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Rev. Soc. Bras. Med. Trop ; 54: e01452020, 2021. tab, graf
Artículo en Inglés | SES-SP, ColecionaSUS, LILACS | ID: biblio-1143891

RESUMEN

Abstract INTRODUCTION: We evaluated the association between genetic polymorphisms in exon 1 (A/O alleles) and promoter regions at positions -550 (H/L variant, rs11003125) and -221 (X/Y variant, rs7096206) MBL2 and periportal fibrosis regression. METHODS: This was a retrospective cohort study involving 114 Brazilians infected with Schistosoma mansoni, who were subjected to follow-up for three years after specific treatment for schistosomiasis to estimate the probability of periportal fibrosis regression. RESULTS: A risk association was observed between polymorphism at the exon 1 MBL2 and periportal fibrosis regression. CONCLUSIONS: This study suggests that the polymorphism of exon 1 MBL2 may potentially be used to predict periportal fibrosis regression in this population.


Asunto(s)
Humanos , Animales , Esquistosomiasis/genética , Lectina de Unión a Manosa/genética , Polimorfismo Genético , Brasil , Exones/genética , Estudios Retrospectivos , Predisposición Genética a la Enfermedad , Polimorfismo de Nucleótido Simple , Genotipo , Cirrosis Hepática/genética
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