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Southeast Asian J Trop Med Public Health ; 1997 Dec; 28(4): 838-43
Artículo en Inglés | IMSEAR | ID: sea-32098

RESUMEN

Features of Schistosoma mansoni infection in SCID mice, which lack functional T- and B-lymphocytes, were investigated. The retarded development of parasites as well as reduction of liver egg recovery in SCID mice was significantly lower than those in congenic counterpart C.B-17 mice. Furthermore, the rate of parasite recovery from SCID mice with primary infection was always lower than that from C.B-17 mice by 20%, showing the innate resistance to S. mansoni infection. SCID mice vaccinated with UV-attenuated S. mansoni cercariae did not show protective immunity against a homologous challenge infection. The present innate resistance exhibited in SCID mice is discussed in relation to cell mediated immunity of macrophage activation by IFN-gamma which would not involve T-lymphocytes but is initiated by IL-12 and TNF-alpha cytokines. SCID mice may provide novel information on the host-parasite relationship in schistosome infections.


Asunto(s)
Animales , Femenino , Interacciones Huésped-Parásitos/inmunología , Masculino , Ratones , Ratones Endogámicos/parasitología , Ratones SCID/parasitología , Schistosoma mansoni/inmunología , Esquistosomiasis mansoni/inmunología , Factores de Tiempo
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