Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Añadir filtros








Intervalo de año
1.
Medicina (B.Aires) ; 60 Suppl 2: 17-20, 2000.
Artículo en Español | LILACS, BINACIS | ID: biblio-1165065

RESUMEN

Generalized activation of the immune system after HIV infection leads to an exacerbation of all apoptotic mechanisms. CD4+, CD8+ T lymphocytes and B lymphocytes are sensitized to apoptotic stimuli. Macrophages are important in the removal of apoptotic cells, they prevent apoptotic cell accumulation during in vitro culture and they may lead to enhanced CD4+ T lymphocyte cell death through indirect mechanisms. A simple procedure for prolonged culture of peripheral blood mononuclear cells from HIV+ patients is discussed, in relation to its convenience to evaluate apoptosis, cell to cell interaction and HIV replication in the absence of exogenously added stimuli or co-culture of allogeneic cells. In this system, HIV replication takes place primarily in cells of macrophage lineage that may be activated into differentiation through removal of apoptotic debris during the culture.


Asunto(s)
Humanos , Linfocitos T CD4-Positivos/fisiología , Infecciones por VIH/virología , VIH/fisiología , Apoptosis , Fagocitos/fisiología , Fagocitosis/fisiología , Replicación Viral , Activación de Linfocitos , Comunicación Celular , Técnicas de Cultivo de Célula/métodos , Carga Viral
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA