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1.
Actual. SIDA. infectol ; 30(108): 7-16, 20220000. graf, tab
Article in Spanish | LILACS, BINACIS | ID: biblio-1363203

ABSTRACT

Las infecciones de piel y partes blandas (IPPB) en niños son una de las principales causas de prescripción de antimicrobianos. El objetivo del estudio fue describir las características clínicas y microbiológicas de las IPPB ambulatorias de niños asistidos en dos hospitales zonales. Se realizó un estudio prospectivo entre el 1/11/2017 y el 1/11/2018. Se incluyeron pacientes entre 1 mes y 15 años internados en dos hospitales. Se evaluó: edad, sexo, localidad, factores predisponentes, tipo de IPPB, muestras biológicas realizadas, aislamiento microbiológico, tratamiento empírico indicado y evolución del cuadro. Se realizó antibiograma y determinación genética. Se calculó chi2, IC95, OR; α=5%. N= 94. 58,7% masculinos. 12 pacientes <1 año, 85 >1 año (promedio de edad 4 años, 1-15). El 36% de Tandil y 63,8% de Florencio Varela. El 59,6% corresponden a IPPB purulentas. Se aislaron microorganismos en un 59,6%. Los aislamientos principales: SAMR (40,4%), SAMS (7,4%), S. agalactiae (2,1%) y S. pyogenes (2,1%). El 100% de SAMR son portadores de gen mecA y SCCmec tipo IV, sin multirresistencia. No hubo diferencia estadística entre los factores de riesgo evaluados para el desarrollo de IPPB por SAMR. El 52,1% de los niños recibió tratamiento antibiótico combinado, siendo la más indicada TMS-SMX + CLI en 36 eventos. (38,3%). La evolución fue favorable: no hubo diferencia significativa entre el subgrupo que se aisló SAMR y el que no se aisló SAMR; 91,9% (34/37) y 92,6% (50/54) correspondientemente (chi2: 0,01; p= 0,97 IC95: 0,26-3,88). El principal agente etiológico fue SAMRco, debiendo adecuar los tratamientos a este microorganismo.


Skin and soft tissue infections (SSIs) in children are one of the main causes of antimicrobial prescription. The aim of the study was to describe the clinical and microbiological characteristics of outpatient SSIs in children attended in two hospitals. A prospective study was conducted between 11/1/2017 and 11/1/2018. Patients between 1 month and 15 years old, hospitalized were included. We evaluated: age, sex, locality, predisposing factors, type of IPPB, biological samples taken, microbiological isolation, empirical treatment indicated and evolution of the condition. An antibiogram and genetic determination were performed. Chi2, CI95, OR; α=5% were calculated. N= 94. 58.7% male. 12 patients <1 year, 85 >1 year (mean age 4 years, 1-15). 36% were from Tandil and 63.8% from Florencio Varela. 59.6% corresponded to purulent SSIs. The diagnostic yield was 59.6%. Main isolates: MRSA (40.4%), MSSA (7.4%), S. agalactiae (2.1%) and S. pyogenes (2.1%). 100% of MRSA carried the mecA gene and SCCmec type IV, with no multidrug resistance. There was no statistical difference between the risk factors evaluated. 52.1% of children received combined antibiotic treatment, the most indicated being TMS-SMX + CLI in 36 events. (38,3%). Evolution was favorable: there was no significant difference between the subgroup that isolated MRSA and the subgroup that did not isolate MRSA; 91.9% (34/37) and 92.6% (50/54) respectively (chi2: 0.01; p= 0.97 CI95: 0.26-3.88). The main etiological agent was MRSA, and treatments should be adapted to this microorganism


Subject(s)
Humans , Infant, Newborn , Infant , Child, Preschool , Child , Adolescent , Skin Diseases/microbiology , Social Class , Staphylococcal Infections/microbiology , Hygiene/education , Prospective Studies , Risk Factors , Sanitary Profiles , Methicillin-Resistant Staphylococcus aureus , Anti-Infective Agents/administration & dosage
2.
Rev. chil. endocrinol. diabetes ; 15(1): 29-34, 2022. ilus
Article in Spanish | LILACS | ID: biblio-1359364

ABSTRACT

Los cuidados actuales de la diabetes incluyen altos niveles de tecnología y los pacientes utilizan diferentes dispositivos que pueden ayudar en su control metabólico, pero pueden impactar negativamente en su piel. Sensores de glucosa como el Freestyle, Dexcom, el Enlite de Medtronic y los sistemas de infusión continua de insulina contienen diferentes productos químicos que están en contacto directo con la piel del paciente y pueden causar una dermatitis irritativa o de contacto alérgica. Las lesiones incluyen eczema, prurito, heridas, cicatrices y cambios en la pigmentación de la piel. Los productos químicos involucrados que pueden ocasionarlas son el isobornil acrilato, N, N- dimetilacrilamida, etil cianoacrilato y colophonium, forzando a los pacientes a cambiar los sitios de infusión, el set de infusión o el sensor mismo más pronto de lo esperado, para reducir el nivel de daño en la piel. Existe gran número de productos que permiten proteger la piel y reducir el contacto de la piel con la cánula de la bomba o el sensor. Para reducir o prevenir el daño existen productos como cremas o spray y parches de hidrocoloide que actúan como barrera y existen técnicas para aplicar y retirar cuidadosamente los parches y adhesivos de los dispositivos. Una vez que las lesiones se han producido, el tratamiento incluye pomadas y a veces corticoides tópicos y/o antibióticos. Para prevenir o reducir el daño de la piel asociado al sensor y uso de la bomba de insulina, la industria que los produce debería incluir la información en relación a los productos químicos incluidos en cada dispositivo.


Diabetes care nowadays includes a high level of technology and patients use different devices which can help them in their glycemic control, but can have a negative impact on their skin. Glucose sensors such as Freestyle, Dexcom, Medtronic Enlite and also continuous subcutaneous insulin infusion systems contain different chemical products which are in direct contact with the patient's skin and can cause irritative or allergic contact dermatitis. Lesions include eczema, pruritus, wounds, scars and changes in skin pigmentation. The chemical products which can induce them are isobornyl acrylate, N, N- dimethylacrylamide, ethyl cyanoacrylate and colophonium, forcing patients to change the infusion site, set or the sensor itself, earlier than expected, in order to reduce the level of skin damage. There are a number of products which can protect the skin and reduce it's contact with the pump cannula or the sensor. To reduce or prevent damage, we have products such as barrier cream or spray films and hydrocolloid blister plasters and actions such as careful application and removal of device's patches and adhesives. Once lesions are established, treatment includes ointments and sometimes topical steroids and/ or antibiotics. In order to prevent or reduce skin damage related to sensor and insulin pump use, the manufacturers should include the information related to the chemicals included in each device.


Subject(s)
Humans , Skin Diseases/etiology , Insulin Infusion Systems/adverse effects , Skin/injuries , Blood Glucose Self-Monitoring/adverse effects , Adhesives/adverse effects , Dermatitis, Allergic Contact/etiology , Glycemic Control/adverse effects
3.
Rev. cienc. salud ; 20(1): 1-23, ene.-abr. 2022. tab
Article in Spanish | LILACS, COLNAL | ID: biblio-1367565

ABSTRACT

Introducción: se buscó analizar la prevalencia de enfermedades dermatológicas de la población de un asentamiento urbano precario próximo al vertedero municipal de Asunción (Paraguay), atendiendo a la exposición de las condiciones socioambientales. Materiales y métodos: estudio descriptivo y transversal con una muestra no probabilística intencional que incluyó a 77 personas de entre 5 meses y 76 años. Resultados: en el momento del examen físico, el 96.2 % de las personas presentó, al menos, una lesión cutánea, y el 79.2 %, una o más enfermedades infecciosas de piel; sin embargo, el 77.9 % no había recu-rrido a consulta médica. Las más sobresalientes fueron las micosis (35.1 %), las bacterianas (35.1 %) y las ectoparasitosis (27.3 %). Se identificó que la prevalencia de enfermedades bacterianas de piel apunta a una posible mayor exposición a condiciones adversas como: un clima subtropical de altas temperaturas y húmedo, una alta relación de convivientes en el hogar por dormitorio, problemas de provisión de agua y suelos de arena en los hogares, así como un sistema de evacuación de excretas deficiente, la presencia de animales con escasa vigilancia sanitaria, la proximidad a arroyos y cauces al aire libre depositarios de materia cloacal y el impacto recurrente de raudales los días de intensa lluvia. Conclusión: los resul-tados sugieren que la alta prevalencia de enfermedades cutáneas infecciosas podría relacionarse con una mayor exposición a condiciones socioambientales locales adversas, que son factores relevantes por tener en cuenta para mejorar la atención a la salud de las enfermedades dermatológicas de la población urbana que habita en un asentamiento urbano precario


Introduction: This study analyzes the prevalence of dermatological diseases in the population of a precarious urban settlement near the municipal landfill of Asunción (Paraguay), in relation to expo-sure to socio-environmental conditions. Materials and methods: descriptive, cross-sectional study with a non-probabilistic purposive sample that included 77 people aged between 5 months and 76 years. Results: at the time of physical examination, 96.2% of the people presented at least one skin lesion and 79.2% one or more infectious skin diseases, but 77.9% had not consulted a doctor. The most prominent were mycoses (35.1%), bacterial (35.1%) and ectoparasitoses (27.3%). It was identified that the preva-lence of bacterial skin diseases points to possible increased exposure to adverse conditions such as: a subtropical climate with high temperatures and humidity, a high ratio of people living in the household per bedroom, water supply problems and sandy soils in homes, as well as a deficient excreta disposal system, the presence of animals with poor sanitary surveillance, proximity to streams and open-air waterways that deposit sewage and the recurrent impact of floods on days of heavy rainfall. Conclusion:the results suggest that the high prevalence of infectious skin diseases could be related to increased exposure to adverse local socio-environmental conditions, which are relevant factors to be taken into to improve the health care of skin diseases in the urban population living in a slum settlement


Introdução: este estudo analisa a prevalência de doenças dermatológicas na população de um assen-tamento urbano precário próximo ao aterro sanitário municipal de Asunción (Paraguai) em relação à exposição às condições socioambientais. Materiais e métodos: estudo descritivo, transversal, com uma amostra não-probabilística de propósito que incluiu 77 pessoas com idade entre 5 meses e 76 anos. Resultados: no momento do exame físico, 96,2% das pessoas tinham pelo menos uma lesão de pele e 79,2% tinham uma ou mais doenças infecciosas de pele, mas 77,9% não tinham consultado um médico. As mais importantes foram micoses (35,1%), bacterianas (35,1%) e ectoparasitoses (27,3%). A preva-lência de doenças bacterianas da pele foi identificada como apontando para um possível aumento da exposição a condições adversas tais como: um clima subtropical com altas temperaturas e umidade, uma alta proporção de pessoas vivendo na casa por quarto, problemas de abastecimento de água e solos arenosos nas habitações, bem como um sistema de eliminação de excrementos deficiente, a presença de animais com vigilância sanitária deficiente, proximidade a riachos e cursos de água abertos que depositam águas residuais, e o impacto recorrente de enchentes em dias de chuvas fortes. Conclusão:Os resultados sugerem que a alta prevalência de doenças infecciosas de pele pode estar relacionada ao aumento da exposição a condições sócio-ambientais locais adversas, que são fatores relevantes a serem considerados para melhorar os cuidados com doenças de pele na população urbana que vive em uma favela


Subject(s)
Humans , Environmental Health , Paraguay , Skin Diseases , Urban Population , Prevalence , Cross-Sectional Studies
4.
Rev. Méd. Inst. Mex. Seguro Soc ; 59(6): 568-573, 01-dic-2021.
Article in Spanish | LILACS | ID: biblio-1357661

ABSTRACT

Considerando que las huellas dactilares son impresiones de las crestas epidérmicas de los dedos con un patrón único, irrepetible y permanente, estas son la base del método biométrico más empleado en la actualidad. Entre sus diversos usos destaca la identificación para múltiples actividades como acceder al trabajo o a teléfonos celulares, la operación de cuentas bancarias, las investigaciones criminales, etcétera. La ausencia o deterioro de las crestas epidérmicas, denominada adermatoglifia, impide la identificación por biometría dactilar. La adermatoglifia se origina por múltiples causas, incluyendo las enfermedades dermatológicas, lesiones traumáticas de los dedos, denervación, envejecimiento, quimioterapia, entre otras. Abordamos brevemente el origen, usos y sistemas para el registro de las huellas dactilares. El objetivo principal es enfatizar la existencia de personas con incapacidad para registrar sus huellas, una condición relevante por el riesgo potencial de discriminación, especialmente cuando el registro de las huellas es obligatorio.


Considering that fingerprints are impressions of the epidermal ridges of the fingers with a unique, unrepeatable, and permanent pattern, they are the basis of the biometric identification method most used today. Among its various uses stand out identification for multiple activities such as authentication to access work and cell phones, operation of bank accounts, criminal investigations, etc. The absence or deterioration of the epidermal ridges, called adermatoglyphia, prevents identification by finger biometrics. Adermatoglyphia originates from multiple causes, including several skin diseases, traumatic injuries of the fingers, denervation, aging, chemotherapy, among others. The origin, uses, and systems for fingerprints verification are briefly addressed here. The main objective is to emphasize the existence of people with fingerprint verification failure, a relevant condition due to the potential risk of discrimination, especially when fingerprint verification is mandatory.


Subject(s)
Humans , Biometry , Dermatoglyphics , Biometric Identification , Social Discrimination , Skin Diseases , Aging
5.
An. bras. dermatol ; 96(6): 655-671, Nov.-Dec. 2021. tab, graf
Article in English | LILACS | ID: biblio-1355628

ABSTRACT

Abstract The skin demonstrates what is happening in the body in many diseases, as it reflects some internal processes on the surface. In this sense, skin as an organ, goes beyond its protective and barrier functions, as it provides clues for the identification of some systemic diseases. The dermatologist then raises diagnostic hypotheses for conditions related to all systems and refers them to the appropriate specialty. With easy access to examination by trained eyes and biopsies, the skin can present specific or non specific alterations on histopathology. In the first case this combination establishes the diagnosis of the disease itself. Non specific manifestations can occur in a variety of contexts and then histopathology is not specific of a particular disease. This article is divided into two parts that will cover large groups of diseases. In this first part, cutaneous manifestations of the main rheumatologic diseases are described, which are the ones with the greatest interface with dermatology. The authors also talk about vascular manifestations and granulomatous diseases. In the second part, endocrinological, hematological, oncological, cardiovascular, renal, gastrointestinal diseases, pruritus and its causes are discussed, and finally, the dermatological manifestations of SARS-CoV-2 coronavirus infection. The authors' intention is that, by using direct and easily accessible language, aim to provide practical material for consultation and improvement to all dermatologists who recognize the importance of a comprehensive assessment of their patients.


Subject(s)
Humans , Skin Diseases/etiology , Skin Diseases/diagnostic imaging , Collagen Diseases , COVID-19 , SARS-CoV-2
6.
An. bras. dermatol ; 96(6): 735-745, Nov.-Dec. 2021. graf
Article in English | LILACS | ID: biblio-1355622

ABSTRACT

Abstract Dermoscopy is an essential in vivo diagnostic technique in the clinical evaluation of skin tumors. Currently, the same can also be said about its implications when approaching different clinical situations in Dermatology. A growing number of reports on dermatological scenarios and diseases have been published, in which dermoscopy has been of great diagnostic help. The term ‟entomodermoscopy" was coined to describe dermoscopic findings in skin infestations and also in dermatoses of infectious etiology. In part I of this article, the main dermoscopic descriptions of zoodermatoses and bacterial infections will be addressed. In many of them, such as scabies, pediculosis, myiasis, and tungiasis, it is possible to identify the pathogen and, consequently, attain the diagnosis more quickly and use the technique to follow-up therapeutic effectiveness. In other situations that will be described, dermoscopy can allow the observation of clinical findings with greater detail, rule out differential diagnoses, and increase the level of confidence in a clinical suspicion.


Subject(s)
Humans , Skin Diseases , Skin Diseases, Parasitic/diagnosis , Skin Neoplasms , Bacterial Infections , Dermoscopy
7.
Article in Portuguese | LILACS | ID: biblio-1353116

ABSTRACT

Nevo epidérmico verrucoso inflamatório linear e diagnóstico diferencial com a psoríase linear: a respeito de um caso RELATO DE CASOMaria Isabel Muniz Zemero1, Maria Amélia Lopes dos Santos1, Alena Margareth Darwich Mendes1, Carla Andrea Avelar Pires1,O nevo epidérmico verrucoso inflamatório linear (NEVIL) é uma variedade clínica rara de nevo epidérmico verrucoso, que se manifesta no início da infância, como lesões inflamatórias de superfície ceratósica, que coalescem e se distribuem em faixa, acompanhando as linhas de Blaschko. Faz diagnóstico diferencial com a psoríase linear, sendo difícil a diferenciação, dado os aspectos clínicos e histopatológicos comuns aos dois, enfantizando-se a necessidade de conhecer as características específicas de cada um. O objetivo deste relato é demonstrar uma afecção relativamente rara, descrita em uma menina de 5 anos, evoluindo desde os primeiros dias de vida com placas papuloceratósicas dispostas linearmente, acompanhadas de sinais inflamatórios e áreas erosadas ocupando grandes lábios, períneo e face interna e superior da coxa esquerda. Também pápulas e placas ceratósicas na região cervical posterior e borda lateral externa da planta do pé esquerdo, ascendendo ao longo da região posterior deste membro. Os critérios clínicos e histopatológicos corroboram o diagnóstico de NEVIL na diferenciação com a psoríase linear, ressaltando a importância do estabelecimento de critérios/ ferramentas que auxiliem na diferenciação destas duas dermatoses visando agilizar o diagnóstico, otimizar o tratamento e minimizar o desconforto para esses pacientes. O acompanhamento a longo prazo dos portadores é sugerido pela possibilidade ainda que mínima de malignização do NEVIL. (AU)


Inflammatory linear verrucous epidermal nevus and differential diagnosis with linear psoriasis: about a caseCASE REPORTMaria Isabel Muniz Zemero1, Maria Amélia Lopes dos Santos1, Alena Margareth Darwich Mendes1, Carla Andrea Avelar Pires1,Inflammatory Linear Verrucous Epidermal Nevus (ILVEN) is a rare clinical variety of verrucous epidermal nevus that manifests in early childhood as inflammatory lesions of keratosis surface, which coalesce and spread in band, following Blaschko lines. It makes a differential diagnosis with Linear Psoriasis; it is difficult to differentiate them given the clinical and histopathological aspects common to both, emphasizing the need to know the specific characteristics of each. The purpose of this report is to demonstrate a relatively rare affection, expressed in a 5-year-old girl, evolving from the first days of life with papulokeratosic plaques arranged linearly, followed by inflammatory signs and eroded areas, placed linearly, overtaking labia majora, perineum, the inner and upper face of the left thigh. Also, the patient showed keratotic papules and plaques in the posterior cervical region and external lateral border of the left foot plant, ascending along the posterior region of this limb. The clinical and histopathological criteria corroborate the diagnosis of ILVEN in differentiation with linear psoriasis, emphasizing the importance of establishing criteria/instruments to assist in distinguishing these two dermatoses in order to expedite the diagnosis, to optimize the treatment and minimize patients' discomfort. Long-term follow-up of patients with this disease is suggested due to the possibility, albeit minimal, of ILVEN malignancy. (AU)


Subject(s)
Humans , Female , Child, Preschool , Psoriasis , Skin Diseases , Diagnosis, Differential , Ectromelia , Nevus, Sebaceous of Jadassohn/diagnosis , Genitalia/pathology , Keratosis
11.
Medicina (B.Aires) ; 81(4): 546-554, ago. 2021. graf
Article in Spanish | LILACS | ID: biblio-1346505

ABSTRACT

Resumen Las urgencias dermatológicas constituyen un motivo de consulta frecuente en los departamentos de urgencias. Con el objetivo de determinar la prevalencia de las consultas por urgencias dermato lógicas, describir las mismas, analizar la coincidencia entre los diagnósticos recibidos por los pacientes, en los casos que realizaron dos consultas por el mismo cuadro, y analizar el comportamiento de las variables de acuerdo al subsector del sistema de salud en el cual fueron atendidos: subsector público, y subsector privado, se realizó un estudio prospectivo, observacional, analítico, de corte transversal y multicéntrico. Se incluyeron 2801 pacientes. La prevalencia de las consultas por urgencias dermatológicas en adultos fue de 15% en el mismo período horario (subsector público: 10.6% y subsector privado: 22.5%, p < 0.05). Motivó la consulta una enfermedad infecciosa en el 35.5%, alérgica en el 29.6% y neoplásica en el 8.6%. Se hospitalizó el 0.7% de los pacientes. El 31.7% de los pacientes había realizado consultas previas. En estos casos se encontró coincidencia entre los diagnósticos realizados en el 80.7% de los atendidos de forma precedente por un médico dermatólogo, y el 52.6% de los evaluados por médicos no dermatólogos. La alta prevalencia de las consultas por urgencias dermatológicas y las diferencias existentes en la probabilidad de recibir un diagnóstico apropiado de acuerdo con la especialización del profesional interviniente, muestran la importancia de la presencia de un médico con formación en dermatología en el área de urgencias.


Abstract Dermatological emergencies are a frequent reason for emergency departments consultation. In order to determine the prevalence of dermatological emergencies, to describe the kind of dermatological diseases that present as emergencies, to analyze the coincidence between the diagnoses received by the patients in those cases with a previous consultations for the same cutaneous manifestation, and to analyze the behavior according to the health system segment in which they were attended: public segment and private segment; a prospective, ob servational, analytical, cross-sectional and multi-center study was carried out. Two thousand eight hundred one patients were included. The prevalence of consultations for dermatological emergencies in adults was 15% in the same time period (public segment: 10.6 and private segment: 22.5%, p < 0.05). The consultation was due to an infectious disease in 35.5%, allergic in 29.6% and neoplastic in 8.6%; 0.7% of patients were hospitalized. In 31.7% of patients who had a previous consultation, a coincidence was found between the diagnoses made in 80.7% of those attended by a dermatologist, and 52.6% evaluated by non-dermatologist physician. The high prevalence of dermatological consultations and the existing differences in the probability of receiving an appropri ate diagnosis according to the specialization of the intervening professional, show the importance of the presence of dermatology-trained physicians in the emergency area.


Subject(s)
Humans , Adult , Skin Diseases/diagnosis , Skin Diseases/epidemiology , Dermatology , Argentina/epidemiology , Cross-Sectional Studies , Prospective Studies , Emergencies
12.
Prensa méd. argent ; 107(5): 258-263, 20210000. tab, ilus
Article in Spanish | LILACS, BINACIS | ID: biblio-1359193

ABSTRACT

El Penfigoide Ampollar por fármacos es una variedad de penfigoide ampollar en la que un medicamento actúa como causa o desencadenante de la enfermedad. Clínicamente se manifiesta como ampollas tensas de contenido seroso localizadas fundamentalmente en abdomen, miembros superiores y raíz de muslos. El estudio histopatológico evidencia ampollas subepidérmicas e infiltrado dérmico mixto con eosinófilos. La inmunofluorescencia directa de piel sana perilesional muestra depósitos lineales de IgG y/o C3. Sin embargo, en hasta 15% de los casos puede ser negativa. Los pacientes diabéticos que reciben tratamiento con fármacos del grupo de los inhibidores de la dipeptidilpeptidasa 4, también conocidos como gliptinas, tienen 3 veces más riesgo de desarrollar esta patología. El tiempo de latencia entre el inicio de la medicación y la aparición de los síntomas es variable, con una media de 10 meses. El tratamiento radica en la suspensión inmediata del fármaco causal y la administración de prednisona oral 0,5 mg/kg/día. El tiempo medio de respuesta es de 10 días. Se presenta un varón de 82 años con una dermatosis ampollar pruriginosa de 3 semanas de evolución posterior al inicio de teneligliptina, cuyo estudio histopatológico fue característico de penfigoide ampollar, y que evolucionó satisfactoriamente al suspender el hipoglucemiante oral, sin aparición de nuevas lesiones a más de un año de seguimiento clínico


Drug-induced bullous pemphigoid is a variety of bullous pemphigoid in which a drug is the cause of the disease. It manifests as serous tense blisters located mainly on the abdomen, upper limbs and root of the tights. The histopathology shows subepidermal bullae and mixed dermal infiltrate with eosinophils. Direct immunofluorescence of healthy perilesional skin shows linear IgG and/or C3 deposits. However, it can be negative in up to 15% of the cases. Diabetic patients receiving dipeptidylpeptidase 4 inhibitors have a 3 times increased risk of developing drug-induced bullous pemphigoid. The mean time between the beginning of the medication and the appearance of the dermatosis is 10 months. Immediate suspension of the offending drug and administration of prednisone 0,5 mg/kg/day is the standard treatment. Average response time is 10 days. We present an 82-year-old-man with a 3-week itchy bullous dermatosis that started 8 months after treatment with teneligliptin, whose histopathological study resembled bullous pemphigoid, and which evolved satisfactorily when the drug was discontinued. No new lesions have been detected after more than one year of clinical follow-up. Key words: bullous pemphigoid, drug-induced bullous pemphigoid, gliptins, teneligliptin, dipeptidylpeptidase 4 inhibitors


Subject(s)
Humans , Male , Aged, 80 and over , Skin Diseases/immunology , Prednisone/therapeutic use , Pemphigoid, Bullous/drug therapy , Pemphigoid, Bullous/therapy , Dipeptidyl-Peptidase IV Inhibitors/therapeutic use
13.
Rev. bras. ciênc. vet ; 28(3): 146-150, jul./set. 2021. il.
Article in Portuguese | LILACS, VETINDEX | ID: biblio-1363943

ABSTRACT

A pele é o maior órgão do corpo e pode ser acometida por uma série de processos patológicos. As doenças dermatológicas em geral são um aspecto frustrante na clínica de animais de grande porte. Desse modo, o objetivo deste estudo foi relatar lesões de pele diagnosticadas em búfalos na região do Baixo Amazonas, estado do Pará. Foram avaliados 156 búfalos das raças Murrah, Mediterrâneo e seus mestiços; adultos e jovens, com idade variando de oito meses a nove anos. No exame físico constatou-se que 36,5% (57/156) dos animais apresentavam abscessos no local de vacinação. Destes, 12,2% (19/156) eram abscessos com presença de alopecia e 1,3% (2/156) com fistulação Além disso, 1,3% (2/156) dos animais apresentaram ainda no local de vacinação, feridas ulceradas com presença de secreção purulenta. Identificou-se que 3,8% (6/156) dos búfalos possuíam lesões provenientes da marcação a fogo, com queimaduras, de aspecto crostoso, eritematoso e exsudativo, na região da garupa.; A maioria 64,1% (100/156) dos animais apresentaram corte das orelhas, 1,9% (3/156) apresentaram lesões por penetração de corno e em 1,2% (2/156) observou-se lesão de pele no membro posterior direito. Conclui-se que foi possível diagnosticar diversas lesões cutâneas nos búfalos na região do Baixo Amazonas, sendo o erro no manejo dos animais as principais causas das lesões diagnosticadas. Além disso, houve correlação entre dois grupos de animais avaliados (com e sem lesão).


The skin is the largest organ in the body and can be affected by a series of pathological processes. Dermatological diseases in general are a frustrating aspect in the clinic of large animals. Thus, the objective of this study was to report skin lesions diagnosed in buffaloes in the region of Baixo Amazonas, state of Pará. 156 buffaloes of the Murrah, Mediterranean and crossbred breeds were taken; Adults and young people, with ages varying from eight months to nine years. On physical examination, it was found that 36.5% (57/156) of the animals had abscesses at the vaccination site. Of these, 12.2% (19/156) were abscesses with the presence of alopecia and 1.3% (2/156) with fistulation. In addition, 1.3% (2/156) of the animals separated at the vaccination site, ulcerated wounds with the presence of purulent secretion. It was identified that 3.8% (6/156) of the buffaloes had the location of the fire mark, with burns, with a crusted, erythematous and exudative aspect, in the croup region. The majority 64.1% (100/156) of the animals separation of the ears, 1.9% (3/156) dissipation by penetration of the horn and in 1.2% (2/156) a skin lesion was observed in any limb posterior right. It was concluded that it was possible to diagnose several cutaneous lesions in buffaloes in the region of Baixo Amazonas, with the error in handling animals being the main causes of the diagnosed injuries. In addition, there was a correlation between two groups of acquired animals (with and without injury).


Subject(s)
Animals , Skin Diseases/veterinary , Buffaloes/injuries , Burns/veterinary , Amazonian Ecosystem , Abscess/veterinary
14.
Int. j. med. surg. sci. (Print) ; 8(2): 1-5, jun. 2021. ilus
Article in English | LILACS | ID: biblio-1284513

ABSTRACT

Epidermoid cyst is a type of cutaneous cyst commonly found in daily practice. The facial area is the most common area for emergence of this benign condition. Simple extirpation is usually performed to remove epidermoid cysts. However, in rare cases, epidermoid cysts can evolve into malignancies such as basal cell carcinoma (BCC) or can mimic them, which adds difficulty when making a proper diagnosis. In cases of doubt, histopathology plays a key role in aiding diagnosis. This case report is about a 33-year-old woman with suspected nodular lesion that mimicked BCC, but after histopathological analysis was confirmed to be epidermoid cyst


El quiste epidermoide es un tipo de quiste cutáneo que se encuentra frecuentemente en la práctica diaria. El área facial es el área más común para la aparición de esta lesión benigna. La extirpación quirúrgica simple es el procedimiento habitual para eliminar los quistes epidermoides. Sin embargo, en casos raros, los quistes epidermoides pueden evolucionar en neoplasias malignas como el carcinoma basocelular (CCB) o pueden imitarlos, lo que añade dificultad al hacer un diagnóstico adecuado. En caso de duda, la histopatología desempeña un papel clave en la ayuda al diagnóstico. Este informe de caso trata sobre una mujer de 33 años con sospecha de lesión nodular que imitaba el CCB, pero después de que se confirmó con el análisis histopatológico, que se trataba de un quiste epidermoide.


Subject(s)
Humans , Female , Adult , Skin Diseases/diagnosis , Epidermal Cyst/diagnosis , Carcinoma, Basal Cell/diagnosis , Diagnosis, Differential , Epidermal Cyst/surgery
15.
An. bras. dermatol ; 96(3): 332-345, May-June 2021. tab, graf
Article in English | LILACS | ID: biblio-1285074

ABSTRACT

Abstract The study of skin, the science of dermatology, has undergone significant transformations throughout the centuries. From the first descriptions of skin diseases in Egyptian papyri and in Hippocratic writings to the first treatises on dermatology, important individuals and discoveries have marked the specialty. In the 18th and 19th centuries, the specialty consolidated itself as a field of medical study based on the first classifications of dermatoses, diagnostic methods, and drug treatments. In the 20th century, the scientific and technological revolution transformed dermatological practice, incorporating new therapeutic resources, as well as surgical and aesthetic procedures. In the face of such a vigorous process, it is important to provide a historical synthesis for the medical community to recognize and understand the origins that supported one of the most relevant specialties in the current medical scenario.


Subject(s)
Humans , History, 15th Century , History, 16th Century , History, 18th Century , History, 19th Century , History, 20th Century , Skin Diseases/diagnosis , Skin Diseases/therapy , Dermatology , Skin , History, Ancient , History, Medieval , Egypt , Esthetics
17.
An. bras. dermatol ; 96(3): 328-331, May-June 2021. graf
Article in English | LILACS | ID: biblio-1285053

ABSTRACT

Abstract Cutis rhomboidalis nuchae was assessed in a 65-year-old patient. Optical microscopy showed basophilic agglomerations in the reticular dermis with decreased elastic fibers. Trans- mission electron microscopy showed elongated, curved and fragmented structures, and in their interior the presence of electron-dense lumps was reduced and irregular, similar to modified elastic fibers, whereas the collagen fibers had a normal aspect. Scanning electron microscopy showed deposits between the bundles of collagen, resembling pebbles or stones. These findings demonstrate that, at one stage of the disease, the collagen remains normal and the alterations are seen in the elastic tissue.


Subject(s)
Humans , Aged , Skin Diseases , Microscopy, Electron, Scanning , Dermis , Microscopy, Electron, Transmission , Elastic Tissue
18.
Vitae (Medellín) ; 28(2): 1-8, 2021-05-18. Ilustraciones
Article in English | LILACS, COLNAL | ID: biblio-1363196

ABSTRACT

Background: "Dividivi" Caesalpinia coriaria (Jacq.) Willd fruits are traditionally used by the Wayuú community in La Guajira (Colombia) to treat oral and skin cavity diseases caused by bacteria and fungi. Streptococcus pyogenes is a gram-positive cocci of group A (beta-hemolytic) that is the cause of pharyngeal disease, scarlet fever, cellulitis, erysipelas, or toxic shock-like syndrome. Alternatively, Candida albicans is a yeast-like fungus that is a normal flora of the digestive tract, vagina, or skin folds; it has been known to be the root cause of opportunistic diseases such as diaper rash, oral and esophagus thrush, or vulvovaginitis. Objective: This study evaluated the antimicrobial activity of methanolic and ethanolic extracts of C. coriaria (Jacq.) Willddry fruits on S. pyogenes ATCC 12384andC. albicans ATTC 14053. Method: C. coriaria extracts were obtained from the Soxhlet method using two solvents (methanol and ethanol 98%) prepared from pulverized fruits. A phytochemical test and an antimicrobial activity assay were performed using the obtained extracts and tested using S. pyogenes ATCC 12384 and C. albicans ATTC 14053 strains. Results: A phytochemical profile was performed, examining the presence of bioactive metabolites (tannins, alkaloids, glycosides, saponins, and anthraquinones) from each extract. Antimicrobial susceptibility tests showed that the ethanolic extract inhibited S. pyogenes ATCC 12384,causing inhibition halos of 14.1 ± 0.1 mm and a Minimum Inhibitory Concentration (MIC) of 172 mg/ml, and C. albicans test shows inhibition halos of 16.1 ± 0.2 mm and MIC of 212 mg/ml. Additionally, the methanolic extract inhibited S. pyogenes with inhibition halos of 15.2 ± 0.2 mm and MIC of 152 mg/ml; no inhibitory effect was observed on C. albicans.Conclusion: This study revealed that C. coriaria has an antimicrobial effect on the tested species opening the field of its possible use as a therapeutic agent


Introducción: Los frutos del "Dividivi" Caesalpinia coriaria (Jacq.) Willd son usados tradicionalmente por la comunidad indígena Wayuú en La Guajira (Colombia) para el tratamiento de enfermedades de la cavidad bucal y cutáneas ocasionadas por bacterias y hongos. Streptococcuspyogenes es un coco grampositivo del grupo A (beta-hemolítico) que es la causa de enfermedad faríngea, escarlatina, celulitis, erisipela o síndrome tipo shock tóxico. Candida albicans es un hongo levaduriforme que es flora normal del tracto digestivo, la vagina o los pliegues de la piel; se sabe que es la causa principal de enfermedades oportunistas como la dermatitis del pañal, aftas bucales y esofágicas, o vulvovaginitis. Objetivo: El objetivo de este estudio fue evaluar la actividad antimicrobiana de extractos metanólicos y etanólicos de frutos secos sobre microorganismos patógenos específicamente S. pyogenes ATCC 12384yC. albicansATTC 14053. Método: A partir de frutos polverizados de C. coriaria, usando el método Soxlet, se evaluaron dos solventes (metanol y etanol al 98%), los cuales, fueron usados para estudiar su actividad antimicrobiana evaluando su efecto en cepas de S. pyogenes ATCC 12384 y C. albicans ATTC 14053. Resultados: Mediante un perfil fitoquímico se determinó la presencia de grupos de metabolitos secundarios con compuestos bioactivos (taninos, alcaloides, glucósidos, saponinas, y antraquinonas). Las pruebas de sensibilidad antimicrobiana mostraron que el extracto etanólico tuvo un efecto inhibidor sobre S. pyogenesATCC 12384 con halos de inhibición de 14.1 ± 0.1 mm y una concentración mínima inhibitoria (CMI) de 172 mg/mL, y sobre C. albicans se presentaron halos de inhibición de 16.1 ± 0.2 mm y CMI de 212 mg/mL, mientras que el extracto metanólico tuvo un efecto inhibidor sobre S. pyogenes con halos de inhibición de 15.2 ± 0.2 mm y CMI de 152 mg/mL no se observó efecto inhibidor sobre C. albicans. Conclusión: Este estudio demostró que C. coriaria tiene efecto antimicrobiano en las especies evaluadas, abriendo un campo de investigación en la evaluación de su uso como agente terapéutico


Subject(s)
Humans , Anti-Infective Agents , Skin Diseases , Streptococcus pyogenes , Candida albicans , Microbial Sensitivity Tests , Mouth Diseases
19.
Arch. argent. pediatr ; 119(5): e536-e539, oct. 2021. tab, ilus
Article in Spanish | LILACS, BINACIS | ID: biblio-1292788

ABSTRACT

El melanoma es la forma más grave de cáncer de piel. La morbimortalidad es variable, ya que se relaciona con las medidas de prevención implementadas, la detección temprana y el acceso al tratamiento temprano. La incidencia ha aumentado en los últimos años a pesar de la mayor concientización con respecto a la exposición a la luz solar y la utilización de cremas protectoras. A su vez, el rango etario se ha ampliado, y esta enfermedad afecta a individuos cada vez más jóvenes. Se estima que del 1 % al 4 % de todos los casos de melanoma ocurren en menores de 20 años.Se presentan dos casos pediátricos, con evolución prolongada y diagnóstico inicial erróneo. Es fundamental para el pediatra general, primer contacto del paciente con el sistema de salud, conocer las características de estas lesiones. Un alto índice de sospecha permitiría la derivación al especialista de forma temprana.


Melanoma is the most serious skin cancer. Morbimortality is variable as it is related to the preventive measures, early detection, and access to early treatment. The incidence has increased in recent years, despite the raise in awareness of avoiding sun exposure and the use of sunscreen. What is more, the disease age range has expanded, affecting increasingly younger individuals. It is estimated that 1 to 4 % of all melanoma cases occurred in people younger than twenty years old.We present two pediatric cases with prolonged evolution and wrong initial diagnosis. Since the general pediatrician is the patient's first contact with the health system, it is extremely important to know the characteristics of these lesions. A high index of suspicion would allow an early referral to the specialist.


Subject(s)
Humans , Child, Preschool , Child , Melanoma/drug therapy , Melanoma/therapy , Skin Diseases/diagnosis , Skin Diseases/drug therapy , Sunscreening Agents/therapeutic use , Incidence
20.
Rev. Eugenio Espejo ; 15(2): 39-46, 20210516.
Article in Spanish | LILACS | ID: biblio-1248214

ABSTRACT

La exposición excesiva al sol constituye una de las causas más comunes de enfermedades cutá-neas. El objetivo de la investigación fue describir los hábitos de fotoprotección de pacientes atendidos en la consulta de dermatología del área III de salud, en el municipio Cienfuegos, Cuba, durante el período comprendido entre los meses de enero y mayo de 2020. Se realizó un estudio observacional, descriptivo y transversal, cuya población estuvo constituida por 3045 pacientes, de los que se seleccionó una muestra de 1066 individuos a través de un muestreo no probabilístico por sujetos voluntarios. Los datos fueron recolectados mediante la aplicación de un cuestionario cerrado, el que fue validado por criterio de especialistas. El estudio contó con la aprobación del Comité de Ética de la Investigación de la Universidad de Ciencias Médicas Dr. "Raúl Dorticós Torrado" de Cienfuegos, Cuba. El grupo con más de 59 años resultó el más representado (37,8%), mientras que los menores de 15 años (6,8%) fue el menos. El género femenino prevaleció (53,4%). El cuidado de la piel ante la sobreexposición solar fue insuficien-te. Predominaron los que no conocen su tipo de piel y aquellos que no recibieron orientaciones sobre su cuidado. También prevalecieron aquellos cuya declaración indica que nunca realizan autoexamen de este importante órgano y los que no utilizan aditamentos de fotoprotección, espe-cíficamente: sombrero, gorra y sombrilla


Excessive sun exposure is one of the most common causes of skin diseases. This research aimed to describe the photoprotection habits of patients treated in the dermatology consultation of health area III, in the municipality of Cienfuegos, Cuba, during the period between the months of January and May 2020. An observational, descriptive, and cross-sectional study was carried out. The population consisted of 3045 patients, from which a sample of 1066 individuals was selected through a non-probabilistic sampling by volunteer subjects. The data were collected by applying a closed questionnaire, which was validated by specialists' criteria. The study was approved by the Research Ethics Committee of the Dr. "Raúl Dorticós Torrado" University of Medical Sciences of Cienfuegos, Cuba. The group over 59 years of age was the most represented (37.8%), while those under 15 years of age (6.8%) were the least. The female gender prevailed (53.4%). Skin care for overexposure to the sun was insufficient. Those ones who do not know their skin type and those who did not receive guidance on their care predominated; as well as those ones whose statement indicates that they never perform self-examination of this important organ and those ones who do not use photoprotection accessories, specifically: hat, cap and umbrella


Subject(s)
Humans , Male , Female , Adolescent , Middle Aged , Aged , Patients , Skin Diseases , Habits , Skin Care , Solar Radiation , Dermatology
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