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The present research work deals with the in- vitro dissolution study of developed sol to gel ocular drug delivery system of brimonidine for conjunctivitis during accelerated stability study. The formulation of brimonidine was developed and optimized formulation coded as X4Y2D containing optimized amount of sodium alginate and HPMC K100LvP was evaluated for the physico-chemical characterization and drug release initially and during accelerated stability study. The drug release was determined using fabricated continuous flow through cell apparatus. The difference between initial drug release and after three month drug release was 2.606% and the calculation was done for shelf life and found 2 years.
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The aim of this study is to find the effect of starch and guar gum 4000 on disintegrating time and dissolution behavior of drug Zolmitriptan from fast dissolving tablet [FDT]. The FDT was prepared by direct compression method. The precompression parameters were evaluated with subjected to angle of repose, bulk and tapped density, hausnefs ratio and Carr's index and all were within limit. The prepared tablets were evaluated for thickness, uniformity of content, hardness, friability, wetting time and in vitro disintegration time and in vivo release of drug. The in vitro release and assay of drug was performance by UV spectrophotometer. The in vivo study reveals that when guar gum [5%] and starch [10%] were used in formulation, the plasma concentration of drug was increased because, it disintegrate tablet rapidly and drug was released rapidly from dosage form and reach quickly in to systemic circulation resultant bioavailability is increased
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Background: Strychnos nux-vomica, commonly known as kuchla, contains strychnine and brucine as main constituents. Minor alkaloids present in the seeds are protostrychnine, vomicine, n-oxystrychnine, pseudostrychnine, isostrychnine, chlorogenic acid, and a glycoside. Seeds are used traditionally to treat diabetes, asthma, aphrodisiac and to improve appetite. Objective: The present study was aimed to evaluate the various pharmacognostical characters and antidiabetic activity of S. nux-vomica seed. Materials and Methods: Pharmacognostical characters were performed as per the WHO guideline. Extraction was carried out in petroleum ether, chloroform, alcohol, hydroalcoholic, aqueous, and phytochemical constituents present in extracts were detected by different chemical tests. Among these extracts hydroalcoholic, aqueous extracts were evaluated for antidiabetic activity on the basis of extractive yield and phytoconstituents, in alloxan-induced diabetic rats using gliclazide as standard. Results: Various analytical values of S. nux-vomica extract were established. Phytoconstituents present in S. nux-vomica extracts were detected. Conclusion: S. nux-vomica extracts show antihyperglycemic activity in experimental animals.
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Orally disintegrating tablets (ODT) are gaining popularity over conventional tablets due to their convenience in administration and suitability for patients having dysphagia. Moreover no water is required for swallowing the tablets and hence suitable for geriatric, pediatric and traveling patients. Super disintegrants (such as Ac-Di-Sol, Crospovidone, sodium starch glycolate), Diluents (Dibasic calcium phosphate) along with sweetening agent (aspartame) were used in the formulation of tablets. The tablets were evaluated for hardness, friability, water absorption ratio, in-vitro disintegration time (DT), in-vitro disintegration time in oral cavity and in vitro drug release. Using the same excipients, the tablets were prepared by direct compression and were evaluated in the similar way. Maximum drug release and minimum DT were observed with Crospovidone excipient prepared by direct compression.
RESUMEN
Effects of diabetes mellitus induced by streptozotocin (DMIS) on the pharmacokinetics of Gatifloxacin were investigated after i.v and oral administration (50mg/mg) to control Sprague-Dawley rats and DMIS rats (at 7th and 29th days after administration of streptozotocin (55mg/kg). After i.v administration to DMIS rats, there was no significant difference in clearance, t1/2, Vd and MRT last. But after oral administration of gatifloxacin to DMIS rats Cmax was significantly increased. This could be supported with the marginal increase in AUC and an increase in bioavailability of drug in chronic (78.7% increase) as well as acute conditions (75.3% increases). Streptozotocin induced toxicity did not influence considerably on the pharmacokinetics of gatifloxacin.