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1.
SJO-Saudi Journal of Ophthalmology. 2012; 26 (3): 299-303
en Inglés | IMEMR | ID: emr-154819

RESUMEN

To assess the long term visual outcomes and refractive status of patients who underwent diode laser for threshold retinopathy of prematurity [ROP] and to investigate the risk factors leading to poor visual outcomes. Fifty-seven patients [114 eyes] with threshold ROP who underwent laser therapy were contacted for reassessment. A chart review was performed for all patients to collect data on visual acuity, retinal status and strabismus. A favorable visual outcome was defined as <20/160 [Snellen acuity] for young adults [cooperative patients], and CSM for children [uncooperative patients] while unfavorable visual outcome was defined as <20/160 or

2.
Medical Journal of Islamic World Academy of Sciences. 2009; 17 (1): 23-36
en Inglés | IMEMR | ID: emr-111128

RESUMEN

Endotoxin [Lipopolysaccharide, LPS] a component of the bacterial wall of gram-negative bacteria, has been recognized as one of the most potent bacterial products in the induction of host inflammatory responses and tissue injury and was used in this study to mimic infections. LPS induces production and release of several cytokines. In response to these cytokines, different effects of endotoxins are seen. The effect of three types of endotoxins [Escherichia coli, Klebsiella pneumoniae and Salmonella typhimurium] on bone marrow, differential counts and peripherial blood parameters were investigated in adult rats. Male spraguo Dawely albino rats weighing 220 - 250 g were used. They were injected i.p. [1 mg/kg body weight] with single dose of 3 types of endotoxins. Blood samples were collected from the experimental animals at 24 and 72 hours of the injection. At 72 hours the bone marrow aspirations were harvested from the femur of the rats for microscopic examination. Endotoxins induced different changes in the cells of bone marrow. Also, lipopolysaccharide caused significant decreases in red blood cells, white blood cells and platelets counts, hemoglobin content and hematocrit percent. Data of the present study point out to the dose of these toxins according to suitable pharmacopeia. Lemulus amebocyte lysate [LAL] test is specificly used for determination of the endotoxin limit. This recommendation should be observed to avoid the toxic effects of endotoxins


Asunto(s)
Masculino , Animales de Laboratorio , Infecciones por Bacterias Gramnegativas/complicaciones , Médula Ósea/microbiología , Sangre/microbiología , Escherichia coli , Lipopolisacáridos/efectos adversos , Klebsiella pneumoniae , Salmonella typhimurium , Ratas Sprague-Dawley , Eritrocitos , Leucocitos , Plaquetas , Hemoglobinas , Hematócrito
3.
Medical Journal of Islamic World Academy of Sciences. 2006; 15 (2): 65-72
en Inglés | IMEMR | ID: emr-79079

RESUMEN

The effects of bacterial endotoxins [Escherichia coli, Klebsiella pneumoniae, and Salmonella typhimurium] on glucose and blood urea nitrogen [BUN] levels and aspartate aminotransferase [ASAT], alanine aminotransferase [ALAT] and lactate dehydrogenase [LDH] activities were studied. Three groups of rats were injected [1 mg/kg body weight, i.p.] with three types of bacterial endotoxins [E. coli, K. pneumoniae and S. typhimurium] as a single dose. The control group was injected i.p. [1 mg/kg] in 0.9% normal saline. Blood sampling was performed from the orbital vein plexus after 24 and 72 hr of injection. Glucose level was increased significantly after 24 hr of after each 3 solutions of endotoxin. Its level showed non-significant decrease after 72 hr post-treatment. However, endotoxins caused significant increases in BUN, ASAT and LDH at 24 and 72 hr post-treatment. On the other hand, the ALAT activity was significantly decreased after the referred observation periods of endotoxins injection. The variation in serum glucose level after 24 and 72 hr post-treatment may be referred to different reasons. On the other hand, the increase of BUN concentration may be due to the toxic effect of bacterial endotoxins resembling to that occurring in renal damage and impairment of renal function. However, the changes in serum aminotransferases and LDH activities may be due to endotoxins induced hepatic microcirculatory disturbance and to the subsequent liver injury and tissue hypoxia


Asunto(s)
Animales de Laboratorio , Enzimas , Ratas Sprague-Dawley , Glucosa , Nitrógeno de la Urea Sanguínea
4.
Journal of Drug Research of Egypt. 1990; 19 (1-2): 367-73
en Inglés | IMEMR | ID: emr-16453
5.
Medical Journal of Cairo University [The]. 1989; 57 (Supp. 3): 135-40
en Inglés | IMEMR | ID: emr-13880

RESUMEN

Twenty patients with acne vulgaris, twenty patients with dandruff and 18 control subject were included in this study. Determination of the serum total testosterone and estradiol levels were performed by a specific-radioimmunoassay method. The mean serum total testosterone levels in females and males with acne vulgaris were found to be significantly higher than that of controls. An insignificant change was observed concerning total testosterone and estradiol levels in male patients with dandruff. But the serum testosterone and estradiol levels in female patients with dandruff were significantly higher than in male controls. The significance of these results in the pathogenesis and treatment of acne vulgaris is discussed


Asunto(s)
Testosterona , Dermatitis Seborreica , Estradiol
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