RESUMEN
The obesity related glomerulopathology attracts more and more attention due to the proteinuria induced by podocyte injury. TRPC6,which on the slit diaphragm of podocyte, and other factors contain together of the signal translation, cell polarization and cell skeleton structure of podocyte. Therefore the ion channels become the research front filed of kidney disease from the view on electrophysiology. Under this background, we introduce the biological function of TRPC6 and review its role on proteinuria induced by obesity. At last we sum up and outlook the application of TRPC6 as a treated target in proteinuria related obesity in the future.
RESUMEN
Objective: To explore the changes of incidence of major vascular lesions after intensive intervention of multiple controllable risk factors in the type 2 diabetes mellitus (T2DM) patients in Han population in Northeast China, and to establish an effective, standardized and cost-effective intervention scheme for the primary prevention of major vascular lesions of the T2DM patients. Methods: A total of 300 T2DM patients newly diagnosed or diagnosed in one year without major vascular lesions were randomly divided into conventional treatment group (n= 150) and intensive intervention group (n=150). The clinical study method of parallel control was used to intervene in the some controllable risk factors for 2 years to varying degrees. The body mass index (BMD, waist/hip ratio (WHR), systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood glucose (FPG), 2 h postprandial blood glucose (2 h PBG), glycosylated hemoglobin (HbAlc), serum total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-c), high density lipoprotein (HDL-c), intima media thickness (IMT) and incidence of majoy vascular lesions of atherosclerosis (AS) of the patients in two groups were measured, and the medical expenses of the patients were analyzed statistically. Results: After 2-year-follow-up, the DBP, FBG, 2 h PBG, HbAlc, TG, TC and HDL-c of the patients in conventional treatment group were significantly lower than those before treatment (P