Andrological responses to prolonged administration of oxytetracycline and metronidazole with reference to the serum testosterone level in rats

In this study, the effect of daily administration of oxytetracycline Hcl [2 mg100 gm. b. wt. i.m] or metronidazole [15 mg/100 gm. b. wt. orally] for 60 successive days on fertility of male rats was investigated. Histological changes of male sex organs were analysed. These drugs insignificantly decreased epididymal sperm cell concentration compared with the control. Non significant changes were observed in the rate of sperm motility and head abnormalities. Oxytetracycline or mertonidazole had no significant effects on the weight of testes, epididymes and accessory sex organs. These drugs induced insignificant changes in serum testosterone level of treated rats

Interaction of vecuronium with chlorpromazine and verapamil in dog's neuromuscular preparations

The present work investigates the interaction between Vecuronium and chlorpromazine or veracamil on the upper lip muscles and the anterior tibialis muscle of the dog. The onset time, duration of action and recovery index were measured. Pretreatment with chlorpromazine and verapamil resulted in potentiation of the neuromuscular blocking action of Vecuronium. The importance of such findings in anaesthetic practice was referred to

growth promoting effect of clanobutin sodium [bykahepar] in chicken with reference to some of its side effects

Clanobutin sodium [Bykahepar[R]] a choleretic and digestant agent was administered to three groups of male [Baladi-chickens]. The drug was injected once per week for 12 weeks. Histopathological changes were investigated. Congestion, degenerative changes and hyperplasia occurred with highly distended gall bladder. Chickens administered clanobutin sodium at a dose of 10 or 20 mg/kg. b. wt. showed an insignificant increase in growth rate than the control. The treated chickens suffered a significant increase in alkaline phosphatase, GOT, GPT and cholesterol levels than the control. It could be concluded that clanobutin sodium at higher doses results in retardation of growth and impairment of the function of the liver