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China Journal of Chinese Materia Medica ; (24): 2152-2155, 2007.
Artículo en Chino | WPRIM | ID: wpr-307489

RESUMEN

<p><b>OBJECTIVE</b>To observe the effect of Bushen Yiqi Hexue recipe on endometrial P21 and PCNA expression of embryo implantation dysfunctional mice.</p><p><b>METHOD</b>The expression of P21 protein was analyzed by means of immunoblot and immunohistochemical method. The expression of PCNA protein was analyzed by means of immunohistochemical method.</p><p><b>RESULT</b>The expression and disappearance of P21 and PCNA protein in endometrium of embryo implantation dysfunctional mice lagged behind in a temporal and cell specific manner. Bushenyiqihexue recipe could improve the expression of P21 and PCNA protein in a temporal and cell specific manner, and then improve the decidual reaction of endometrium of embryo implantation dysfunctional mice.</p><p><b>CONCLUSION</b>Improving the expression of P21 and PCNA protein in endometrium and eventually regulating endometrium decidual reaction is one of the mechanisms of improved embryo implantaion by Bushen Yiqi Hexue recipe.</p>


Asunto(s)
Animales , Femenino , Ratones , Inhibidor p21 de las Quinasas Dependientes de la Ciclina , Metabolismo , Combinación de Medicamentos , Medicamentos Herbarios Chinos , Farmacología , Implantación del Embrión , Fisiología , Endometrio , Metabolismo , Immunoblotting , Inmunohistoquímica , Plantas Medicinales , Química , Antígeno Nuclear de Célula en Proliferación , Metabolismo
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