Clinical analysis of 10 cases of olfactory neuroblastoma / 浙江大学学报·医学版

<p><b>OBJECTIVE</b>To review the diagnosis, treatment and prognosis of olfactory neuroblastoma.</p><p><b>METHODS</b>Clinical data were retrospectively reviewed in 10 cases of olfactory neuroblastoma admitted from 1998 to 2002, including data of transmission electron microscopic (TEM) observation in 4 cases. According to Kadish's classification, 2 cases were in stage A, 4 in stage B and 4 in stage C. Three patients were treated with surgery alone, 7 with combined surgery and radiation.</p><p><b>RESULT</b>Among 10 cases, the overall 5-year survival rate was 60 %(6/10); 3 patients died from local recurrence, 1 lost follow-up. TEM demonstrated granules in the cytoplasm of 3 patients.</p><p><b>CONCLUSION</b>The combined surgery and radiation can achieve excellent local control. Transmission electron microscope is important for its diagnosis.</p>

Management of sinonasal inverted papilloma: endoscopic approach and lateral rhinotomy / 浙江大学学报·医学版

<p><b>OBJECTIVE</b>To compare endoscopic approach with lateral rhinotomy for treatment of the sinonasal inverted papilloma in terms of advantage, indications and limitations of the procedures.</p><p><b>METHODS</b>Eighty-six cases with inverted papilloma were reviewed retrospectively, among which 23 cases underwent transnasal endoscopic procedures including 10 combined with Caldwell-Luc intervention, and 63 cases underwent lateral rhinotomy. The follow-up period ranged from 11 - 36 m (mean 23 m). The data were processed statistically by SPSS 10.0 software.</p><p><b>RESULT</b>Both procedures permitted removal of most sinonasal inverted papilloma. The endoscopic surgery provided an excellent visualization, and preserved a vital anatomic structure and left no facial scar. Lateral rhinotomy was associated with postoperative facial scar or deformity. The recurrence rate in lateral rhinotomy group was 9.5% and in endoscopic approach was 13% (P >0.05).</p><p><b>CONCLUSION</b>Endoscopic approach is favored for the treatment of non-massively extending sinonasal inverted papilloma because of an acceptable recurrence and a better cosmetic results.</p>