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Artículo en Chino | WPRIM | ID: wpr-282592

RESUMEN

<p><b>OBJECTIVE</b>To characterize the profile of chromosomal imbalances in esophageal cancer (EC) with or without family history in Linzhou, Henan Province of China.</p><p><b>METHODS</b>Comparative genomic hybridization (CGH) was used to examine 13 cases with positive family history of EC and 32 cases with negative family history of EC. RESULTS DNA copy number gains on chromosome 10q was observed only in the cases with postivie family history of EC (30%), and none in cases with a negative family history (P<0.05). DNA copy number losses on chromosome 15q were significantly higher in cases with postivie family history (38% vs 6%, P<0.05). The frequency of DNA copy number gains in 3q, 5p, 7p, 8q and DNA copy number losses in 3p, 19q, 9q were similar in the two groups (both beyond 20%) (P>0.05).</p><p><b>CONCLUSIONS</b>Frequent DNA copy number gains on chromosome 10q and losses on chromosome 15q in EC casers with postivie family history indicate that these chromosome sites may harbor the genes related to high susceptibility to EC. Such chromosomal sites as 3q, 5p, 7p, 8q, 3p, 19q, and 9q may contain important genes related with the environmental risk factors of esophageal carcinogenesis.</p>


Asunto(s)
Adulto , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , China , Trastornos de los Cromosomas , Genética , Cromosomas Humanos Par 10 , Genética , Cromosomas Humanos Par 15 , Genética , Hibridación Genómica Comparativa , Métodos , Neoplasias Esofágicas , Genética , Salud de la Familia , Eliminación de Gen , Predisposición Genética a la Enfermedad , Genética
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