RESUMEN
This study reported the preparation of some new bridgehead nitrogen compounds using the beta-keto ester and indane-1,3-dione with 3-amino- 1,2,4-triazole and aminobenzimidazole
Asunto(s)
Compuestos de Nitrógeno/farmacología , Análisis Espectral/métodosRESUMEN
The pyrazolo [1,5-a] pyrimidine derivatives IV and VI underwent pyrimidine ring opening, then recyclized when heated with aqueous alcoholic alkali solution to give the corresponding pyrazolo [3,4-b] pyridine V and VII, respectively. In a similar manner, the triazolo [4,3-a] pyrimidine VIII underwent recyclization to the corresponding triazolo [1,5-a] pyrimidine IX
Asunto(s)
Pirimidinas/síntesis química , Pirimidinas/análogos & derivadosRESUMEN
The biindone I reacted with morpholine or piperidine and formaldehyde to give the corresponding Mannich bases IIa-b. Treatment of I with formaldehyde, and formaldehyde in AcOH, afforded II and IV, respectively. Compounds V and VI were prepared by treating I with benzaniline and isatinanil, respectively. Coupling of I with benzenediazonium chloride led to the formation of VII
Asunto(s)
Química , Aminas/química , Compuestos de DiazonioRESUMEN
In alcoholic methylamine solution, 2-alkylpyrimidines underwent rearrangement to 2-methylaminopyridines. Similarly, in alkaline medium, even a nonquaternized 2-methyl-5-nitropyrimidine formed 2-amino-5-nitropyridine