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Objective:To study changes of serum concentrations of high mobility group protein B1 (HMGB1),endo- thelin (ET )-1 and macrophage migration inhibitory factor (MIF ) in patients with type 2 diabetes mellitus (T2DM)complicated coronary heart disease (CHD)and explore their correlations with inflammatory factors.Meth-ods:The 120 patients with T2DM+ CHD treated in our hospital from May 2013 to Sep 2014 were enrolled in obser-vation group,including 30 cases with SAP,30 cases with UAP,30 cases with NSTEMI and 30 cases with STEMI. Another 30 T2DM cases without cardiovascular diseases during the same period were enrolled as pure DM group.En- zyme linked immunosorbent assay was used to measure concentrations of HMGB1,ET-1,MIF,CRP,TNF-α,IL-6, IL-8,IL-17 and IL-23,and they were compared among above groups.Results:Compared with pure DM group, there were significant rise in serum concentrations of HMGB1 [(3.49±0.52)μg/L vs.(9.18±1.02)μg/L],ET- 1 [(104.54±12.56)ng/L vs.(256.56±34.16)ng/L],MIF [(87.78±10.52)ng/L vs.(178.32±21.34)ng/L], CRP [(6.28±0.84)mg/L vs.(16.52±2.15)mg/L],TNF-α[(8.54±1.09)ng/L vs.(21.91±2.76)ng/L],IL- 6 [(2.25±0.34)ng/L vs.(6.34±0.82)ng/L],IL-8 [(7.23±0.94)ng/L vs.(15.41±1.97)ng/L],IL-17 [(65.34±8.32)ng/L vs.(141.62±20.18)ng/L]and IL-23 [(125.22±14.23)ng/L vs.(321.12±41.54)ng/L] in observation group,P<0.05 or <0.01. The serum concentrations of HMGB1,ET-1 and MIF were SAP group
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Objective:To analyze the correlation among serum adiponectin (APN) ,heme oxygenase‐1 (HO‐1) con‐centrations and severity of coronary lesion in patients with acute coronary syndrome (ACS) .Methods :A total of 78 ACS patients ,who hospitalized and received therapy in our hospital from Oct 2013 to Oct 2014 ,were enrolled as ACS group .According to severity of coronary lesion ,they were further divided into single vessel coronary disease group (single vessel group ,n=15) ,double‐vessel coronary disease group (double‐vessel group ,n=37) and multi‐vessel coronary disease group (multi‐vessel group , n = 26 ) . Another 72 subjects without coronary heart disease (CHD) ,who received physical examination in our hospital during the same period ,were selected as non‐CHD con‐trol group .Serum concentrations of APN and HO‐1 were measured in all groups . The correlation among serum APN ,HO‐1 concentrations and severity of coronary lesion were analyzed .Results:Compared with non‐CHD con‐trol group ,there were significant reductions in serum concentrations of APN [ (15.27 ± 2.31) mg/L vs .(5.73 ± 0.88) mg/L] and HO‐1 [ (55.09 ± 8.63)μg/L vs .(23.17 ± 3.09)μg/L] in ACS group ,P<0.01 both .Compared with single vessel group ,there were significant reductions in serum concentrations of APN [(9.72 ± 1.13) mg/L vs . (7.05 ± 0.93) mg/L vs .(4.23 ± 0.52) mg/L] and HO‐1 [(38.16 ± 7.52)μg/L vs .(28.17 ± 5.31)μg/L vs .(20.32 ± 3.28)μg/L] in double‐vessel group and multi‐vessel group ,and those of multi‐vessel group were significantly low‐er than those of double‐vessel group ,P<0.05 or <0.01 .Linear regression analysis indicated that serum concentra‐tions of APN and HO‐1 were significant inversely correlated with severity of coronary lesion (B= -2.869 , -2.742 , P<0.05 ,<0.01 respectively) .Conclusion:Serum concentrations of APN and HO‐1 significantly reduce in ACS patients ,and their levels are significant inversely correlated with severity of coronary lesion ,so they are help‐ful to judging patient's condition and guiding treatment .
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Objective: To analyze the correlation among serum adiponectin (APN), heme oxygenase-1 (HO-1) concentrations and severity of coronary lesion in patients with acute coronary syndrome (ACS). Methods: A total of 78 ACS patients, who hospitalized and received therapy in our hospital from Oct 2013 to Oct 2014, were enrolled as ACS group. According to severity of coronary lesion, they were further divided into single vessel coronary disease group (single vessel group, n=15), double-vessel coronary disease group (double-vessel group, n=37) and multi-vessel coronary disease group(multi-vessel group, n=26). Another 72 subjects without coronary heart disease (CHD), who received physical examination in our hospital during the same period, were selected as non-CHD control group. Serum concentrations of APN and HO-1 were measured in all groups. The correlation among serum APN, HO-1 concentrations and severity of coronary lesion were analyzed. Results: Compared with non-CHD control group, there were significant reductions in serum concentrations of APN [(15.27±2.31) mg/L vs. (5.73±0.88) mg/L] and HO-1 [(55.09±8.63) μg/L vs. (23.17±3.09) μg/L] in ACS group, P<0.01 both. Compared with single vessel group, there were significant reductions in serum concentrations of APN[(9.72±1.13) mg/L vs. (7.05±0.93) mg/L vs. (4.23±0.52) mg/L] and HO-1 [(38.16±7.52) μg/L vs. (28.17±5.31) μg/L vs. (20.32±3.28) μg/L] in double-vessel group and multi-vessel group, and those of multi-vessel group were significantly lower than those of double-vessel group, P<0.05 or <0.01. Linear regression analysis indicated that serum concentrations of APN and HO-1 were significant inversely correlated with severity of coronary lesion (r=-2.869, -2.742, P<0.05 both). Conclusion: Serum concentrations of APN and HO-1 significantly reduce in ACS patients, and their levels are significant inversely correlated with severity of coronary lesion, so they are helpful to judging patient’s condition and guiding treatment.
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Neurolymphomatosis(NL) is characterized by lymphomatous infiltration of the peripheral nervous system. We report a case of neurolymphomatosis(NL) which was confirmed by sural nerve biopsy. Sural nerve specimen from a 49-year-old female patient with weakness of limbs was examined with routine histochemical and immunohistochemistry staining, in which the first antibodies against CD3, CD20, CD45, CD45RO and CD68 were used. Numerous T-lymphoma cells invaded in the adipose tissue of epineurium of sural nerve. The nerve biopsy showed marked axonal degeneration of myelinated fibers. The clinical and histopathologic findings confirmed the diagnosis of neurolymphomatosis.