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1.
An. bras. dermatol ; 96(3): 332-345, May-June 2021. tab, graf
Article in English | LILACS | ID: biblio-1285074

ABSTRACT

Abstract The study of skin, the science of dermatology, has undergone significant transformations throughout the centuries. From the first descriptions of skin diseases in Egyptian papyri and in Hippocratic writings to the first treatises on dermatology, important individuals and discoveries have marked the specialty. In the 18th and 19th centuries, the specialty consolidated itself as a field of medical study based on the first classifications of dermatoses, diagnostic methods, and drug treatments. In the 20th century, the scientific and technological revolution transformed dermatological practice, incorporating new therapeutic resources, as well as surgical and aesthetic procedures. In the face of such a vigorous process, it is important to provide a historical synthesis for the medical community to recognize and understand the origins that supported one of the most relevant specialties in the current medical scenario.


Subject(s)
Humans , History, 15th Century , History, 16th Century , History, 18th Century , History, 19th Century , History, 20th Century , Skin Diseases/diagnosis , Skin Diseases/therapy , Dermatology , Skin , History, Ancient , History, Medieval , Egypt , Esthetics
2.
Rev. bras. cir. plást ; 34(4): 567-570, oct.-dec. 2019. ilus
Article in English, Portuguese | LILACS | ID: biblio-1047930

ABSTRACT

O pioderma gangrenoso (PG) é doença inflamatória da pele, que pode se desenvolver espontaneamente, associado a certas doenças sistêmicas e neoplásicas, ou ao trauma cirúrgico, incluindo os das mamas. Há relatos cada vez mais frequentes, considerando o aumento desse procedimento nos dias atuais. A manifestação clínica das úlceras é característica e deve ser lembrada nas evoluções cicatriciais desfavoráveis com intensa reação inflamatória, perdas teciduais, secreção sanguinolenta e/ ou purulenta, fundo granuloso e bordas elevadas. Relatase o caso de paciente que teve pioderma gangrenoso após mamoplastia redutora. Respondeu ao corticosteroide sistêmico, e vem evoluindo sem recidivas até o momento.


Pyoderma gangrenosum (PG) is an inflammatory disease of the skin that may develop spontaneously. It is associated with certain systemic and neoplastic diseases, including those of the breasts. PG is also associated with surgical trauma. It has been increasingly reported, along with the increase in the incidence of reduction mammoplasty procedures. The clinical manifestation of ulcers is characteristic of PG and it should be considered in cases of poor healing with intense inflammatory reaction, tissue loss, bloody and/ or purulent secretion, granular background, and lesions with high edges. We describe a patient who developed PG after reduction mammoplasty. She has since responded to systemic corticosteroids and has had no relapse to date.


Subject(s)
Humans , Female , Middle Aged , History, 21st Century , Postoperative Complications , Skin Diseases , Autoimmune Diseases , Mammaplasty , Pyoderma Gangrenosum , Diagnosis, Differential , Postoperative Complications/surgery , Postoperative Complications/therapy , Skin Diseases/surgery , Skin Diseases/complications , Skin Diseases/therapy , Autoimmune Diseases/diagnosis , Autoimmune Diseases/therapy , Surgical Procedures, Operative , Surgical Procedures, Operative/methods , Mammaplasty/methods , Pyoderma Gangrenosum/surgery , Pyoderma Gangrenosum/complications , Pyoderma Gangrenosum/therapy
3.
An. bras. dermatol ; 94(4): 462-469, July-Aug. 2019. tab, graf
Article in English | LILACS | ID: biblio-1038307

ABSTRACT

Abstract: Cutaneous mucinoses are a heterogeneous group of dermatoses in which excess deposition of mucin in the dermis gives the skin a waxy appearance, with papules and plaques that can vary from self-healing mucinosis to even disrupting the normal shape of a patient's face, conferring a leonine facies, or be part of life threatening diseases like scleromyxedema. This review will describe the most recent classification on lichen myxedematosus in the generalized (scleromyxedema) and the localized forms, as well as the different organ systems involved in scleromyxedema, diagnostic workup, current management, and prognosis.


Subject(s)
Humans , Skin Diseases/diagnosis , Skin Diseases/pathology , Scleromyxedema/diagnosis , Scleromyxedema/pathology , Skin/pathology , Skin Diseases/classification , Skin Diseases/therapy , Scleromyxedema/classification , Scleromyxedema/therapy , Fibroblasts/pathology , Mucins
4.
Rev. Hosp. Ital. B. Aires (2004) ; 38(2): 82-84, jun. 2018. ilus.
Article in Spanish | LILACS | ID: biblio-1023177

ABSTRACT

Las dermatosis autoinfligidas representan un motivo habitual de consulta, así como un desafío diagnóstico y terapéutico. Se caracterizan por la autoprovocación de lesiones cutáneas de manera consciente o inconsciente en el contexto de trastornos psiquiátricos complejos. Comunicamos el caso de una paciente que consultó al Servicio de Dermatología por úlceras irregulares y sobreinfectadas localizadas en rostro, de 2 meses de evolución. El caso representó una dificultad diagnóstica ya que solo a partir del interrogatorio exhaustivo y los exámenes complementarios, que descartaron otras patologías, se arribó al diagnóstico de úlceras autoprovocadas en contexto de patología psiquiátrica que requirió manejo interdisciplinario. (AU)


Self-inflicted dermatoses are a frequent cause for consultation and represent a diagnostic and therapeutic challenge. They are characterized by the conscious or unconscious self-generation of cutaneous lesions in the context of complex psychiatric disorders. We report the case of a patient who consulted at the dermatology department with two months history of irregular and superinfected ulcers located on the face. This case represented a diagnostic difficulty since only from an exhaustive interrogation and complementary examinations, which ruled out other pathologies, we arrived at the diagnosis of self-inflicted ulcers in the context of psychiatric pathology that required interdisciplinary management. (AU)


Subject(s)
Humans , Skin Ulcer/psychology , Mental Disorders/complications , Signs and Symptoms , Skin Diseases/diagnosis , Skin Diseases/etiology , Skin Diseases/pathology , Skin Diseases/psychology , Skin Diseases/therapy , Skin Ulcer/pathology , Skin Ulcer/therapy , Facial Injuries/pathology , Facial Injuries/therapy , Degloving Injuries/etiology , Degloving Injuries/therapy
7.
Arq. bras. med. vet. zootec. (Online) ; 69(4): 860-864, jul.-ago. 2017. ilus
Article in Portuguese | LILACS, VETINDEX | ID: biblio-876613

ABSTRACT

Relata-se um caso de lesão cutânea secundária à infecção por Corynebacterium pseudotuberculosis em bovino. Abscessos e múltiplas lesões cutâneas nodulares, variando de 8x10 para 20x25cm de diâmetro, firmes, sensíveis ao toque e sem mobilidade, algumas com superfície ulcerada, circundada por halo avermelhado e drenando secreção piossanguinolenta, e outras com superfícies alopécicas, foram identificados na região torácica lateral do animal. Exames histopatológicos e o isolamento do agente de fragmentos obtidos após remoção cirúrgica das lesões confirmaram tratar-se da forma cutânea da infecção pelo C. pseudotuberculosis. As lesões microscópicas caracterizaram-se por dermatite nodular piogranulomatosa e ulcerativa. A avaliação da susceptibilidade in vitro do C. pseudotuberculosis a antimicrobianos demonstrou que o agente era resistente à amicacina, kanamicina, neomicina e penicilina G, apresentando sensibilidade à ampicilina adicionada de subactam, amoxicilia com ácido clavulônico, cefalexina, cefalotina, cefotaxima, enrofloxacina, gentamicina e tetraciclina. A retirada cirúrgica das lesões e o tratamento com enrofloxacina resultaram na cura do animal. Lesões de pele observadas em casos de ptiose, carcinoma de células escamosas e na forma atípica da actinobacilose devem ser consideradas no diagnóstico diferencial da forma cutânea da infecção por C. pseudotuberculosis em bovinos. Os dados apresentados demonstram que a infecção pelo C. pseudotuberculosis deve ser considerada no diagnóstico diferencial das lesões de pele em bovinos no Brasil.(AU)


We report a case of secondary skin lesionby infection with Corynebacterium pseudotuberculosis in bovine. Abscesses and multiple nodular lesions, ranging from 8x10 to 20x25 cm in diameter, firm, sensitive to touch, and without mobility, some with ulcerated surface, surrounded by reddish halo and draining piosanguinolenta secretion, and other surfaces with alopecia, were identified in the skin of the animal`s thoracic area. Histopathology and isolation of the agent from fragments obtained after surgical removal of the lesions confirmed the cutaneous infection by C. pseudotuberculosis. Microscopic lesions were characterized by lumpy skin disease and ulcerative pyogranulomatous. Evaluation of in vitro susceptibility to antimicrobial demonstrated that the agent was resistant to amikacin, kanamycin, neomycin and penicillin G, and sensitive to ampicillin + subactam, amoxicilia with clavulonic acid, cephalexin, cephalothin, cefotaxime, enrofloxacin, gentamicin, and tetracycline. The surgical removal of the lesions, and treatment with enrofloxacin resulted in animal cure. Skin lesions observed in case of ptiose, squamous cell carcinoma and atypical form of Actinobacillosis should be considered in the differential diagnosis of cutaneous form of C. pseudotuberculosis infection in cattle. The data presented demonstrate that infection with C. pseudotuberculosis should be considered in the differential diagnosis of skin lesions in cattle in Brazil.(AU)


Subject(s)
Animals , Cattle , Corynebacterium pseudotuberculosis , Dermatitis/veterinary , Skin Diseases/surgery , Skin Diseases/therapy
8.
An. bras. dermatol ; 92(4): 521-525, July-Aug. 2017. tab
Article in English | LILACS | ID: biblio-886995

ABSTRACT

Abstract: Sensitive skin is a condition characterized by stinging, burning and itching sensations. The diagnosis, pathophysiology and treatment of sensitive skin are still under discussion. In the last years, studies on its epidemiology have been performed, showing a high prevalence and impact on quality of life. Brazilian population was also considered in these studies. Cosmetics, climate changes and skin barrier impairment are the main factors that contribute for skin hyperreactivity. New studies are trying to bring new knowledge about the theme. This review will describe data on epidemiology, triggering factors, pathophysiology, diagnosis and treatment.


Subject(s)
Humans , Skin Diseases , Somatosensory Disorders , Skin Diseases/diagnosis , Skin Diseases/etiology , Skin Diseases/therapy , Skin Diseases/epidemiology , Brazil/epidemiology , Skin Tests/methods , Causality , Surveys and Questionnaires , Cosmetics/adverse effects , Somatosensory Disorders/diagnosis , Somatosensory Disorders/etiology , Somatosensory Disorders/therapy , Somatosensory Disorders/epidemiology , Dermatitis/diagnosis , Dermatitis/physiopathology , Dermatitis/epidemiology , Environment
9.
An. bras. dermatol ; 92(1): 63-71, Jan.-Feb. 2017.
Article in English | LILACS | ID: biblio-838008

ABSTRACT

Abstract: The mind-skin connection has been studied since the nineteenth century. The last 40 years have set the development of new research areas which allowed the clarifying of how these two dimensions interact. The diseases that involve skin and mind constitute the field of psychodermatology and require that specialists in dermatology, psychiatry and psychology together and integrated take part in it, since skin, nervous system and mind are simultaneously affected. This paper aims to expose how psychodermatoses are currently conceptualized and the need of integration of these three specialties for conveniently treating the patients.


Subject(s)
Humans , Patient Care Team , Psychophysiologic Disorders/psychology , Psychophysiologic Disorders/therapy , Skin Diseases/psychology , Skin Diseases/therapy , Psychiatry , Psychology, Clinical , Psychophysiology , Stress, Psychological/physiopathology , Touch Perception , Dermatologists
10.
Rev. bras. cir. plást ; 32(1): 128-134, 2017. ilus
Article in English, Portuguese | LILACS | ID: biblio-832687

ABSTRACT

Introdução: Necrólise epidérmica tóxica é uma erupção mucocutânea aguda grave, geralmente induzida por medicamentos, associada a alta taxa de morbidade e mortalidade. Os cuidados com as lesões mucosas e cutâneas e a abordagem multidisciplinar são muito importantes para o prognóstico e sequelas futuras. Objetivos: Discutir os principais aspectos dessa síndrome por meio da revisão de literatura, ilustrada por um caso clínico. Métodos: Revisão de literatura utilizando bases de dados on-line PubMed e Scielo. Incluímos artigos em língua inglesa, portuguesa, francesa e espanhola, e ilustração com caso clínico pediátrico. Termos procurados foram "toxic epidermal necrolysis", "Stevens-Johnson overlap", ''necrólise epidérmica tóxica'', ''síndrome Stevens-Johnson''. Resultados: Apresentamos dados para guiar o manejo de pacientes com necrólise epidérmica tóxica para cirurgiões plásticos, pediatras, intensivistas, dermatologistas e emergencistas. O caso tratado teve evolução favorável, sem sequelas cutâneas. Conclusão: O alto nível de suspeição é imprescindível para um diagnóstico e estratificação de risco adequados e instituição precoce de medidas de suporte, e o tratamento deve ser realizado por uma equipe multidisciplinar treinada para reduzir sequelas e mortalidade.


Introduction: Toxic epidermal necrolysis is a severe acute mucocutaneous condition usually induced by drugs associated with a high rate of morbidity and mortality. The care of the mucous lesions and skin and a multidisciplinary approach are very important for the prognosis and future sequelae. Objectives: To discuss the main aspects of this syndrome through a literature review illustrated by a clinical case. Methods: Review of the literature using the PubMed and SciELO online databases was performed. Articles in English, Portuguese, French, and Spanish were included and illustrated with a pediatric clinical case. The keywords used were as follows: "toxic epidermal necrolysis," "Stevens-Johnson overlap," "necrólise epidérmica tóxica," and "síndrome Stevens-Johnson." Results: We presented data to guide the management of patients with toxic epidermal necrolysis for plastic surgeons, pediatricians, intensivists, dermatologists, and emergency physicians. The case treated had a favorable disease course without sequelae. Conclusion: A high level of suspicion is necessary for an adequate diagnosis and risk stratification, and early support measures and treatment should be performed by a multidisciplinary team trained to minimize damage and mortality.


Subject(s)
Humans , Male , Infant , History, 21st Century , Skin Diseases , Surgical Procedures, Operative , Wounds and Injuries , Review Literature as Topic , Keratinocytes , Stevens-Johnson Syndrome , Exanthema , Skin Diseases/surgery , Skin Diseases/drug therapy , Skin Diseases/therapy , Surgical Procedures, Operative/methods , Wounds and Injuries/surgery , Wounds and Injuries/drug therapy , Wounds and Injuries/therapy , Keratinocytes/pathology , Stevens-Johnson Syndrome/surgery , Stevens-Johnson Syndrome/drug therapy , Stevens-Johnson Syndrome/therapy , Exanthema/surgery , Exanthema/pathology , Exanthema/therapy
11.
An. bras. dermatol ; 91(3): 336-343, tab, graf
Article in English | LILACS | ID: lil-787293

ABSTRACT

Abstract Graft-versus-host disease (GVHD) is a major complication of allogeneic hematopoietic stem cell transplants (allo-HSCT) associated with significant morbidity and mortality. The earliest and most common manifestation is cutaneous graft-versus-host disease. This review focuses on the pathophysiology, clinical features, prevention and treatment of cutaneous graft-versus-host disease. We discuss various insights into the disease's mechanisms and the different treatments for acute and chronic skin graft-versus-host disease.


Subject(s)
Humans , Skin Diseases/etiology , Hematopoietic Stem Cell Transplantation/adverse effects , Graft vs Host Disease/etiology , Skin Diseases/therapy , Chronic Disease , Photopheresis/methods , Exanthema/etiology , Exanthema/therapy , Glucocorticoids/therapeutic use , Graft vs Host Disease/therapy
12.
Rev. cuba. enferm ; 31(4): 0-0, oct.-dic. 2015.
Article in Portuguese | LILACS, BDENF, CUMED | ID: lil-797699

ABSTRACT

Introdução: ao se identificar os tipos mais frequentes de lesões que acometem os clientes internados, o enfermeiro deve planejar, organizar, implementar e avaliar as ações de cuidado a portadores de lesões ulcerativas, cirúrgicas e/ou traumáticas procurando minimizar o tempo de internação, diminuir os custos das internações prolongadas em decorrência de complicações e iatrogenias. Objetivo: caracterizar o perfil de clientes hospitalizados com lesões cutâneas. Métodos: estudo quantitativo e exploratório realizado nas enfermarias de clínica médica de um Hospital Universitário no Estado do Rio de Janeiro com 50 clientes que apresentavam alguma lesão cutânea no período de abril a julho de 2014. Foram utilizados dois instrumentos para coleta de dados: análise documental em prontuário e entrevista estruturada. Os dados foram submetidos à análise estatística simples. Resultados: maioria do sexo feminino (58 percento), média de idade de 58,33 ± 16,83 anos. A lesão cutânea mais prevalente foi a úlcera por pressão (20,3 percento) e quanto ao local, as lesões estavam localizadas nos membros inferiores (25,4 percento). Conclusão: o cuidado das lesões torna-se um aspecto importante na sistematização da assistência de enfermagem, pois o enfermeiro não deve contemplar somente a realização dos curativos, mas avaliar os fatores etiológicos e de risco relacionados à lesão cutânea(AU)


Introducción: para identificar los tipos más frecuentes de lesiones que afectan a los pacientes internados, el enfermero debe delinear, organizar, implementar y estimar las acciones de cuidado a los portadores de lesiones ulcerosas, quirúrgicas o traumáticas, procurando minimizar el tiempo de internación, disminuir los costos de las internaciones prolongadas y efectos de complicaciones e iatrogenias. Objetivo: caracterizar el perfil de los pacientes hospitalizados con lesiones de piel. Métodos: estudio exploratorio cuantitativo, llevado a cabo en las salas clínicas de un Hospital Universitario en el estado de Río de Janeiro con 50 pacientes que presentaron alguna lesión cutánea en el período de abril a julio de 2014. Se utilizaron dos instrumentos para recolectar datos: documento de análisis de tabla y entrevista estructurada. Los datos fueron sometidos a análisis estadístico simple. Resultados: predominóel sexo femenino (58 por ciento) y la edad media de 58,33 ± 16,83 años. La lesión cutánea más frecuente fue la úlcera de decúbito (20,3 por ciento) y en cuanto a la ubicación, las lesiones se localizaron en las extremidades inferiores (25,4 por ciento). Conclusión: el cuidado de la lesión se convierte en un aspecto importante en la sistematización de la atención de enfermería, porque la enfermera no debe contemplar sólo la realización de los vendajes, sino evaluar los factores etiológicos y el riesgo relacionados con la lesión cutánea(AU)


Introduction: the nurse must intervene in order to prevent and identify injuries, providing guidance related to the process of hospitalization and high planning this client, seeking to minimize the time and costs of hospitalization. Objective: to characterize the profile of clients hospitalized with skin lesions. Method: quantitative and exploratory study carried out in the clinical wards of a University Hospital in the State of Rio de Janeiro with 50 customers who presented some skin lesion in the period from April to July 2014. Two instruments were used to collect data: document analysis in chart and structured interview. The data were subjected to statistical analysis simple. Results: most female (58 percent), mean age of 58.33 ± 16.83 years. The most prevalent skin lesion was the pressure ulcer (20.3 percent) and as for the location, the lesions were located in the lower limbs (25.4 percent). Conclusion: the care of injury becomes an important aspect in the systematization of nursing care, because the nurse should not contemplate only the realisation of the dressings, but evaluate the etiological factors and risk related to skin lesion(AU)


Subject(s)
Humans , Female , Middle Aged , Skin Diseases/prevention & control , Skin Diseases/therapy , Hospitalization , Nursing Care/methods , Nursing Staff, Hospital/ethics
13.
An. bras. dermatol ; 90(5): 631-637, tab, graf
Article in English | LILACS | ID: lil-764410

ABSTRACT

AbstractBACKGROUND:Some research indicates that physicians do not dominate the expected dermatological content for the proper exercise of the profession. This fact compromises their diagnostic and therapeutic performance, generating unnecessary costs.OBJECTIVE:The aim of this study was to evaluate the relevance of Dermatology and the knowledge acquired in the specialty during the undergraduate course in clinical practice of graduates at the State University of Campinas Medical School (FCM/UNICAMP).METHOD:A questionnaire with 22 closed questions and two open ones was electronically sent to physicians who had graduated more than 10 years ago and others for less than 10 years. In the first group, physicians were trained by the same curriculum and in the second group there were subjects trained by the old and the new curriculum.RESULTS:Of the 126 respondents, 83% had completed a specialization course. Among all, 82% did not study dermatology after graduation. The majority considered that Dermatology has high relevance in clinical practice, regardless of the group. There was a statistically significant difference between non-dermatologist doctors graduated for more than 10 years and those graduated for less than 10 years regarding confidence about lesion diagnosis, diagnostic investigation and treatment of skin diseases. Physicians who have graduated for a longer time feel more insecure in relation to patients with dermatoses. Concerning contributions offered by graduation program completion they prioritized outpatient care, ability to diagnose, knowledge of pathology, research and knowledge of lesions.CONCLUSION:This study has shown that Dermatology is relevant in medical practice and more recent graduates from the FCM/UNICAMP feel less insecure when treating a patient with dermatoses.


Subject(s)
Adult , Female , Humans , Male , Clinical Competence/standards , Dermatology/education , Education, Medical, Undergraduate/standards , Schools, Medical/standards , Brazil , Curriculum/standards , Qualitative Research , Surveys and Questionnaires , Skin Diseases/diagnosis , Skin Diseases/therapy , Time Factors , Universities
17.
Biol. Res ; 48: 1-11, 2015. graf, tab
Article in English | LILACS | ID: lil-734617

ABSTRACT

BACKGROUND: Honey is a natural product obtained from the nectar that is collected from flowers by bees. It has several properties, including those of being food and supplementary diet, and it can be used in cosmetic products. Honey imparts pharmaceutical properties since it has antibacterial and antioxidant activities. The antibacterial and antioxidant activities of Thai honey were investigated in this study. RESULTS: The honey from longan flower (source No. 1) gave the highest activity on MRSA when compared to the other types of honey, with a minimum inhibitory concentration of 12.5% (v/v) and minimum bactericidal concentration of 25% (v/v). Moreover, it was found that MRSA isolate 49 and S. aureus were completely inhibited by the 50% (v/v) longan honey (source No. 1) at 8 and 20 hours of treatment, respectively. Furthermore, it was observed that the honey from coffee pollen (source No. 4) showed the highest phenolic and flavonoid compounds by 734.76 mg gallic/kg of honey and 178.31 mg quercetin/kg of honey, respectively. The antioxidant activity of the honey obtained from coffee pollen was also found to be the highest, when investigated using FRAP and DPPH assay, with 1781.77 mg FeSO4•7H2O/kg of honey and 86.20 mg gallic/kg of honey, respectively. Additionally, inhibition of tyrosinase enzyme was found that honey from coffee flower showed highest inhibition by 63.46%. CONCLUSIONS: Honey demonstrates tremendous potential as a useful source that provides anti-free radicals, anti-tyrosinase and anti-bacterial activity against pathogenic bacteria causing skin diseases.


Subject(s)
Apitherapy , Flavonoids/analysis , Honey/analysis , Monophenol Monooxygenase , Methicillin-Resistant Staphylococcus aureus/drug effects , Phenols/analysis , Pollen/chemistry , Anti-Bacterial Agents/pharmacology , Antioxidants/pharmacology , Biphenyl Compounds , Coffee/chemistry , Fluorescence Recovery After Photobleaching , Flowers/chemistry , Free Radicals/analysis , Honey/classification , Microbial Sensitivity Tests , Monophenol Monooxygenase/antagonists & inhibitors , Monophenol Monooxygenase/drug effects , Picrates , Pollen/classification , Skin Diseases/microbiology , Skin Diseases/therapy , Skin Lightening Preparations/pharmacology , Thailand , Time Factors , Viscosity
18.
JPAD-Journal of Pakistan Association of Dermatologists. 2015; 25 (1): 52-54
in English | IMEMR | ID: emr-171490

ABSTRACT

Terra firma-forme dermatosis [TFFD] is a recently described cutaneous pigmentation disorder. It is a bizarre, acquired and idiopathic dermatosis and is characterized by brown, dirt-like discoloration that cannot be removed by bathing with water or rubbed off with routine detergent soap, but can be removed by isopropyl alcohol. A 20-year-old male came for treatment of chickenpox. Incidentally we observed multiple hyperpigmented plaques on the trunk and back, which disappeared on rubbing with isopropyl alcohol. He had normal washing habits and lesions disappeared after scrub bath. We propose scrub bath as one of the treatment modality


Subject(s)
Young Adult , Skin Diseases/therapy , Pigmentation Disorders
20.
Rev. cuba. plantas med ; 19(4): 421-432, out.-dez. 2014. ilus, tab
Article in Spanish | LILACS, CUMED | ID: lil-750679

ABSTRACT

INTRODUCCIÓN: Faramea occidentalis (L.) A. Rich. (Rubiaceae) se utiliza de forma tradicional como astringente, galactógeno y como antiséptico en el tratamiento de enfermedades de la piel, principalmente erupciones cutáneas, por lo que es frecuentemente empleada para baños en los recién nacidos con estas afecciones. Hasta el momento no existen reportes de estudios fitoquímicos sobre los metabolitos secundarios de interés biológico y terapéutico presentes en los extractos de esta planta. OBJETIVO: determinar los metabolitos secundarios de interés biológico y terapéutico presentes en la especie F. occidentalis. MÉTODOS: la planta fue colectada en la localidad de Cienaguilla, municipio Campechuela, provincia Granma, Cuba, e identificada por especialistas del Jardín Botánico Cupaynicú en el municipio Guisa. Fracciones de los órganos aéreos y subterráneos de la planta se lavaron, desinfectaron, secaron, pulverizaron y se sometieron a extracciones asistidas por ultrasonido con solventes de polaridad creciente. A los extractos se les realizó el tamizaje fitoquímico, cuyos resultados fueron corroborados por análisis cromatográfico mediante cromatografía de capa fina y espectroscopía ultravioleta-visible. RESULTADOS: el tamizaje fitoquímico, realizado a los extractos de raíces, tallos y hojas de la planta y la cromatografía de capa fina aplicada a la tintura de las hojas, permitió constatar la presencia de varias familias de metabolitos secundarios de interés biológico y farmacológico, principalmente, alcaloides y coumarinas, siendo más abundantes en los extractos acuoso y etanólico. CONCLUSIONES: la presencia de abundantes alcaloides y coumarinas en F. occidentalis pudiera ser responsable de su actividad antiséptica.


INTRODUCTION: Faramea occidentalis (L.) A. Rich.(Rubiaceae) is a plant traditionally used as astringent, galactogen and antiseptic in the treatment of skin disorders, mainly rash. Therefore, it is commonly used to bathe newborns suffering from these conditions. No reports are available of phytochemical studies about the secondary metabolites of biological and therapeutic interest contained in extracts from this plant. OBJECTIVE: determine the secondary metabolites of biological and therapeutic interest present in the species F. occidentalis. METHODS: plant samples were collected from the locality of Cienaguilla, municipality of Campechuela, in the province of Granma, Cuba, and identified by specialists from Cupaynicú Botanical Garden in the municipality of Guisa. Fractions of aerial and underground plant parts were washed, disinfected, dried and pulverized, and then subjected to ultrasound-assisted extraction with increasing polarity solvents. The extracts underwent phytochemical screening, and results were corroborated by thin layer chromatography and ultraviolet-visible spectroscopy. RESULTS: phytochemical screening of root, stem and leaf extracts, and thin layer chromatography of the leaf tincture allowed confirmation of the presence of several families of secondary metabolites of biological and pharmacological interest, mainly alkaloids and coumarins, which were more abundant in aqueous and ethanolic extracts. CONCLUSIONS: the presence of abundant alkaloids and coumarins in F. occidentalis could be the cause of its antiseptic activity.


Subject(s)
Humans , Skin Diseases/therapy , Plant Preparations/chemistry , Phytotherapy/methods
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