1.
Indian J Physiol Pharmacol
;
1994 Jul; 38(3): 223-5
Artículo
en Inglés
| IMSEAR
| ID: sea-108692
RESUMEN
Neem leaf alcoholic extract (NLE) was investigated for its effects on the ECG and blood pressure of rat. Intravenous administration of NLE (100, 300 and 1000 mg/kg) resulted in initial bradycardia followed by cardiac arrhythmia in rats. NLE produced a significant and dose-related fall in blood pressure which was immediate, sharp and persistent. Pre-treatment with either atropine or mepyramine failed to prevent the hypotensive effect of NLE.