RESUMEN
Effect of chronic treatment with hydralazine (40 mg/kg/day) on isolated heart, anococcygeus muscle and myometrial preparations from rats has been studied. The treatment for 6 weeks caused a significant increase in isoprenaline induced positive inotropic response in rat heart. However, isoprenaline induced positive chronotropic effects were not altered significantly by chronic hydralazine treatment. Chronic hydralazine treatment also failed to alter noradrenaline induced contractile effects on rat anococcygeus muscle. However, on myometrial preparations from hydralazine treated rats showed an increase in adrenaline induced relaxations. The results of the present study can be explained on the basis of the effect of hydralazine on adenylate cyclase-cyclic adenosine monophosphate (cAMP).
Asunto(s)
Animales , Femenino , Hidralazina/farmacología , Masculino , Ratas , Ratas Wistar , Factores de TiempoRESUMEN
The effect of nifedipine, a calcium antagonist on fasting blood glucose level, glucose tolerance, glucose-induced insulin and glucagon secretion was studied in healthy nondiabetic volunteers. Nifedipine 10mg twice daily for four weeks did not affect fasting blood glucose level, glucose tolerance, glucose-induced insulin and glucagon secretion.
Asunto(s)
Adulto , Glucemia , Humanos , Masculino , Nifedipino/farmacologíaAsunto(s)
Adulto , Humanos , Lípidos/sangre , Masculino , Metronidazol/farmacología , Nitroimidazoles/farmacología , Tinidazol/farmacologíaRESUMEN
Carbamazepine (CA) and sodium valproate (SV) were studied for their actions of central nervous system and neuromuscular junction. CA and SV given ip neither possessed analgesic nor hypothermic activity in rats, nor did they alter the pentobarbitone sleeping time in mice. The drug had no effect on the frog rectus muscle nor did they alter its responses to acetylcholine. Both CA and SV produced a dose related decrease in indirectly evoked contractions of rat diaphragm and cat gastrocnemius muscle without much altering the directly evoked responses. This effect may be due to their local anaesthetic property, which was observed in infiltration test in guinea pigs.
Asunto(s)
Animales , Anuros , Temperatura Corporal/efectos de los fármacos , Carbamazepina/farmacología , Gatos , Sistema Nervioso Central/efectos de los fármacos , Potenciales Evocados/efectos de los fármacos , Ratones , Contracción Muscular/efectos de los fármacos , Unión Neuromuscular/efectos de los fármacos , Conejos , Ratas , Sueño/efectos de los fármacos , Factores de Tiempo , Ácido Valproico/farmacologíaAsunto(s)
Acetilcolina/farmacología , Animales , Atropina/farmacología , Calcio/farmacología , Interacciones Farmacológicas , Epinefrina/farmacología , Histamina/farmacología , Contracción Miocárdica/efectos de los fármacos , Potasio/farmacología , Conejos , Ranidae , Especificidad de la Especie , Ácido Valproico/farmacologíaRESUMEN
Six basic amides were screened for local anaesthetic activity and compared with procaine and lignocaine. Amongst the basic amides screened, piperidino-N-(alpha-4-ethoxy phenyl- beta-phenyl) ethyl and Diethylamino-N (alpha-4-ethoxy- beta-phenyl) ethyl acetamide were found to be more effective as compared to lignocaine. They were found to be non-irritant, and non-toxic even in high doses.