prenatal investigation of chromosomal abnormalities through the use of epidemiological and echographic markers on the first trimester, allows to identify pregnant women with an increased risk of Down syndrome. Objectives: To analyze maternal age, nuchal translucency, venous ductus and nasal bone, during the first trimester screening, in pregnant women who underwent prenatal cytogenetic diagnosis, in order to evaluate effectiveness in early detection of Down syndrome and the value for reducing the number of invasive tests. Methods: A descriptive retrospective cross-sectional study was carried out and a sample of 3439 pregnant women was studied. The cytogenetic study ordered at Havana Provincial Center for Medical Genetics was carried out from January 3, 2006 to December 30, 2008. Results: Advanced maternal age showed 87 percent sensitivity and 99 percent of false positive rate. Nuchal translucency accounted 10 percent of sensitivity. The nasal bone showed no association with positive karyotypes for Down syndrome. A statistical association of the venous ductus presence could not be established since the search was not systematically. Conclusions: The estimation of Down syndrome risk based solely on advanced maternal age determines high false positive rate. Therefore, this marker, together with the evaluation of the first trimester ultrasound markers for recalculating the individual risk, can increase the diagnostic effectiveness and decrease the number of invasive tests(AU)

Humans , Female , Pregnancy , Pregnancy Trimester, First , Prenatal Diagnosis/methods , Mass Screening/adverse effects , Down Syndrome/diagnosis , Nuchal Translucency Measurement/methods , Epidemiology, Descriptive , Cross-Sectional Studies , Retrospective Studies , Cytogenetics/methods
Rev. chil. obstet. ginecol. (En línea) ; 84(6): 460-468, dic. 2019. tab, graf, ilus
Article in Spanish | LILACS | ID: biblio-1092761


Introducción y objetivo El aborto es la pérdida del producto de la concepción antes de la viabilidad fetal y se considera la principal complicación del embarazo. El objetivo de nuestro trabajo es evaluar los resultados iniciales y en mediano plazo del manejo con Aspiración Manual Endouterina (AMEU) del aborto en el primer trimestre. Métodos Análisis estadístico de serie de casos de 53 pacientes sometidas a AMEU en el Hospital Carlos Van Buren, Valparaíso desde noviembre 2017 a junio 2018 por aborto del primer trimestre. El diagnóstico fue clínico y mediante ultrasonografía. Se efectuó un cuestionario de satisfacción posterior al procedimiento. Resultados Se analizaron 53 pacientes, cuya edad promedio es de 29 años, 19 nulíparas, 34 multíparas, con edad gestacional promedio de 8 semanas. Se analizaron 53 biopsias de contenido intrauterino que resultaron en 53 abortos, de éstos 39 retenidos y 14 incompletos. Se registró un 3% de complicaciones (1 caso de perforación uterina que sólo requirió manejo médico y 1 caso de evacuación incompleta). El cuestionario reveló en una mayoría, el alivio de los síntomas y satisfacción en relación al procedimiento. Conclusión La AMEU es una buena alternativa en el manejo del aborto debido a menores costos, baja tasa de complicaciones y alta eficacia. Los centros que disponen de diversas alternativas para el manejo del aborto deben asegurarse de que la mujer participe activamente en la elección en cuanto a su resolución.

ABSTRACT Introduction and objective Miscarriage is the loss of the product of conception before fetal viability and it is considered the main complication of pregnancy. The main objective of our study is to evaluate initial and midterm reports using Manual Vacuum Aspiration (MVA) as management of first trimester miscarriage. Methods Statistic analysis of a case series of 53 patients submitted to MVA at Hospital Carlos Van Buren, Valparaíso since November 2017 until June 2018 with first trimester miscarriage. The diagnosis was clinical and ultrasonographic. A post procedure satisfaction questionnaire was carried out. Results Fifty-three patients were analyzed, with mean age of 29 years, 19 were nulliparous, 34 multiparous, mean gestational age of 8 weeks. Fifty-three intrauterine biopsies were analyzed, of which 53 were miscarriage, 39 retained sacs and 14 incomplete. We had 3% of complications (1 case of uterine perforation requiring only medical treatment and 1 case incomplete vacuum). The questionnaire revealed in a majority, the relief of symptoms and satisfaction with the procedure. Conclusion MVA is a good alternative in the management of miscarriage due to less costs, low rate of complications and high efficacy. The centres with various alternatives for miscarriage management must ensure that the women actively participates in the election of the resolution.

Humans , Female , Adult , Vacuum Curettage/methods , Abortion , Pregnancy Trimester, First , Vacuum Curettage/adverse effects , Surveys and Questionnaires , Abortion, Incomplete , Gestational Age , Misoprostol/administration & dosage
Rev. Bras. Saúde Mater. Infant. (Online) ; 19(4): 1023-1032, Sept.-Dec. 2019. tab, graf
Article in English | LILACS | ID: biblio-1057116


Abstract Objectives: temporal-spatial analysis of prenatal indicators in the municipalities of the state of Tocantins based on the use of five-year intervals from 2001 to 2015. Methods: the indicators subject to analysis were: average prenatal care (APCPW), proportion of prenatal care in the first trimester (PPCFT) and proportion of pregnant women with vaccine on time (PWVT). Data from the DATASUS platform were used for spatialization of indicators through Thematic Maps, using the QGIS software. Results: indicators of proportion of prenatal care in the first trimester and proportion of pregnant women with vaccine on time showed gradual improvement in their indicators after 15 years of analysis, with values above 75% and 90%, respectively, showing compatibility with the current national scenario. However, APCPW has revealed that no municipality had more than 3 prenatal care visits within 15 years. Conclusions: among the indicators analyzed, the average of prenatal care, although it showed improvement in the 15-year interval, is the one with the greatest deficiency in the state and should therefore have a greater focus on primary care. Thus, it emphasizes the need to encourage the development of organized health systems and the use of specific policy actions to improve not only this indicator, but also the others, to improve prenatal quality.

Resumo Objetivos: análise temporal e espacial de indicadores do pré-natal nos municípios do Estado do Tocantins, baseando-se na utilização de intervalos quinquenais dentro do período de 2001 a 2015. Métodos: os indicadores sujeitos a análise foram: média de atendimentos de pré-natal (MAPNG), proporção de pré-natal no primeiro trimestre (PGPNPT) e proporção de gestantes com vacina em dia (PGVD). Utilizaram-se dados da plataforma do DATASUS para espacia-lização dos indicadores mediante Mapas Temáticos, através do software QGIS. Resultados: os indicadores de início do pré-natal no primeiro trimestre e proporção de gestantes com vacina em dia exibiram melhora gradual no indicador após 15 anos de análise, com valores superiores a 75% e 90%, respectivamente, demostrando compatibilidade com o atual cenário nacional. Entretanto, a MAPNG revelou que nenhum munícipio apresentou atendimento superior a 3 no intervalo de 15 anos. Conclusões: dentre os indicadores analisados, a média de atendimentos de pré-natal, embora tenha apresentado melhora no intervalo de 15 anos, é o que apresenta maior deficiência no estado, devendo, portanto, possuir maior foco na atenção primária. Desse modo, enfatiza-se a necessidade de encorajar o desenvolvimento de sistemas de saúde organizados e emprego de ações políticas específicas que permitam a melhora de não apenas esse indi-cador, como também os demais, para melhoria da qualidade do pré-natal.

Humans , Female , Pregnancy , Prenatal Care/statistics & numerical data , Quality of Health Care , Health Status Indicators , Spatial Analysis , Spatio-Temporal Analysis , Pregnancy Trimester, First , Primary Health Care , Brazil , Family Health , Women's Health
Säo Paulo med. j ; 137(5): 391-400, Sept.-Oct. 2019. tab, graf
Article in English | LILACS | ID: biblio-1059105


ABSTRACT BACKGROUND: The prevalence of congenital abnormalities in general populations is approximately 3-5%. One of the most important applications of obstetric ultrasound is in detection of fetal structural defects. OBJECTIVE: To assess fetal structural anomalies diagnosed using ultrasound in the three trimesters of pregnancy. DESIGN AND SETTING: Retrospective cohort study at the Mário Palmério University Hospital of the University of Uberaba (Universidade de Uberaba, UNIUBE), from March 2014 to December 2016. METHODS: Ultrasound data at gestational weeks 11-13 + 6, 20-24 and 32-36 were recorded to identify fetal anomalies in each trimester and in the postnatal period. The primary outcome measurements were sensitivity, specificity, positive predictive value and negative predictive value for detection of fetal anomalies and their prevalence. RESULTS: The prevalence of anomalies detected using ultrasound was 2.95% in the prenatal period and 7.24% in the postnatal period. The fetal anomalies most frequently diagnosed using ultrasound in the three trimesters were genitourinary tract anomalies, with a prevalence of 27.8%. Cardiac anomalies were diagnosed more often in the postnatal period, accounting for 51.0% of all cases. High specificity, negative predictive value and accuracy of ultrasound were observed in all three trimesters of pregnancy. CONCLUSION: Ultrasound is safe and has utility for detecting fetal anomalies that are associated with high rates of morbidity and mortality. However, the low sensitivity of ultrasound for detecting fetal anomalies in unselected populations limits its utility for providing reassurance to examiners and to pregnant women with normal results.

Humans , Female , Pregnancy , Adolescent , Adult , Young Adult , Congenital Abnormalities/diagnostic imaging , Ultrasonography, Prenatal/methods , Fetal Diseases/diagnostic imaging , Fetus/abnormalities , Pregnancy Trimester, Second , Pregnancy Trimester, Third , Pregnancy Trimester, First , Congenital Abnormalities/epidemiology , Brazil/epidemiology , Prevalence , Retrospective Studies , Fetus/diagnostic imaging
Bol. méd. postgrado ; 35(1): 31-34, Ene-Jun. 2019. tab
Article in Spanish | LILACS, LIVECS | ID: biblio-1120642


La Enfermedad Trofoblástica Gestacional (ETG) es una patología de la primera mitad del embarazo caracterizada por una degeneración hidrópica de las vellosidades coriales que abarca la placenta y el resto del complejo ovular; es generalmente benigna pero puede malignizarse y distribuirse hacia otros tejidos. Se realizó un estudio descriptivo transversal con recolección retrospectiva de datos cuyo objetivo fue determinar los factores de riesgo de la ETG en pacientes que acudieron al Servicio de Emergencia Gineco-Obstétrica del Hospital Dr. Antonio María Pineda durante el período enero-agosto 2018. Dentro de la muestra se incluyeron las historias clínicas de 55 pacientes siendo la mayor parte mujeres menores de 28 años, de procedencia urbana, multigestas, sin antecedentes de aborto espontáneo o embarazo molar y sin uso de dispositivos intrauterinos o uso prolongado de anticonceptivas orales. En conclusión, se hace necesario un mayor seguimiento a mujeres embarazadas jóvenes con las características anteriormente expuestas con la finalidad de realizar un diagnóstico temprano de la enfermedad y de esta manera implementar medidas que garanticen su salud y vida(AU)

Gestational Trophoblastic Disease (TSG) is a pathology of the first half of pregnancy characterized by a hydropic degeneration of the chorionic villi that spans the placenta and the rest of the ovular complex; it is usually benign, but it can become malignant and spread to other tissues. A descriptive transversal study with retrospective review of medical charts was performed in order to determine the risk factors for TSG of patients evaluated at the Servicio de Emergencia Gineco-Obstétrica of the Hospital Dr. Antonio Maria Pineda during the January-August 2018 period. Fifty-five medical charts were reviewed. Results show that TSG was more common in women < 28 years old that lived in urban areas, which had several pregnancies, with no prior history of spontaneous abortion, molar pregnancy, use of intrauterine devices or prolonged use of contraceptive pills. In conclusion, a follow-up of young pregnant women is necessary in order to have an on time diagnosis of this disease as well as promote measures that guarantee the patients' health as well as her life(AU)

Humans , Female , Adult , Placenta Diseases , Pregnancy Trimester, First , Risk Factors , Gestational Trophoblastic Disease/physiopathology , Trophoblasts , Gynecology , Obstetrics
Arch. endocrinol. metab. (Online) ; 63(2): 121-127, Mar.-Apr. 2019. tab, graf
Article in English | LILACS | ID: biblio-1001217


ABSTRACT Objective We investigated the utility of maternal fetuin-A, N-terminal proatrial natriuretic peptide (pro-ANP), high-sensitivity C-reactive protein (hs-CRP), and fasting glucose levels at 11-14 gestation weeks for predicting pregnancies complicated by gestational diabetes mellitus (GDM). Subjects and methods This prospective cohort study included 327 low-risk pregnant women who completed antenatal follow-up at a tertiary research hospital between January and April 2014. Maternal blood samples were collected between 11-14 gestational weeks in the first trimester of pregnancy and then stored at -80 °C until further analyses. During follow-up, 29 (8.8%) women developed GDM. The study population was compared 1:2 with age- and body mass index-matched pregnant women who did not develop GDM (n = 59). Fasting plasma glucose (FPG) levels and serum fetuin-A, pro-ANP, and hs-CRP levels were measured using automated immunoassay systems. Results There was a significant negative correlation between fetuin-A and hs-CRP (CC = -0.21, p = 0.047) and a positive correlation between FPG and hs-CRP (CC = 0.251, p = 0.018). The areas under the receiver operating characteristic curve for diagnosing GDM were 0.337 (p = 0.013), 0.702 (p = 0.002), and 0.738 (p < 0.001) for fetuin-A, hs-CRP, and FPG, respectively. The optimal cut-off values were > 4.65, < 166, and > 88.5 mg/dL for maternal hs-CRP, fetuin-A, and FPG, respectively. Conclusion Reduced fetuin-A, elevated hs-CRP, and FPG levels in women in the first trimester can be used for the early detection of GDM. Further research is needed before accepting these biomarkers as valid screening tests for GDM.

Humans , Female , Pregnancy , Adolescent , Adult , Young Adult , Pregnancy Trimester, First/blood , Blood Glucose/metabolism , C-Reactive Protein/metabolism , Insulin Resistance , Decision Support Techniques , Diabetes, Gestational/diagnosis , Insulin/blood , Biomarkers/blood , Logistic Models , Odds Ratio , Predictive Value of Tests , Retrospective Studies , Follow-Up Studies , Sensitivity and Specificity , Diabetes, Gestational/blood
Blood Research ; : 175-180, 2019.
Article in English | WPRIM | ID: wpr-763079


BACKGROUND: Previous Caucasian studies have described venous thromboembolism in pregnancy; however, little is known about its incidence during pregnancy and early postpartum period in the Chinese population. We investigated the risk of venous thromboembolism in a “real-world” cohort of pregnant Chinese women with no prior history of venous thromboembolism. METHODS: In this observational study, 15,325 pregnancies were identified in 14,162 Chinese women at Queen Mary Hospital, Hong Kong between January 2004 and September 2016. Demographic data, obstetric information, and laboratory and imaging data were retrieved and reviewed. RESULTS: The mean age at pregnancy was 32.4±5.3 years, and the median age was 33 years (interquartile range, 29–36 yr). Pre-existing or newly diagnosed diabetes mellitus was present in 627 women (4.1%); 359 (0.7%) women had pre-existing or newly detected hypertension. There was a small number of women with pre-existing heart disease and/or rheumatic conditions. Most deliveries (86.0%) were normal vaginal; the remaining were Cesarean section 2,146 (14.0%). The incidence of venous thromboembolism was 0.4 per 1,000 pregnancies, of which 83.3% were deep vein thrombosis and 16.7% were pulmonary embolism. In contrast to previous studies, 66.7% of venous thrombosis occurred in the first trimester. CONCLUSION: Chinese women had a substantially lower risk of venous thromboembolism during pregnancy and the postpartum period compared to that of Caucasians. The occurrence of pregnancy-related venous thromboembolism was largely confined to the early pregnancy period, probably related to the adoption of thromboprophylaxis, a lower rate of Cesarean section, and early mobilization.

Asian Continental Ancestry Group , Cesarean Section , Cohort Studies , Diabetes Mellitus , Early Ambulation , Female , Heart Diseases , Hong Kong , Humans , Hypertension , Incidence , Observational Study , Postpartum Period , Pregnancy , Pregnancy Trimester, First , Pregnant Women , Pulmonary Embolism , Venous Thromboembolism , Venous Thrombosis
Article in English | WPRIM | ID: wpr-760681


OBJECTIVE: To evaluate the performance of the preeclampsia (PE) screening algorithm of the Fetal Medicine Foundation (FMF) during the first trimester in a Brazilian population using maternal characteristics, mean arterial pressure (MAP), and uterine artery Doppler data. METHODS: This is a prospective cohort study that evaluated 701 pregnant women during the first trimester ultrasound screening for chromosomal abnormalities (11–13+6 weeks). All patients provided information regarding clinical and obstetric history, MAP, and mean uterine artery pulsatility index (mean PI). Patients were assigned to four groups based on the presence of PE and gestational age at delivery: group 1 (control), patients without hypertensive disorders (n=571); group 2, PE and delivery before 34 weeks of gestation (n=7); group 3, PE and delivery before 37 weeks of gestation, including patients from group 2 and patients that presented PE with delivery between 34 and 37 weeks (n=17); and group 4, PE and delivery before 42 weeks of gestation, including patients from both groups 2 and 3 and patients that presented PE with delivery between 37 and 42 weeks of gestation (n=34). RESULTS: After the exclusion of 96 patients, we evaluated the data of 605 patients. By combining maternal characteristics, MAP, and the mean uterine artery PI for the detection of PE, we found a sensitivity of 71.4% in group 2, 50% in group 3, and 41.2% in group 4 (false positive rate=10%). CONCLUSION: Using maternal characteristics, MAP, and uterine artery Doppler data, we were able to identify a significant proportion of patients who developed preterm PE.

Arterial Pressure , Chromosome Aberrations , Cohort Studies , Female , Gestational Age , Humans , Mass Screening , Pre-Eclampsia , Pregnancy , Pregnancy Trimester, First , Pregnancy , Pregnant Women , Prospective Studies , Ultrasonography , Uterine Artery
Article in English | WPRIM | ID: wpr-760664


OBJECTIVE: To determine whether vaginal application of 40 mg isosorbide-5-mononitrate (ISMN) has a comparable cervical ripening efficacy to and lesser side effects than 400 µg misoprostol in women scheduled for the first trimester induced abortion using a manual vacuum aspirator (MVA). METHODS: We conducted a prospective randomized open- label study in 70 women at 6–12 weeks of pregnancy at the R G Kar Medical College and Hospital, Kolkata, India, over a period of two years from 2015 to 2017. Forty milligrams of ISMN and 400 µg misoprostol were vaginally applied for cervical priming. The primary outcome measure was the cervical response assessed by the passage of the appropriate and largest sized MVA cannula through the internal os without resistance, at the beginning of the procedure. RESULTS: The base line cervical dilatation was found to be significantly higher in the misoprostol group than in the ISMN group (7.65±1.38 vs. 6.9±1.26 mm; P=0.025, 95% confidence interval, −1.4046 to −0.953). However, when the women were sub-analyzed based on parity, there was no statistically significant difference in the same parameters among the multigravid women. The need for further cervical dilatation was significantly higher in the ISMN group when the primigravid women were compared, although the multigravid women responded favorably to ISMN. CONCLUSION: In the primigravid women, misoprostol appears to exert a higher efficacy as a cervical ripening agent in contrast to ISMN. However, ISMN can be used in multigravid women for the same purpose as in this group, misoprostol did not show any significant improvement in efficacy over ISMN.

Abortion, Induced , Catheters , Cervical Ripening , Female , Humans , India , Labor Stage, First , Misoprostol , Outcome Assessment, Health Care , Parity , Pregnancy , Pregnancy Trimester, First , Prospective Studies , Vacuum
Braz. j. med. biol. res ; 52(2): e7559, 2019. tab, graf
Article in English | LILACS | ID: biblio-984027


The visual system of women changes during pregnancy. Few reports have addressed the effects of pregnancy on color vision. We aimed to compare the color vision of women in the first, second, and third trimesters of pregnancy. Fifty women were divided into first (n=10), second (n=10), third trimester pregnancy groups (n=10), and non-pregnant group (n=20). We used the Farnsworth D15 and Lanthony desaturated D15 (D15d) tests. The hue ordering quantified the amount of error (C-index) and the chromatic selectivity of the errors (S-index). Bland-Altman analysis was applied to the hue ordering data. No difference was found for Farnsworth D15 test results obtained from the pregnant groups and the non-pregnant group (P<0.0083). For the Lanthony D15 desaturated test, the third trimester pregnant group had higher C-index and S-index than non-pregnant women and first-trimester pregnant women (P<0.0083). The Bland-Altman analysis showed that the limits of agreement increased as pregnancy advanced, and the errors were biased to the D15d test. In this study, color vision was impaired during pregnancy. Color vision evaluation could be used as an indicator of the functional status of the central vision during pregnancy.

Humans , Female , Pregnancy , Adult , Vision Tests/methods , Color Perception , Color Vision , Pregnancy Complications , Pregnancy Trimester, Second , Pregnancy Trimester, Third , Pregnancy Trimester, First
Article in Chinese | WPRIM | ID: wpr-819032


OBJECTIVE@#To assess the clinical application of single nucleotide polymorphism microarray (SNP array) in prenatal genetic diagnosis for fetuses with absent nasal bone.@*METHODS@#Seventy four fetuses with absent nasal bone detected by prenatal ultrasound scanning were recruited from Women's Hospital, Zhejiang University School of Medicine during June 2015 and October 2018. The chromosome karyotypes analysis and SNP array were performed. The correlation between absent fetal nasal bone and chromosome copy number variants was analyzed.@*RESULTS@#Among 74 fetuses, 19 were detected to have chromosomal abnormalities, including 16 cases of trisomy-21, 1 case of trisomy-18 and two cases of micro-deletion/duplication. Among 46 cases with isolated absence of nasal bone, 3 had trisomy-21, and 1 had a micro-duplication. Absence of nasal bone in association with nuchal translucency thickening had a higher rate of abnormal karyotypes compared with isolated absence of nasal bone (=32.27,<0.01).@*CONCLUSIONS@#Fetuses with absent nasal bone and nuchal translucency thickening are likely to have chromosome abnormalities, and SNP array testing is recommended to exclude the chromosome abnormalities.

Chromosome Aberrations , Female , Fetus , Humans , Nasal Bone , Congenital Abnormalities , Oligonucleotide Array Sequence Analysis , Reference Standards , Polymorphism, Single Nucleotide , Genetics , Pregnancy , Pregnancy Trimester, First , Prenatal Diagnosis , Methods