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Chinese Journal of Natural Medicines (English Ed.) ; (6): 937-941, 2015.
Artículo en Inglés | WPRIM | ID: wpr-812461

RESUMEN

The present study was designed to isolate and purify chemical constituents from solid culture of endophyte Aspergillus terreus LQ, using silica gel column chromatography, gel filtration with Sephadex LH-20, and HPLC. Fumigaclavine I (1), a new alkaloid, was obtained, along with seven known compounds, including fumigaclavine C (2), rhizoctonic acid (3), monomethylsulochrin (4), chaetominine (5), spirotryprostatin A (6), asperfumoid (7), and lumichrome (8). The structure of compound 1 was elucidated by various spectroscopic analyses (UV, MS, 1D and 2D NMR). The in vitro cytotoxicity of compound 1 was determined by MTT assay in human hepatocarcinoma cell line SMMC-7721, showing weaker cytotoxicity, compared with cisplatin, a clinically used cancer chemotherapeutic agent.


Asunto(s)
Humanos , Antineoplásicos , Química , Aspergillus , Química , Línea Celular Tumoral , Supervivencia Celular , Endófitos , Química , Alcaloides de Claviceps , Química , Espectroscopía de Resonancia Magnética , Estructura Molecular , Oryza , Microbiología
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