effects of diethylstilbestrol administration on rat kidney. Ultrastructural study

To assess the histological and ultrastructural changes that can be induced by diethylstilbestrol [DES] on renal tissues using histological, immunohistochemical, and ultrastructural methods. Thirty adult male Wistar rats were divided into 3 groups [10 rats each]: Group 1 - control; Group 2 - received DES at a dose of 60 micro g/kg/day, dissolved in 0.1 ml corn oil for 20 days; and Group 3 - received the same dose of DES for 50 days by oral gavage. The renal tissues were studied histologically, immunohistochemically [using an anti-BCL2-associated X protein [BAX protein] antibody], and ultrastructurally. This study was carried out at the Anatomy Department, Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia between December 2011 and December 2012. The DES administration for 50 days caused noticeable degeneration, and alteration of the morphology of the renal tissues in the form of damaged renal tubules with loss of the brush border of the proximal convoluted tubules and increased cellularity of the glomeruli. In addition, there was a significant increase in BAX protein expression based on immunoreactivity, and in renal tubules, as well as glomerular cells. These changes were less obvious after 20 days of treatment. Non-steroidal, synthetic estrogens showed harmful effects on the renal tissues and altered their morphology with an increased number of apoptotic cells, and these changes were duration dependent

Micromorphological studies on the lympho-reticular tissue in the vagina of the one-humped she-camel

The lining epithelium of the she-camel's vagina was subjected to different degrees of infiltration by lymphocytes, individually or in groups from the subepithelial connective tissue layer. At the early follicular phase, the lymphocytic infiltration was little, while it was very little during the growing follicular phase. Some migrated lymphocytes reached the superficial cell layers and desquamated with them in the lumen. At the late follicular phase, high lymphocytic infiltration was noticed all-over the vaginal length. During early, mid and late luteal phases, some leukocytic and high lymphocytic infiltrations were noticed in the anterior and middle vaginal parts. In the lamina propria, subepithelial diffuse lympho-reticular tissue was more in the anterior and middle parts of the vagina than in the posterior part and vestibule. Aggregated lymph nodules were noticed at the junctions especially the cervico-vaginal one where they surrounded the mucosal invaginations in a manner like tonsils