Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Añadir filtros








Intervalo de año
1.
China Journal of Chinese Materia Medica ; (24): 1067-1070, 2011.
Artículo en Chino | WPRIM | ID: wpr-252940

RESUMEN

<p><b>OBJECTIVE</b>To explore the protective effects and mechanism of ethanol extract of Inonotus obliquus (EEIO) injection on asthmatic mice.</p><p><b>METHOD</b>OVA was injected intraperitoneally and inhaled to produce the asthmatic model. Thirty two mice were randomly divided into four groups: control group, asthma group and I. obliquus groups of high and low dose. The concentrations of IL-4, IL-5, IL-13 and IFN-gamma in BALF, the phosphor-p38 MAPK in lung tissues were respectively measured by ELISA and Western blotting. The number of inflammatory cells in BALF and histopathology changes were observed.</p><p><b>RESULT</b>In asthmatic group, the number of inflammatory cells and the concentrations of IL-4, IL-5, IL-13 in BALF and phospho-p38 MAPK in lung tissue were higher, while IFN-gamma were lower than those in normal control mice (P < 0.05). In I. obliquus group, the number of inflammatory cells, the concentrations of IL-4, IL-5, IL-13 in BALF and phosphor-p38 MAPK in lung tissue were lower, but were higher than those in normal control mice (P < 0.05), and histropathology damage was alleviated significantly. There was no significant difference observed among the efficacies in the I. obliquus groups of high and low dose.</p><p><b>CONCLUSION</b>p38 MAPK may play a role in pathological process of asthma. I. obliquus effectively treats asthma by inhibiting the expression of phosphor-p38 MAPK, correcting the unbalance of IFN-gamma/IL-4 and decreasing the number of inflammatory cells.</p>


Asunto(s)
Animales , Ratones , Antiasmáticos , Farmacología , Asma , Quimioterapia , Metabolismo , Patología , Basidiomycota , Química , Basófilos , Metabolismo , Líquido del Lavado Bronquioalveolar , Biología Celular , Alergia e Inmunología , Modelos Animales de Enfermedad , Interferón gamma , Metabolismo , Interleucina-13 , Metabolismo , Interleucina-4 , Metabolismo , Interleucina-5 , Metabolismo , Pulmón , Patología , Linfocitos , Metabolismo , Ratones Endogámicos BALB C , Neutrófilos , Metabolismo , Fitoterapia , Extractos Vegetales , Farmacología , Proteínas Quinasas p38 Activadas por Mitógenos , Metabolismo
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA