RESUMEN
OBJECTIVE: The aim of this study is to prove the clinical significance by evaluating pregnancy outcomes from intrauterine growth restriction using waves of the Doppler velocimetry of uterine and umbilical artery and amniotic fluid index. METHODS: Throughout the period of January 2000 to May 2005 at our hospital, we reviewed 127 cases diagnosed with intrauterine growth restriction after 24 weeks of pregnancy and the existences of diastolic notch of uterine artery (DNUT), absent or reversed end-diastolic velocity of umbilical artery (AEDV) and oligohydramnios were considered abnormal. We set the group that had no abnormal signs as the control group (62 cases), and respectively compared the groups that had oligohydramnios (24 cases), unilateral DNUT (27 cases), bilateral DNUT (10 cases) and AEDV (13 cases) with the control group. And we compared the groups that had only one abnormal sign, that is oligohydramnios (20 cases), bilateral DNUT (7 cases), AEDV (7 cases) and the group showing 2 or more complicated abnormal signs those above (9 cases) with the control group. RESULTS: Perinatal outcomes such as preterm birth, low birth weight, lower 5-min Apgar score (A/S), neonatal acidosis, admission rate of neonatal intensive care unit (NICU) and perinatal mortality were poor statistically in groups with DNUT, AEDV and oligohydramnios compared to those which have none of these abnormal signs. And those with DNUT had worse results when affected on both sides. And those with AEDV showed worse perinatal outcomes compared to those with bilateral DNUT or oligohydramnios; any overlapping of these abnormal signs indicated worse perinatal outcomes, which had statistic significance. CONCLUSION: Close observation of the fetal well-being by analysis on the wave velocimetry of the blood flow such as the uterine arteries and umbilical arteries and the measurement of the amniotic fluid volume enables predicting the perinatal prognosis of the intrauterine-growth restricted fetuses which may contribute in reducing the perinatal morbidity and mortality.
Asunto(s)
Femenino , Humanos , Recién Nacido , Embarazo , Acidosis , Líquido Amniótico , Puntaje de Apgar , Feto , Recién Nacido de Bajo Peso , Cuidado Intensivo Neonatal , Mortalidad , Oligohidramnios , Mortalidad Perinatal , Resultado del Embarazo , Nacimiento Prematuro , Pronóstico , Reología , Arterias Umbilicales , Arteria UterinaRESUMEN
OBJECTIVE: To compare the clinical results between laparoscopically assisted vaginal hysterectomy (LAVH) and total vaginal hysterectomy (TVH). METHODS: We reviewed the medical records of patients who underwent LAVH and TVH from January 2002 to December 2004 in 00 university hospital without the history of uterine prolapse or pelvic relaxation. We evaluated age, parity, previous abdominal operations, indication of hysterectomy, size of the uterus, operation time, hemoglobin change, hospital day, the degree of postoperative pain and initiation of diet and postoperative complications. RESULTS: The age and parity of the patients in both groups were not different statistically. There were history of previous abdominal operations in 20.8% of LAVH group and 25.3% of TVH group which didn't have statistic significance. Major indications of the operation were uterine myomas in both groups. The average weight of the extracted uterus were 272.9+/-114.5 gm and 225.6+/-87.0 gm in the LAVH group and the TVH group respectively which had significance, and the operation time were 81.1+/-23.4 minutes and 71.1+/-37.8 minutes respectively which had significance. There were no difference in the hemoglobin drop of the postoperative day 1, but the hemoglobin drop of the postoperative day 4 was larger in the LAVH group. Postoperative complications occurred more often in the TVH group (15.2%) than LAVH group (11.9%) but didn't have significance, and the complications were treated by conservative managements and observation of the progress. And also the hospital day, the degree of postoperative pain and initiation of diet had no significance. CONCLUSION: Both LAVH and TVH had no statistic difference in the postoperative morbidity and recuperation. Moreover the indications of operation for both surgeries had no statistic difference, but LAVH had a preference for the larger size of uterus. Furthermore in order to increase the satisfactions of patients and remedy the weak points of procedures, research on the indications and contra-indications between the operative approaches and training on the operative procedures are required.
Asunto(s)
Femenino , Humanos , Dieta , Histerectomía , Histerectomía Vaginal , Leiomioma , Registros Médicos , Dolor Postoperatorio , Paridad , Complicaciones Posoperatorias , Relajación , Procedimientos Quirúrgicos Operativos , Prolapso Uterino , ÚteroRESUMEN
OBJECTIVE: Comparative genomic hybridization (CGH) is a new fluorescence in situ hybridization (FISH) technique to identify genomic aberrations in cancers. The purpose of this study was to analyze non-random chromosomal DNA aberrations involved in cervical squamous cell carcinoma cell lines from Korean women. METHODS: We analyzed non-random chromosomal DNA aberrations involved in cervical squamous cell carcinoma cell lines from Korean women, SNU-17, SNU-682, and SNU-902 using CGH. RESULTS: Chromosomal DNA gains of 5p, 5q22-q23, 8q11.2-q12, 14q21-qter, and 20 as well as chromosomal DNA losses of 21 were found frequently. Chromosomal DNA gains on chromosome 3q, 6P, 7p13-pter, 9p22-pter, 9q21-qter, 15q21-q22, 17q22-qter, 18p11.3-pter, 18q11.2-q21, 19p13.3-pter, 19q13.2-q13.3, and 22q12-qter, with losses on 4p14-pter, 10p11.2-p13 and 10q24 were observed in 2 of 3 cell lines. CONCLUSION: Non-random aberrations which were disclosed in this study might be candidate regions for the abnormal genes involved in the tumorigenesis of cervical squamous cell carcinomas. Datas about chromosomal aberrations of Korean squamous cell carcinoma cell lines in this study could afford very useful basic information for the development of diagnostic and therapeutic modalties targeting the abnormal genes associated with uterine cervical cancer in Korea.
Asunto(s)
Femenino , Humanos , Carcinogénesis , Carcinoma de Células Escamosas , Línea Celular , Aberraciones Cromosómicas , Hibridación Genómica Comparativa , ADN , Fluorescencia , Hibridación in Situ , Corea (Geográfico) , Neoplasias del Cuello UterinoRESUMEN
An ultrasonographic examination revealed increased fetal bladder size and decreased AFI as well as fetal bilateral hydronephrosis at 173weeks' gestation. Diagnosis of the fetal posterior urethral valve syndrome was made. Percutaneous fetal bladder puncture with aspiration and amniocentesis was performed. The fetus was normal male karyotype and with a predicted good renal function(sodium concentration, chloride concentration, and osmolarity at 74 mEq/L, 60 mEq/L, and 148 mOsm, respectively). So, the fetus underwent amnioinfusion and vesico-amniotic shunting procedure (VASP) using a double-basket catheter at 194weeks' gestation in order to prevent development of dysplastic kidneys and hypoplastic lungs. The healthy male baby was delivered at 384weeks' gestation and had normally functioning kidney. Cutaneous vesicostomy was performed for the newborn since the urethral orifice was small. The one year old infant is now well and waiting for urethroscopic valve ablation procedure.
Asunto(s)
Humanos , Lactante , Recién Nacido , Masculino , Embarazo , Amniocentesis , Catéteres , Cistostomía , Diagnóstico , Feto , Hidronefrosis , Cariotipo , Riñón , Pulmón , Concentración Osmolar , Punciones , Vejiga UrinariaRESUMEN
OBJECTIVE: This study was performed to evaluate the effects of oral administration of iron supplements during pregnancy on maternal hemoglobin concentrations and birth weights. METHOD: Data from clinical records of 141 pregnant women and their babies were analysed. Studied mothers were classified to 3 groups such as non iron supplement group (groupI), 2-3 months supplement group (group II), and over 4 months supplement group (group III) by the duration (months) of oral supplement prescribed. RESULTS: There was positive correlation between hemoglobin levels and iron supplement duration. Proportions of anemia showed decreasing basis with the increasing iron supplement duration. The maternal hemoglobin levels showed decreasing basis with the increasing birth weight. There was positive correlation between iron supplement duration and maternal hemoglobin levels, but there was no significant correlation between iron supplement duration and birth weight. For the groupI(non-supplement group), maternal hemoglobin levels were decreased with the increasing birth weight but there was no significant correlations between hemoglobin levels and birth weights with increased iron supplement duration. CONCLUSION: There was a significant inverse correlation between maternal hemoglobin levels and birth weight in non-iron supplement group but there was no significant correlations between hemoglobin levels and birth weights with increased iron supplement duration.
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Femenino , Humanos , Embarazo , Administración Oral , Anemia , Peso al Nacer , Hierro , Madres , Parto , Mujeres EmbarazadasRESUMEN
Isolated fetal ascites may be different from general category of nonimmune hydrops in both prenatal course and prognosis. We experienced one case of isolated fetal ascites of unknown origin treated by in utero ultrasound-directed paracentesis and so present it with brief review of literature.