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1.
China Journal of Orthopaedics and Traumatology ; (12): 698-702, 2018.
Artículo en Chino | WPRIM | ID: wpr-691145

RESUMEN

<p><b>OBJECTIVE</b>To evaluate the clinical outcome of intelligent inflated reduction combined with percutaneous pedicle screw fixation in treating thoracolumbar burst fractures.</p><p><b>METHODS</b>The clinical data of 22 patients with thoracolumbar burst fractures of single segment treated from January 2013 to December 2015 were retrospectively analyzed. There were 12 males and 10 females, aged from 32 to 56 years old with an average of (42.4±8.6) years. Self-made intelligent pneumatic reset instrument was applied to 22 cases under anaesthesia reduction, and then percutaneous pedicle screw fixation was performed. Clinical features were observed and the clinical effects were evaluated by VAS, ODI, kyphotic angle (Cobb angle) and the injured vertebral anterior border height before and after operation.</p><p><b>RESULTS</b>All the patients were followed up from 1 to 2.5 years with an average of 18 months. All fractures obtained bone healing, no complications such as loosening, displacement, breakage of pedicle screw and kyphosis were found. Preoperative, 1 week postoperative, and final follow-up, VAS scores of lumbar pain were 7.82±0.85, 3.09±0.92, 1.05±0.72;ODI scores were 84.2±11.2, 46.3±9.0, 12.2±4.3;Cobb angle were (16.3±5.4)°, (3.7±2.2)°, ( 5.5±2.6)°; the injured vertebral anterior border heights were (59.5±7.8)%, (86.9±6.0)%, (83.5±5.5)%, respectively. There was significant differences in VAS, ODI scores between any two times(<0.05). At 1 week postoperative and final follow-up, Cobb angle, injuried vertebral anterior border height were obviously improved (<0.05), and there was no significant difference between postoperative 1 week and final follow-up (>0.05).</p><p><b>CONCLUSIONS</b>It is safe and feasible surgical technique that intelligent inflated reduction combined with percutaneous pedicle screw fixation for thoracolumbar burst fractures. It has advantage of little trauma, reliable fixation, and less complication, etc. Therefore, it is a better choice for single-segment thoracolumbar burst fractures.</p>

2.
Chinese Acupuncture & Moxibustion ; (12): 317-320, 2008.
Artículo en Chino | WPRIM | ID: wpr-297032

RESUMEN

<p><b>OBJECTIVE</b>To study on clinical role of acupuncture at Tanzhong (CV 17) for treatment of postpartum hypolactation and to provide clinical basis for indications of acupoints.</p><p><b>METHODS</b>This was a single blind randomized controlled multi-center study by Beijing obstetrical and gynecological hospital, Beijing Mother and Child health institute and Haidian Mother and Child health institute, 276 cases of postpartum hypolactation were randomly divided into an acupuncture group and a Chinese drug group. The acupuncture group were treated with acupuncture at Tanzhong (CV 17) and the Chinese drug group with traditional drug Tongre Decoction. Degree of breast engorge, lactating volume, prolactin, neonate body weight, artificial feeding frequency and volume, urination frequency and crying time of neonate were recorded for comparison of therapeutic effects.</p><p><b>RESULTS</b>After treatment, degree of breast engorge, lactating volume, neonate body weight, artificial feeding frequency and volume, urination frequency and crying time of neonate were significantly improved in the two groups, with no significant difference between the two groups.</p><p><b>CONCLUSION</b>Acupuncture at Tanzhong (CV 17) can effectively promote lactation with a same therapeutic effect as the traditional Chinese drug Tongru Decocnon.</p>


Asunto(s)
Adulto , Femenino , Humanos , Puntos de Acupuntura , Terapia por Acupuntura , Trastornos de la Lactancia , Terapéutica , Trastornos Puerperales , Terapéutica , Método Simple Ciego
3.
Chinese Journal of Applied Physiology ; (6): 94-97, 2006.
Artículo en Chino | WPRIM | ID: wpr-254596

RESUMEN

<p><b>AIM</b>To investigate effect and mechanism of vasonatrin peptide (VNP) on Ca2+ activated K+ channels (K(Ca)) of vascular smooth muscle cells (VSMCs) isolated from rat mesentery arteries.</p><p><b>METHODS</b>Changes of K(Ca) induced by VNP were measured by the means of whole cell recording mode of patch clamp, furthermore effects of HS-142-1(0.3 g/L), 8-Br-cGMP and methylene blue (MB) were observed.</p><p><b>RESULTS</b>K(Ca) was significantly enhanced by VNP (10(-6) mol/L), which was mimicked by 8-Br-cGMP(10(-3) mol/L) and blocked completely by HS-142-1 or MB (2 x 10(-5) mol/L).</p><p><b>CONCLUSION</b>VNP increases K(Ca) of VSMCs isolated from rat mesenteric arteries, by binding with natriuretic peptide guanylate cyclase-coupled receptors and increasing the intracellular level of cGMP in VSMCs.</p>


Asunto(s)
Animales , Masculino , Ratas , Factor Natriurético Atrial , Farmacología , Arterias Mesentéricas , Biología Celular , Metabolismo , Músculo Liso Vascular , Metabolismo , Fisiología , Canales de Potasio Calcio-Activados , Metabolismo , Ratas Sprague-Dawley
4.
Acta Physiologica Sinica ; (6): 187-190, 2003.
Artículo en Chino | WPRIM | ID: wpr-318919

RESUMEN

The purpose of this study was to investigate the vasorelaxing effect of vasonatrin peptide (VNP) on human intramammary artery (HIMA).The vasorelaxing effect of VNP on HIMA was measured by means of perfusion in vitro. The effects of HS-142-1, TEA, 8-Br-cGMP and methylene blue (MB) were also observed. It was found that VNP caused a concentration-dependent relaxation in HIMA which was independent of the endothelium. 8-Br-cGMP (0.1-1000 micromol/L) also caused a concentration-dependent relaxation in HIMA. The vasorelaxing effect of VNP disappeared in the presence of HS-142-1 (20 micromol/L), an antagonist of the natriuretic peptide guanylate cyclase (GC) receptor. MB (10 micromol/L), an inhibitor of GC, not only blocked completely the relaxation of HIMA, but also enhanced the vascular contraction induced by norepinephrine. TEA (1 mmol/L), an antagonist of calcium activated potassium channels (K(Ca)), reduced but not completely blocked the vasorelaxing effect of VNP. These findings suggest that VNP can relax HIMA, which is independent of the endothelium. This effect is possibly achieved by the binding of VNP with the natriuretic peptide GC receptors in the smooth muscle cells (SMCs), leading to an increase in intracellular cGMP level. Moreover, the vasorelaxing effect of VNP is associated with K(Ca).


Asunto(s)
Anciano , Humanos , Persona de Mediana Edad , Factor Natriurético Atrial , Farmacología , Relación Dosis-Respuesta a Droga , Técnicas In Vitro , Arterias Mamarias , Fisiología , Canales de Potasio Calcio-Activados , Metabolismo , Receptores Acoplados a la Guanilato-Ciclasa , Metabolismo , Vasodilatación , Fisiología
5.
Chinese Journal of Applied Physiology ; (6): 350-353, 2002.
Artículo en Chino | WPRIM | ID: wpr-339717

RESUMEN

<p><b>AIM</b>To investigate the effect of vasonatrin peptide (VNP) on the expression of C-type natriuretic peptide receptor (NPR-C) in hypoxic rat hearts.</p><p><b>METHODS</b>Rats were divided randomly into three groups: control group, hypoxia group(3-28 d) and VNP (25-75 microg/kg per day) + hypoxia group. The plasma concentration of atrial natriuretic peptide (ANP) in rats was measured by the means of radioimmunoassay. Furthermore, quantitative PCR was used to examine the NPR-C mRNA level in rat hearts.</p><p><b>RESULTS</b>The plasma concentration ANP in rats was significantly higher than that of control group, and VNP (75 microg/kg per day) made it more higher. Hypoxia for 3 day of had no significant effect on the NPR-C mRNA level in rat hearts, while hypoxia for 7-28 d significantly increased the level of NPR-C mRNA in a time dependent manner. VNP (50-75 microg/kg per day) significantly reduced the NPR-C mRNA level in rat hearts in a dose dependent manner.</p><p><b>CONCLUSION</b>VNP increases the plasma concentration of ANP in hypoxic rats. Hypoxia can increase expression of NPR-C in rat hearts significantly, which can be inhibited by VNP.</p>


Asunto(s)
Animales , Masculino , Ratas , Factor Natriurético Atrial , Sangre , Farmacología , Hipoxia , Metabolismo , Péptido Natriurético Tipo-C , Metabolismo , Péptidos Natriuréticos , Metabolismo , Ratas Sprague-Dawley , Receptores del Factor Natriurético Atrial , Metabolismo
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