RESUMEN
Background and Objectives: Various mutations on endothelial Nitric Oxide synthase [eNOs] gene can cause reduced production of NO and may accelerate the process of atherosclerosis. The study was designed to investigate the frequency of T-786C gene polymorphism in a group of patients suffering from CAD in North West of Iran, The association of the polymorphism with other risk factors including: Antioxidant activity indices, Lipid Peroxidation and MDA were also determined
Material and Methods: One hundred twenty subjects including 60 patients with angiographically diagnosed CAD and 60 age and sex matched normal control were studied. Exclusion criteria were; diabetes melitus smoking, preexisting malignancies and liver disease. The activities of SOD, GPX and TAC enzymes in the blood samples were determined in both groups using Randox Kits in an automated chemical analyzer [Abbott, model Alcyon 300,USA]. The concentration of MDA in the serum samples were assayed by spectrophotometerically using Thiobarbitoric acid reaction. The genotype studies were also carried out concomitantly using allele specific PCR
Results: Erythrocyte SOD, GPX activities and blood TAC level were reduced significantly in patients with CAD [P<0.05 in all cases]. The levels of serum MDA in CAD patients were significantly higher than controls [P<0.05]. The significantly higher frequency of eNOs -786C genotype was detected in CAD patients that indicate the significant association of C allels with CAD
Conclusion: The association between oxidative stress parameters and decrease Antioxidant activity may suggest their involvement in the pathogenesis of atherosclerosis. Increased frequency of T-786C polymorphism might be another risk factor in the progression of coronary artery disease
RESUMEN
Cardiovascular diseases are the most common causes of death worldwide and stress is the reason behind many negative emotions. Surgery is one of the most stressful situations. Coping styles and life expectancy affect people's mental and physical efficacy. The present study aims to determine the effectiveness of training life expectancy and effective coping styles to deal with negative emotions on cardiac surgery patients' mental health at Sari-based Fateme Zahra Hospital in 2013. In this quasi-experimental study, 30 candidates for coronary artery bypass surgery referring to this center was selected using the available sampling method. They were then randomly included into two 15-member groups as experimental and control group. Stress management, anger management, and hopefulness training courses were held individually for 7 sessions. Before and after the intervention, the patients of both groups answered the questionnaires including the Coping Manners Questionnaire [by Lazarus and Folkman], Snyder's Hope Scale, and the General Health Questionnaire-12 [GHQ-12]. Data analysis implied that there is a significant difference between the average general health in the experimental and control groups after training. Investigating the subscales of coping strategies in the experimental and control groups after training showed that there is a significant difference between direct coping, planned problem solving, and positive reappraisal in the two groups. In patients with coronary heart disease, high stress, and negative emotions [anger, anxiety, depression] also as the candidates of coronary artery bypass surgery, training raised life expectancy level and the practical methods for coping with life can be great help to their mental health condition