RESUMEN
Pegylated liposomal doxorubicin is an important antineoplastic agent with activity in a variety of solid tumors. It has a totally different profile of pharmacokinetics and toxicity compared with doxorubicin. It rarely causes side-effects like cardiotoxicity or hair loss, but frequently results in many kinds of mucocutaneous reactions, including palmar-plantar erythrodysesthesia, diffuse follicular rash, intertrigo-like eruption, new formation of melanotic macules, stomatitis and radiation recall dermatitis. We present a rare case of multiple myeloma who immediately developed serious stomatitis and esophatitis associated with minor palmar-plantar erythrodysesthesia after a single course of pegylated liposomal doxorubicin.
.Asunto(s)
Anciano , Femenino , Humanos , Antibióticos Antineoplásicos/efectos adversos , Doxorrubicina/análogos & derivados , Esofagitis/inducido químicamente , Síndrome Mano-Pie/etiología , Estomatitis/inducido químicamente , Doxorrubicina/efectos adversos , Esofagitis/patología , Mucosa Gástrica/efectos de los fármacos , Síndrome Mano-Pie/patología , Mucosa Bucal/efectos de los fármacos , Mieloma Múltiple/complicaciones , Mieloma Múltiple/tratamiento farmacológico , Polietilenglicoles/efectos adversos , Estomatitis/patologíaRESUMEN
Immunoglobulin light chain amyloidosis is the most common acquired systemic amyloidosis. Its presentation is often insidious and progressive, which may delay diagnosis. The authors describe a rare case of immunoglobulin light chain amyloidosis in a 34-year-old man with scleroderma-like manifestation substantiated by multifarious laboratory investigations and the histopathologic feature of involved skin lesions stained with Congo red and crystal violet. This helps to maintain a high clinical suspicion of the disease when confronting similar skin presentation.