RESUMEN
To investigate the role of biochemical changes in the umbilical cord and placenta in developing preeclampsia [PE]. Thirty women with PE and 15 healthy pregnant women as controls were enrolled in this study. Vascular endothelial growth factor [VEGF], soluble vascular endothelial growth factor receptor 1 [sVEGFR-1], platelet-derived endothelial cell growth factor [PD-ECGF], neutrophil elastase and nitric oxide [NO] were measured. Both serum [maternal and fetal] and tissue [placenta and umbilical cord] levels of VEGF, sVEGFR-1, PD-ECGF and neutrophil elastase were significantly increased, whereas NO was significantly decreased [except placental tissue showed no changes] in preeclamptic patients. The cord serum level of PD-ECGF was significantly higher in severe PE compared to mild PE and normal pregnant women. The placental and cord tissue levels of PD-ECGF and neutrophil elastase were significantly higher in severe PE, while the cord tissue level of NO was significantly lower in severe PE. Our data showed that umbilical cord vessels and stroma can serve as an additional source of vasoactive and angiogenic substances that contribute to the biochemical Changes OCCUrring in PE
RESUMEN
The synthesis and in vitro antimicrobial evaluation of 5-arylglyoxylidenethiazolidine -2, 4-diones and 5-[arylglyoxaylidene, arylidene- and isatinly idene]-3 phenacyl thiazoldine-2, 4-diones are described. Some of the products displayed a week activity when tested for in vitro antimicrobial properties against Staphlocaoccus aureus and Candida albicans but did not shown any effect on Escherichia coli