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Journal of Southern Medical University ; (12): 558-561, 2008.
Artículo en Chino | WPRIM | ID: wpr-280149

RESUMEN

<p><b>OBJECTIVE</b>To investigate the effects of Newcastle disease virus (NDV) infection on the expression of survivin and cell cycle in human tongue squamous carcinoma TSCCa cells.</p><p><b>METHODS</b>The proliferation of TSCCa cells infected with NDV in vitro was evaluated by means of MTT assay, and survivin expression in the infected cells was detected using RT-PCR and Western blotting. Flow cytometry was performed to assess the changes in the cell apoptosis, cell cycle and cell proliferation index (PI) of the cells.</p><p><b>RESULTS</b>NDV infection resulted in decreased survivin expression and increased apoptosis of TSCCa cells, with reduced cell percentage in G2/M and S phases and lowered PI of the cells, showing significant differences from those of the negative control cells (P<0.05).</p><p><b>CONCLUSION</b>NDV infection can inhibit survivin expression, affect the cell cycle of TSCCa cells and induce their apoptosis.</p>


Asunto(s)
Humanos , Apoptosis , Fisiología , Western Blotting , Carcinoma de Células Escamosas , Metabolismo , Patología , Virología , Ciclo Celular , Fisiología , Línea Celular Tumoral , Interacciones Huésped-Patógeno , Proteínas Inhibidoras de la Apoptosis , Proteínas Asociadas a Microtúbulos , Genética , Virus de la Enfermedad de Newcastle , Fisiología , Reacción en Cadena de la Polimerasa de Transcriptasa Inversa , Neoplasias de la Lengua , Metabolismo , Patología , Virología
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