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OBJECTIVE To investigate the distribution and antimicrobial resistance among clinical isolates of Acinetobacter baumannii(ABA) from July 1 to Dect 31 2007 in Haidian Hospital of Beijing.METHODS A retrospective study on clinical distribution and antimicrobial resistance of 22 antibiotics to ABA was undertaken.RESULTS ABA frequently detected out in phlegm specimen with the detection rate of 86.4%.The drug-resistance to SCF and AMK was the lowest.CONCLUSIONS ABA had severe drug-resistance,SCF and AMK keep better activity to ABA.Rational selection and use of antibacterials is important to prevent the appearance of drug-resistance of ABA.
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OBJECTIVE To understand the drug-resistant status of Acinetobacter baumanii and provide scientific basis for infection treatment.METHODS Eight multidrug-resistant A.baumannii(MDR-AB) strains isolated from nosocomial inpatients in intensive care unit(ICU) were collected in May 2007 and tested for drug sensitivity and MIC determination as well.We typed A.baumannii isolates with pulsed-field gel electrophoresis(PFGE) to determine whether they derived from the same clone.RESULTS Four isolates from nosocomial inpatients were resistant to multiple antibiotics including carbapenem.The PFGE types identified from eight isolates were same.All A.baumannii isolates are closely related.CONCLUSIONS The prevalence of nosocomial infection is due to transmission of the same strains among the patients in ICU.This finding highly suggests that isolate 1 was the source of this nosocomial infection and the problem of hand hygiene maybe the main transmission route.