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1.
Braz. J. Pharm. Sci. (Online) ; 58: e19836, 2022. tab, graf
Article in English | LILACS | ID: biblio-1394041

ABSTRACT

Abstract A capillary electrophoresis method was developed for the first time and optimized for the determination of paracetamol, pseudoephedrine, dextromethorphan, chlorpheniramine, 4-aminophenol and ephedrine in tablet formulation. Optimum electrophoretic conditions were achieved by using a background electrolyte of 75 mmol L-1 sodium borate buffer at pH 8.0, a capillary temperature of 30°C, a separation voltage of 30 kV and a pressure injection of the sample at 50 mbar for 10 s. Calibration graphs showed a good linearity with a coefficient of determination (R2) of at least 0.999 for all compounds. Intraday and interday precision (expressed as relative standard deviation (RSD) %) were lower than 1.39% for capillary electrophoresis method. The developed method was demonstrated to be simple and rapid for the determination of paracetamol, pseudoephedrine, dextromethorphan, chlorpheniramine, 4-aminophenol and ephedrine in tablet formulation providing recoveries in the range between 99.62 and 100.57% for all analytes.


Subject(s)
Chlorpheniramine/antagonists & inhibitors , Electrophoresis, Capillary/methods , Dextromethorphan/antagonists & inhibitors , Ephedrine/antagonists & inhibitors , Pseudoephedrine/antagonists & inhibitors , Aminophenols/antagonists & inhibitors , Acetaminophen/agonists , Buffers , Diagnosis , Methods
2.
Allergy, Asthma & Respiratory Disease ; : 298-301, 2017.
Article in Korean | WPRIM | ID: wpr-209997

ABSTRACT

The diagnosis of fixed drug eruption is straightforward because of characteristic findings, including recurrence of similar lesions at the same site and healing with residual hyperpigmentation. However, generalized or multiple fixed drug eruption, a rare variant form, can be a diagnostic challenge. Acebrophylline is a widely prescribed oral bronchodilator with mucosecretolyic and anti-inflammatory activity and is known to be relatively safe. A 34-year-old woman presented with recurrent numerous erythematous patches after ingestion of cold medications containing clarithromycin, loxoprofen, acebrophylline, and pseudoephedrine. Skin biopsy results showed vacuolar degeneration of the basal cell layer, scattered necrotic keratinocytes in the epidermis, and perivascular lymphohistiocytic infiltration in the upper dermis. A patch test showed negative results. However, in an oral challenge with acebrophylline 3 hours later, lesions reappeared at the same sites. To the best of our knowledge, this is the first case report of acebrophylline-induced generalized fixed drug eruption.


Subject(s)
Adult , Female , Humans , Biopsy , Clarithromycin , Dermis , Diagnosis , Drug Eruptions , Eating , Epidermis , Hyperpigmentation , Keratinocytes , Patch Tests , Pseudoephedrine , Recurrence , Skin
3.
Journal of the Korean Society of Emergency Medicine ; : 134-138, 2016.
Article in Korean | WPRIM | ID: wpr-77159

ABSTRACT

Ischemic colitis is the consequence of a sudden reduction in colon blood supply, which in turn results in ischemic injury. The splenic flexure and rectosigmoid junction are the areas most often affected. Ischemic colitis occurs with greater frequency in the elderly and is caused by various medications and procedures. Pseudoephedrine acts as a vasoconstrictor directly affecting adrenal receptors of nasal mucous membrane. Pseudoephedrine occasionally causes vascular insufficiency due to intense vasoconstriction, even at standard doses. Ischemic colitis associated with pseudoephedrine has been reported in other countries,, but it has never been reported in Korea. In this paper, we describe 3 cases of ischemic colitis that occurred after taking pseudoephedrine for nasal congestion.


Subject(s)
Aged , Humans , Colitis, Ischemic , Colon , Colon, Transverse , Estrogens, Conjugated (USP) , Gastrointestinal Hemorrhage , Korea , Mucous Membrane , Pseudoephedrine , Vasoconstriction
4.
IJPR-Iranian Journal of Pharmaceutical Research. 2015; 14 (2): 435-442
in English | IMEMR | ID: emr-167948

ABSTRACT

A mixture of acetaminophen, diphenhydramine hydrochloride and pseudoephedrine hydrochloride is used for the symptomatic treatment of common cold. In this study, a derivative spectrophotometric method based on zero-crossing technique was proposed for simultaneous determination of acetaminophen, diphenhydramine hydrochloride and pseudoephedrine hydrochloride. Determination of these drugs was performed using the [1]D value of acetaminophen at 281.5 nm, [2]D value of diphenhydramine hydrochloride at 226.0 nm and [4]D value of pseudoephedrine hydrochloride at 218.0 nm. The analysis method was linear over the range of 5-50, 0.25-4, and 0.5-5 microg/mL for acetaminophen, diphenhydramine hydrochloride and pseudoephedrine hydrochloride, respectively. The within-day and between-day CV and error values for all three compounds were within an acceptable range [CV<2.2% and error<3%]. The developed method was used for simultaneous determination of these drugs in pharmaceutical dosage forms and no interference from excipients was observed


Subject(s)
Spectrophotometry , Diphenhydramine/chemistry , Pseudoephedrine/chemistry , Tablets
5.
Asia Pacific Allergy ; (4): 281-284, 2013.
Article in English | WPRIM | ID: wpr-749958

ABSTRACT

Fixed drug eruption is an uncommon adverse drug reaction caused by delayed cell-mediated hypersensitivity. Levocetirizine is an active (R)-enatiomer of cetirizine and there have been a few reports of fixed drug eruption related to these antihistamines. We experienced a case of levocetirizine-induced fixed drug eruption and cross-reaction with other piperazine derivatives confirmed by patch test. A 73-year-old female patient presented with recurrent generalized itching, cutaneous bullae formation, rash and multiple pigmentation at fixed sites after taking drugs for common cold. She took bepotastine besilate (Talion®) and levocetirizine (Xyzal®) as antihistamine. She took acetaminophen, pseudoephedrine 60 mg / triprolidine 2.5 mg (Actifed®), dihydrocodeinebitartrate 5 mg / di-methylephedrine hydrochloride 17.5 mg / chlorpheniramine maleate 1.5 mg / guaifenesin 50 mg (Codening®) and aluminium hydroxide 200 mg / magnesium carbonate 120 mg (Antad®) at the same time. Patch test was done with suspected drugs and the result was positive with levocetirizine. We additionally performed patch test for other antihistamines such as cetirizine, hydroxyzine, fexofenadine and loratadine. Piperazine derivatives (cetirizine and hydroxyzine) were positive, but piperidine derivatives (fexofenadine and loratadine) were negative to patch test. There was no adverse drug reaction when she was challenged with fexofenadine. We report a case of levocetirizine-induced fixed drug eruption confirmed by patch test. Cross-reactions were only observed in the piperazine derivatives and piperidine antihistamine was tolerant to the patient.


Subject(s)
Aged , Female , Humans , Acetaminophen , Carbon , Cetirizine , Chlorpheniramine , Common Cold , Drug Eruptions , Drug-Related Side Effects and Adverse Reactions , Exanthema , Guaifenesin , Histamine Antagonists , Hydroxyzine , Hypersensitivity , Loratadine , Magnesium , Patch Tests , Pigmentation , Pruritus , Pseudoephedrine , Triprolidine
6.
China Journal of Chinese Materia Medica ; (24): 687-690, 2013.
Article in Chinese | WPRIM | ID: wpr-350705

ABSTRACT

<p><b>OBJECTIVE</b>To establish an HPLC method for the determination of ephedrine hydrochloride, D-pseudo-ephedrine and amygdalin in Xiao'er Pingchuan Qutan granule.</p><p><b>METHOD</b>Pheny ether chromatographic column (4.6 mm x 250 mm, 5 microm) was adopted, with acetonitrile-0.1% phosphoric acid (containing 0.1% three ethylamine) (3:97) as the mobile phase. The UV detection wavelength was at 210 nm, with the flow rate of 1 mL x min(-1), and column temperature was at 35 degrees C.</p><p><b>RESULT</b>The linearity of ephedrine hydrochloride, D-pseudo-ephedrine and amygdalin ranged between 0.078 60-3.144 microg (r = 1.000 0), 0.103 4-2.068 microg (r = 0.999 7) and 0.430 5-3.157 microg (r = 0.999 8), respectively. Their average recoveries were 98.46% (RSD 1.1%), 103.0% (RSD 1.5%) and 97.15% (RSD 2.1%), respectively.</p><p><b>CONCLUSION</b>The method is simple, stable and reliable that it can be used to determine the content of ephedrine hydrochloride, D-pseudo-ephedrine and amygdalin in Xiao'er Pingchuan Qutan granule.</p>


Subject(s)
Amygdalin , Chemistry , Chromatography, High Pressure Liquid , Drugs, Chinese Herbal , Chemistry , Ephedrine , Chemistry , Linear Models , Pseudoephedrine , Chemistry , Reproducibility of Results , Time Factors
7.
China Journal of Chinese Materia Medica ; (24): 3291-3294, 2013.
Article in Chinese | WPRIM | ID: wpr-238606

ABSTRACT

<p><b>OBJECTIVE</b>To establish an HPLC method for determining the contents of scopolamine hydrobromide, atropine sulfate, ephedrine hydrochloride and pseudoephedrine hydrochloride in Zhichuanling oral liquid.</p><p><b>METHOD</b>Agela Durashell RP-C18 (4. 6 mm x250 mm, 5 microm) was adopted, with acetonitrile-sodium phosphate buffer solution (0. 07 mol L-1 sodium phosphate solution with 17.5 mmol L-1 sodium dodecylsulfate adjusted to pH 6.0 with phosphoric acid solution) (30:70) as the mobile phase. The flow rate was 0. 9 mL min -1, the detection wavelength was 207 nm, and the column temperature was 25 degree C.</p><p><b>RESULT</b>Scopolamine hydrobromide, atropine sulfate, ephedrine hlvdrochloride and pseudoephedrine hydrochloride showed good linear relations with peak areas within the concentration range of 0. 021 21-1. 060 5 pg (r =0. 999 3) , 0. 011 14-0. 557 microg (r = 0. 999 6) , 0. 200 56-10. 028 microg (r =0. 999 7) and 0.070 33-3. 516 5 gg (r =0. 999 6), respectively, with the average recoveries of 101.9% , 99. 80%, 100. 3%, 100. 2% (n=6).</p><p><b>CONCLUSION</b>The method was so quick, simple, highly reproducible and specific that it could be used as one of quality control methods of Zhichuanling oral liquid.</p>


Subject(s)
Atropine , Chromatography, High Pressure Liquid , Methods , Ephedrine , Pseudoephedrine , Scopolamine
8.
Acta Pharmaceutica Sinica ; (12): 94-97, 2013.
Article in Chinese | WPRIM | ID: wpr-235698

ABSTRACT

This paper reports the establishment of a method for rapid identification 15 effective components of anti common cold medicine (paracetamol, aminophenazone, pseudoephedrine hydrochloride, methylephedrine hydrochloride, caffeine, amantadine hydrochloride, phenazone, guaifenesin, chlorphenamine maleate, dextromethorphen hydrobromide, diphenhydramine hydrochloride, promethazine hydrochloride, propyphenazone, benorilate and diclofenac sodium) with MRM by LC-MS/MS. The samples were extracted by methanol and were separated from a Altantis T3 column within 15 min with a gradient of acetonitrile-ammonium acetate (containing 0.25% glacial acetic acid), a tandem quadrupole mass spectrometer equipped with electrospray ionization source (ESI) was used in positive ion mode, and multiple reaction monitoring (MRM) was performed for qualitative analysis of these compounds. The minimum detectable quantity were 0.33-2.5 microg x kg(-1) of the 15 compounds. The method is simple, accurate and with good reproducibility for rapid identification many components in the same chromatographic condition, and provides a reference for qualitative analysis illegally added chemicals in anti common cold medicine.


Subject(s)
Acetaminophen , Acetanilides , Amantadine , Aminopyrine , Anti-Inflammatory Agents, Non-Steroidal , Antipyretics , Antipyrine , Caffeine , Chlorpheniramine , Chromatography, Liquid , Diclofenac , Diphenhydramine , Drug Contamination , Drug Stability , Ephedrine , Guaifenesin , Promethazine , Pseudoephedrine , Reproducibility of Results , Salicylates , Spectrometry, Mass, Electrospray Ionization , Tandem Mass Spectrometry
9.
Chinese Journal of Biotechnology ; (12): 1082-1091, 2011.
Article in Chinese | WPRIM | ID: wpr-324500

ABSTRACT

In order to successfully express the carbonyl reductase gene mldh in Bacillus subtilis and complete coenzyme regeneration by B. subtilis glucose dehydrogenase, the promoter PrpsD and the terminator TrpsD from B. subtilis rpsD gene were used as the expression cassette to be a recombinant plasmid pHY300plk-PrpsD-TrpsD. After that, the carbonyl reductase gene mldh was inserted into the previous plasmid and a plasmid pHY300plk-PrpsD-mldh-TrpsD was achieved, followed by transformed into B. subtilis Wb600 to obtain a recombinant B. subtilis Wb600 (pHY300plk-PrpsD-mldh-TrpsD). Subsequently, the results for whole-cell biotransformation from recombinant B. subtilis showed that it could be used to catalyze MAK (1-phenyl- 1-keto-2-methylaminopropane) to d-pseudoephedrine in the presence of glucose. The yield of d-pseudoephedrine could be up to 97.5 mg/L and the conversion rate of MAK was 24.1%. This study indicates the possibility of biotransformation production of d-pseudoephedrine from recombinant B. subtilis.


Subject(s)
Alcohol Oxidoreductases , Genetics , Bacillus subtilis , Genetics , Metabolism , Glucose 1-Dehydrogenase , Chemistry , Metabolism , Mutagenesis, Insertional , Pseudoephedrine , Metabolism , Recombinant Proteins , Genetics , Recombination, Genetic
10.
Acta Pharmaceutica Sinica ; (12): 581-585, 2011.
Article in Chinese | WPRIM | ID: wpr-348915

ABSTRACT

The paper is to establish a method for simultaneous determination of 5 kinds of alkaloids in ephedra and poppy which are in Kechuanning tablets. Solid-phase extraction (SPE) was adopted in pretreatment, and a UPLC method with 2 different wavelengths had been developed: 210 nm for the detection of morphine, codeine phosphate, ephedrine hydrochloride and pseudoephedrine hydrochloride, and 251 nm for papaverine hydrochloride. The column used was Acquity UPLC BEH C18 (100 mm x 2.1 mm ID, 1.7 microm) with linear gradient elution using acetonitrile and 0.1% phosphoric acid. The flow rate was 0.4 mL.min-1, and the column temperature was 30 degrees C. The linear response range was 0.375 0 - 12.50 microg.mL-1 for morphine, 0.064 32 - 2.144 microg.mL-1 for codeine phosphate, 0.030 06 - 1.002 microg.mL-1 for papaverine hydrochloride, 1.126 - 37.52 microg.mL-1 for ephedrine hydrochloride, 0.287 8 - 9.592 microg.mL-1 for pseudoephedrine hydrochloride (r = 0.999 7). The average recoveries of these compounds were 99.26%, 100.6%, 95.29%, 100.1% and 97.48%, respectively. This is a more reasonable and credible method of quality control for Kechuanning tablets.


Subject(s)
Alkaloids , Chromatography, High Pressure Liquid , Codeine , Drugs, Chinese Herbal , Chemistry , Ephedra , Chemistry , Ephedrine , Morphine , Papaver , Chemistry , Papaverine , Plants, Medicinal , Chemistry , Pseudoephedrine , Quality Control , Solid Phase Extraction , Tablets
11.
Korean Journal of Perinatology ; : 48-58, 2010.
Article in Korean | WPRIM | ID: wpr-19111

ABSTRACT

PURPOSE: In Korea, pregnancy termination is frequently reported among women who took medications for an acute or chronic disease during pregnancy, for fear of teratogenic risk. We have previously shown that a service providing evidence-based information is helpful for women who week counseling to make a rational decision regarding their pregnancies. This study aimed to evaluate whether termination of pregnancy based on such perceptions, is justified using the 'DRug Exposure and risk Assessment in Moms' (DREAM) registry. METHODS: The study included 5,032 consenting pregnant women from the clinic and call center at the Korean Motherisk Program, from November 1999 to October 2008. The DREAM registry recorded the pregnancy outcomes (preterm birth, low birth weight, intrauterine fetal death, and congenital anomaly) of 3,328 women. RESULTS: Among women exposed to medications, time of exposure ranged from 3.5-4.6 weeks of gestation. There were 1,308 different drugs prescribed to these women. The drug most frequently prescribed was acetaminophen followed by chlorpheniramine maleate, and pseudoephedrine. There were 4.7% (n=156/3,328) women who underwent a voluntary abortion for fear of birth defects. We compared frequency of birth defects between exposed women and unexposed pregnant women in our institution during gestation. The frequency of major congenital malformations was 2.5% (n=74/2,977) in exposed group and 2.9% (n=75/2,573) in unexposed group (P=0.32). There was no statistically significant difference between exposed and control group in the rate of preterm births, intrauterine fetal death and low-birth weight babies. CONCLUSION: We did not observe increased risk of congenital malformations and adverse pregnancy outcomes in a population of pregnant women exposed to a variety of medications. Therefore these medications are not considered teratogen.


Subject(s)
Female , Humans , Infant, Newborn , Pregnancy , Acetaminophen , Chlorpheniramine , Chronic Disease , Congenital Abnormalities , Counseling , Fetal Death , Infant, Low Birth Weight , Korea , Maleates , Parturition , Pregnancy Outcome , Pregnant Women , Premature Birth , Pseudoephedrine , Risk Assessment
12.
Journal of Southern Medical University ; (12): 1703-1704, 2010.
Article in Chinese | WPRIM | ID: wpr-330853

ABSTRACT

<p><b>OBJECTIVE</b>An HPLC method was developed to determinate Ibuprofen and Pseudoephedrine Hydrochloride and Chlorpheniramine Maleate in Compound BuluoWeimaNamin Tablets.</p><p><b>METHODS</b>Using HPLC with Kromasil C18 column, and acetonitrile -0.5% SDS- phosphate (580:420:1) as the mobile phase. The wavelength for detection was 262 nm.</p><p><b>RESULTS</b>Better linearities and good correlation coefficients were obtained: the concentration ranges of ibuprofen, pseudoephedrine hydrochloride and chlorpheniramine maleate were over 2.062-14.434 microg (r=0.9999), 0.296-2.072l microg (r=0.9999), and 0.0204~0.1428 microg (r=0.9998), respectively. The recoveries of ibuprofen, pseudoephedrine hydrochloride and chlorpheniramine maleate were 99.98% (RSD=0.52%), 99.72 (RSD=0.82%) and 99.545 (RSD=0.76%), respectively.</p><p><b>CONCLUSION</b>The method was convenient, accurate and specific. It can be used as a method to control quality of Compound Buluoweimanamin Tablets.</p>


Subject(s)
Chlorpheniramine , Chromatography, High Pressure Liquid , Methods , Ibuprofen , Pseudoephedrine , Tablets , Chemistry
13.
SPJ-Saudi Pharmaceutical Journal. 2010; 18 (2): 103-106
in English | IMEMR | ID: emr-129308

ABSTRACT

A simple, precise, and accurate method and validated for the analysis of pseudophedrin hydrochloride, dextromethrophan hydrobromide chlorpheniramine maleate, and paracetamol in tablet formulations. The method has shown adequate separation of the four ingredients from each other. Separation was achieved on a silica column [5 micro m, 125 X 4,6 mm inner diameter] using a mobile phase consisting of methanaol/ammonium dihyddrogen phosphate buffer [90:10, v/v] at a flow rate of 1.0 ml/min and UV detection at 220 nm. This new method is validated in accordance with USP requirements for new methods for assay determination, which include accuracy, precision, selectivity, linearity and range, probustness and ruggedness. The current method demonstrates good linearity over the range of 0.15-0.45 mg/ml of pseudophedrine hydrochloride with r[2] of 0.996, and in the range of 0.075-0.225 mg/ml of dextromethorphan hydrobromide with r[2] of 0.992, and in the range of 0.01-0.03 mg/ml of chlorpheniramine maleate with r[2] of 0.994, and in the range of 0.25-0.75 mg/ml of paracetamol with r[2] of 0.991. The average recovery of the method is 99.7%, 98.1%, and 99.2% for pseudophedrine hydrochloride, dextromethorphan hydrobromide, chlorpheniramien maleate, and paracetamol, respectively. The degree of reproducibility of the results obtained as a result of small deliberate variations in the method parameters and by changing analytical operator has proven that the method is robust and rugged


Subject(s)
Chromatography, High Pressure Liquid , Pseudoephedrine/analysis , Dextromethorphan/analysis , Chlorpheniramine/analysis , Acetaminophen/analysis
14.
China Journal of Chinese Materia Medica ; (24): 980-983, 2009.
Article in Chinese | WPRIM | ID: wpr-263088

ABSTRACT

<p><b>OBJECTIVE</b>To establish a method for the determination of ephedrine and pseudoephedrine in Herba Ephedrae and Maxing Shigan Tang by capillary zone electrophoresis.</p><p><b>METHOD</b>The conditions of the experiment were optimized with a fused-silica capillary of 60 cm x 50 microm (50 cm effective length) in a running buffer of 50 mmol x L(-1) borax-20 mmol x L(-1) threonine (pH 9.27) and an applied voltage of 15 kV (room temperature). Samples were introduced by hydrodynamic injections (10 cm x 20 s)and determined with on-column UV monitoring at 210 nm. Phenobarbital was chosen as the internal standard.</p><p><b>RESULT</b>Ephedrine and pseudoephedrine are separated successfully within 8 min. The linear responses covered the ranges from 21.3 to 213 mg x L(-1) (r = 0.9996) for ephedrine and from 8.4 to 84 mg x L(-1) (r = 0.9995) for pseudoephedrine. The detection limits (S/N = 3) of ephedrine and pseudoephedrine were shown to be 1.45 and 1.48 microg x mL(-1), respectively, The quantitation limits (S/N = 10) of ephedrine and pseudoephedrine were shown to be 4.81 and 4.93 mg x L(-1), respectively. The average recoveries for ephedrine and pseudoephedrine were 97.5% and 98.6% with RSD less than 5.0%.</p><p><b>CONCLUSION</b>The method is simple, rapid, cost-effective and precise with satisfactory results.</p>


Subject(s)
Drugs, Chinese Herbal , Electrophoresis, Capillary , Methods , Ephedra sinica , Chemistry , Ephedrine , Plants, Medicinal , Chemistry , Pseudoephedrine , Reproducibility of Results
15.
Intestinal Research ; : 129-132, 2009.
Article in Korean | WPRIM | ID: wpr-132450

ABSTRACT

Ischemic colitis is the most common form of gastrointestinal ischemia. Factors that can contribute to the development of ischemic colitis include atherosclerosis, congestive heart failure, sustained hypovolemia, vasculitis, and mechanical colonic obstruction. Also, pharmacologic agents, including diuretics, pseudoephedrine, non-steroidal anti-inflammatory drugs, and oral contraceptives may be the cause of colonic ischemia. Oral sulfate-free polyethylene glycol (SF-PEG, Colyte-F(R)) has frequently been used as a cleaning agent in bowel preparation for colonoscopy. Some cases of ischemic colitis produced by oral hyperosmotic laxatives have been reported; however, no case has been reported regarding ischemic colitis caused by SF-PEG. Herein we report a rare case of ischemic colitis caused by oral sulfate-free polyethylene glycol, which was given for bowel preparation before colonoscopy in a 70-year-old man with chronic constipation.


Subject(s)
Aged , Humans , Atherosclerosis , Colitis, Ischemic , Colon , Colonoscopy , Constipation , Contraceptives, Oral , Diuretics , Heart Failure , Hypovolemia , Ischemia , Laxatives , Polyethylene Glycols , Pseudoephedrine , Vasculitis
16.
Intestinal Research ; : 129-132, 2009.
Article in Korean | WPRIM | ID: wpr-132447

ABSTRACT

Ischemic colitis is the most common form of gastrointestinal ischemia. Factors that can contribute to the development of ischemic colitis include atherosclerosis, congestive heart failure, sustained hypovolemia, vasculitis, and mechanical colonic obstruction. Also, pharmacologic agents, including diuretics, pseudoephedrine, non-steroidal anti-inflammatory drugs, and oral contraceptives may be the cause of colonic ischemia. Oral sulfate-free polyethylene glycol (SF-PEG, Colyte-F(R)) has frequently been used as a cleaning agent in bowel preparation for colonoscopy. Some cases of ischemic colitis produced by oral hyperosmotic laxatives have been reported; however, no case has been reported regarding ischemic colitis caused by SF-PEG. Herein we report a rare case of ischemic colitis caused by oral sulfate-free polyethylene glycol, which was given for bowel preparation before colonoscopy in a 70-year-old man with chronic constipation.


Subject(s)
Aged , Humans , Atherosclerosis , Colitis, Ischemic , Colon , Colonoscopy , Constipation , Contraceptives, Oral , Diuretics , Heart Failure , Hypovolemia , Ischemia , Laxatives , Polyethylene Glycols , Pseudoephedrine , Vasculitis
17.
Egyptian Journal of Chemistry. 2009; 52 (3): 325-347
in English | IMEMR | ID: emr-135687

ABSTRACT

Two diastercoisomers ephedra drugs namely; ephedrine [eph.] and pseudoephedrine [psi-eph.] hydrochloride, have been investigated for their chirality using thermal analysis [TA] measurement [TG/DTA] and electron ionization mass spectrometry [EI-MS] at 70 eV. Monte Carlo conformational search technique was used for exploration of conformational space of ephedrine and psi-eph., using Amber force field molecular mechanics method. MO-calculations were performed using semi-empirical PM3 procedure on the obtained conformational sample for investigation of the different molecular properties. The calculations include bond length, bond order, charge distribution, ionization energy and heat of formation, in neutral and positively charged forms for the two drugs. The effect of diastereoisomerism on thermal analysis decomposition behavior of these drugs was studied. The obtained data confirmed the chirality and declared the structure reactivity relationship of these drugs


Subject(s)
Pseudoephedrine , Differential Thermal Analysis/methods , Mass Spectrometry/methods , Molecular Structure
18.
Article in English | IMSEAR | ID: sea-149026

ABSTRACT

Rhinos® SR is a fixed combination of 5 mg loratadine and 60 mg pseudoephedrine immediate release and 60 mg pseudoephedrine sustained release. The present study was aimed to assess the efficacy of Rhinos® SR on nasal airway resistance (NAR) objectively using rhinomanometer and on nasal symptoms in patients with perennial allergic rhinitis (PAR) in a tropical country. This was a randomized, double-blind, parallel group study in 59 PAR patients who visited the ENT clinic at Dr. Soetomo General Hospital, Surabaya. Outpatients of both gender, having moderate to severe PAR for a minimal of 2 years, aged 12 years or older, with a total nasal symptom score (TNSS) > 6 and a nasal congestion score > 2, received Rhinos® SR or placebo twice daily for 7 days. The primary efficacy parameter was the decrease in the NAR values (measured by rhinomanometer on Day 1) of Rhinos® SR from those of placebo. The NAR values were calculated as the area under the curve (AUC) of NAR versus time. The secondary efficacy parameters were the percentage reduction of the clinical symptoms (nasal and nonnasal) evaluated by both the patient and the physician after 1 week use of Rhinos® SR or placebo. From 59 eligible patients, all completed this 1-week trial. For NAR values, after the baseline were considered as 100%, the AUC0-10 h were not significantly different between Rhinos® SR and placebo. However, as the pseudoephedrine reached its peak concentration, i.e. 2 hrs for the immediate release and 6 hrs for the sustained release, then AUC0-2 h and AUC0-6 h of Rhinos® SR were significantly lower compared to those of placebo. Total nasal symptom score (TNSS) evaluated by the patient (sum of the last 3 mornings) for Rhinos® SR decreased 33.0% from baseline (p < 0.001), for placebo decreased 21.9% from baseline (p = 0.002), but the decrease by Rhinos® SR was not significantly different from the decrease by placebo. TNSS evaluated by the physician, nasal congestion score (NCS) and total symptom score (TSS, total nasal and nonnasal), and even the individual symptom scores, evaluated by the patient and the physician, showed similar pattern, i.e. both Rhinos® SR and placebo decreased the symptoms significantly from baseline, and the decreases by Rhinos® SR were larger than the decreases by placebo, but the decreases by Rhinos® SR and placebo were not statistically different. No adverse event was found in this study. From the present study it was concluded that in patients with moderate to severe PAR in a tropical country, Rhinos® SR was effective in relieving nasal congestion by objective measurements of NAR. Rhinos® SR twice a day for 7 days was also effective in reducing the clinical symptoms of PAR although the reductions did not reach statistical significance compared to those by placebo, and was well tolerated.


Subject(s)
Rhinitis , Pseudoephedrine , Loratadine
19.
Intestinal Research ; : 135-139, 2008.
Article in Korean | WPRIM | ID: wpr-128539

ABSTRACT

Ischemic colitis is the most prevalent form of ischemic vascular compromise of the gastrointestinal tract. Although frequent in the elderly with co-morbidity, numerous pharmacologic agents including diuretics, pseudoephedrine, nonsteroidal anti-inflammatory drugs, oral contraceptives, and cocaine may produce colonic ischemia by mesenteric vasoconstriction. Oral hyperosmotic laxatives are frequently used as cleansing agents in bowel preparation for both radiologic and endoscopic studies. They are regarded as safe and effective agents, but can produce a rapid osmotic-mediated fluid loss, resulting in transient meseneteric hypoperfusion and subsequent ischemic colitis. Here, we describe a case of acute ischemic colitis caused by the oral osmotic laxative magnesium citrate, which was given for bowel preparation before a barium enema in a young healthy patient without underlying disease.


Subject(s)
Aged , Humans , Barium , Citric Acid , Cocaine , Colitis , Colitis, Ischemic , Colon , Colonoscopy , Contraceptives, Oral , Detergents , Diuretics , Enema , Gastrointestinal Tract , Ischemia , Laxatives , Magnesium , Organometallic Compounds , Pseudoephedrine , Vasoconstriction
20.
Journal of the Korean Academy of Rehabilitation Medicine ; : 182-187, 2007.
Article in Korean | WPRIM | ID: wpr-723988

ABSTRACT

OBJECTIVE: To investigate the changes of sperm quality by taking adrenergic agonist in spinal cord injured (SCI) males treated by repeated electro-ejaculation. METHOD: Twenty-six SCI males were induced three times to ejaculate with rectal probe electrical stimulation, and then semen analysis for their antegrade and retrograde ejaculates was performed, at weekly interval, while they either took pseudoephedrine (Sudafed(R)) for 2 weeks or no medication as a control. RESULTS: Before pseudoephedrine medication, there was no significant difference in sperm quality between two groups. However, after 2 weeks' medication, SCI males taking pse-udoephedrine showed increased semen concentration, motile sperm count and sperm motility of the antegrade ejaculates compared to control group, although there was no difference in any parameter of the retrograde ejaculates. Moreover, sperm motility of the antegrade ejaculates significantly improved after 2 weeks' medication compared with those at the baseline. CONCLUSION: Pseudoephedrine, a sympathomimetic adrenergic agonist, may potentiate the improvement of sperm quality in SCI males undergoing repeated electro-ejaculation for short periods.


Subject(s)
Humans , Male , Adrenergic Agonists , Electric Stimulation , Pseudoephedrine , Semen , Semen Analysis , Sperm Count , Sperm Motility , Spermatozoa , Spinal Cord Injuries , Spinal Cord
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