RESUMEN
Background: Pomegranate is a medical plant with antioxidant effects. The aim of the study was to investigate the effect of pomegranate juice on pituitary- thyroid axis in adult male rats
Materials and methods: In this experimental study, 50 adult male rats with mean weight body of 200 +/- 20 gr were divided in to 5 groups of 10 rat each: control, sham, and three experimental groups which received in minimal pomegranate juice [3ml per day], medium [6ml per day], and maximal amounts [9ml per day], respectively, for 10 days using gavage method. One day after the last gavage, the blood sample collected by bloodletting from the heart. After preparing serum, the level of T3, T4, and TSH hormones were measured using ELISA method
Results: Mean body weight in experimental groups didn't show any significant difference in comparison with control and sham groups. Serum levels of T3 hormone in groups receiving maximum dose of pomegranate juice showed significant decrease compared to control and sham groups. Serum level of T4 hormone in experimental groups received pomegranate juice showed significant decrease compared to control and sham groups. Serum level of TSH hormone in minimum dose of pomegranate juice showed significant increase compared to control and sham groups
Conclusion: Pomegranate juice reduced pituitary-thyroid axis activity in adult male rats
RESUMEN
Background: Thioacetamide is a liver toxin that causes centrilobular necrosis. In this study, the protective effect of fish oil omega3 supplements and aqueous extract of Glycyrrhiza glabra root against disorder in liver enzymes level induced by thioacetamide in male rats was investigated
Materials and methods: In this experimental study, 63 male rats were divided into 9 groups: The control group, the sham group, the thioacetamide group, the experimental groups 1-6. Experimental groups received a daily dose of 100, 200 and 300 mg/kg fish oil omega-3 supplements and the aqueous extract of Glycyrrhiza glabra root orally respectively for 3 month followed by an inter peritoneal dose of 150 mg/kg thioacetamide at the end of the experiment. The serum levels of SGOT, SGPT, ALP, GGT and LDH were measured
Results: The serum level of SGPT showed a significant decrease in the experimental groups 1, 5 and 6 compared to the group received thioacetamide. The serum level of GGT showed a significant decrease in the experimental groups 1, 2, 5 and 6 compared to the group received thioacetamide. The serum levels of SGOT, ALP and LDH in all experimental groups did not show significant changes compared to the group received thioacetamide [P<0.05]
Conclusion: Fish oil omega3 supplements and aqueous extract of Glycyrrhiza glabra root had protective effects against disorder in liver enzymes level induced by thioacetamide in male rats
RESUMEN
Background: Diabetes mellitus is a major endocrine disorder and growing health problem in most countries. We studied effects of Avicennia marina fruits aqueous and hydroalcoholic extract in the diabetic rat by streptozotocin
Materials and methods: In this experimental study, 45 male rats were divided into 9 groups of 5, including sham group, diabetes sham, positive sham [diabetes + 0.9% normal saline] and treated diabetic groups orally with aqueous and hydroalcoholic extract of Avicennia marina fruits [30, 60, 120 mg/kg daily for three consecutive days]. Twenty-four hours after the last treatment rats, blood samples were collected from heart for determining the blood glucose and insulin concentration levels using glucose oxidase and enzyme-linked immunosorbent assay [ELISA] methods respectively
Results: All doses of Avicennia marina fruits aqueous and hydroalcoholic extract significantly decreased serum glucose level of diabetic test rats compared to treated diabetic sham rats. 60mg/kg of Avicennia marina fruits hydroalcoholic extract and all doses of Avicennia marina fruits aqueous extract significantly increased serum insulin level of diabetic test rats compared to treated diabetic sham rats
Conclusion: In this study, we have shown that Avicennia marina fruits aqueous and hydroalcoholic extract can significantly decrease the blood glucose
RESUMEN
Background: Thioacetamide causes kidney dysfunction. Medical plants had been used to cure some kidney diseases. The present study was done to evaluate the protect effects of aqueous extract of Glycyrrhiza glabra root on disorder of kidney functions induced by thioacetamide in male rats
Materials and methods: In this experimental study, 35 male rats were divided into 5 groups: control group, sham group received a single dose of 150mg/kg thioacetamide intraperitoneally, experimental groups 1, 2 and 3 received the aqueous extract of Glycyrrhiza glabra root at the doses of 100, 200, and 300mg/kg daily orally during 3 months respectively and then a single dose of thioacetamide at 150 mg/kg as intraperitoneal injection. The serum levels of creatinine, BUN, sodium and potassium were measured
Results: Pretreatment with the aqueous extract of Glycyrrhiza glabra root at all doses increased the serum level of BUN compared to thioacetamide group, but there was no significant difference. Pretreatment with the aqueous extract of Glycyrrhiza glabra root at all doses significantly reduced serum levels of potassium and sodium compared to thioacetamide group. Pretreatment with 300 mg/kg of aqueous extract of Glycyrrhiza glabra root significantly reduced serum level of creatinine compared to thioacetamide group
Conclusion: Results showed protective effects of aqueous extract of Glycyrrhiza glabra root on functional kidney disorders induced by thioacetamide in male rats. The protective effects of this extract can be due to its antioxidant effects
RESUMEN
Background: Components of olive oil include oleic acid, hydrocarbons [as squalene], sterols [as betasitosterol], polyphenols [tyrosol, hydroxyltyrosol, oleuropeinand, and others], tocopherols and terpenoids. Olive oil ingredients have anti-inflammatory, antioxidant, anti-arrhythmic, anti-inflammatory and vasodilatory effects. The present study was done to evaluate the effects of olive oil on kidney, lipid and liver function in male rat
Materials and methods: In this experimental study, 14 male rats were divided into 2 groups. In control group, each rat underwent no stress such as injection, oral gavage and etc. in experimental group, each rat received 0.4 mL olive oil orally per day for 3 months. All animals bled after 3 months. The blood samples were tested for creatinine, nitrogen urea blood [BUN], total cholesterol, LDL and HDL cholesterol, triglyceride, sodium, glucose, SGOT, SGPT, ALP, GGT, albumin and total protein serum levels
Results: No significant differences were noticed in sodium, BUN, total cholesterol, LDL cholesterol, HDL cholesterol and triglyceride serum levels in rats treated with olive oil compared to control group. There were no significant differences in SGOT, SGPT, ALP, GGT, albumin and total protein serum levels between rats treated with olive oil and control group
Conclusion: The results showed that olive oil had no effects on kidney, lipid and liver function