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Biol. Res ; 35(2): 231-238, 2002. ilus
Artículo en Inglés | LILACS | ID: lil-323346

RESUMEN

Thy-1 is an abundant neuronal glycoprotein in mammals. Despite such prevalence, Thy-1 function remains largely obscure in the absence of a defined ligand. Recently described evidence that Thy-1 interacts with beta 3 integrin on astrocytes will be discussed. Thy-1 binding to beta 3 integrin triggers tyrosine phosphorylation of focal adhesion proteins in astrocytes, thereby promoting focal adhesion formation, cell attachment and spreading. Thy-1 has been reported to modulate neurite outgrowth by triggering a cellular response in neurons. However, our data indicate that Thy-1 can also initiate signaling events that promote adhesion of adjacent astrocytes to the underlying surface. Preliminary results suggest that morphological changes observed in the actin cytoskeleton of astrocytes as a consequence of Thy-1 binding is mediated by small GTPases from the Rho family. Our findings argue that Thy-1 functions in a bimodal fashion, as a receptor on neuronal cells and as a ligand for beta 3 integrin receptor on astrocytes. Since Thy-1 is implicated in the inhibition of neurite outgrowth, signaling events in astrocytes are likely to play an important role in this process


Asunto(s)
Humanos , Animales , Antígenos Thy-1 , Astrocitos , Glicoproteínas de Membrana Plaquetaria , Transducción de Señal , Antígenos Thy-1 , Astrocitos , Glicoproteínas de Membrana Plaquetaria , Receptores de Vitronectina , Proteínas de Unión al GTP rho
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