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Indian J Physiol Pharmacol ; 1998 Jan; 42(1): 95-100
Artículo en Inglés | IMSEAR | ID: sea-106770

RESUMEN

Six male post-detoxified opiate dependent subjects were evaluated for abuse liability of buprenorphine (0.6 mg), morphine (16 mg), pentazocine (30 mg) and distilled water (placebo) intramuscular injection in a single blind cross-over random order. Subjective states, drug discrimination, drug linking, sedation and euphoria were assessed at pre-injection, 30 min and 4 hrs post-injection. Buprenorphine caused significant euphoria and was identified as heroin. On all parameters, buprenorphine resembled morphine rather than pentazocine and placebo. The data suggest that abuse liability of buprenorphine is similar to morphine i.e. moderate rather than low.


Asunto(s)
Adolescente , Adulto , Analgésicos Opioides , Buprenorfina , Niño , Euforia/efectos de los fármacos , Dependencia de Heroína/psicología , Humanos , Masculino , Encuestas y Cuestionarios , Trastornos Relacionados con Sustancias/psicología
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