RESUMEN
Curacron profenofos is 0-[4-Bromo-2 chlorophenyl]-O-ethyi-S-propyl phosphorothioate. Its chemical formula C11H15BrCIO3PS. It is a broad-spectrum organophosphorous insecticide for control of pests in cotton growing areas. Inhibition of acetyi and pseudocholinesterase by this compound results in signs and symptoms of toxicity signs and symptoms [cholinergic syndrome]: bradycardia, respiratory-circulatory arrest, vomiting and diam'iea in a variety of animals including man. In this work experiments were carried out in vivo to study its effect on the activity of AChE enzyme obtained from whole and five different parts of rat brain, namely basal ganglia, frontal cortex, medulla oblongata, pons, and cerebellum. This work was carried out by 2 experiments: Exp. A: Depending on the dose of intraperitoneal infusion of curacon. Exp. B: Depending on the time course post infusion of a constant dose of curacron 100 mg/kg BW [dose causing 50% inhibition] in vivo. The results showed that the inhibition occurred in all brain parts, but it was highly marked in the enzyme obtained from the cerebellum [the part responsible for balance and coordination of movements]. The results also indicated that the inhibition of AChE produced by i.p. injection with curacon was dose and time dependent
RESUMEN
The purpose of this study is to evaluate the usefulness of echo-cardiography in the detection of valvular cardiac affection in rheumatic patients without clinically evident carditis. Thirty rheumatic patients without evidence of carditis or murmur were examined clinically and were further assessed by laboratory investigations and with echocardiography with the Toshiba 270 ultrasound phase array scanner. The results proved that rheumatic valvulitis was detected in 33% of patients by echocardiography in spite of absense of clinical signs. Echocardiography is a valuable and sensitive diagnostic tool for sub-clinical cardiac affection in acute rheumatic fever, that is not detected by clinical and auscultatory findings