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Journal of Veterinary Science ; : 177-180, 2009.
Artículo en Inglés | WPRIM | ID: wpr-151429

RESUMEN

The presence of galectin-3 was immunohistochemically quantified in bovine intestines infected with paratuberculosis (Johne's disease) to determine whether galectin-3 was involved in the formation of granulation tissue associated with the disease. Mycobacterium avium subsp. paratuberculosis infection was histochemically confirmed using Ziehl-Neelsen staining and molecularly diagnosed through rpoB DNA sequencing. Galectin-3 was detected in the majority of inflammatory cells, possibly macrophages, in the granulomatous lesions within affected tissues, including the ileum. These findings suggest that galectin-3 is associated with the formation of chronic granulation tissues in bovine paratuberculosis, probably through cell adhesion and anti-apoptosis mechanisms.


Asunto(s)
Animales , Bovinos , Enfermedades de los Bovinos/patología , Enfermedad Crónica , Galectina 3/metabolismo , Inmunohistoquímica , Intestino Delgado/microbiología , /crecimiento & desarrollo , Paratuberculosis/patología , ARN Polimerasa II/genética
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