RESUMEN
Objective To investigate the correlation between NAD (P)H oxidase p22phox C242T polymorphism and transient ischemic attack (TIA). Methods This study involved 138 Chinese patients with TIA and 130 control subjects, from whom genomic DNA was obtained to determine the p22phox C242T polymorphism using polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). Results The CT genotype frequencies in the TIA group and control group were 0.268 and 0.139, respectively, and no TT genotype was found. The CT genotype and T allele frequency of the TIA group was significant higher than that of the control group (p<0.05). Conclusion The NAD(P)H oxidase p22phox C242T polymorphism may serve as a risk factor for TIA.
RESUMEN
<p><b>OBJECTIVE</b>Genic susceptibility could increase the risk of transient ischemic attack (TIA). The objective of this study is to investigate the relationship between the polymorphism of platelet glycoprotein GPIb α Kozak gene and TIA in Qindao Han population.</p><p><b>METHODS</b>The polymorphisms of platelet glycoprotein GPIb α Kozak gene -5T/C in TIA patients and normal control were detected with sequence-specific primers polymerase chain reaction (PCR-SSP).</p><p><b>RESULTS</b>The prevalence of the CC genotype and C alleles were significantly higher in TIA patients than in the control group (P<0.05). The positive correlation between C allele and TIA was showed by logistic regression analysis (P=0.016).</p><p><b>CONCLUSION</b>The -5T/C polymorphism of the platelet glycoprotein GPIb α Kozak gene is implicated in the pathogenesis of TIA. C allele is an independent risk factor for TIA.</p>