Holt-Oram Syndrome Rare Hand-Heart Disorder

Back ground: Holt-Oram is rare autosomal disorder, clinically characterised by congenital cardiac defects and morphological abnormalities of the upper limbs. Case characteristics:10 days old neonate born to first degree consangunious parents presented with upper limb anomaly and cardiac defects. Obseravations : Hypoplastic left thumb with ASD, VSD and PDAwas present. Message- Neonate with upper limb anomaly should be evaluated for congenital hear disease