Microbial toxicity of juliflorine, julifloricine and benzene insoluble alkaloidal fraction of prosopis juliflora

Juliflorine, julifloricine and benzene insoluble alkaloidal fraction of Prosopis juliflora, which have been found to possess atimicrobial activity, were studied in vitro for microbial toxicity by Pseudomonas Fluorescens test and genotoxicity by Ames Salmonella/Microsomal mutagenicity test. In P. Fluorescens system, EC50 values were determined as 120.2 micro g/ml for juliflorine; 524.8 micro g/ml for julifloricine and 112.2 micro g/ml for benzene insoluble alkaloidal fraction. Thus the fraction is more toxic and julifloricine least - on other hand the fraction has strong antibacterial activity. None of the alkaloidal was found mutagenic up to 500 micro g per plate and hence these are noncarcinogenic

Comparative study on susceptibility of Leishmania isolated from dermal leishmaniasis to antifungal drug terbinafine and classic antileishmanial drugs

Antileishmanial activity of Terbinafine, Sodium stibogluconate and Meglumine antimoniate against Leishmania tropica promastigotes was compared. The minimum inhibitory concentration [MIC] of Terbinafine was 400 g/ml of fluid phase of medium while MIC of Sodium stibogluconate was 750 g/ml of fluid phase of medium. In case of Meglumine antimoniate, 1000 g/ml failed to inhibit the growth of L tropica promastigotes. Thus, in vitro effect of Terbinafine was superior to Sodium stibogluconate and Meglumine antimoniate in terms of concentration of drug required to inhibit the growth of L. tropica promastigotes