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Braz. j. med. biol. res ; 32(7): 861-5, July 1999.
Artículo en Inglés | LILACS | ID: lil-234892

RESUMEN

Polyomavirus is a DNA tumor virus that induces a variety of tumors in mice. Its genome encodes three proteins, namely large T (LT), middle T (MT), and small T (ST) antigens, that have been implicated in cell transformation and tumorigenesis. LT is associated with cell immortalization, whereas MT plays an essential role in cell transformation by binding to and activating several cytoplasmic proteins that participate in growth factor-induced mitogenic signal transduction to the nucleus. The use of different MT mutants has led to the identification of MT-binding proteins as well as analysis of their importance during cell transformation. Studying the molecular mechanisms of cell transformation by MT has contributed to a better understanding of cell cycle regulation and growth control


Asunto(s)
Humanos , Animales , Ratones , Antígenos Transformadores de Poliomavirus/genética , Transformación Celular Neoplásica/genética , Infecciones por Papillomavirus/genética , Poliomavirus/genética , Transducción de Señal/genética , Antígenos Transformadores de Poliomavirus/metabolismo , Transformación Celular Neoplásica/metabolismo , Mutación , Infecciones por Papillomavirus/metabolismo , Poliomavirus , Transducción de Señal , Transcripción Genética
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