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Acta cir. bras ; 35(2): e202000205, 2020. graf
Artículo en Inglés | LILACS | ID: biblio-1130618

RESUMEN

Purpose To investigate the effects of induction of selective liver hypothermia in a rodent model. Methods Seven male Wistar rats were subjected to 90 minutes of partial 70% liver ischemia and topic liver 26°C hypothermia (H group). Other seven male Wistar rats were subjected to 90 minutes of partial 70% normothermic liver ischemia (N group). Five additional rats underwent a midline incision and section of liver ligaments under normothermic conditions and without any liver ischemia (sham group). All animals were sacrificed 24-h after reperfusion, and livers were sampled for analyses. Pathology sections were scored for sinusoidal congestion, ballooning, hepatocelllular necrosis and the presence of neutrophilic infiltrates. Results At the end of the experiment, liver tissue expressions of TNF-ɑ, IL-1β, iNOS and TNF-ɑ/IL-10 ratio were significantly reduced in the H group compared to N group, whereas IL-10 and eNOS were significantly increased in H group. Histopathological injury scores revealed a significant decrease in ischemia/reperfusion (I/R) injuries in H group. Conclusion Selective liver hypothermia prevented I/R injury by inhibiting the release of inflammatory cytokines, preserves microcirculation, prevents hepatocellular necrosis and leukocyte infiltration, allowing maintenance of the liver architecture.


Asunto(s)
Animales , Masculino , Ratas , Daño por Reperfusión/prevención & control , Lesión Pulmonar Aguda/prevención & control , Hipotermia Inducida/métodos , Hígado/irrigación sanguínea , Temperatura Corporal , Daño por Reperfusión/metabolismo , Daño por Reperfusión/patología , Citocinas/metabolismo , Factor de Necrosis Tumoral alfa , Ratas Wistar , Mediadores de Inflamación/metabolismo , Óxido Nítrico Sintasa/metabolismo , Modelos Animales de Enfermedad , Lesión Pulmonar Aguda/patología , Isquemia/patología , Hígado/patología , Necrosis/patología , Óxido Nítrico/metabolismo
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