A Case of Doxifluridine-Induced Ro/SSA-Positive Cutaneous Lupus Erythematosus / 대한피부과학회지

Anti-Ro/SSA antibody positive drug-induced lupus erythematosus is characterized by erythematous papules at the photodistributed area after drug intake, positive anti-Ro/SSA antibody tests and histopathologic features of lupus erythematosus. A 68-year-old man was referred to our clinic with multiple erythematous violacious plaques on the face of 2 months' duration. After surgical removal of stomach cancer, he had been taking doxifluridine for 10 months. A histopathologic study revealed findings consistent with lupus erythematosus and the anti-Ro/SSA antibody was positive on the serologic test. Based on these findings, we diagnosed this case as anti-Ro/SSA antibody positive drug-induced lupus erythematosus, and report it with review of the literature.

Occupational Contact Urticaria Syndrome Induced by Cefotiam Dihydrochloride in a Nurse

We herein report a case of occupational contact urticaria syndrome induced by cefotiam di-hydrochloride in a nurse. She had generalized pruritic wheals accompanied by palpitations and tachypnea during the preparation of cefotiam solution. A scratch patch test with cefotiam di-hydrochloride, a major component of cefotiam ingredient showed multiple erythema and wheals within 5 minutes, accompanied by palpitations and tachypnea. No delayed type reaction was observed. Based on her clinical history and scratch test result, we diagnosed her condition as contact urticaria syndrome caused by cefotiam.

A Case of Trichoadenoma / 대한피부과학회지

Trichoadenoma is a rare benign tumor and it appears as a solitary tumor on the face and buttock. Histologically, it is characterized by numerous horny cysts lined with stratified squamous epithelium and solid epithelial tumor nests. This tumor is less mature than trichofolliculoma and more differentiated than trichoepithelioma, and it is considered as a tumor with differentiation toward the infundibular portion of the pilosebaceous canal. A 39-year-old woman presented with asymptomatic, solitary, 1.5x1.5 cm sized, pedunculated mass on her buttock for 2 years. Histopathologic examination showed characteristic features of trichoadenoma. Trichoadenoma is so rare that only 3 cases have been reported in the Korean literature.

A Case of Tufted Hair Folliculitis after Scalp Injury / 대한피부과학회지

Tufted hair folliculitis is a progressive, recurrent and inflammatory disease of the scalp characterized by a tufted appearance of the hairs and may result in permanent scarring alopecia. A 41-year-old man presented with tufted hairs within a 3x4cm sized indurated cicatrical patch which is getting wider. He had a scalp laceration history to the lesion 1 year ago. Histopathologic findings showed widened follicular infundibulum, dense perifollicular inflammatory cell infiltrations and dermal fibrosis. We report a case of tufted hair folliculitis developed secondarily to the scalp injury.

Two Cases of Granulation Tissues Arising on the Periungual Area / 대한피부과학회지

Granulation tissues may arise around the nail in response to trauma to the nail or to ingrowing nails. Drugs, such as retinoids or antiviral agents may be the cause of granulation tissue of the whole body or nails. We experienced two cases of granulation tissue developed on the proximal nail folds and subungual area after putting on tight cast and Korean traditional socks respectively. We reported the cases with review of the literature.

A Case of Annular Pustular Psoriasis / 대한피부과학회지

Pustular psoriasis refers to a group of disorder characterized by recalcitrant, sterile pustular eruption. It classified into four clinical patterns: Zumbusch, annular, exanthematous, and localized. Annular pustular psoriasis consists of gyrate, annular lesions with an erythematous, scaly, pustular margin. In contrast to the Zumbusch variety, the annular type is benign and less severe. We herein report a case of annular pustular psoriasis of a 9-year-old girl with review of the literature.

A Case of Primary Cutaneous CD30 Negative Large T cell Lymphoma / 대한피부과학회지

Primary CD30 negative large T cell lymphomas consist of CD30 negative large tumor cells without prior or concurrent mycosis fungoides. Clinically, it presents with solitary, localized or generalized plaques, nodules, or tumors and most cases show an aggressive clinical course. The histologic appearance may be identical to that of classic mycosis fungoides undergoing transformation into large cell lymphoma and large tumor cells represent at least 30 percent of the total tumor cell population. We experienced a case of CD30 negative large T cell lymphoma and report it with a review of literatures.

A Case of Acute Generalized Exanthematous Pustulosis with Erythema Multiforme-like lesions / 대한피부과학회지

Acute generalized exanthematous pustulosis(AGEP) is a disease entity caused mostly by drugs or viral infections. Clinically, it manifests as generalized erythema and tiny pustules with fever, but may manifest targetoid lesions, purpura, edema, blisters and mucosal erosions in addition to pustules. We describe a case of AGEP with erythema multiforme-like features in a 46 year old woman who presented with acute onset of high fever and a noticeably polymorphic eruption consisting of numerous tiny pustules on erythematous bases, edematous targetoid lesions and purpuric lesions. The histology revealed subcorneal neutrophilic pustules on the tiny pustular lesions and markedly papillary dermal edema on the erythema multiforme-like lesions. Systemic corticosteroid and antihistamines were initiated, resulting in rapid resolution without recurrence.

A Case of Nasal Glioma / 대한피부과학회지

Nasal glioma is a rare, benign, congenital tumor, which is ectopic sequested brain tissue that has lost its intracranial connection. It is thought to be the result of an abnormality in embryonic development. A 2-month-old female patient presented with firm, noncompressible, pinkish, 0.6 cm-diameter, protruding mass on the glabella from birth. No intracranial connection was found by MRI. Histopathological finding showed an unencapsulated pale-staining fibrillary glial tissue, which contains astrocytes and some neurons. Immunohistochemically, the glial tissue and astrocytes were positive for GFAP(glial fibrillary acidic protein), and neurons were positive for NSE(neuron-specific enolase).

A Case of Bowen's Disease on the Vulva / 대한피부과학회지

Bowen's disease was originally described by Bowen in 1912 and is believed to be a squamous cell carcinoma in situ. It develops on any part of the skin surfaces or mucous membranes. But the lesions on the vulvar region are relatively rare. The gross appearance of vulvar lesion, which shows erosion, ulceration or pigmentation, is different from that of typical Bowen's disease. We, herein, report a case of Bowen's disease arising on a vulvar region with a review of the literature.

A Case of Acral Type Acanthosis Nigricans Associated with Lymphoma / 대한피부과학회지

Acanthosis nigricans is a symmetric eruption characterized by a hyperpigmented, velvety cutaneous thickening that can develop on any part of the body, but characteristically affects the flexural area of the body. But many dark-skinned people have velvety hyperkeratosis of the dorsum of the hands and feet, a variant of acanthosis nigricans called acral acanthotic anomaly or acral type acanthosis nigricans. Malignant acanthosis nigricans is associated with a malignant tumor-most commonly an abdominal, and particularly a gastric carcinoma. To our knowledge, this is the first report of acral type acanthosis nigricans associated with non-Hodgkin"s lymphoma.

A Case of Porokeratosis Developing after Immunosuppression Therapy in Renal Transplant Patient / 대한피부과학회지

We report a case of a 55-year-old male renal transplant patient, who showed 1 cm sized six round brownish macules on both arms and legs for 8 months. These lesions were stable without change in size or number and histopathologically were consistent with the finding of porokeratosis. We think that this lesion is the mixed type which shares the character of Mibelli's porokeratosis and disseminated superficial actinic porokeratosis.

A Case of Acral Persistent Papular Mucinosis

Acral persistent papular mucinosis is a subtype of the localized papular mucinosis. Clinically, ivory to flesh-colored papules develop exclusively on the back of the hands, the extensor surface of the wrists, and occasionally the distal forearms. Histologically, mucin accumulates in the upper reticular dermis, typically sparing a subepidermal zone and fibroblasts are not increased in number. On experiencing a case of numerous papules on both hands and forearms of a fifty year-old woman, we present it as acral persistent papular mucinosis.