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Psychiatry Investigation ; : 130-133, 2011.
Artículo en Inglés | WPRIM | ID: wpr-35977

RESUMEN

OBJECTIVE: Psychiatric disorders such as depression, anxiety and alcohol dependence are associated with serotonin metabolism. We assessed the methylation level of the serotonin transporter (5-HTT) promoter region in control and alcohol dependent patients. METHODS: Twenty seven male patients who met the Diagnostic and Statistical Manual of Mental Disorder IV (DSM-IV) criteria for alcohol dependence were compared with fifteen controls. Polymerase chain reaction (PCR) assays of bisulfate-modified DNA were designed to amplify a part of the CpG island in the 5HTT gene. Pyrosequencing was performed and the methylation level at seven CpG island sites was measured. RESULTS: We found no differences in the methylation patterns of the serotonin transporter linked promoter region (5-HTTLPR) between alcohol-dependent and control subjects. CONCLUSION: Our negative finding may be because 5-HTT epigenetic variation may not affect the expression for 5-HTT or there may be other methylation site critical for its expression. To find out more conclusive result, repeating the study in more methylation sites with a larger number of samples in a well-controlled setting is needed.


Asunto(s)
Humanos , Masculino , Alcoholismo , Ansiedad , Islas de CpG , Depresión , ADN , Epigenómica , Trastornos Mentales , Metilación , Reacción en Cadena de la Polimerasa , Regiones Promotoras Genéticas , Serotonina , Proteínas de Transporte de Serotonina en la Membrana Plasmática
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