Asunto(s)
Adenosina/farmacología , Animales , Aspirina/farmacología , Plaquetas/efectos de los fármacos , AMP Cíclico/sangre , Femenino , Inosina/farmacología , Masculino , Adhesividad Plaquetaria/efectos de los fármacos , Agregación Plaquetaria/efectos de los fármacos , Pruebas de Función Plaquetaria , ConejosRESUMEN
The acute effect of single dose of ethanol (1.5 g kg) and aspirin (10 mg/kg) alone and in combination, on platelet aggregation time and platelet adhesiveness were studied in rabbits. There was a significant and comparable increase in aggregation time both by aspirin and ethanol. Similarly platelet adhesiveness was decreased by both the agents.
Asunto(s)
Animales , Aspirina/farmacología , Etanol/farmacología , Femenino , Masculino , Adhesividad Plaquetaria/efectos de los fármacos , Agregación Plaquetaria/efectos de los fármacos , ConejosRESUMEN
Platelet functions (platelet aggregation and adhesiveness) were studied in volunteers of different blood groups. The platelet aggregation time was found to be significantly (P less than 0.01) more in blood group O as compared A, B and AB blood groups. Similarly, platelet adhesive index was higher in A, B and AB blood groups when compared to that of blood group O. The administration of a single dose of aspirin (4 mg/kg, po) increased the platelet aggregation time and reduced the platelet adhesive index in all the blood groups.
Asunto(s)
Aspirina/farmacología , Antígenos de Grupos Sanguíneos , Femenino , Humanos , Masculino , Adhesividad Plaquetaria/efectos de los fármacos , Agregación Plaquetaria/efectos de los fármacosRESUMEN
Platelet aggregation time was significantly (P less than 0.01) decreased in female rabbits treated with oral contraceptive (a preparation containing low dose of estrogen) as also by injection of diethylstilbestrol (10 mg/kg), while in animals that received indomethacin (10 mg/kg) or aspirin (30 mg/kg) (PG synthetase inhibitors) along with oral contraceptives or diethylstilbestrol there was no significant alteration in platelet aggregation time. The increased synthesis of prostaglandins or some of the intermediary product like TXA2 might be responsible for this effect.