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1.
Ciênc. Saúde Colet ; 26(supl.3): 5089-5098, Oct. 2021. tab, graf
Article in English | LILACS | ID: biblio-1345723

ABSTRACT

Abstract This article aims to investigate whether difficulty in taking medication is associated with stroke among older adults with Systemic Arterial Hypertension (SAH) and to explore their association with living arrangements. Cross-sectional study was based on 3,502 older adults with SAH from the four universities pole of Frailty in Brazilian Older People (Fibra) Study, Brazil, including 14 municipalities of the five Brazilian regions. We used the medical diagnosis of stroke and difficulty in taking medications (self-reported difficulty and financial difficulty affording prescribed medications). Multivariate analysis was performed using logistic regression. Differently from women, older men with SAH, which report difficulty in taking medication (unintentional non-adherence), have higher odds of stroke. When stratified by living arrangements, those living with a partner have even higher odds of stroke compared to those without difficulty in taking medication and living alone. None association was found for difficulty affording prescribed medication for both men and women. Unintentional difficulty in taking medication plays a role in SAH treatment among men. Primary care strategies for controlling blood pressure should not be focus only on patients but targeting spouses as well.


Resumo O objetivo deste artigo é investigar se a dificuldade em tomar medicamentos está associada ao acidente vascular encefálico (AVE) entre idosos com hipertensão arterial sistêmica (HAS) e explorar esta associação com arranjos familiares. Estudo seccional baseado em 3.502 idosos com HAS dos quatro polos do Estudo Fibra, Brasil, incluindo 14 cidades das cinco regiões brasileiras. Foi usado o diagnóstico médico de AVE e a dificuldade em tomar medicamentos (dificuldade autorrelatada e dificuldade financeira). Utilizou-se a regressão logística na análise multivariada. Diferentemente das mulheres, homens com HAS que relataram dificuldade em tomar medicamentos (não adesão não intencional) apresentam maior chance de ter AVE. Quando estratificado por arranjos familiares, homens que moravam com o cônjuge apresentaram chance ainda maior de ter AVE, quando comparados com aqueles sem dificuldade em tomar medicamentos e que vivem sozinhos. Nenhuma associação foi encontrada para dificuldade financeira, tanto para mulheres quanto para homens. Dificuldades não intencionais em tomar medicamentos têm um papel importante no controle da HAS entre homens. Estratégias de controle da pressão arterial realizadas na atenção primária não devem focar apenas nos pacientes, mas nos cônjuges destes pacientes.


Subject(s)
Humans , Male , Female , Aged , Stroke/epidemiology , Frailty , Hypertension/epidemiology , Blood Pressure , Cross-Sectional Studies , Medication Adherence
2.
Arq. bras. cardiol ; 117(3): 426-434, Sept. 2021. tab
Article in English, Portuguese | LILACS | ID: biblio-1339193

ABSTRACT

Resumo Fundamento: A fibrilação ou flutter atrial (FFA) é a arritmia cardíaca sustentada mais comum. Existem poucos dados sobre a epidemiologia da FFA na América do Sul. Objetivo: O presente estudo procurou descrever a epidemiologia clínica da FFA e o uso de anticoagulantes na avaliação da linha de base do Estudo Longitudinal da Saúde do Adulto (ELSA-Brasil). Métodos: Foram analisados dados de 13.260 participantes do ELSA-Brasil. A FFA foi definida pelo eletrocardiograma ou por autorrelato. Modelos de regressão logística foram construídos para analisar fatores associados à FFA. Este estudo também analisou se idade e sexo estavam associados ao uso de anticoagulantes para evitar acidente vascular cerebral. O nível de significância foi de 5%. Resultados: A idade mediana foi de 51 anos, e 7.213 (54,4%) participantes eram mulheres. A FFA foi detectada em 333 (2,5%) participantes. O aumento da idade (razão de chances [RC]:1,05; intervalo de confiança de 95% [IC95%]: 1,04-1,07), hipertensão (RC:1,44; IC95%:1,14-1,81) coronariopatia (RC: 5,11; IC95%:3,85-6,79), insuficiência cardíaca (RC:7,37; IC95%:5,00-10,87) e febre reumática (RC:3,38; IC95%:2,28-5,02) foram associadas à FFA. Dos 185 participantes com FFA e pontuação no CHA2DS2-VASc≥2, apenas 20 (10,8%) usavam anticoagulantes (50,0% entre aqueles com FFA no eletrocardiograma de linha de base). O uso de anticoagulantes nesse grupo foi associado a maior idade (1,8% vs 17,7% naqueles com idade ≤ 54 e ≥ 65 anos, respectivamente; p=0,013). Observou-se uma tendência ao menor uso de anticoagulantes em mulheres (7,1% vs. 16,4% em mulheres e homens, respectivamente; p=0,055). Conclusões: No recrutamento do ELSA-Brasil, 2,5% dos participantes tinham FFA. O baixo uso de anticoagulantes era comum, o que representa um desafio para os cuidados de saúde nesse cenário.


Abstract Background: Atrial fibrillation or flutter (AFF) is the most common sustained cardiac arrhythmia. Limited data can be found on AFF epidemiology in South America. Objective: The present study sought to describe the clinical epidemiology of AFF and the use of stroke prevention medication in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) baseline assessment. Methods: This study analyzed data from 13,260 ELSA-Brasil participants. AFF was defined according to ECG recording or by self-report. Logistic regression models were built to analyze factors associated with AFF. This study also analyzed if age and sex were associated with anticoagulant use for stroke prevention. Significance level was set at 5%. Results: Median age was 51 years and 7,213 (54.4%) participants were women. AFF was present in 333 (2.5%) participants. Increasing age (odds ratio [OR]:1.05; 95% confidence interval [95%CI]: 1.04-1.07), hypertension (OR:1.44; 95%CI: 1.14-1.81), coronary heart disease (OR: 5.11; 95%CI: 3.85-6.79), heart failure (OR:7.37; 95%CI: 5.00-10.87), and rheumatic fever (OR:3.38; 95%CI: 2.28-5.02) were associated with AFF. From 185 participants with AFF and a CHA2DS2-VASc score ≥2, only 20 (10.8%) used anticoagulants (50.0% among those with AFF in the baseline ECG). Stroke prevention in this group was associated with a higher age (1.8% vs 17.7% in those aged ≤ 54 and ≥ 65 years, respectively; p=0.013). A trend towards a reduced anticoagulant use was observed in women (7.1% vs. 16.4% in women and men, respectively; p=0.055). Conclusions: At the ELSA-Brasil baseline, 2.5% of the participants had AFF. The lack of stroke prevention was common, which is an especially challenging point for healthcare in this setting.


Subject(s)
Humans , Male , Female , Adult , Aged , Atrial Fibrillation/diagnosis , Atrial Fibrillation/epidemiology , Stroke/diagnosis , Stroke/prevention & control , Stroke/epidemiology , Cross-Sectional Studies , Risk Factors , Longitudinal Studies , Risk Assessment , Electrocardiography , Self Report , Middle Aged , Anticoagulants/therapeutic use
3.
Rev. inf. cient ; 100(4): e3484, 2021. tab, graf
Article in Spanish | LILACS, CUMED | ID: biblio-1289658

ABSTRACT

RESUMEN Introducción: Las enfermedades cerebrovasculares agudas se consideran una epidemia vascular y un problema socio-sanitario de primer orden. Objetivo: Describir el comportamiento de la enfermedad cerebrovascular en pacientes de una zona rural perteneciente al Policlínico Comunitario "Juan Bruno Zayas"de Cifuentes, provincia Villa Clara, durante el año 2019. Método: Se realizó un estudio observacional de tipo descriptivo transversal. La muestra estuvo constituida por 32 pacientes que cumplieron los criterios de inclusión y exclusión. Se aplicó un cuestionario a pacientes y familiares cercanos, además, de la revisión de historias clínicas individuales y familiares con el propósito de identificar la etiopatogenia, mes en que ocurrió el evento cerebrovascular, factores de riesgo asociados, tipo de enfermedad cerebrovascular, variante, y forma de presentación clínica. Resultados: Predominó el grupo de edades de 60-69 años, sexo masculino y color de la piel negro. Los factores de riesgo más frecuentes fueron: hipertensión arterial sistémica, tabaquismo y dislipidemia. Marzo fue el mes donde hubo mayor número de casos diagnosticados como enfermedad cerebrovascular. Prevaleció el infarto cerebral como variante más frecuente. Conclusiones: La enfermedad cerebrovascular aguda siempre está asociada a los factores de riesgo clásicos. Existe predominio del ictus de origen isquémico sobre el hemorrágico. Más de la mitad de los pacientes tiene cifras elevadas de tensión arterial durante el evento cerebral. Se evidencia mayor frecuencia de casos durante los meses de menores temperaturas.


ABSTRACT Introduction: Acute cerebrovascular diseases are considered a vascular epidemic and a first-order social and health problem. Objective: To describe the behavior of cerebrovascular disease in patients who residing in a rural area associated to the Policlínico Comunitario "Juan Bruno Zayas" in Cifuentes, Villa Clara, period time 2019. Method: A cross-sectional, descriptive observational study was carried out. The sample selected envolved 32 patients who met the inclusion and exclusion criteria. A questionnaire was administered to patients and close relatives, and individual and family medical records were reviewed to identify the etiopathogenesis, month in which the cerebrovascular event occurred, associated risk factors, type of cerebrovascular disease, variant, and form of clinical presentation. Results: Group age 60 to 69 and male black patients, were predominant. Most common risk factors were: systemic arterial hypertension, smoking and dyslipidemia. March was the month with the highest number of cases diagnosed with cerebrovascular disease. Cerebral infarction prevailed as the most frequent variant. Conclusions: Acute cerebrovascular disease is always associated with classical risk factors. Ischemic stroke predominates over hemorrhagic stroke. More than half of patients have elevated blood pressure during the cerebral event. Arising cases were higher during the months with lower temperatures.


RESUMO Introdução: As doenças cerebrovasculares agudas são consideradas uma epidemia vascular e um problema sócio-sanitário de primeira ordem. Objetivo: descrever o comportamento da doença cerebrovascular em pacientes de uma área rural pertencente à Policlínico Comunitario "Juan Bruno Zayas", de Cifuentes, província de Villa Clara, durante o ano de 2019. Método: Foi realizado um estudo observacional descritivo transversal. A amostra foi composta por 32 pacientes que atenderam aos critérios de inclusão e exclusão. Foi aplicado questionário aos pacientes e familiares próximos, além da revisão dos prontuários individuais e familiares para identificação da etiopatogenia, mês em que ocorreu o evento cerebrovascular, fatores de risco associados, tipo de doença cerebrovascular, variante e forma de apresentação clínica. Resultados: Predominou a faixa etária de 60 a 69 anos, sexo masculino e cor da pele negra. Os fatores de risco mais frequentes foram: hipertensão arterial sistêmica, tabagismo e dislipidemia. Março foi o mês com maior número de casos diagnosticados como doença cerebrovascular. O infarto cerebral prevaleceu como a variante mais frequente. Conclusões: A doença cerebrovascular aguda está sempre associada a fatores de risco clássicos. Há predomínio do AVC de origem isquêmica sobre o hemorrágico. Mais da metade dos pacientes apresentam níveis elevados de pressão arterial durante o evento cerebral. Há maior frequência de casos nos meses de menor temperatura.


Subject(s)
Humans , Male , Female , Middle Aged , Aged , Aged, 80 and over , Stroke/etiology , Stroke/epidemiology , Hypertension/epidemiology , Cross-Sectional Studies , Observational Study
4.
Medicina (B.Aires) ; 81(4): 588-596, ago. 2021. graf
Article in English | LILACS | ID: biblio-1346511

ABSTRACT

Abstract Up to 15% of all strokes affect young patients and the incidence of ischemic stroke in this population is rising. Nevertheless, there is limited information of cerebrovascular events in this population both in our country and in Latin America. The aim of our study was to evaluate the clinical characteristics and risk factors of young adults with stroke in Argentina. This is a prospective, multicenter study of stroke in young adults (18 - 55 years) in Argentina. Patients presenting with a cerebrovascular event within 180 days were included. Stroke subtypes were classified according to TOAST criteria. A total number of 311 patients were enrolled (men 53.9%, mean age: 43.3 years). Ischemic strokes occurred in 91.8% (brain infarcts 82.6%, transient ischemic attack 9.2%) and hemorrhagic strokes in 8.2%. The most frequent vascular risk factors (including ischemic and hemorrhagic strokes) were: hypertension 120 (41%), smoking 92 (31.4%), dyslipidemia 81 (27.6%) and, over weight/obesity: 74 (25.3%). Stroke subtypes were: large artery disease 12.3%, cardioembolism 7.5, small artery occlusion 11.5%, other defined etiology 27.1%, and undetermined etiology 41.6%. Our study demonstrates that vascular risk factors are very frequent in young adults with stroke. Our findings underline that urgent strategies are required for primary and secondary stroke prevention in this group of patients.


Resumen Aproximadamente un 15% de todos los ataques cerebrovasculares afectan a pacientes jóvenes y su incidencia estaría en aumento. Existe escasa información sobre el ataque cerebral en esta población tanto en nuestro país como en Latinoamérica. El objetivo de nuestro estudio fue evaluar las características clínicas y los factores de riesgo de los adultos jóvenes con ictus en Argentina. Realizamos un estudio prospectivo y multicéntrico en adultos jóvenes (18-55 años) en Argentina, que presentaron un evento cerebrovascular dentro de los 180 días previos. Los subtipos de ictus se clasificaron según los criterios de TOAST. Se incluyeron un total de 311 pacientes (hombres 53.9%, edad media: 43,3 años). Los ataques cerebrovasculares isquémicos ocurrieron en el 91.8% (infartos cerebrales 82.6%, ataque isquémico transitorio 9.2%) y los eventos hemorrágicos correspondieron al 8.2%. Los factores de riesgo vascular más frecuentes (incluyendo los eventos isquémicos y hemorrágicos) fueron: hipertensión 120 (41%), tabaquismo 92 (31.4%), dislipidemia 81 (27.6%) y sobrepeso/obesidad: 74 (25.3%). Los subtipos de ictus isquémicos fueron: arteriopatía de gran vaso 12.3%, cardioembolismo 7.5%, oclusión de pequeña arteria 11.5%, otra etiología definida 27.1% y etiología indeterminada 41.6%. Los factores de riesgo vascular son muy frecuentes en los adultos jóvenes con ictus. Nuestros hallazgos subrayan que se requieren estrategias urgentes para la prevención primaria y secundaria del ictus en este grupo particular de pacientes en nuestro país.


Subject(s)
Humans , Male , Adult , Young Adult , Brain Ischemia/etiology , Brain Ischemia/epidemiology , Ischemic Attack, Transient , Stroke/epidemiology , Hypertension/complications , Hypertension/epidemiology , Argentina/epidemiology , Prospective Studies , Risk Factors , Stroke/etiology
5.
Säo Paulo med. j ; 139(2): 117-122, Mar.-Apr. 2021. tab
Article in English | LILACS | ID: biblio-1181011

ABSTRACT

ABSTRACT BACKGROUND: Stroke is the second leading cause of death in Brazil and the main cause of disability. Inability to identify alarm signals causes delays in seeking emergency services, thereby leading to a worse prognosis. OBJECTIVES: To assess the population's knowledge of how to recognize and prevent stroke. DESIGN AND SETTING: Prospective cross-sectional study on data derived from a questionnaire that was administered during the 2016 World Stroke Campaign, launched in the city of São Paulo, Brazil. METHODS: Data on 806 interviewees were evaluated using descriptive statistics and univariate and multivariate analyses. RESULTS: Among all the interviewees, 52.1% knew how to conceptualize stroke; 70.07% knew someone who had suffered a stroke; and 29.03% listed three or more risk factors. Only 27.5% mentioned controlling high blood pressure as a preventive measure. In the event of witnessing a stroke, 57.8% would call the emergency service and 2.9% would check the timing. Less educated individuals were 5.6 times more likely (95% confidence interval, CI 3.45-9.02) to have poor knowledge of stroke, compared with the more educated group. Knowing someone who had had a stroke reduced the chances of not knowing the terms relating to the disease (odds ratio, OR = 0.56; 95% CI 0.4-0.78). CONCLUSIONS: Despite the severity and prevalence of stroke, the population still has little information on this disease. In this context, the importance of mounting campaigns to improve prevention and treatment and to contribute to healthcare policies becomes evident.


Subject(s)
Humans , Stroke/prevention & control , Stroke/epidemiology , Brazil/epidemiology , Cross-Sectional Studies , Prospective Studies , Risk Factors
6.
Säo Paulo med. j ; 139(2): 156-162, Mar.-Apr. 2021. tab
Article in English | LILACS | ID: biblio-1181005

ABSTRACT

ABSTRACT BACKGROUND: Stroke is the principal cause of disability around the world and the ensuing functional dependence (FD) can be correlated with different factors. OBJECTIVE: To determine how demographic factors and clinical characteristics after stroke distinguish patients who achieve functional independence from those who do not. DESIGN AND SETTING: Observational study at specialized neurovascular clinic in Alagoas, Brazil. METHODS: FD was classified according to the modified Rankin scale (mRs): 0 to 2 points were classified as independent (FD-), and 3 to 5 points were classified as dependent (FD+). Logistic regression analysis included age, sedentary lifestyle, the Center for Epidemiological Studies - Depression Scale (CES-D) and the National Institutes of Health Stroke Scale (NIHSS). The Mann-Whitney test and χ2 test were used to compare groups. RESULTS: We included 190 stroke patients with a mean age of 60.02 ± 14.22 years. We found that 34.8% of the patients were classified as FD+. Lower NIHSS and CES-D scores were more associated with achieving functional independence. Most of the patients had access to physical therapy, and the mean duration of rehabilitation therapy was 65.2 minutes per week. Females had higher prevalence of depressive symptoms (P = 0.005) and rehabilitation time was shorter for hemorrhagic stroke (P = 0.02). CONCLUSION: We found a FD rate four times greater than in another Brazilian study. Lower stroke severity and fewer depressive symptoms were associated with achieving functional independence. Less than half of the patients were referred to a rehabilitation service at hospital discharge and few had access to multidisciplinary treatment.


Subject(s)
Humans , Female , Middle Aged , Aged , Stroke/epidemiology , Stroke Rehabilitation , Patient Discharge , Brazil/epidemiology , Disability Evaluation
8.
Frontiers of Medicine ; (4): 903-912, 2021.
Article in English | WPRIM | ID: wpr-922519

ABSTRACT

A nationwide survey was conducted from October 2018 to September 2019 to assess the prevalence of hyperhomocysteinemia (Hhcy) and its influencing factors in China. A standardized questionnaire was used to collect information. Hhcy was defined as the level of serum homocysteine (HCY) ⩾ 15.0µmol/L. The H-type hypertension (HHYP) was defined as hypertension with an elevated serum HCY 15.0µmol/L). Finally, 110 551 residents ⩾ 40 years of age from 31 provinces in the mainland of China were included. Overall, the median serum HCY level was 10.9µmol/L (interquartile range 7.9-15.1). A total of 28 633 participants (25.9%) were defined as Hhcy. The Hhcy prevalence ranged from 7.9% in Shanghai to 56.8% in Tianjin. The data showed that serum HCY levels were associated with age, male gender, cigarette smoking, hypertension, diabetes, ethnicity, endurance in exercise (inverse), and fruit and vegetable intake (inverse). In addition, 15 486 participants were defined as HHYP, and the rate was 14.0%. HHYP was an independent predictor of stroke with an adjusted odds ratio of 1.752 (95% CI 1.338-2.105). The geographical distribution pattern of the Hhcy epidemic reflects dynamic differences, and national strategies should be carried out to further improve the care of patients with Hhcy across China.


Subject(s)
China/epidemiology , Humans , Hyperhomocysteinemia/epidemiology , Hypertension/epidemiology , Male , Prevalence , Risk Factors , Stroke/epidemiology
9.
Rev. bras. neurol ; 56(4): 11-16, out.-dez. 2020. tab
Article in English | LILACS | ID: biblio-1140801

ABSTRACT

OBJECTIVE: To determine the frequency of mortality, length of stay and nosocomial pneumonia outcomes, as well as their distribution according to predictor variables, in stroke patients treated at the emergency room of a tertiary hospital. METHODS: A retrospective cohort study, with a sample of patients attended between January 1 and December 31, 2018. Based on the data collected in the medical records, the sample was characterized. Therefore, the frequency of each outcome was checked, as well as its distribution according to the predictor variables. RESULTS: The sample population consisted of 210 patients. The frequencies observed in death and nosocomial pneumonia were 17.6% and 17.1%, respectively. The general mean length of stay was 13.8 ±12.9 days. Statistically significant differences were observed both in the occurrence of nosocomial pneumonia and atrial fibrillation (AF); days of hospitalization in intensive care unit; total days of hospitalization; orotracheal intubation; use of nasoenteral tube and surgical procedure secondary to stroke. Morever, there was also the relation of total time of hospitalization regarding dyslipidemia; orotracheal intubation; use of nasoenteral tube and surgical procedure secondary to stroke. CONCLUSION: The results found in the frequency of mortality, nosocomial pneumonia and mean total number of days of hospitalization are comparable with other Brazilian studies. However, it is possible to optimize the time of care provided for patients who arrive in the emergency room. In addition, the decrease of hospitalization days in dyslipidemic patients and the increase of nosocomial pneumonia in AF patients require further studies to verify such findings


OBJETIVO: Averiguar a frequência dos desfechos mortalidade, tempo de internação e pneumonia nosocomial, bem como sua distribuição de acordo com variáveis preditoras, em pacientes vítimas de acidente vascular cerebral (AVC) atendidos na emergência de um hospital terciário. MÉTODOS: Estudo de coorte retrospectiva, com uma amostra de pacientes atendidos entre 1º de janeiro e 31 de dezembro de 2018. Com base nos dados coletados em prontuário, a amostra foi caracterizada. Desta forma, foi verificada a frequência de cada desfecho e sua distribuição conforme as variáveis preditoras. RESULTADOS: A população da amostra foi de 210 pacientes. A frequência observada em óbito e pneumonia nosocomial foi de 17,6% e 17,1%, respectivamente. O tempo médio geral de internação foi de 13,8 ±12,9 dias. Foram observadas diferenças estatisticamente significativas, tanto na ocorrência de pneumonia nosocomial quanto a fibrilação atrial (FA); dias de internação em unidade de terapia intensiva; total de dias de internação; intubação orotraqueal; uso de sonda nasoenteral e procedimento cirúrgico secundário ao AVC. Além disso, verificou-se também a relação de tempo total de internação quanto à dislipidemia; intubação orotraqueal; uso de sonda nasoenteral e procedimento cirúrgico secundário ao AVC. CONCLUSÃO: Os resultados encontrados na frequência de mortalidade, pneumonia nosocomial e média do número total de dias de hospitalização são comparáveis com outros estudos brasileiros. Entretanto, é possível otimizar o tempo de atendimento dos pacientes que chegam ao pronto-socorro. Ademais, a diminuição dos dias de hospitalização em pacientes dislipidêmicos e o aumento da pneumonia nosocomial em pacientes com FA necessitam mais estudos para verificar tais achados


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Young Adult , Stroke/mortality , Stroke/epidemiology , Retrospective Studies , Risk Factors , Mortality , Healthcare-Associated Pneumonia , Hospitalization , Length of Stay/statistics & numerical data
10.
Medicina (B.Aires) ; 80(supl.6): 65-70, dic. 2020. graf
Article in Spanish | LILACS | ID: biblio-1250321

ABSTRACT

Resumen La pandemia por COVID-19 y el aislamiento social preventivo y obligatorio (ASPO) han generado cambios en la organización y utilización del sistema de salud en todo el mundo. Analizamos el impacto de la situación sanitaria en el número de consultas ambulatorias, internaciones y acceso a terapias de revascularización por enfermedad cerebrovascular. Se analizó el período desde el 1 marzo al 31 de julio de 2020. Se comparó con el mismo período de 2019. Se evaluaron total de consultas ambulatorias e internaciones, escala NIHSS (National Institute of Health Stroke Scale) al ingreso, tipo de enfermedad cerebrovascular y uso de terapias de revascularización. Ingresaron 197 pacientes con eventos cerebrovasculares agudos en 2019 y 150 pacientes en 2020. Hubo un descenso significativo en el número de internaciones por eventos isquémicos totales y accidentes isquémico transitorios en el comparativo de los 5 meses. Se vio además un aumento en trombosis venosas cerebrales y hemorragias cerebrales. El acceso a fibrinolisis intravenosa y trombectomía mecánica se mantuvo estable, pero con prolongación del tiempo puerta-aguja. Las consultas ambulatorias descendieron 67%, siendo mayor el descenso en abril y más marcado en consultas de seguimiento. El número de internaciones y de consultas ambulatorias durante el ASPO descendió sustancialmente. Esto pareciera obedecer al cumplimiento estricto de la cuarentena y no a mecanismos fisiopatológicos relacionados con el COVID-19. Debe educarse a la población sobre la necesidad del control de enfermedades crónicas y de eventos agudos y se deben garantizar medidas de seguridad en los centros de salud.


Abstract The COVID-19 pandemic and preventive and compulsory social isolation (PCSI) have generated changes in the organization and use of the health system around the world. We analyze the impact of the health situation on the number of outpatient visits, hospitalizations and access to revascularization therapy for cerebrovascular disease. The period from March 1 to July 31, 2020 was analyzed. It was compared with the same period in 2019. Total outpatient and hospital visits were evaluated, NIHSS scale (National Institute of Health Stroke Scale) upon admission, type of cerebrovascular disease and use of revascularization therapies; 197 patients with acute cerebrovascular events were admitted in 2019 and 150 patients in 2020. There was a significant decrease in the number of hospitalizations for total ischemic events and transient ischemic attacks in the comparison of 5 months. An increase in cerebral venous thrombosis and cerebral hemorrhages was also seen. Access to intravenous fibrinolysis and mechanical thrombectomy remained stable, but with prolonged door-to-needle time. Outpatient visits fell 67%, the decrease being greater in April and more marked in follow-up visits. The number of hospitalizations and outpatient visits during the PCSI dropped substantially. This seems to be due to strict compliance with quarantine and not to pathophysiological mechanisms related to COVID-19. The population should be educated about the need to control chronic diseases and acute events and safety measures should be guaranteed in health centers.


Subject(s)
Humans , Stroke/prevention & control , Stroke/epidemiology , COVID-19 , Outpatients , Argentina/epidemiology , Social Isolation , Pandemics , SARS-CoV-2 , Hospitalization
11.
Arq. bras. cardiol ; 115(6): 1144-1151, dez. 2020. tab, graf
Article in English, Portuguese | LILACS | ID: biblio-1152951

ABSTRACT

Resumo Fundamento O acidente vascular encefálico isquêmico (AVEi) e a doença arterial coronariana (DAC) coexistem frequentemente e compartilham fatores de risco para doença aterosclerótica. Segundo a American Heart Association , os subtipos de AVEi podem ser considerados equivalentes de risco para DAC, mas a evidência para o AVEi não-aterosclerótico não está bem definida. Além disso, o escore de cálcio coronário (CAC) é um marcador preciso para estimar o risco de DAC. Entretanto, a distribuição do CAC pelos subtipos de AVEi ainda não foi bem caracterizada. Objetivos Comparar o CAC entre os grupos de AVEi ateroscleróticos e não ateroscleróticos, e determinar quais covariáveis estão associadas a CAC alto no AVEi Métodos Em um estudo transversal, incluímos todos os pacientes com AVEi, com idades entre 45 a 70 anos no momento do acidente vascular, consecutivamente admitidos em um hospital de reabilitação entre agosto de 2014 e dezembro de 2016, sem DAC prevalente. Todos os pacientes passaram por tomografia computadorizada (TC), para medir o CAC. CAC≥100 foi considerado alto risco de DAC. O nível de significância foi p<0,05. Resultados Dos 244 pacientes estudados (média de idade de 58,4±6,8 anos; 49% do sexo feminino), 164 (67%) apresentavam etiologia não-aterosclerótica. As proporções de CAC≥100 foram semelhantes entre os grupos ateroscleróticos e não-ateroscleróticos (33% [n=26] x 29% [n=47]; p= 0,54). Entre todos os pacientes com AVEi, apenas os de idade ≥60 anos foram associados independentemente a CAC≥100 (RC 3,5; 95% IC 1,7-7,1), ajustado para hipertensão, dislipidemia, diabetes, sedentarismo, e histórico familiar de DAC. Conclusão O AVEi aterosclerótico não apresentou risco maior de DAC quando comparado ao AVEi não-aterosclerótico de acordo com o CAC. Apenas a faixa etária ≥60 anos - mas não a etiologia - foi associada independentemente a CAC≥100. (Arq Bras Cardiol. 2020; 115(6):1144-1151)


Abstract Background Ischemic Stroke (IS) and Coronary Artery Disease (CAD) frequently coexist and share atherosclerotic disease risk factors. According to the American Heart Association, IS subtypes may be considered CAD risk equivalents, but the evidence for non-atherosclerotic IS is uncertain. Additionally, the Coronary Calcium Score (CCS) is an accurate marker to address CAD risk; however, CCS distribution between IS subtypes is not well characterized. Objectives To compare the CCS between atherosclerotic and non-atherosclerotic IS groups; and to determine which covariates were associated with high CCS in IS. Methods This cross-sectional design included all patients with IS, 45 to 70 years of age at the time of the stroke, consecutively admitted to a rehabilitation hospital between August 2014 and December 2016, without prevalent CAD. All patients underwent CT scanning for CCS measurement. CCS≥100 was considered a high risk for CAD, with a significance level of p<0.05. Results From the 244 studied patients (mean age 58.4±6.8 years; 49% female), 164 (67%) had non-atherosclerotic etiology. The proportions of CCS≥100 were similar between the atherosclerotic and the non-atherosclerotic groups (33% [n=26] x 29% [n=47]; p= 0.54). Among all IS patients, only age ≥60 years was independently associated with CCS≥100 (OR 3.5; 95%CI 1.7-7.1), accounting for hypertension, dyslipidemia, diabetes, sedentarism, and family history of CAD. Conclusion Atherosclerotic IS did not present a greater risk of CAD when compared to non-atherosclerotic IS according to CCS. Only age ≥60 years, but not etiology, was independently associated with CCS≥100.


Subject(s)
Humans , Male , Female , Aged , Coronary Artery Disease/etiology , Coronary Artery Disease/epidemiology , Coronary Artery Disease/diagnostic imaging , Brain Ischemia/etiology , Brain Ischemia/epidemiology , Stroke/etiology , Stroke/epidemiology , Ischemic Stroke , Calcium , Cross-Sectional Studies , Risk Factors , Coronary Angiography , Middle Aged
12.
Arch. cardiol. Méx ; 90(4): 398-405, Oct.-Dec. 2020. tab, graf
Article in Spanish | LILACS | ID: biblio-1152813

ABSTRACT

Resumen Antecedentes y objetivos: El sistema de calificación APACHE II permite predecir la mortalidad intrahospitalaria en terapia intensiva. Sin embargo, no está validado para cirugía cardíaca, ya que no posee buena capacidad diferenciadora. El objetivo es determinar el valor pronóstico de APACHE II en el postoperatorio de procedimientos cardíacos. Materiales y métodos: Se analizó en forma retrospectiva la base de cirugía cardíaca. Se incluyó a pacientes intervenidos entre 2017 y 2018, de los cuales se calculó la puntuación APACHE II. Se utilizó curva ROC para determinar el mejor valor de corte. El punto final primario fue mortalidad intrahospitalaria. Como puntos finales secundarios se evaluó la incidencia de bajo gasto cardíaco (BGC), accidente cerebrovascular (ACV), sangrado quirúrgico y necesidad de diálisis. Se realizó un modelo de regresión logístico multivariado para ajustar a las variables de interés. Resultados: Se analizó a 559 pacientes. La media del sistema de calificación APACHE II fue de 9.9 (DE 4). La prevalencia de mortalidad intrahospitalaria global fue de 6.1%. El mejor valor de corte de la calificación para predecir mortalidad fue de 12, con un área bajo la curva ROC de 0.92. Los pacientes con APACHE II ≥ 12 tuvieron significativamente mayor mortalidad, incidencia de BGC, ACV, sangrado quirúrgico y necesidad de diálisis. En un modelo multivariado, el sistema APACHE II se relacionó de modo independiente con mayor tasa de mortalidad intrahospitalaria (OR, 1.14; IC95%, 1.08-1.21; p < 0.0001). Conclusiones: El sistema de clasificación APACHE II demostró ser un predictor independiente de mortalidad intrahospitalaria en pacientes que cursan el postoperatorio de cirugía cardíaca.


Abstract Background and objectives: The APACHE II score allows predicting in-hospital mortality in patients admitted to intensive care units. However, it is not validated for patients undergoing cardiac surgery, since it does not have a good discriminatory capacity in this clinical scenario. The aim of this study is to determine prognostic value of APACHE II score in postoperative of cardiac surgery. Materials and methods: The study was performed using the cardiac surgery database. Patients undergoing surgery between 2017 and 2018, with APACHE II score calculated at the admission, were included. The ROC curve was used to determine a cut-off value The primary endpoint was in-hospital death. Secondary endpoints included low cardiac output (LCO), stroke, surgical bleeding, and dialysis requirement. A multivariable logistic regression model was developed to adjust to various variables of interest. Results: The study evaluated 559 patients undergoing cardiac surgery. The mean of APACHE II Score was 9.9 (SD 4). The prevalence of in-hospital death was 6.1%. The best prognostic cut-off value for the primary endpoint was 12, with a ROC curve of 0.92. Patients with an APACHE II score greater than or equal to 12 had significantly higher mortality, higher incidence of LCO, stroke, surgical bleeding and dialysis requirement. In a multivariate logistic regression model, the APACHE II score was independently associated with higher in-hospital death (OR, 1.14; 95CI%, 1.08-1.21; p < 0.0001). Conclusions: The APACHE II Score proved to be an independent predictor of in-hospital death in patients undergoing postoperative cardiac surgery, with a high capacity for discrimination.


Subject(s)
Humans , Male , Female , Middle Aged , Aged , Aged, 80 and over , Postoperative Complications/epidemiology , Hospital Mortality , Cardiac Surgical Procedures/adverse effects , Postoperative Complications/mortality , Prognosis , Cardiac Output, Low/epidemiology , Cross-Sectional Studies , Retrospective Studies , Blood Loss, Surgical/statistics & numerical data , Renal Dialysis/statistics & numerical data , APACHE , Stroke/epidemiology , Cardiac Surgical Procedures/mortality
13.
Med. infant ; 27(2): 92-100, Diciembre 2020. Tab, ilus
Article in Spanish | LILACS, BINACIS, UNISALUD | ID: biblio-1147907

ABSTRACT

Introducción: La incidencia de ACV (Accidente Cerebrovascular) en niños es de 2-13/100.000 niños por año, siendo una de las 10 causas más frecuentes de muerte en la infancia. La misma varía entre 6-40% dependiendo de las series publicadas y de los subtipos de ACV. Existen diferencias importantes entre el ACV en niños y adultos, ya que las características neurológicas y de la hemostasia son muy distintas en cada grupo. En niños deben ser investigados múltiples factores de riesgo que a menudo se superponen entre sí. Materiales y métodos: Trabajo descriptivo retrospectivo por revisión de historias clínicas, de una población de niños con diagnóstico de ACV ingresados en UCIP en un período de 10 años. Resultados: Se confirmó el diagnóstico de ACV en un total de 84 pacientes. El 70,24% de la población correspondía a ACVH (Accidente Cerebrovascular Hemorrágico) y un 29,76% ACVI (Accidente Cerebrovascular Isquémico). El 60,71 % eran masculinos. La mediana del tiempo entre el inicio de los síntomas y el ingreso a UCIP, en ambos grupos fue de 1 día con rango entre 1-17 días para los ACVH y 1-9 para los ACVI. Se evaluaron variables clínicas, de diagnóstico y de tratamiento según ambos tipos de ACV. Conclusión: El ACV requiere de un abordaje multidisciplinario. La realización de neuro-imágenes es un pilar fundamental para el diagnóstico y no debe ser pospuesto. El monitoreo y tratamiento está enfocado en minimizar el daño en el parénquima cerebral circundante (AU)


Introduction: The incidence of stroke in children is 2-13/100,000 children a year, being one of the 10 most common causes of death in childhood. Mortality varies between 6 and 40% depending on the series reported and according to the different subtypes of stroke. There are important differences between childhood and adult stroke, as the neurological features and characteristics of hemostasis vary greatly. In children, multiple risk factors that often overlap should be investigated. Material and methods: A retrospective descriptive review of the clinical records of a series of patients with stroke admitted to the pediatric intensive care unit (PICU) over a period of 10 years was conducted. Results: The diagnosis of stroke was confirmed in 84 patients; 70.24% had hemorrhagic and 29.76% ischemic stroke. Overall, 60.71% were boys. Median time between symptom onset and admission to the PICU was one day in both groups, ranging from 1-17 días for those with hemorrhagic and from 1-9 days for those with ischemic stroke. Clinical, diagnostic, and treatment variables were evaluated for both types of stroke. Conclusion: Stroke requires a multidisciplinary approach. Neuroimaging is essential for the diagnosis and should not be postponed. Monitoring and treatment is focused on minimizing damage to the surrounding brain parenchyma (AU)


Subject(s)
Humans , Infant , Child, Preschool , Child , Adolescent , Intensive Care Units, Pediatric , Cerebral Hemorrhage , Brain Ischemia , Stroke/surgery , Stroke/classification , Stroke/diagnosis , Stroke/etiology , Stroke/epidemiology , Stroke/diagnostic imaging , Retrospective Studies
14.
Rev. cuba. salud pública ; 46(4): e2580, oct.-dic. 2020. tab, graf
Article in Spanish | LILACS, CUMED | ID: biblio-1156628

ABSTRACT

Introducción: La virulencia del SARS-CoV-2 puede generar una predisposición a sufrir un accidente cerebrovascular. Hasta un 5 por ciento de los pacientes con COVID-19 presentan un ictus, de los cuales el 80 por ciento son isquémicos. La mortalidad en estos casos alcanza el 40 por ciento. Objetivo: Identificar la tendencia de las investigaciones sobre el accidente cerebrovascular relacionado con la COVID-19. Métodos: Estudio bibliométrico. Se consultaron las bases de datos Scopus y MEDLINE (a través de su buscador PubMed). Se analizaron indicadores de producción, autorías, cobertura geográfica, red de colaboración y publicación. Resultados: Se recuperaron 92 documentos publicados en 57 revistas. El crecimiento fue lineal (R2 = 0,98). El índice de transitoriedad fue del 89,09 por ciento. El 92,40 por ciento de las publicaciones presentaron coautoría. Fraser JF de la University of Kentucky fue el autor con más artículos y mejor posición en la red de colaboración. Los países más prolíficos fueron: Estados Unidos (45,65 por ciento), Italia (18,47 por ciento), China (15,21 por ciento), Reino Unido (13,04 por ciento) y España (10,86 por ciento). La tasa de colaboración internacional fue del 39,24 por ciento. Los países con un mejor outdegree (número de aristas que salen del vértice) y betweenness (intermediación) fueron Estados Unidos (54; 209,06), Alemania (34; 83,86), Italia (30; 24,83), Irán (30; 18,51) y España (26; 31,22). Las revistas con más artículos fueron: Stroke (n = 10), European Journal of Neurology (n = 5) y Journal of Stroke and Cerebrovascular Diseases (n = 4). Conclusiones: Los resultados obtenidos proporcionan referencias a investigadores, instituciones y países para poder planificar y desarrollar estudios en salud pública sobre el accidente cerebrovascular relacionado con la COVID-19 con mayor nivel de evidencia científica(AU)


Subject(s)
Humans , Coronavirus Infections , Stroke/epidemiology , Bibliometric Indicators , Betacoronavirus
15.
Rev. bras. cir. cardiovasc ; 35(5): 797-814, Sept.-Oct. 2020. tab, graf
Article in English | SES-SP, LILACS, SES-SP | ID: biblio-1137348

ABSTRACT

Abstract Objective: There is currently much debate about which patients would benefit more after on- or off-pump coronary artery bypass grafting (CABG). The aim of this meta-analysis and meta-regression is to investigate the effect of age on short-term clinical outcomes after these approaches. Methods: To identify potential studies, systematic searches were carried out in the Excerpta Medica dataBASE (EMBASE), PubMed, Web of Science, and the Cochrane Central Register of Controlled Trials (CENTRAL). The search strategy included the key concepts of "cardiopulmonary bypass" AND "coronary artery bypass grafting" AND "off pump" OR "on pump". This was followed by a meta-analysis and meta-regression investigating the effect of age on the incidences of stroke, myocardial infarction (MI), and mortality. Results: Thirty-seven studies including 15,324 participants were analysed. Overall, there was a significant odds reduction for patients receiving off-pump CABG suffering a stroke (odds ratio [OR] 0.770, 95% confidence intervals [CI] 0.594, 0.998, P=0.048); however, when patients were subdivided according to different age bands, this difference disappeared. There were also no significant differences in the odds of mortality (OR 0.876, 95% CI 0.703, 1.093, P=0.241) or MI (OR 0.937, 95% CI 0.795, 1.105, P=0.439). Meta-regression analysis revealed no significant relationship between age and stroke (P=0.652), age and mortality (P=548), and age and MI (P=0.464). Conclusion: Patients undergoing CABG are becoming older and may suffer from multiple comorbidities increasing their risk profile. However, with respect to short-term clinical outcomes, the patient's age does not help in determining whether off- or on-pump is superior.


Subject(s)
Humans , Male , Stroke/etiology , Stroke/epidemiology , Coronary Artery Bypass, Off-Pump/adverse effects , Myocardial Infarction , Postoperative Complications , Quality of Life , Coronary Artery Bypass , Treatment Outcome
16.
Arch. cardiol. Méx ; 90(3): 266-273, Jul.-Sep. 2020. tab, graf
Article in Spanish | LILACS | ID: biblio-1131043

ABSTRACT

Resumen Objetivo: Se denomina bloqueo interauricular avanzado (BIA) a la existencia de una onda P ≥ 120 ms y bifásica +/- en las derivaciones inferiores (II-III-VF) del electrocardiograma (ECG) de superficie, el cual constituye un factor predictivo significativo del desarrollo de fibrilación auricular. En fecha reciente se han descrito cuatro patrones de BIA atípicos (BIA-At) con base en la morfología y la duración de la onda P, sin conocer si comparten patogenia y características clínicas similares. Método: Estudio observacional, descriptivo y retrospectivo de pacientes, visitados en el Servicio de Cardiología, en ritmo sinusal y con BIA. Las variables analizadas se obtuvieron de la historia clínica informatizada. El análisis de la onda P se efectuó al aumentar el tamaño del electrocardiograma y mediante calipers electrónicos. El análisis estadístico se realizó con SPSS 19.0, con nivel de significación de p < 0.05. Resultados: Se incluyó a 75 pacientes con media de edad de 74.4 ± 11.7 años, con 62.7% de varones. Se compararon los grupos de pacientes con BIA típico (BIA-T) y BIA-At. El primero se relacionó con la existencia de diabetes mellitus (p = 0.001), enfermedad renal crónica estadio ≥ 3 (p = 0.036), bloqueo auriculoventricular (p = 0.006) y una menor fracción de expulsión ventricular media (p = 0.025); no hubo diferencias respecto de la prevalencia de fibrilación auricular/flúter o accidente cerebrovascular. Sólo la diabetes se acompañó de riesgo de ser un BIA-T (OR: 6.4; p = 0.002; IC 95%: 2.0-21.1). Conclusiones: La diabetes mellitus constituye el único factor de riesgo de que un BIA sea típico. Los pacientes con BIA-T y BIA-At presentan similar prevalencia de fibrilación auricular y accidente cerebrovascular, por lo que son objeto de un mismo tratamiento clínico.


Abstract Objective: It is called advanced interatrial block (IAB) to the existence of a P wave ≥ 120 ms and biphasic ± in the lower leads II-III-VF of the surface electrocardiogram (ECG), which constitutes a significant predictive factor for the development of atrial fibrillation. Recently, four patterns of atypical aIAB (At-IAB) have been described based on the morphology and duration of the P wave, but it’s unknown if they share the same pathogenesis and clinical characteristics. Method: An observational, descriptive and retrospective study was performed with patients, visited in cardiology, who have a sinus rhythm and with aIAB. The analyzed variables were obtained from the computerized clinical history. The analysis of the P wave was made by increasing the size of the ECG and by electronic calipers. Statistical analysis was performed with SPSS 19.0; level of significance: p < 0.05. Results: A total of 75 patients with an average age of 74.4 ± 11.7 years and with a 62.7% males, were included. It was compared the group of patients with typical aIAB (T-aIAB) and with At-aIAB. The first one was associated with the existence of diabetes mellitus (p = 0.001), chronic kidney disease stage ≥ 3 (p = 0.036), atrioventricular block (p = 0.006) and a lower mean ventricular ejection fraction (p = 0.025); there were no differences regarding the prevalence of atrial fibrillation/flutter or stroke. Only diabetes was associated with the risk of T-aIAB (odds ratio: 6.4; p = 0.002; 95% confidence interval: 2.0-21.1). Conclusions: Diabetes mellitus is the only risk factor for an aIAB to be typical. Patients with T-aIAB and At-aIAB have a similar prevalence of atrial fibrillation and stroke, so they must follow the same clinical management.


Subject(s)
Humans , Male , Female , Middle Aged , Aged , Aged, 80 and over , Atrial Fibrillation/epidemiology , Electrocardiography , Interatrial Block/physiopathology , Atrial Fibrillation/etiology , Prevalence , Retrospective Studies , Risk Factors , Stroke/epidemiology , Diabetes Mellitus/epidemiology , Renal Insufficiency, Chronic/epidemiology , Atrioventricular Block/epidemiology , Interatrial Block/complications , Interatrial Block/diagnosis
17.
Medicina (B.Aires) ; 80(5): 442-446, ago. 2020. graf
Article in Spanish | LILACS | ID: biblio-1287196

ABSTRACT

Resumen Aproximadamente uno de cada 10 pacientes que sufre un accidente cerebrovascular isquémico (ACVi) padece cáncer concomitantemente. Nuestro objetivo fue evaluar características clínicoradiológicas del ACVi en pacientes con cáncer y compararlas con otros sin cáncer. Fue un estudio caso-control retrospectivo que incluyó pacientes con ACVi entre julio 2013 y septiembre 2018. Los casos tenían diagnóstico de cáncer y ACVi, y los controles solamente ACVi. Se comparó edad, sexo, factores de riesgo vascular, patrones radiológicos de lesiones, etiología y evolución clínica entre ambos grupos. Hubo 57 casos, 61% (n = 35) eran varones. La edad media fue 75 ± 11 años, sin diferencias en prevalencia de factores de riesgo vascular. En los casos hubo más pacientes con antecedentes de trombosis venosa profunda y/o tromboembolismo pulmonar (8% vs. 1%, p = 0.01). En 52 se conocía la presencia del cáncer antes del ACVi. El 91% se trató de tumores sólidos (n = 52) y en 54% el tumor no presentaba metástasis. El puntaje NIHSS promedio fue 3.8 ± 4 en los casos, y 9 ± 7 en los controles (p = 0.01). Las lesiones de pequeña arteria fueron menos frecuentes en los casos (2% vs. 26%, p = 0.001). Las lesiones de aspecto embólico fueron más comunes entre los casos (82% vs. 35%, p = 0.001). Aquellos con cáncer tuvieron menor NIHSS, menor frecuencia de lesiones de pequeña arteria, y mayor frecuencia de lesiones de aspecto embólico. La recurrencia a 90 días fue 3 veces mayor y la mortalidad 6 veces mayor en pacientes con cáncer (10% vs. 3%, y 18% vs. 3%. p = 0.08 y 0.001 respectivamente).


Abstract One in 10 patients with ischemic stroke has comorbid cancer. Our goal was to compare stroke patients with cancer against those without cancer in terms of clinical and radiological features, and the underlying mechanism. We conducted a retrospective case-control study in patients admitted with ischemic stroke between July 2013 and September 2018. Cases had a concomitant diagnosis of cancer and acute ischemic stroke, controls only of ischemic stroke. Age, gender, vascular risk factors (VRF), pattern of ischemic lesion in neuroimaging, etiology and clinical outcome were compared between groups. Fifty-seven cases were identified, 61% were male (n = 35), and mean age was 75 ± 11. Fiftytwo had known oncologic disease at the onset of stroke. Most of them had solid tumors (91%, n = 52), and 54% (n = 31) had a non-metastatic tumor at the time of stroke. Prevalence of common VRF between groups was not significantly different. Previous deep venous thrombosis and pulmonary thromboembolism were more frequent in the cancer cohort (8% vs. 1%, p = 0.01). The average NIHSS was 3.8 ± 4 in the cancer group and 9±7 in the control group (p = 0.01). Small artery disease as the etiology of stroke was significantly less common in the cancer group (2% vs. 26%, p = 0.001). Regarding neuroimaging, the embolic pattern was more frequent in patients with cancer (82% vs. 35%, p = 0.001). In these patients recurrence and mortality at 90 days was three and six times higher (10% vs. 3%, and 18% vs. 3%. p = 0.08 and 0.001, respectively).


Subject(s)
Humans , Male , Female , Middle Aged , Aged , Aged, 80 and over , Brain Ischemia/epidemiology , Stroke/epidemiology , Neoplasms/epidemiology , Case-Control Studies , Retrospective Studies , Stroke/etiology , Stroke/diagnostic imaging , Neoplasms/complications
18.
Arch. cardiol. Méx ; 90(2): 137-141, Apr.-Jun. 2020. tab, graf
Article in English | LILACS | ID: biblio-1131022

ABSTRACT

Abstract Objective: The objective of PHASE-MX registry is to validate the efficacy and safety of the pharmacoinvasive strategy in comparison with percutaneous coronary intervention (PCI) in patients with acute myocardial infarction with ST segment elevation (STEMI) in a metropolitan region of Mexico. The primary outcome will consist of the composite of cardiovascular death, re-infarction, stroke and cardiogenic shock. Methods: The PHASE-MX registry will include a prospective cohort of patients with STEMI who received reperfusion treatment (mechanical of pharmacological) in the first 12 h after the onset of symptoms. The registry is designed to compare the efficacy and safety of primary PCI and pharmacoinvasive strategy. The simple size was calculated in 344 patients divided into two groups, with an estimated loss rate of 10%. Patients included in the PHASE-MX cohort will be followed for up to one year. Conclusion: In Mexico, only 5 out of 10 patients with STEMI have access to reperfusion therapy. Pharmacoinvasive strategy is takes advantage of the accessibility of fibrinolysis and the effectiveness of PCI. The present research protocol aims to provide information that serves as a link between information derived from controlled clinical trials and records derived from real world experience.


Resumen Objetivo: El objetivo del registro PHASE-MX es validar la eficacia y seguridad de la estrategia farmacoinvasiva en comparación con la angioplastia coronaria transluminal percutánea primaria (ACTPp) en pacientes con infarto agudo de miocardio con elevación del segmento ST (IAMCEST) en una región metropolitana de México. El desenlace primario es el compuesto de muerte cardiovascular, reinfarto, accidente vascular cerebral y choque cardiogénico. Métodos: El registro PHASE-MX es una cohorte prospectiva de pacientes con IAMCEST que recibieron tratamiento de reperfusión (mecánico o farmacológico) en las primeras 12 horas desde el inicio de los síntomas, atendidos en el Instituto Nacional de Cardiología Ignacio Chávez. El análisis estadístico se basa en la no inferioridad de la estrategia farmacoinvasiva en comparación con la ACTPp. Se calcula un tamaño de muestra de 344 pacientes divididos en dos grupos (angioplastia primaria y estrategia farmacoinvasiva), considerada una tasa de pérdidas de 10%. Los pacientes incluidos en la cohorte PHASE-MX se seguirán durante un año. Discusión: En México, sólo 5 de cada 10 pacientes con IAMCEST tienen acceso al tratamiento de reperfusión. La estrategia farmacoinvasiva aprovecha la accesibilidad de la fibrinólisis y la efectividad de la ACTPp, por lo que podría resultar el método de elección en el tratamiento del IAMCEST en la mayoría de los casos. El presente protocolo de investigación pretende aportar información que sirva como enlace entre la información derivada de los estudios clínicos controlados y los registros derivados de la experiencia del mundo real.


Subject(s)
Humans , Male , Female , Reperfusion/methods , Percutaneous Coronary Intervention/methods , ST Elevation Myocardial Infarction/therapy , Research Design , Shock, Cardiogenic/epidemiology , Registries , Prospective Studies , Cohort Studies , Follow-Up Studies , Stroke/epidemiology , Percutaneous Coronary Intervention/adverse effects , Mexico
19.
Pan Afr. med. j ; 35(50)2020.
Article in French | AIM, AIM | ID: biblio-1268670

ABSTRACT

Introduction : l'accident vasculaire cérébral (AVC) constitue un problème majeur de santé publique, tant par le nombre de personnes atteintes, que par ses conséquences médicales, sociales et économiques. L'objectif était de dégager les facteurs de mauvais pronostic vital à la phase aiguë de l'AVC artériel. Méthodes: il s'agit d'une étude prospective durant 4 mois portant sur les patients présentant une symptomatologie évocatrice d'AVC aux deux CHU de Sfax, Tunisie. Le suivi a été de 1 mois. Résultats: nous avons colligé 200 patients. Après un mois de suivi, la mortalité était de 19,9%. Les facteurs de mauvais pronostic vital étaient: le sexe masculin, la consommation de tabac, l'antécédent d'AVC, le score de Glasgow bas, le NIHSS élevé, les céphalées, les crises épileptiques symptomatiques aigues, le signe de Babinski, la mydriase, l'aphasie, la déviation conjuguée de la tête et des yeux, les chiffres élevés de pression artérielle systolique (PAS), pression artérielle diastolique (PAD) et pression artérielle pulmonaire (PAP), l'hyperthermie, l'hyperglycémie, l'hyperleucocytose, l'augmentation des CRP, créatinine, urée et la troponine Tc, la nature hémorragique de l'AVC, l'œdème péri lésionnel, l'effet de masse, l'engagement, la topographie sylvienne totale de l'ischémie, la présence de signes précoces d'ischémie, l'hémorragie méningée, l'inondation ventriculaire, l'hydrocéphalie, le recours à une assistance respiratoire, au traitement anti-œdémateux et antihypertenseur, la transformation hémorragique, l'épilepsie vasculaire, les complications infectieuses, métaboliques et de décubitus. Conclusion: l'identification des facteurs prédictifs du devenir vital permet d'optimiser les procédures thérapeutiques et mieux organiser les filières de prise en charge. Une étude comparative sera envisagée afin de mesurer l'impact des mesures correctives


Subject(s)
Prognosis , Stroke/diagnosis , Stroke/epidemiology , Tunisia
20.
Rev. eletrônica enferm ; 22: 1-8, 2020.
Article in English, Portuguese | LILACS, BDENF | ID: biblio-1121712

ABSTRACT

Objetivo: Investigar a relação entre a resiliência, a capacidade funcional e o apoio social de pessoas com sequelas de acidente vascular encefálico. Método: Estudo transversal, realizado com 108 indivíduos com sequelas de acidente vascular encefálico, cadastrados em Unidades de Saúde da Família, do município de João Pessoa, Paraíba, Brasil. Os instrumentos utilizados foram: Escala de Resiliência, Índice de Barthel e Escala de Apoio Social. Para análise, utilizou-se estatística descritiva e inferencial. Resultados: Houve maior frequência do sexo feminino (57,4%), 60 anos ou mais (59,2%), com companheiro (47,2%) e cuidador (76,6%). Os participantes apresentaram mais frequentemente o nível de resiliência moderada (64,8%), dependência funcional (93,6%) para realização das atividades diárias e médio apoio social (48,2%). Foi verificado que quanto maior a capacidade funcional e o apoio social, maior a resiliência. Conclusão: A capacidade funcional e o apoio social são preditores da resiliência de pessoas com sequelas de acidente vascular encefálico.


Objective: To investigate the relationship between resilience, functional capacity and social support of people with stroke sequelae. Method: Cross-sectional study, conducted with 108 individuals with sequelae of stroke, registered in Family Health Units, of the municipality of João Pessoa, Paraíba, Brazil. The instruments used were: Resilience Scale, Barthel Index and the Social Support Scale. For analysis, descriptive and inferential statistics were used. Results: There was a higher frequency of females (57.4%), 60 years old or more (59.2%), with partner (47.2%) and caregiver (76.6%). The participants presented more frequently the level of moderate resilience (64.8%), functional dependence (93.6%) for performing daily activities and medium social support (48.2%). It was verified that the greater the functional capacity and social support, the greater the resilience. Conclusion: Functional capacity and social support are predictors of resilience of people with sequelae of stroke.


Subject(s)
Humans , Male , Female , Middle Aged , Social Support , Activities of Daily Living , Stroke/nursing , Resilience, Psychological , Linear Models , Cross-Sectional Studies , Stroke/psychology , Stroke/epidemiology , Nursing Care
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