Hepatoprotective effect of carnosine on liver biochemical parameters in chronic ethanol intoxicated Rat

The aim of the present study is to investigate the effect of ethanol and the action of carnosine treatment on certain liver parameters, enzymes, total proteins and glycogen in rats. These enzymes including Krebs cycle enzyme: succinate dehydrogenase [SDH]; glycolytic enzymes: lactate dehydrogenase [LDH] d its isoenzymes; glycogenolytic metabolic machineries: glycogen phosphorylase, G-6-Pase and glycoge" drolytic enzymes: acid phosphatase [AP] and alkaline phosphatase [ALP]; amino acid metabolic enzymes aspartate aminotransferase [AST] and alanine aminotransferase [ALT] and nucleic acid catabolic enzyme: 5-nucleotidase. The chronic ethanol-intoxicated rats showed a marked disturbance in all the parameters measured, indicating the toxic effect of ethanol by inducing oxidative stress on liver tissue. Administration of carnosine ameliorated the toxic effects of ethanol

Biochemical modifications induced in rabbits by schistosoma mansoni antigens and the beneficial effect of carnosine treatment

This immunological study involved individual injection of the three Schistosoma mansoni antigens [Ags], soluble egg antigen [SEA], cercarial antigen preparation [CAP] or soluble worm antigen preparation [SWAP] in three rabbits groups [Ag], respectively. Three other groups each received the same specific antigen conjoined with administration of L-carnosine [Ag-C] were also included in this study. Determination of three hepatic parameters and ten serum proteins was done. These were total protein, glycogen content and glycogen phosphorylase b activity of liver as well as serum total protein and nine protein fractions [alpha 2-macrglobulin, beta galactosidase, phosphorylase b, serum albumin, fumarase, carbonic anhydrase, beta- lactoglobulin, alpha-lactalbumin and aprotinin]. Conjoined carnosine treatment produced numerous variations. SEA-I-C group presented sex decreased parameters. In CAP-I-C animals, hepatic glycogen content was increased; while phosphorylase b activity was decreased as well as the concentration of serum parameters, total serum protein, alpha2-macroglobulin, phosphorylase b, albumin, fumarase, carbonic anhydrase, alpha-lactalbumin and aprotinin. In SWAP-I-C group, the concentration of only one fraction was decreased; carbonic anhydrase. In batch A, both the Ags. of the egg and cercaria, developmental stages having transient residence in the animal host, showed more affection by the specific Ag. Although, carnosine modified the results of all the three groups in batch B, its effect on both the egg and cercaria Ags. was still more than that of worm

Promoting effects of carnosine on serum proteins in normal and partially hepatectomized mice

The effect of carnosine administration for 15 and 30 days on 13 different serum proteins, total protein, albumin, prealbumin, alpha-and beta-lipoproteins, alpha-1-macroglobulin, alpha-1 acid glycoprotein, alpha-1 antitrypsin, cholinesterase, ceruloplasmin, hemopexin, haptoglobin and transferrin and 3 liver parameters [DNA, RNA and weight] were investigated in healthy [HC] and partially hepatectomized [PHC] mice. HC15 days animals presented 4 increased parameters, while the PHCl5 days mice presented 11 promoted parameters. In 30 days groups, HC30 days mice demonstrated increased 13 parameters, while the PHC30 days showed promotion of all parameters. These results pointed to the protein promoting effect of carnosine in both normal and partially hepatectomized mice. However, the more actively regenerating liver cells in the operated mice were more labile to stimulation by carnosine administration

Hepatoprotective effect of carnosine on liver biochemical parameters in chronic ethanol intoxicated rat

The aim of the present study was to investigate the effect of ethanol and the action of carnosine treatment on certain liver parameters; enzymes, total proteins and glycogen in rats. These enzymes including krebs cycle enzyme [succinate dehydrogenase [SDH]], glycolytic enzymes [lactate dehydrogenase [LDH]] and its isoenzymes [glycogenolytic], metabolic machineries [glycogen phosphorylase, G-6-Pase [G-6-P ase]] and glycogen [hydrolytic enzymes] acid phosphatase [AP] and alkaline phosphatase [ALT], amino acid metabolic enzymes [aspartate aminotransferase [AST] and alanine aminotransferase [ALT]] and nucleic acid catabolic enzyme [5'-nucleotidase]. The chronic ethanol-intoxicated rats showed a marked disturbance in all the measured parameters indicating the toxic effect of ethanol by inducing oxidative stress on liver tissue. Administration of carnosine ameliorated the toxic effect of ethanol by enhancement all of the measured parameters

Effect of carnosine administration on certain metabolic parameters in Bilharzial infected hamsters

This study was designed to test the ability of carnosine to cure the metabolic disturbances induced by Schistosoma mansoni parasite. Results indicated that, parasitic infection caused elevation of liver weight/body weight of S. mansoni infected hamsters, induced lipid peroxidation and reduced glycogen level. Moreover, the adenylate energy charge [AEC], ATP/ADP and ATP/AMP concentration ratios were markedly lower in infected hamsters. Administration of carnosine [10 mg/day] for 15 days either concurrent with infection, two and four weeks post exposure was effective in reducing worm burden and egg count only when given at the time of infection. It was also effective in renormalizing most of the measured parameters confirming the glycogen repletion, the antioxidant and AEC correcting actions of carnosine