Effect of some antibiotics and disinfectants on enteric bacteria isolated from some food

Antibacterial effect of erythromycin, streptomycin, kanamycin, ampicillin, chloramphenicol, tetracycline, amoxycillin and gentamicin as well as iodophor and savlon on bacteria isolated from milk, Kareish cheese, Domiatti cheese and meat products was investigated by using both disc and well methods. The majority of tested microorganisms in this study showed a high susceptibility to streptomycin, kanamycin, chloramphenicol, tetracycline and gentamicin, while, resistant to erythromycin, ampicillin and amoxycillin. Salmonella muenster was susceptible to all antibiotics used, but Salmonella typhimurium and Sal. newport were resistant to erythromycin and ampicillin. The results revealed that most tested microorganisms were sensitive to iodophor then savlon. The possible implication to animal and human heath were discussed

influence of some dopamigergic agents on serum prolactin concentrations in male rats

The effects of several dopaminergic agents on prolactin [PRL] release were determined in male rats. The central nervous system stimulant, 4 aminopyridine, which affect turnover of monoamines [2.6 mg/kg] induced a non significant decrease in serum PRL level, while dopamine precursor L-dopa [100 mg/kg] resulted in a significant inhibition on PRL levels. Pencillamine and discultiram, a dopamine beta-hydroxylase inhibitors at a dose of 300 and 480 mg/kg respectively, had no effect on serum PRL level. It is concluded that neurotransmitter dopamine is responsible for inhibition of PRL release, since the dopamine precursor L-dopa inhibits PRL and the dopamine receptor blocker haloperidol [HAL] increases its release

Interaction between verapamil and some oral hypoglycaemic drugs in normal and alloxan diabetic rats

Eight albino rats of both sexes, weighing 250 - 300 gm were used. Rats were divided into two groups each of forty, one of them as normal fasted and the other as alloxan diabetic one. Diabetic rats obtained by subcutaneous injection of alloxan in a dose of 120 mg/kg body weight. The drug interaction between verapamil and three common oral hypo-glycaemic drugs were studied. Sulfonylurea drugs [tolbutamide and glibenclamide] and N.N. dimethyl guanyl-guanidine were used. Verapamil alone, increased blood sugar level in normal fasted and alloxan diabetic rats. Also, in combination verapamil interfere with the hypoglycaemic effect of the beforementioned oral hypoglycaemic drugs in normal fasted and alloxan diabetic rats. This result was explained as a result of interference with insulin secretion by blocking slow-inward conducting channels of Ca++

Probable interaction between calcium entry blocker [Verapamil] and hypoglycaemic drugs in rats

Eighty albino rats of both sexes, weighing 250-300 g were used. Rats were divided into two groups each of 40, one of them as normal fasted and the other as alloxan diabetic one. Diabetic rats were obtained by subcutaneous injection of alloxan in a dose of 120 mg/kg body weight. The drug interaction between verapamil and three common oral hypoglycemic drugs were studied. Sulfonylurea drugs [tolbutamide and glibenclamide] and N,N-dimethyl guanyl-guanidine were used. Verapamil alone, increased blood sugar level in normal fasted and alloxan diabetic rats. Also, in combination verapamil interfere with the hypoglycemic effect of the before mentioned oral hypoglycemic drugs in normal fasted and alloxan diabetic rats. This result was explained as a result of interference with insulin secretion by blocking slow-inward conducting channels of Ca ++