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Asia Pacific Allergy ; (4): 203-209, 2012.
Artículo en Inglés | WPRIM | ID: wpr-749907

RESUMEN

Recent technical approaches to investigating drug hypersensitivity have provided a great deal of information to solve the mechanisms that remain poorly understood. First, immunological investigations and in silico analysis have revealed that a novel interaction between T cells and antigen-presenting cells, namely the pharmacological interaction concept, is involved in drug recognition and the hapten theory. Second, progress in immunology has provided a new concept of CD4+ T cell subsets. Th17 cells have proven to be a critical player in acute generalized exanthematous pustulosis. Our recent findings suggest that this subset might contribute to the pathogenesis of Stevens-Johnson syndrome/toxic epidermal necrolysis. Third, alarmins, molecules associated with innate immunity, are also associated with exaggeration and the persistence of severe drug hypersensitivity. The latest innovative techniques are providing a new landscape to examine drug hypersensitivity.


Asunto(s)
Pustulosis Exantematosa Generalizada Aguda , Alarminas , Alergia e Inmunología , Células Presentadoras de Antígenos , Simulación por Computador , Hipersensibilidad a las Drogas , Hipersensibilidad , Inmunidad Innata , Receptores de Antígenos de Linfocitos T , Subgrupos de Linfocitos T , Linfocitos T , Células Th17
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