Effect of green tea, curcumin and ginger extracts and its combination on liver and kidney functions in rats after carbon tetrachioride exposure

Oxidative stress is a major factor in the pathogenesis of diabetic complications. We studied the effects of green tea, curcumin and ginger extracts or its combinations on the kidney and liver function for rats exposure to CCL[4] injection. The results indicated that, all treated groups with low and high concentrations of ginger extract had uric acid and urea nitrogen lower than untreated group [control positive groups]. Moreover green tea had the most significant protection for kidney function against CCI[4]. In additional, there was a significant difference in serum glucose level between the low [10 gm] and high [20 gm] concentration of each individual herb or herbal combinations. The high concentration of the herb or its combinations resulted in a significantly lower serum AST and ALT levels than the low herbal concentration. But, all investigated herbs had significant protection for liver function against CCI[4]. It was concluded that, concurrent treatment of investigated herbs extract gave significant protection against CCI[4] though the values did not reach the normal levels

Effect of green tea, curcumin and ginger extracts on serum lipid profile in rats after carbon tetrachloride exposure

Oxidative stress is a major factor in the pathogenesis of diabetic complications. The current study aimed to investigate the effects of green tea, curcumin and ginger extracts or its combinations on the kidney and liver function for rats exposure to CCL4 injection. The results indicated that, green tea reduced food intake and body weight in rats. The food intake did not show any important variation between both dosage of tested herbs and aqueous extract of green tea, ginger and curcumin. Body weight gain percentage of the control positive group and other groups treated with herbs decreased significantly at [p< 0.05] as compared to the control negative group. The results observed that, rats suffering from CCL4 and treated with of green tea, curcumin and ginger or its combination were associated with decreased serum concentrations of total cholesterol and triglyceride, an increase in the proportion of high-density-lipoprotein cholesterol, and a decreased proportion of low and very-low-density-lipoprotein cholesterols, as compared to positive control group

Effect of propolis extract as natural substance on lowering blood sugar and cholesterol level in hyperglycaemic rats

The present work was conducted to study the effect of propolis extract on lowering blood sugar and cholesterol level in alloxan diabetic rats. Various nutritional and biochemical parameters were estimated. Propolis extract was added to the diet of rats at three levels [0.25%, 0.5% and 1.0%] for 4 weeks. The obtained results indicated that the addition of propolis extract to the diet of rats produced a positive effect on body weight gain [BWG] and feed efficiency ratio [FER]. The values of cholesterol, triglycerides [TG] and very low-density lipoprotein- cholesterol [VLDL-c] significantly increased for positive control [+] compared with negative control [-], but HDL-c was significantly lower. Addition of propolis extract resulted in a significant reduction in cholesterol, TC, VLDL-c, aspartate amino transferase [AST] and alanine amino transferase [ALT] except the 0.25% propolis group for AST. The percentage decrease in cholesterol value was from about 45.9% to 64.7%, while percentage increase in HDL value was from about 37.5 to 91.3%. Glucose level in control [+] was 311.5 +/- 75.3 1 mg/dl vs 128.5 +/- 26.13 mg/dl for control [-]